[논문]Does adenomatous polyposis coli gene promoter 1 A methylation increase non‐small cell lung cancer risk? A meta‐analysis

Hu, Baoli; Zhang, Hangfeng; Wei, Haitao; Wang, Zuopei; Zhang, Feng; Wang, Xiaolong; Li, Li

doi:10.1111/1759-7714.12450

Does adenomatous polyposis coli gene promoter 1 A methylation increase non‐small cell lung cancer risk? A meta‐analysis 원문보기

Thoracic cancer, v.8 no.5, 2017년, pp.410 - 416

Hu, Baoli (Department Cardiothoracic Surgery Huaihe Hospital of Henan University Kaifegn China) , Zhang, Hangfeng (Department Cardiothoracic Surgery Huaihe Hospital of Henan University Kaifegn China) , Wei, Haitao (Department Cardiothoracic Surgery Huaihe Hospital of Henan University Kaifegn China) , Wang, Zuopei (Department Cardiothoracic Surgery Huaihe Hospital of Henan University Kaifegn China) , Zhang, Feng (Department Cardiothoracic Surgery Huaihe Hospital of Henan University Kaifegn China) , Wang, Xiaolong (Department Cardiothoracic Surgery Huaihe Hospital of Henan University Kaifegn China) , Li, Li (Department of Clinical Teaching and Research, School of Nursing Henan University Kaifegn China)

Abstract ▼ AI-Helper

BackgroundThe promoter region of the adenomatous polyposis coli (APC) gene is hypermethylated in several types of cancers, including non‐small cell lung cancer (NSCLC). The prevalence of methylation in the promoter region of this gene in tumor tissues and autologous controls has not been consistent in previous studies. We evaluated the frequency of APC gene promoter 1A methylation between tumor tissues and autologous controls in NSCLC patients by meta‐analysis.MethodsOpen published studies of APC gene promoter 1A methylation between tumor tissues and autologous samples in NSCLC patients were identified using a systematic search. Odds ratios (OR) and 95% confidence intervals (CI) of APC gene promoter 1A methylation in lung cancer tissues versus autologous controls were calculated. Fourteen studies, involving a total of 1345 patients and 2182 samples, were finally included.ResultsThe pooled proportion of APC promoter 1A methylation was 0.62 (95% CI 0.52–072) and 0.34 (95% CI 0.21–0.50) in cancer tissues and autologous controls, respectively. The APC gene promoter 1A methylation rate in cancer tissues was much higher than in autologous controls, with a pooled OR of 3.66 (95% CI 2.12–6.33). A strong and significant correlation of APC gene promoter 1A methylation between tumor tissues and autologous controls was detected (correlation coefficient rpearson = 0.77; P = 0.0013).ConclusionThe proportion of APC promoter 1A methylation in lung cancer tissues was higher than in autologous controls, indicating that promoter 1A methylation of the APC gene may play an important role in NSCLC carcinogenesis.

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Does adenomatous polyposis coli gene promoter 1 A methylation increase non‐small cell lung cancer risk? A meta‐analysis 원문보기

Abstract ▼ AI-Helper

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