[논문]Association between Changes in Serum 25-Hydroxyvitamin D Levels and Survival in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy

Kim, Ji Su; Haule, Caspar Christian; Kim, Joo Heung; Lim, Sung Mook; Yoon, Kwang Hyun; Kim, Jee Ye; Park, Hyung Seok; Park, Seho; Kim, Seung Il; Cho, Young Up; Park, Byeong-Woo

doi:10.4048/jbc.2018.21.2.134

Association between Changes in Serum 25-Hydroxyvitamin D Levels and Survival in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy 원문보기

Journal of breast cancer= 한국유방암학회지, v.21 no.2, 2018년, pp.134 - 141

Kim, Ji Su (Department of Surgery, Yonsei University College of Medicine, Seoul, Korea .) , Haule, Caspar Christian (Department of Surgery, Muhimbili National Hospital, Dar es Salaam, Tanzania .) , Kim, Joo Heung (Department of Surgery, Yonsei University College of Medicine, Seoul, Korea .) , Lim, Sung Mook (Department of Surgery, Yonsei University College of Medicine, Seoul, Korea .) , Yoon, Kwang Hyun (Department of Surgery, Yonsei University College of Medicine, Seoul, Korea .) , Kim, Jee Ye (Department of Surgery, Yonsei University College of Medicine, Seoul, Korea .) , Park, Hyung Seok (Department of Surgery, Yonsei University College of Medicine, Seoul, Korea .) , Park, Seho (Department of Surgery, Yonsei University College of Medicine, Seoul, Korea .) , Kim, Seung Il (Department of Surgery, Yonsei University College of Medicine, Seoul, Korea .) , Cho, Young Up (Department of Surgery, Yonsei University College of) , Park, Byeong-Woo

Abstract ▼ AI-Helper

PurposeWe investigated the changes in serum 25-hydroxyvitamin D (25[OH]D) levels before and after neoadjuvant chemotherapy (NCT) and the associations with pathologic complete response (pCR) and survival in patients with breast cancer.MethodsSerum 25(OH)D concentrations were measured pre- and post-NCT in 374 patients between 2010 and 2013. Based on a cutoff of 20 ng/mL, patients were categorized into “either sufficient” or “both deficient” groups. The associations with clinicopathological data, including pCR and survival, were analyzed using multivariable analyses.ResultsPatients with either pre- or post-NCT sufficient 25(OH)D levels accounted for 23.8%, and the overall pCR rate was 25.9%. Most patients showed 25(OH)D deficiency at diagnosis and 65.8% showed decreased serum levels after NCT. Changes in 25(OH)D status were associated with postmenopause status, rural residence, baseline summer examination, and molecular phenotype, but not pCR. No association between survival and 25(OH)D status was found, including in the subgroup analyses based on molecular phenotypes.ConclusionMost Korean patients with breast cancer showed vitamin D deficiency at diagnosis and a significant decrease in the serum concentration after NCT. No association with oncologic outcomes was found. Therefore, although optimal management for vitamin D deficiency is urgent for skeletal health, further research is warranted to clearly determine the prognostic role of vitamin D in patients with breast cancer who are candidates for NCT.

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참고문헌 (28)

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Association between Changes in Serum 25-Hydroxyvitamin D Levels and Survival in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy 원문보기

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Association between Changes in Serum 25-Hydroxyvitamin D Levels and Survival in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy 원문보기

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