[논문]Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer's Disease

Kwak, Kyeong-Ah; Lee, Seung-Pyo; Yang, Jin-Young; Park, Young-Seok

doi:10.1155/2018/6392986

Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer's Disease 원문보기

Stem cells international, v.2018, 2018년, pp.6392986 -

Kwak, Kyeong-Ah (Department of Oral Anatomy, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea) , Lee, Seung-Pyo (Department of Oral Anatomy, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea) , Yang, Jin-Young (Department of Dental Hygiene, Daejeon Institute of Science and Technology, Daejeon, Republic of Korea) , Park, Young-Seok (Department of Oral Anatomy, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea)

Abstract ▼ AI-Helper

Alzheimer's disease (AD), a progressive neurodegenerative disorder featuring memory loss and cognitive impairment, is caused by synaptic failure and the excessive accumulation of misfolded proteins. Many unsuccessful attempts have been made to develop new small molecules or antibodies to intervene in the disease's pathogenesis. Stem cell-based therapies cast a new hope for AD treatment as a replacement or regeneration strategy. The results from recent preclinical studies regarding stem cell-based therapies are promising. Human clinical trials are now underway. However, a number of questions remain to be answered prior to safe and effective clinical translation. This review explores the pathophysiology of AD and summarizes the relevant stem cell research according to cell type. We also briefly summarize related clinical trials. Finally, future perspectives are discussed with regard to their clinical applications.

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Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer's Disease 원문보기

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