[논문]Mucin 1 Gene ( MUC1 ) and Gastric-Cancer Susceptibility

Saeki, Norihisa; Sakamoto, Hiromi; Yoshida, Teruhiko

doi:10.3390/ijms15057958

Mucin 1 Gene ( MUC1 ) and Gastric-Cancer Susceptibility 원문보기

International journal of molecular sciences, v.15 no.5, 2014년, pp.7958 - 7973

Saeki, Norihisa (Division of Genetics, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan) , Sakamoto, Hiromi (E-Mails: hsakamot@ncc.go.jp (H.S.)) , Yoshida, Teruhiko (tyoshida@ncc.go.jp (T.Y.))

Abstract ▼ AI-Helper

Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia. It is classified into intestinal and diffuse types. While the intestinal-type GC (IGC) is almost certainly caused by Helicobacter pylori (HP) infection, its role in the diffuse-type GC (DGC) appears limited. Recently, genome-wide association studies (GWAS) on Japanese and Chinese populations identified chromosome 1q22 as a GC susceptibility locus which harbors mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein. MUC1 has been known as an oncogene with an anti-apoptotic function in cancer cells; however, in normal gastric mucosa, it is anticipated that the mucin 1 protein has a role in protecting gastric epithelial cells from a variety of external insults which cause inflammation and carcinogenesis. HP infection is the most definite insult leading to GC, and a protective function of mucin 1 protein has been suggested by studies on Muc1 knocked-out mice.

주제어

참고문헌 (79)

1. Brenner H. Rothenbacher D. Arndt V. Epidemiology of gastric cancer Methods of Molecular Biology, Cancer Epidemiology Verma M. Humana Press Totowa, NJ, USA 2009 472 467
2. Yasui W. Sentani K. Motoshita J. Nakayama H. Molecular pathobiology of gastric cancer Scand. J. Surg 2006 95 225 231 17249269

상세보기
3. Peek R.M. Jr. Blaser M.J. Helicobacter pylori and gastrointestinal tract adenocarcinomas Nat. Rev. Cancer 2002 2 28 37 11902583

상세보기
4. Ricci V. Romano M. Boquet P. Molecular cross-talk between Helicobacter pylori and human gastric mucosa World J. Gastroenterol 2011 17 1383 1399 21472096
5. Forman D. Helicobacter pylori and gastric cancer Scand. J. Gastroenterol. Suppl 1996 220 23 26 8898432

상세보기
6. Pilpilidis I. Kountouras J. Zavos C. Katsinelos P. Upper gastrointestinal carcinogenesis: H. pylori and stem cell cross-talk J. Surg. Res 2011 166 255 264 20452613

상세보기
7. Fock K.M. Ang T.L. Epidemiology of Helicobacter pylori infection and gastric cancer in Asia J. Gastroenterol. Hepatol 2010 25 479 486 20370726

상세보기
8. Sakamoto H. Yoshimura K. Saeki N. Katai H. Shimoda T. Matsuno Y. Saito D. Sugimura H. Tanioka F. Kato S. Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer Nat. Genet 2008 40 730 740 18488030

상세보기
9. Saeki N. Saito A. Choi I.J. Matsuo K. Ohnami S. Totsuka H. Chiku S. Kuchiba A. Lee Y.S. Yoon K.A. A functional single nucleotide polymorphism in mucin 1 , at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer Gastroenterology 2011 140 892 902 21070779
10. Shi Y. Hu Z. Wu C. Dai J. Li H. Dong J. Wang M. Miao X. Zhou Y. Lu F. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1 Nat. Genet 2011 43 1215 1218 22037551

상세보기
11. Abnet C.C. Freedman N.D. Hu N. Wang Z. Yu K. Shu X.O. Yuan J.M. Zheng W. Dawsey S.M. Dong L.M. A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma Nat. Genet 2010 42 764 767 20729852

상세보기
12. Gibson G. Rare and common variants: Twenty arguments Nat. Rev. Genet 2012 13 135 145 22251874

상세보기
13. Palmer L.J. Cardon L.R. Shaking the tree: Mapping complex disease genes with linkage disequilibrium Lancet 2005 366 1223 1234 16198771
14. Hirakawa M. Tanaka T. Hashimoto Y. Kuroda M. Takagi T. Nakamura Y. JSNP: A database of common gene variations in the Japanese population Nucleic Acids Res 2002 30 158 162 11752280

상세보기
15. Yoshida T. Ono H. Kuchiba A. Saeki N. Sakamoto H. Genome-wide germline analyses on cancer susceptibility and GeMDBJ database: Gastric cancer as an example Cancer Sci 2010 101 1582 1589 20507324

상세보기
16. Miki D. Kubo M. Takahashi A. Yoon K.A. Kim J. Lee G.K. Zo J.I. Lee J.S. Hosono N. Morizono T. Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations Nat. Genet 2010 42 893 896 20871597

상세보기
17. Aoki A. Ozaki K. Sato H. Takahashi A. Kubo M. Sakata Y. Onouchi Y. Kawaguchi T. Lin T.H. Takano H. SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population J. Hum. Genet 2011 56 47 51 21107343

상세보기
18. Hirota T. Takahashi A. Kubo M. Tsunoda T. Tomita K. Doi S. Fujita K. Miyatake A. Enomoto T. Miyagawa T. Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population Nat. Genet 2011 43 893 896 21804548

상세보기
19. Low S.K. Takahashi A. Cha P.C. Zembutsu H. Kamatani N. Kubo M. Nakamura Y. Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA Hum. Mol. Genet 2012 21 2102 2110 22286173

상세보기
20. Onouchi Y. Ozaki K. Burns J.C. Shimizu C. Terai M. Hamada H. Honda T. Suzuki H. Suenaga T. Takeuchi T. A genome-wide association study identifies three new risk loci for Kawasaki disease Nat. Genet 2012 44 517 521 22446962

상세보기
21. Wu C. Wang G. Yang M. Huang L. Yu D. Tan W. Lin D. Two genetic variants in prostate stem cell antigen and gastric cancer susceptibility in a Chinese population Mol. Carcinog 2009 48 1131 1138 19554573

상세보기
22. Matsuo K. Tajima K. Suzuki T. Kawase T. Watanabe M. Shitara K. Misawa K. Ito S. Sawaki A. Muro K. Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese Int. J. Cancer 2009 125 1961 1964 19582881

상세보기
23. Lu Y. Chen J. Ding Y. Jin G. Wu J. Huang H. Deng B. Hua Z. Zhou Y. Shu Y. Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population Int. J. Cancer 2010 127 2183 2189 20131315

상세보기
24. Ou J. Li K. Ren H. Bai H. Zeng D. Zhang C. Association and haplotype analysis of prostate stem cell antigen with gastric cancer in Tibetans DNA Cell Biol 2010 29 319 323 20230293

상세보기
25. Lochhead P. Frank B. Hold G.L. Rabkin C.S. Ng M.T. Vaughan T.L. Risch H.A. Gammon M.D. Lissowska J. Weck M.N. Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals Gastroenterology 2011 140 435 441 21070776
26. Zeng Z. Wu X. Chen F. Yu J. Xue L. Hao Y. Wang Y. Chen M. Sung J.J. Hu P. Polymorphisms in prostate stem cell antigen gene rs2294008 increase gastric cancer risk in Chinese Mol. Carcinog 2011 50 353 358 21268123

상세보기
27. Song H.R. Kim H.N. Piao J.M. Kweon S.S. Choi J.S. Bae W.K. Chung I.J. Park Y.K. Kim S.H. Choi Y.D. Association of a common genetic variant in prostate stem-cell antigen with gastric cancer susceptibility in a Korean population Mol. Carcinog 2011 50 871 875 21538581

상세보기
28. Sala N. Muñoz X. Travier N. Agudo A. Duell E.J. Moreno V. Overvad K. Tjonneland A. Boutron-Ruault M.C. Clavel-Chapelon F. Prostate stem-cell antigen gene is associated with diffuse and intestinal gastric cancer in Caucasians: Results from the EPIC-EURGAST study Int. J. Cancer 2011 130 2417 2427 21681742
29. Ng W. Loh A.X. Teixeira A.S. Pereira S.P. Swallow D.M. Genetic regulation of MUC1 alternative splicing in human tissues Br. J. Cancer 2008 99 978 985 19238635

상세보기
30. Song H.R. Kim H.N. Kweon S.S. Choi J.S. Shim H.J. Cho S.H. Chung I.J. Park Y.K. Kim S.H. Choi Y.D. Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population Tumour Biol 2014 35 3133 3137 24254309

상세보기
31. Xu Q. Yuan Y. Sun L.P. Gong Y.H. Xu Y. Yu X.W. Dong N.N. Lin G.D. Smith P.N. Li R.W. Risk of gastric cancer is associated with the MUC1 568 A/G polymorphism Int. J. Oncol 2009 35 1313 1320 19885554

상세보기
32. Li F. Zhong M.Z. Li J.H. Liu W. Li B. Case-control study of single nucleotide polymorphisms of PSCA and MUC1 genes with gastric cancer in a Chinese Asian Pac. J. Cancer Prev 2012 13 2593 2596 22938426

원문보기 상세보기
33. Jia Y. Persson C. Hou L. Zheng Z. Yeager M. Lissowska J. Chanock S.J. Chow W.H. Ye W. A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer Cancer Causes Control 2010 21 313 321 19924550

상세보기
34. Palmer A.J. Lochhead P. Hold G.L. Rabkin C.S. Chow W.H. Lissowska J. Vaughan T.L. Berry S. Gammon M. Risch H. Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations Eur. J. Cancer Prev 2013 21 541 544 22805490
35. Zheng L. Zhu C. Gu J. Xi P. Du J. Jin G. Functional polymorphism rs4072037 in MUC1 gene contributes to the susceptibility to gastric cancer: evidence from pooled 6580 cases and 10,324 controls Mol. Biol. Rep 2013 40 5791 5796 24072653

상세보기
36. Carvalho F. Seruca R. David L. Amorim A. Seixas M. Bennett E. Clausen H. Sobrinho-Simões M. MUC1 gene polymorphism and gastric cancer—An epidemiological study Glycoconj. J 1997 14 107 111 9076520
37. Ho S.B. Niehans G.A. Lyftogt C. Yan P.S. Cherwitz D.L. Gum E.T. Dahiya R. Kim Y.S. Heterogeneity of mucin gene expression in normal and neoplastic tissues Cancer Res 1993 53 641 651 7678777

상세보기
38. Ho S.B. Shekels L.L. Toribara N.W. Kim Y.S. Lyftogt C. Cherwitz D.L. Niehans G.A. Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium Cancer Res 1995 55 2681 2690 7780985

상세보기
39. Utsunomiya T. Yonezawa S. Sakamoto H. Kitamura H. Hokita S. Aiko T. Tanaka S. Irimura T. Kim Y.S. Sato E. Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients Clin. Cancer Res 1998 4 2605 2614 9829723

상세보기
40. Reis C.A. David L. Seixas M. Burchell J. Sobrinho-Simões M. Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma Int. J. Cancer 1998 79 402 410 9699534

상세보기
41. Lee H.S. Lee H.K. Kim H.S. Yang H.K. Kim Y.I. Kim W.H. MUC1, MUC2, MUC5AC , and MUC6 expressions in gastric carcinomas: Their roles as prognostic indicators Cancer 2001 92 1427 1434 11745219
42. Wang R.Q. Fang D.C. Alterations of MUC1 and MUC3 expression in gastric carcinoma: Relevance to patient clinicopathological features J. Clin. Pathol 2003 56 378 384 12719460

상세보기
43. Wang J.Y. Chang C.T. Hsieh J.S. Lee L.W. Huang T.J. Chai C.Y. Lin S.R. Role of MUC1 and MUC5AC expressions as prognostic indicators in gastric carcinomas J. Surg. Oncol 2003 83 253 260 12884239

상세보기
44. Barresi V. Vitarelli E. Grosso M. Tuccari G. Barresi G. Relationship between immunoexpression of mucin peptide cores MUC1 and MUC2 and Lauren’s histologic subtypes of gastric carcinomas Eur. J. Histochem 2006 50 301 309 17213039

상세보기
45. Kocer B. Soran A. Kiyak G. Erdogan S. Eroglu A. Bozkurt B. Solak C. Cengiz O. Prognostic significance of mucin expression in gastric carcinoma Dig. Dis. Sci 2004 49 954 964 15309883

상세보기
46. Terada T. An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: II. Expression of MUC1, MUC2, MUC5AC , and MUC6 in normal mucosa and in 42 cases Int. J. Clin. Exp. Pathol 2013 6 613 621 23573307
47. Tanaka M. Kitajima Y. Sato S. Miyazaki K. Combined evaluation of mucin antigen and E-cadherin expression may help select patients with gastric cancer suitable for minimally invasive therapy Br. J. Surg 2003 90 95 101 12520583

상세보기
48. Ohno T. Aihara R. Kamiyama Y. Mochiki E. Asao T. Kuwano H. Prognostic significance of combined expression of MUC1 and adhesion molecules in advanced gastric cancer Eur. J. Cancer 2006 42 256 263 16356709

상세보기
49. Owen D.A. Stomach Histology for Pathologists Mills S.E. Lippincott Williams and Wilkins Philadelphia, PA, USA 2007 589
50. Reis C.A. David L. Correa P. Carneiro F. de Bolós C. Garcia E. Mandel U. Clausen H. Sobrinho-Simões M. Intestinal metaplasia of human stomach displays distinct patterns of mucin ( MUC1, MUC2, MUC5AC , and MUC6 ) expression Cancer Res 1999 59 1003 1007 10070955

상세보기
51. Vernygorodskyi S. Immunohistochemical evaluation of mucin expression in precancerous tissue of stomach Exp. Oncol 2013 35 114 117 23828387

상세보기
52. Jonckheere N. van Seuningen I. The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers Biochimie 2010 92 1 11 19818375

상세보기
53. Bafna S. Kaur S. Batra S.K. Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells Oncogene 2010 29 2893 2904 20348949

상세보기
54. Kufe D.W. Mucins in cancer: Function, prognosis and therapy Nat. Rev. Cancer 2009 9 874 885 19935676

상세보기
55. Gendler S.J. MUC1, the renaissance molecule Mammary Gland Biol. Neoplasia 2001 6 339 353
56. McAuley J.L. Linden S.K. Png C.W. King R.M. Pennington H.L. Gendler S.J. Florin T.H. Hill G.R. Korolik V. McGuckin M.A. MUC1 cell surface mucin is a critical element of the mucosal barrier to infection J. Clin. Investig 2007 117 2313 2324 17641781
57. Lindén S.K. Sheng Y.H. Every A.L. Miles K.M. Skoog E.C. Florin T.H. Sutton P. McGuckin M.A. MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy PLoS Pathog 2009 5 e1000617 19816567

상세보기
58. McGuckin M.A. Every A.L. Skene C.D. Linden S.K. Chionh Y.T. Swierczak A. McAuley J. Harbour S. Kaparakis M. Ferrero R. Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis Gastroenterology 2007 133 1210 1218 17919495
59. Vinall L.E. King M. Novelli M. Green C.A. Daniels G. Hilkens J. Sarner M. Swallow D.M. Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis Gastroenterology 2002 123 41 49 12105832
60. Li M. Huang L. Qiu H. Fu Q. Li W. Yu Q. Sun L. Zhang L. Hu G. Hu J. Helicobacter pylori infection synergizes with three inflammation-related genetic variants in the GWASs to increase risk of gastric cancer in a Chinese population PLoS One 2013 8 e74976 24069371

상세보기
61. Carson D.D. The cytoplasmic tail of MUC1: A very busy place Sci. Signal 2008 1 10.1126/scisignal.127pe35

상세보기
62. Behrens M.E. Grandgenett P.M. Bailey J.M. Singh P.K. Yi C.H. Yu F. Hollingsworth M.A. The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF Oncogene 2010 29 5667 5677 20697347

상세보기
63. Masckauchán T.N. Shawber C.J. Funahashi Y. Li C.M. Kitajewski J. Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells Angiogenesis 2005 8 43 51 16132617
64. Murata-Kamiya N. Kurashima Y. Teishikata Y. Yamahashi Y. Saito Y. Higashi H. Aburatani H. Akiyama T. Peek R.M. Jr. Azuma T. Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells Oncogene 2007 26 4617 4626 17237808

상세보기
65. Lévy L. Neuveut C. Renard C.A. Charneau P. Branchereau S. Gauthier F. van Nhieu J.T. Cherqui D. Petit-Bertron A.F. Mathieu D. Transcriptional activation of interleukin-8 by β-catenin-Tcf4 J. Biol. Chem 2002 277 42386 42393 12200448

상세보기
66. Guang W. Twaddell W.S. Lillehoj E.P. Molecular Interactions between MUC1 Epithelial Mucin, β-Catenin, and CagA Proteins Front. Immunol 2012 3 10.3389/fimmu.2012.00105

상세보기
67. Park Y.S. Guang W. Blanchard T.G. Kim K.C. Lillehoj E.P. Suppression of IL-8 production in gastric epithelial cells by MUC1 mucin and peroxisome proliferator-associated receptor-γ Am. J. Physiol. Gastrointest. Liver Physiol 2012 303 G765 G774 22766852
68. Guang W. Czinn S.J. Blanchard T.G. Kim K.C. Lillehoj E.P. Genetic regulation of MUC1 expression by Helicobacter pylori in gastric cancer cells Biochem. Biophys. Res. Commun 2014 445 145 150 24491543

상세보기
69. Perrais M. Rousseaux C. Ducourouble M.P. Courcol R. Vincent P. Jonckheere N. van Seuningen I. Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells Gastric Cancer 2014 17 235 246 23703470

상세보기
70. Navabi N. Johansson M.E. Raghavan S. Lindén S.K. Helicobacter pylori infection impairs the mucin production rate and turnover in the murine gastric mucosa Infect. Immun 2013 81 829 837 23275091

상세보기
71. Wei X. Xu H. Kufe D. Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene Cancer Res 2007 67 1853 1858 17308127

상세보기
72. Weinberg R.A. The Biology of Cancer Garland Science New York, NY, USA 2007
73. Raina D. Kharbanda S. Kufe D. The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts J. Biol. Chem 2004 279 20607 20612 14999001

상세보기
74. Raina D. Ahmad R. Kumar S. Ren J. Yoshida K. Kharbanda S. Kufe D. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage EMBO J 2006 25 3774 3783 16888623

상세보기
75. Rahn J.J. Chow J.W. Horne G.J. Mah B.K. Emerman J.T. Hoffman P. Hugh J.C. MUC1 mediates transendothelial migration in vitro by ligating endothelial cell ICAM-1 Clin. Exp. Metastasis 2005 22 475 483 16320110

상세보기
76. Hikita S.T. Kosik K.S. Clegg D.O. Bamdad C. MUC1 * mediates the growth of human pluripotent stem cells PLoS One 2008 3 e3312 18833326

상세보기
77. Stroopinsky D. Rosenblatt J. Ito K. Mills H. Yin L. Rajabi H. Vasir B. Kufe T. Luptakova K. Arnason J. MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells Cancer Res 2013 73 5569 5579 23867470

상세보기
78. Mehla K. Singh P.K. MUC1: A novel metabolic master regulator Biochim. Biophys. Acta 2014 1845 126 135 24418575
79. Saeki N. Ono H. Sakamoto H. Yoshida T. Genetic factors related to gastric cancer susceptibility identified using a genome-wide association study Cancer Sci 2013 104 1 8 23057512

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Mucin 1 Gene ( MUC1 ) and Gastric-Cancer Susceptibility 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (79)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트