[논문]Diagnosis of Lymphoid Malignancy by PCR for Analysis of Antigen Receptor Rearrangement after Blood Transfusion in a Dog with Acute Lymphocytic Leukemia

Kim, Suhee; Kim, Hyunwoo; Lee, Soo-Hyeon; Cho, Ilhan; Kang, Seongwoo; Bae, Junwoo; Kim, Woosun; Ahn, Soomin; Choi, Jihye; Kim, Sang-Ki; Do, Yoonjung; Yoo, Jae Gyu; Park, Jinho; Yu, DoHyeon

doi:10.4110/in.2017.17.4.269

Diagnosis of Lymphoid Malignancy by PCR for Analysis of Antigen Receptor Rearrangement after Blood Transfusion in a Dog with Acute Lymphocytic Leukemia 원문보기

Immune network : official journal of the Korean association of immunobiologists, v.17 no.4, 2017년, pp.269 - 274

Kim, Suhee (Animal Diseases and Biosecurity Team, National Institute of Animal Science, Rural Development Administration, Wanju 55365, Korea .) , Kim, Hyunwoo (Department of Veterinary Laboratory Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea .) , Lee, Soo-Hyeon (Department of Companion & Laboratory Animal Science, College of Industrial Science, Kongju National University, Yesan 32439, Korea .) , Cho, Ilhan (Department of Veterinary Laboratory Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea .) , Kang, Seongwoo (Department of Veterinary Laboratory Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea .) , Bae, Junwoo (Department of Veterinary Laboratory Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea .) , Kim, Woosun (Department of Veterinary Laboratory Medicine, Co) , Ahn, Soomin , Choi, Jihye , Kim, Sang-Ki , Do, Yoonjung , Yoo, Jae Gyu , Park, Jinho , Yu, DoHyeon

Abstract ▼ AI-Helper

Acute lymphocytic leukemia (ALL) is uncommon lymphoid malignancy in dogs, and its diagnosis is challenging. A 14-year-old spayed female mixed breed dog was transferred to a veterinary medical teaching hospital for an immediate blood transfusion. The dog showed lethargy, pale mucous membranes, and a weak femoral pulse. Complete blood count revealed non-regenerative anemia and severe leukopenia with thrombocytopenia. ALL was tentatively diagnosed based on the predominance of immature lymphoblasts on blood film examination. For confirmation of lymphoid malignancy, PCR for antigen receptor rearrangement (PARR) on a peripheral blood sample and flow cytometry analysis were performed after blood transfusion. Flow cytometry analysis revealed that lymphocyte subsets were of normal composition, but PARR detected a T-cell malignancy. The dog was diagnosed with ALL and survived 1 wk after diagnosis. In conclusion, after blood transfusion, flow cytometry was not a reliable diagnostic method for an ALL dog, whereas PARR could detect lymphoid malignancy. Our results suggest that PARR should be the first-line diagnostic tool to detect canine lymphoid malignancy after a blood transfusion.

주제어

참고문헌 (11)

1 Leifer CE Matus RE Lymphoid leukemia in the dog. Acute lymphoblastic leukemia and chronic lymphocytic leukemia Vet Clin North Am Small Anim Pract 1985 15 723 739 3875921

상세보기
2 Adam F Villiers E Watson S Coyne K Blackwood L Clinical pathological and epidemiological assessment of morphologically and immunologically confirmed canine leukaemia Vet Comp Oncol 2009 7 181 195 19691647
3 Tasca S Carli E Caldin M Menegazzo L Furlanello T Gallego LS Hematologic abnormalities and flow cytometric immunophenotyping results in dogs with hematopoietic neoplasia: 210 cases (2002–2006) Vet Clin Pathol 2009 38 2 12 19171020

상세보기
4 Yu DH Li YH Lee JH Noh DH Song RH Lee MJ Choi US Park JH Detection of canine lymphoma by the amplification of antigen receptor gene rearrangements J Vet Clin 2009 26 419 422
5 Burnett RC Vernau W Modiano JF Olver CS Moore PF Avery AC Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes Vet Pathol 2003 40 32 41 12627711

상세보기
6 Lana SE Jackson TL Burnett RC Morley PS Avery AC Utility of polymerase chain reaction for analysis of antigen receptor rearrangement in staging and predicting prognosis in dogs with lymphoma J Vet Intern Med 2006 20 329 334 16594590

상세보기
7 Morris J Dobson JM Haematopoietic system Morris J Dobson JM Small Animal Oncology Malden, MA Blackwell Science 2001 228 251
8 Young KM Vail DM Canine acute myeloid leukemia, chronic myeloproliferative diseases, and myelodysplasia Withrow SJ MacEwen EG Vail DM Withrow & MacEwen's Small Animal Clinical Oncology 4th ed St. Louis, MO Saunders Elsevier 2007 756 768
9 Avery AC Avery PR Determining the significance of persistent lymphocytosis Vet Clin North Am Small Anim Pract 2007 37 267 282 vi 17336675

상세보기
10 Vernau W Moore PF An immunophenotypic study of canine leukemias and preliminary assessment of clonality by polymerase chain reaction Vet Immunol Immunopathol 1999 69 145 164 10507302

상세보기
11 Villiers E Baines S Law AM Mallows V Identification of acute myeloid leukemia in dogs using flow cytometry with myeloperoxidase, MAC387, and a canine neutrophil-specific antibody Vet Clin Pathol 2006 35 55 71 16511792

상세보기

LOADING...

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Diagnosis of Lymphoid Malignancy by PCR for Analysis of Antigen Receptor Rearrangement after Blood Transfusion in a Dog with Acute Lymphocytic Leukemia 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (11)

이 논문을 인용한 문헌

연구과제 타임라인

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Diagnosis of Lymphoid Malignancy by PCR for Analysis of Antigen Receptor Rearrangement after Blood Transfusion in a Dog with Acute Lymphocytic Leukemia 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (11)

이 논문을 인용한 문헌

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트