[논문]Role of Frontostriatal Connectivity in Adolescents With Excessive Smartphone Use

Chun, Ji-Won; Choi, Jihye; Cho, Hyun; Choi, Mi-Ran; Ahn, Kook-Jin; Choi, Jung-Seok; Kim, Dai-Jin

doi:10.3389/fpsyt.2018.00437

Role of Frontostriatal Connectivity in Adolescents With Excessive Smartphone Use 원문보기

Frontiers in psychiatry, v.9, 2018년, pp.437 -

Chun, Ji-Won (Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine , Seoul , South Korea) , Choi, Jihye (Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine , Seoul , South Korea) , Cho, Hyun (Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine , Seoul , South Korea) , Choi, Mi-Ran (Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine , Seoul , South Korea) , Ahn, Kook-Jin (Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine , Seoul , South Korea) , Choi, Jung-Seok (Department of Psychiatry, SMG-SNU Boramae Medical Center , Seoul , South Korea) , Kim, Dai-Jin (Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University o)

Abstract ▼ AI-Helper

As smartphone use has grown rapidly over recent decade, it has been a growing interest in the potential negative impact of excessive smartphone use. In this study, we aim to identify altered brain connectivity associated with excessive smartphone use, and to investigate correlations between withdrawal symptoms, cortisol concentrations, and frontostriatal connectivity. We focused on investigating functional connectivity in frontostriatal regions, including the orbitofrontal cortex (OFC), midcingulate cortex (MCC), and nucleus accumbens (NAcc), which is related to reward processing and cognitive control. We analyzed data from 38 adolescents with excessive smartphone use (SP) and 42 healthy controls (HC). In the SP group compared with HC, we observed lower functional connectivity between the right OFC and NAcc, and between the left OFC and MCC. Moreover, functional connectivity between the MCC and NAcc was greater in SP compared with HC. Subsequently, we examined the relationship between Internet use withdrawal symptoms, cortisol concentrations, and functional connectivity between the OFC and NAcc in SP and HC. We observed that more severe withdrawal symptoms were associated with higher cortisol concentrations in adolescents with excessive smartphone use. The most interesting finding was that we observed a negative correlation between OFC connectivity with the NAcc and both withdrawal symptoms and cortisol concentrations. The functional connectivity between the OFC and NAcc, and between the OFC and MCC are related to cognitive control of emotional stimuli including reward. The current study suggests that adolescents with SP had reduced functional connectivity in these regions related to cognitive control. Furthermore, Internet use withdrawal symptoms appear to elicit cortisol secretion, and this psychophysiological change may affect frontostriatal connectivity. Our findings provide important clues to understanding the effects of excessive use of smartphones on brain functional connectivity in adolescence.

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참고문헌 (71)

1. Billieux J Philippot P Schmid C Maurage P De Mol J Van der Linden M . Is dysfunctional use of the mobile phone a behavioural addiction? Confronting symptom-based versus process-based approaches . Clin Psychol Psychother. ( 2015 ) 22 : 460 – 8 . 10.1002/cpp.1910 24947201

상세보기
2. Konijnenberg A Bannwarth L Yilmaz D Kocer A Venien-Bryan C Sobott F . Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment . Protein Sci. ( 2015 ) 24 : 1292 – 300 . 10.1002/pro.2703 25970171

상세보기
3. Cabrera D Roy D Chisolm MS . Social media scholarship and alternative metrics for academic promotion and tenure . J Am Coll Radiol. ( 2018 ) 15 ( 1 Pt B ): 135 – 41 . 10.1016/j.jacr.2017.09.012 29122503

상세보기
4. Kim DY Delori F Mukai S . Smartphone photography safety . Ophthalmology ( 2012 ) 119 : 2200 – 1 ; author reply 1. 10.1016/j.ophtha.2012.05.005 23034305

상세보기
5. Takao M Takahashi S Kitamura M . Addictive personality and problematic mobile phone use . Cyberpsychol Behav. ( 2009 ) 12 : 501 – 7 . 10.1089/cpb.2009.0022 19817562

상세보기
6. Beard KW Wolf EM . Modification in the proposed diagnostic criteria for Internet addiction . Cyberpsychol Behav. ( 2001 ) 4 : 377 – 83 . 10.1089/109493101300210286 11710263

상세보기
7. Paik A Oh D Kim D . A case of withdrawal psychosis from internet addiction disorder . Psychiatry Investig. ( 2014 ) 11 : 207 – 9 . 10.4306/pi.2014.11.2.207 24843379

상세보기
8. Tao R Huang X Wang J Zhang H Zhang Y Li M . Proposed diagnostic criteria for internet addiction . Addiction ( 2010 ) 105 : 556 – 64 . 10.1111/j.1360-0443.2009.02828.x 20403001

상세보기
9. Korea Internet & Security Agency Survey on Internet Use. Seoul : Korea Internet & Security Agency ( 2016 ).
10. Ling R Pedersen PE Re-negotiation city publisher of the social sphere . In: Ling editor. Mobile Communications. Vol. 31 ( 2006 ). Available online at: https://link.springer.com/book/10.1007%2F1-84628-248-9
11. Hodges JR Jones MT Stockham MA . Effect of emotion on blood corticotrophin and cortisol concentrations in man . Nature ( 1962 ) 193 : 1187 – 8 . 13907952

상세보기
12. Basowitz H Chevalier JA Grinker RR Hamburg DA Korchin SJ Persky H . Adrenal cortical function in anxious human subjects; plasma level and urinary excretion of hydrocortisone . AMA Arch Neurol Psychiatry ( 1956 ) 76 : 549 – 58 . 13371970
13. Mendelson JH Stein S McGuire MT . Comparative psychophysiological studies of alcoholic and nonalcoholic subjects undergoing experimentally induced ethanol intoxication . Psychosomat Med. ( 1966 ) 28 : 1 – 12 . 5909774
14. Nava F Caldiroli E Premi S Lucchini A . Relationship between plasma cortisol levels, withdrawal symptoms and craving in abstinent and treated heroin addicts . J Addict Dis. ( 2006 ) 25 : 9 – 16 . 10.1300/J069v25n02_02 16785214

상세보기
15. Dedovic K Duchesne A Andrews J Engert V Pruessner JC . The brain and the stress axis: the neural correlates of cortisol regulation in response to stress . NeuroImage ( 2009 ) 47 : 864 – 71 . 10.1016/j.neuroimage.2009.05.074 19500680

상세보기
16. Dedovic K D'Aguiar C Pruessner JC . What stress does to your brain: a review of neuroimaging studies . Can J Psychiatry ( 2009 ) 54 : 6 – 15 . 10.1177/070674370905400104 19175975

상세보기
17. Wang J Rao H Wetmore GS Furlan PM Korczykowski M Dinges DF . Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress . Proc Natl Acad Sci USA. ( 2005 ) 102 : 17804 – 9 . 10.1073/pnas.0503082102 16306271

상세보기
18. Kern S Oakes TR Stone CK McAuliff EM Kirschbaum C Davidson RJ . Glucose metabolic changes in the prefrontal cortex are associated with HPA axis response to a psychosocial stressor . Psychoneuroendocrinology ( 2008 ) 33 : 517 – 29 . 10.1016/j.psyneuen.2008.01.010 18337016

상세보기
19. Goldstein RZ Volkow ND . Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications . Nat Rev Neurosci. ( 2011 ) 12 : 652 – 69 . 10.1038/nrn3119 22011681

상세보기
20. Volkow ND Fowler JS Wang GJ Hitzemann R Logan J Schlyer DJ . Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers . Synapse ( 1993 ) 14 : 169 – 77 . 10.1002/syn.890140210 8101394

상세보기
21. Kalivas PW Volkow ND . The neural basis of addiction: a pathology of motivation and choice . Am J Psychiatry ( 2005 ) 162 : 1403 – 13 . 10.1176/appi.ajp.162.8.1403 16055761

상세보기
22. McClure SM York MK Montague PR . The neural substrates of reward processing in humans: the modern role of FMRI . Neuroscientist ( 2004 ) 10 : 260 – 8 . 10.1177/1073858404263526 15155064

상세보기
23. Volkow ND Fowler JS Wang GJ Telang F Logan J Jayne M . Cognitive control of drug craving inhibits brain reward regions in cocaine abusers . NeuroImage ( 2010 ) 49 : 2536 – 43 . 10.1016/j.neuroimage.2009.10.088 19913102

상세보기
24. Hu Y Long X Lyu H Zhou Y Chen J . Alterations in white matter integrity in young adults with smartphone dependence . Front Human Neurosci. ( 2017 ) 11 : 532 . 10.3389/fnhum.2017.00532 29163108

상세보기
25. Montag C Markowetz A Blaszkiewicz K Andone I Lachmann B Sariyska R . Facebook usage on smartphones and gray matter volume of the nucleus accumbens . Behav Brain Res. ( 2017 ) 329 : 221 – 8 . 10.1016/j.bbr.2017.04.035 28442353

상세보기
26. Friston KJ Frith CD Liddle PF Frackowiak RS . Functional connectivity: the principal-component analysis of large (PET) data sets . J Cereb Blood Flow Metabol. ( 1993 ) 13 : 5 – 14 . 10.1038/jcbfm.1993.4 8417010

상세보기
27. Kim D Lee Y Lee J Nam JK Chung Y . Development of Korean Smartphone addiction proneness scale for youth . PLoS ONE ( 2014 ) 9 : e97920 . 10.1371/journal.pone.0097920 24848006

상세보기
28. Oldfield RC . The assessment and analysis of handedness: the Edinburgh inventory . Neuropsychologia ( 1971 ) 9 : 97 – 113 . 5146491

상세보기
29. Kim YS Cheon KA Kim BN Chang SA Yoo HJ Kim JW . The reliability and validity of Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version- Korean version (K-SADS-PL-K) . Yonsei Med J. ( 2004 ) 45 : 81 – 9 . 10.3349/ymj.2004.45.1.81 15004873

상세보기
30. Choi SW Kim DJ Choi JS Ahn H Choi EJ Song WY . Comparison of risk and protective factors associated with smartphone addiction and Internet addiction . J Behav Addict. ( 2015 ) 4 : 308 – 14 . 10.1556/2006.4.2015.043 26690626

상세보기
31. Billieux J Chanal J Khazaal Y Rochat L Gay P Zullino D . Psychological predictors of problematic involvement in massively multiplayer online role-playing games: illustration in a sample of male cybercafe players . Psychopathology ( 2011 ) 44 : 165 – 71 . 10.1159/000322525 21372629

상세보기
32. Beck AT Steer RA Ball R Ranieri W . Comparison of beck depression inventories -IA and -II in psychiatric outpatients . J Personal Assess. ( 1996 ) 67 : 588 – 97 . 10.1207/s15327752jpa6703_13 8991972

상세보기
33. Beck AT Epstein N Brown G Steer RA . An inventory for measuring clinical anxiety: psychometric properties . J Consul Clin Psychol. ( 1988 ) 56 : 893 – 7 . 3204199
34. Brooks BL . A study of low scores in Canadian children and adolescents on the Wechsler Intelligence Scale For Children, Fourth Edition (WISC-IV) . Child Neuropsychol. ( 2011 ) 17 : 281 – 9 . 10.1080/09297049.2010.537255 21218295

상세보기
35. Silverstein A Two-and four-subtest short forms of the Wechsler Adult Intelligence Scale-Revised . J Consul Clin Psychol. ( 1982 ) 50 : 415 .
36. Tzourio-Mazoyer N Landeau B Papathanassiou D Crivello F Etard O Delcroix N . Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain . NeuroImage ( 2002 ) 15 : 273 – 89 . 10.1006/nimg.2001.0978 11771995

상세보기
37. Miller EK Cohen JD . An integrative theory of prefrontal cortex function . Annu Rev Neurosci. ( 2001 ) 24 : 167 – 202 . 10.1146/annurev.neuro.24.1.167 11283309

상세보기
38. Bechara A Damasio H Damasio AR . Emotion, decision making and the orbitofrontal cortex . Cereb Cortex ( 2000 ) 10 : 295 – 307 . 10.1093/cercor/10.3.295 10731224

상세보기
39. Menon V Uddin LQ . Saliency, switching, attention and control: a network model of insula function . Brain Struct Funct. ( 2010 ) 214 : 655 – 67 . 10.1007/s00429-010-0262-0 20512370

상세보기
40. Botvinick M Nystrom LE Fissell K Carter CS Cohen JD . Conflict monitoring versus selection-for-action in anterior cingulate cortex . Nature ( 1999 ) 402 : 179 – 81 . 10.1038/46035 10647008

상세보기
41. Delgado MR . Reward-related responses in the human striatum . Ann N Y Acad Sci. ( 2007 ) 1104 : 70 – 88 . 10.1196/annals.1390.002 17344522

상세보기
42. Haber SN Knutson B . The reward circuit: linking primate anatomy and human imaging . Neuropsychopharmacology ( 2010 ) 35 : 4 – 26 . 10.1038/npp.2009.129 19812543

상세보기
43. Camara E Rodriguez-Fornells A Ye Z Munte TF . Reward networks in the brain as captured by connectivity measures . Front Neurosci. ( 2009 ) 3 : 350 – 62 . 10.3389/neuro.01.034.2009 20198152

상세보기
44. Herve PY Zago L Petit L Mazoyer B Tzourio-Mazoyer N . Revisiting human hemispheric specialization with neuroimaging . Trends Cogn Sci. ( 2013 ) 17 : 69 – 80 . 10.1016/j.tics.2012.12.004 23317751

상세보기
45. Garavan H Ross TJ Stein EA . Right hemispheric dominance of inhibitory control: an event-related functional MRI study . Proc Natl Acad Sci USA. ( 1999 ) 96 : 8301 – 6 . 10393989

상세보기
46. Roh D Bhang SY Choi JS Kweon YS Lee SK Potenza MN . The validation of Implicit Association Test measures for smartphone and Internet addiction in at-risk children and adolescents . J Behav Addict. ( 2018 ): 1 – 9 . 10.1556/2006.7.2018.02 29383939

상세보기
47. van Duijvenvoorde ACK Achterberg M Braams BR Peters S Crone EA . Testing a dual-systems model of adolescent brain development using resting-state connectivity analyses . NeuroImage ( 2016 ) 124 ( Pt A ): 409 – 20 . 10.1016/j.neuroimage.2015.04.069 25969399

상세보기
48. Knutson B Fong GW Adams CM Varner JL Hommer D . Dissociation of reward anticipation and outcome with event-related fMRI . Neuroreport ( 2001 ) 12 : 3683 – 7 . 11726774

상세보기
49. Knutson B Fong GW Bennett SM Adams CM Hommer D . A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI . NeuroImage ( 2003 ) 18 : 263 – 72 . 10.1016/S1053-8119(02)00057-5 12595181

상세보기
50. Ramnani N Elliott R Athwal BS Passingham RE . Prediction error for free monetary reward in the human prefrontal cortex . NeuroImage ( 2004 ) 23 : 777 – 86 . 10.1016/j.neuroimage.2004.07.028 15528079

상세보기
51. Hare TA O'Doherty J Camerer CF Schultz W Rangel A . Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors . J Neurosci. ( 2008 ) 28 : 5623 – 30 . 10.1523/JNEUROSCI.1309-08.2008 18509023

상세보기
52. Liu X Hairston J Schrier M Fan J . Common and distinct networks underlying reward valence and processing stages: a meta-analysis of functional neuroimaging studies . Neurosci Biobehav Rev. ( 2011 ) 35 : 1219 – 36 . 10.1016/j.neubiorev.2010.12.012 21185861

상세보기
53. Yao YW Liu L Ma SS Shi XH Zhou N Zhang JT . Functional and structural neural alterations in Internet gaming disorder: a systematic review and meta-analysis . Neurosci Biobehav Rev. ( 2017 ) 83 : 313 – 24 . 10.1016/j.neubiorev.2017.10.029 29102686

상세보기
54. Goldstein RZ Alia-Klein N Tomasi D Zhang L Cottone LA Maloney T . Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction? Am J Psychiatry ( 2007 ) 164 : 43 – 51 . 10.1176/ajp.2007.164.1.43 17202543
55. Volkow ND Fowler JS Wang GJ Baler R Telang F . Imaging dopamine's role in drug abuse and addiction . Neuropharmacology ( 2009 ) 56 ( Suppl. 1 ): 3 – 8 . 10.1016/j.neuropharm.2008.05.022 18617195

상세보기
56. Parvaz MA Alia-Klein N Woicik PA Volkow ND Goldstein RZ . Neuroimaging for drug addiction and related behaviors . Rev Neurosci. ( 2011 ) 22 : 609 – 24 . 10.1515/RNS.2011.055 22117165

상세보기
57. Chun JW Choi J Kim JY Cho H Ahn KJ Nam JH . Altered brain activity and the effect of personality traits in excessive smartphone use during facial emotion processing . Sci Rep. ( 2017 ) 7 : 12156 . 10.1038/s41598-017-08824-y 28939856

상세보기
58. Yen JY Ko CH Yen CF Wu HY Yang MJ . The comorbid psychiatric symptoms of Internet addiction: attention deficit and hyperactivity disorder (ADHD), depression, social phobia, and hostility . J Adolesc Health ( 2007 ) 41 : 93 – 8 . 10.1016/j.jadohealth.2007.02.002 17577539

상세보기
59. Young KS Rogers RC The relationship between depression and Internet addiction . Cyberpsychol Behav. ( 1998 ) 1 : 25 – 8 .

상세보기
60. Williams ZM Bush G Rauch SL Cosgrove GR Eskandar EN . Human anterior cingulate neurons and the integration of monetary reward with motor responses . Nat Neurosci. ( 2004 ) 7 : 1370 – 5 . 10.1038/nn1354 15558064

상세보기
61. Sheth SA Mian MK Patel SR Asaad WF Williams ZM Dougherty DD . Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation . Nature ( 2012 ) 488 : 218 – 21 . 10.1038/nature11239 22722841

상세보기
62. Cheng J Benassi P De Oliveira C Zaheer J Collins M Kurdyak P . Impact of a mass media mental health campaign on psychiatric emergency department visits . Can J Public Health ( 2016 ) 107 : e303 – e11 . 10.17269/cjph.107.5265 27763847

상세보기
63. Ko K Choi S-H Namkoong K Lee BO Risk factors associated with the development and the course of alcohol withdrawal delirium . J Kor Neuropsychiatr Assoc. ( 2012 ) 51 : 430 – 8 . 10.4306/jknpa.2012.51.6.430

상세보기
64. Lindquist KA Wager TD Kober H Bliss-Moreau E Barrett LF . The brain basis of emotion: a meta-analytic review . Behav Brain Sci. ( 2012 ) 35 : 121 – 43 . 10.1017/S0140525X11000446 22617651

상세보기
65. Pruessner JC Dedovic K Khalili-Mahani N Engert V Pruessner M Buss C . Deactivation of the limbic system during acute psychosocial stress: evidence from positron emission tomography and functional magnetic resonance imaging studies . Biol Psychiatry ( 2008 ) 63 : 234 – 40 . 10.1016/j.biopsych.2007.04.041 17686466

상세보기
66. Arnsten AF Raskind MA Taylor FB Connor DF . The effects of stress exposure on prefrontal cortex: translating basic research into successful treatments for post-traumatic stress disorder . Neurobiol Stress ( 2015 ) 1 : 89 – 99 . 10.1016/j.ynstr.2014.10.002 25436222

상세보기
67. Gusnard DA Raichle ME Raichle ME . Searching for a baseline: functional imaging and the resting human brain . Nat Rev Neurosci. ( 2001 ) 2 : 685 – 94 . 10.1038/35094500 11584306

상세보기
68. Amodio DM Frith CD . Meeting of minds: the medial frontal cortex and social cognition . Nat Rev Neurosci. ( 2006 ) 7 : 268 – 77 . 10.1038/nrn1884 16552413

상세보기
69. Silverman MH Jedd K Luciana M . Neural networks involved in adolescent reward processing: an activation likelihood estimation meta-analysis of functional neuroimaging studies . NeuroImage ( 2015 ) 122 : 427 – 39 . 10.1016/j.neuroimage.2015.07.083 26254587

상세보기
70. Billieux J Van der Linden M Rochat L The role of impulsivity in actual and problematic use of the mobile phone . Appl Cogn Psychol. ( 2008 ) 22 : 1195 – 210 . 10.1002/acp.1429

상세보기
71. Ha JH Chin B Park DH Ryu SH Yu J . Characteristics of excessive cellular phone use in Korean adolescents . Cyberpsychol Behav. ( 2008 ) 11 : 783 – 4 . 10.1089/cpb.2008.0096 18991536

상세보기

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Role of Frontostriatal Connectivity in Adolescents With Excessive Smartphone Use 원문보기

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Role of Frontostriatal Connectivity in Adolescents With Excessive Smartphone Use 원문보기

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