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NTIS 바로가기SLAS discovery : Advancing life sciences R&D, v.22 no.6, 2017년, pp.655 - 666
Wang, Yanli (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA) , Cheng, Tiejun (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA) , Bryant, Stephen H. (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA)
퍼브켐 바이오애세이: 오픈 HTS(고속 대량 스크리닝) 데이터 공유를 향한 10년 동안의 개발
HTS(고속 대량 스크리닝)는 이제 제약 회사와 학술 기관 및 대학의 스크리닝 센터에서 약품 발견을 위해 일상적으로 실시됩니다. 분석 개발, 로봇 자동화 및 컴퓨터 기술의 급속한 발전으로 스크리닝 실험실에서 테라바이트의 데이터가 생성되고 있습니다. HTS 생산성 향상을 위한 기술 개발에도 불구하고 HTS 데이터 통합 및 공유에 대한 노력이 줄어 들었습니다. 그 결과 엄청난 양의 HTS 데이터가 거의 대중에게 공개되지 않았습니다. 이러한 격차를 메우고 화학 물질 및 RNAi 시약에 대해 테스트된 스크리닝 결과에 공개적으로 액세스할 수 있도록 2004년 퍼브켐 바이오애세이 데이터베이스(https://www.ncbi.nlm.nih.gov/pcassay/)가 설치되었습니다. 퍼브켐은 커뮤니티에서 10년이 넘는 개발과 기여를 통해 화학 구조 및 생물학 데이터와 관련된 가장 큰 공공 저장소로 진화했으며, 약물 개발, 의약 화학 연구 및 화학 생물학 연구를 지원하는 전세계 연구자에게 정보 플랫폼을 제공합니다. 여기에서는 퍼브켐 바이오애세이 데이터베이스의 HTS 데이터 내용과 정보 검색 및 데이터 공유를 자극하기 위한 데이터 증착 진행 상황에 대해 검토합니다. 또한 신규 사용자가 손쉽게 정보에 액세스하고 사용할 수 있도록 도와주는 데이터베이스의 데이터 표준 및 기본 유틸리티에 대해 설명합니다.
High-throughput screening (HTS) is now routinely conducted for drug discovery by both pharmaceutical companies and screening centers at academic institutions and universities. Rapid advance in assay development, robot automation, and computer technology has led to the generation of terabytes of data...
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