다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Retrovirology, v.15, 2018년, pp.16 -
Rutsaert, Sofie (HIV Cure Research Center, Department of Internal Medicine, Ghent University, Ghent, Belgium) , Bosman, Kobus (Department of Medical Microbiology, Virology, UMC Utrecht, Utrecht, The Netherlands) , Trypsteen, Wim (HIV Cure Research Center, Department of Internal Medicine, Ghent University, Ghent, Belgium) , Nijhuis, Monique (Department of Medical Microbiology, Virology, UMC Utrecht, Utrecht, The Netherlands) , Vandekerckhove, Linos (HIV Cure Research Center, Department of Internal Medicine, Ghent University, Ghent, Belgium)
AI-Helper
Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped. In order to find a cure that can eradicate the latent reservoir, one must be able to quantify the persisting virus. Traditionally, HIV persistence stud...
1. Chun T-W Stuyver L Mizell SB Ehler LA Mican JAM Baseler M Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy Proc Natl Acad Sci 1997 94 13193 13197 10.1073/pnas.94.24.13193 9371822
2. Hindson BJ Ness KD Masquelier DA Belgrader P Heredia NJ Makarewicz AJ High-throughput droplet digital PCR system for absolute quantitation of DNA copy number Anal Chem 2011 83 8604 8610 10.1021/ac202028g 22035192
3. Ruano G Kidd KK Stephens JC Haplotype of multiple polymorphisms resolved by enzymatic amplification of single DNA molecules Proc Natl Acad Sci USA. 1990 87 6296 6300 10.1073/pnas.87.16.6296 1974719
4. Saiki RK Gelfand DH Stoffel S Scharf SJ Higuchi R Primer-directed enzymatic amplification of dna with a thermostable DNA polymerase Sci Wash 1988 239 487 10.1126/science.2448875
5. Sykes PJ Neoh SH Brisco MJ Hughes E Condon J Morley AA Quantitation of targets for PCR by use of limiting dilution Biotechniques 1992 13 444 449 1389177
6. Simmonds P Balfe P Peutherer JF Ludlam CA Bishop JO Brown AJ Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral mononuclear cells and at low copy numbers J Virol 1990 64 864 872 2296085
7. Vogelstein B Kinzler KW Digital PCR Proc Natl Acad Sci 1999 96 9236 9241 10.1073/pnas.96.16.9236 10430926
8. Agosto LM Yu JJ Dai J Kaletsky R Monie D O’Doherty U HIV-1 integrates into resting CD4 + T cells even at low inoculums as demonstrated with an improved assay for HIV-1 integration Virology 2007 368 60 72 10.1016/j.virol.2007.06.001 17631931
9. Spiegelaere WD Malatinkova E Lynch L Nieuwerburgh FV Messiaen P O’Doherty U Quantification of integrated HIV DNA by repetitive-sampling Alu-HIV PCR on the basis of poisson statistics Clin Chem 2014 60 886 895 10.1373/clinchem.2013.219378 24664400
10. Pinheiro LB Coleman VA Hindson CM Herrmann J Hindson BJ Bhat S Evaluation of a droplet digital polymerase chain reaction format for DNA copy number quantification Anal Chem 2012 84 1003 1011 10.1021/ac202578x 22122760
11. Bosman KJ Nijhuis M van Ham PM Wensing AMJ Vervisch K Vandekerckhove L Comparison of digital PCR platforms and semi-nested qPCR as a tool to determine the size of the HIV reservoir Sci Rep 2015 5 13811 10.1038/srep13811 26350506
13. Madic J Zocevic A Senlis V Fradet E Andre B Muller S Three-color crystal digital PCR Biomol Detect Quantif 2016 10 34 46 10.1016/j.bdq.2016.10.002 27990348
14. Papić B Pate M Henigman U Zajc U Gruntar I Biasizzo M New approaches on quantification of Campylobacter jejuni in poultry samples: the use of digital PCR and real-time PCR against the ISO standard plate count method Front Microbiol 2017 8 331 28303130
15. Wang Y Tsang JYS Cui Y Cui J Lin Y Zhao S Robust and accurate digital measurement for HER2 amplification in HER2 equivocal breast cancer diagnosis Sci Rep 2017 7 6752 10.1038/s41598-017-07176-x 28754904
16. Trypsteen W Vynck M Neve JD Bonczkowski P Kiselinova M Malatinkova E ddpcRquant: threshold determination for single channel droplet digital PCR experiments Anal Bioanal Chem 2015 407 5827 5834 10.1007/s00216-015-8773-4 26022094
17. Jones M Williams J Gärtner K Phillips R Hurst J Frater J Low copy target detection by droplet digital PCR through application of a novel open access bioinformatic pipeline, ‘definetherain’ J Virol Methods 2014 202 46 53 10.1016/j.jviromet.2014.02.020 24598230
18. Strain MC Lada SM Luong T Rought SE Gianella S Terry VH Highly precise measurement of HIV DNA by droplet digital PCR PLoS ONE 2013 8 e55943 10.1371/journal.pone.0055943 23573183
19. Dreo T Pirc M Ramšak Ž Pavšič J Milavec M Žel J Optimising droplet digital PCR analysis approaches for detection and quantification of bacteria: a case study of fire blight and potato brown rot Anal Bioanal Chem 2014 406 6513 6528 10.1007/s00216-014-8084-1 25173868
20. Lievens A Jacchia S Kagkli D Savini C Querci M Measuring digital PCR quality: performance parameters and their optimization PLoS ONE 2016 11 e0153317 10.1371/journal.pone.0153317 27149415
21. Jacobs BKM Goetghebeur E Vandesompele J De Ganck A Nijs N Beckers A Model-based classification for digital PCR: your umbrella for rain Anal Chem 2017 89 4461 4467 10.1021/acs.analchem.6b04208 28350455
22. Taylor SC Carbonneau J Shelton DN Boivin G Optimization of droplet digital PCR from RNA and DNA extracts with direct comparison to RT-qPCR: clinical implications for quantification of Oseltamivir-resistant subpopulations J Virol Methods 2015 224 58 66 10.1016/j.jviromet.2015.08.014 26315318
23. Kiselinova M Pasternak AO De Spiegelaere W Vogelaers D Berkhout B Vandekerckhove L Comparison of droplet digital PCR and seminested real-time PCR for quantification of cell-associated HIV-1 RNA PLoS ONE 2014 9 e85999 10.1371/journal.pone.0085999 24465831
24. Henrich TJ Gallien S Li JZ Pereyra F Kuritzkes DR Low-level detection and quantitation of cellular HIV-1 DNA and 2-LTR circles using droplet digital PCR J Virol Methods 2012 186 68 72 10.1016/j.jviromet.2012.08.019 22974526
25. Vynck M Trypsteen W Thas O Vandekerckhove L De Spiegelaere W The future of digital polymerase chain reaction in virology Mol Diagn Ther 2016 20 437 447 10.1007/s40291-016-0224-1 27351921
26. Malatinkova E Kiselinova M Bonczkowski P Trypsteen W Messiaen P Vermeire J Accurate quantification of episomal HIV-1 two-long terminal repeat circles by use of optimized DNA isolation and droplet digital PCR J Clin Microbiol 2015 53 699 701 10.1128/JCM.03087-14 25502524
27. Sanders R Mason DJ Foy CA Huggett JF Evaluation of digital PCR for absolute RNA quantification PLoS ONE 2013 8 e75296 10.1371/journal.pone.0075296 24073259
28. Busby E Whale AS Ferns RB Grant PR Morley G Campbell J Instability of 8E5 calibration standard revealed by digital PCR risks inaccurate quantification of HIV DNA in clinical samples by qPCR Sci Rep 2017 7 1209 10.1038/s41598-017-01221-5 28446770
29. Dingle TC Sedlak RH Cook L Jerome KR Tolerance of droplet-digital PCR vs real-time quantitative PCR to inhibitory substances Clin Chem 2013 59 1670 1672 10.1373/clinchem.2013.211045 24003063
30. Taylor SC Laperriere G Germain H Droplet Digital PCR versus qPCR for gene expression analysis with low abundant targets: from variable nonsense to publication quality data Sci Rep 2017 7 2409 10.1038/s41598-017-02217-x 28546538
31. McNearney T Hornickova Z Markham R Birdwell A Arens M Saah A Relationship of human immunodeficiency virus type 1 sequence heterogeneity to stage of disease Proc Natl Acad Sci USA 1992 89 10247 10251 10.1073/pnas.89.21.10247 1438212
32. Hindson CM Chevillet JR Briggs HA Gallichotte EN Ruf IK Hindson BJ Absolute quantification by droplet digital PCR versus analog real-time PCR Nat Methods 2013 10 1003 1005 10.1038/nmeth.2633 23995387
33. Hayden RT Gu Z Ingersoll J Abdul-Ali D Shi L Pounds S Comparison of droplet digital PCR to real-time PCR for quantitative detection of cytomegalovirus J Clin Microbiol 2013 51 540 546 10.1128/JCM.02620-12 23224089
34. Whale AS Cowen S Foy CA Huggett JF Methods for applying accurate digital PCR analysis on low copy DNA samples PLoS ONE 2013 8 e58177 10.1371/journal.pone.0058177 23472156
35. Malatinkova E Spiegelaere WD Bonczkowski P Kiselinova M Vervisch K Trypsteen W Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs eLife 2015 4 e09115 10.7554/eLife.09115 26439007
36. Buzon MJ Martin-Gayo E Pereyra F Ouyang Z Sun H Li JZ Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells J Virol 2014 88 10056 10065 10.1128/JVI.01046-14 24965451
37. Henrich TJ Hatano H Bacon O Hogan LE Rutishauser R Hill A HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: an observational study PLOS Med 2017 14 e1002417 10.1371/journal.pmed.1002417 29112956
38. Oliveira MF Chaillon A Nakazawa M Vargas M Letendre SL Strain MC Early antiretroviral therapy is associated with lower HIV DNA molecular diversity and lower inflammation in cerebrospinal fluid but does not prevent the establishment of compartmentalized HIV DNA populations PLoS Pathog 2017 13 e1006112 10.1371/journal.ppat.1006112 28046096
39. Hancock G Morón-López S Kopycinski J Puertas MC Giannoulatou E Rose A Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA. HIVconsv, in antiretroviral therapy-treated subjects J Int AIDS Soc 2017 20 21171 10.7448/IAS.20.1.21171 28537062
40. Rosás-Umbert M Mothe B Noguera-Julian M Bellido R Puertas MC Carrillo J Virological and immunological outcome of treatment interruption in HIV-1-infected subjects vaccinated with MVA-B PLoS ONE 2017 12 e0184929 10.1371/journal.pone.0184929 28953921
41. Mothe B Climent N Plana M Rosàs M Jiménez JL Muñoz-Fernández MÁ Safety and immunogenicity of a modified vaccinia Ankara-based HIV-1 vaccine (MVA-B) in HIV-1-infected patients alone or in combination with a drug to reactivate latent HIV-1 J Antimicrob Chemother 2015 70 1833 1842 25724985
42. Cummins NW Rizza S Litzow MR Hua S Lee GQ Einkauf K Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: a case study PLoS Med 2017 14 e1002461 10.1371/journal.pmed.1002461 29182633
43. ISALA. Analytical treatment interruption in HIV positive patients (ISALA). https://clinicaltrials.gov . NCT02590354.
44. Chun T-W Murray D Justement JS Blazkova J Hallahan CW Fankuchen O Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir Proc Natl Acad Sci USA 2014 111 13151 13156 10.1073/pnas.1414148111 25157148
45. Vibholm L Schleimann MH Højen JF Benfield T Offersen R Rasmussen K Short-course toll-like receptor 9 agonist treatment impacts innate immunity and plasma viremia in individuals with human immunodeficiency virus infection Clin Infect Dis 2017 64 1686 1695 10.1093/cid/cix201 28329286
46. Rasmussen TA Tolstrup M Brinkmann CR Olesen R Erikstrup C Solomon A Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial Lancet HIV 2014 1 e13 e21 10.1016/S2352-3018(14)70014-1 26423811
47. Yucha RW Hobbs KS Hanhauser E Hogan LE Nieves W Ozen MO High-throughput characterization of HIV-1 reservoir reactivation using a single-cell-in-droplet PCR assay EBioMedicine 2017 20 217 229 10.1016/j.ebiom.2017.05.006 28529033
48. Margolis DM Archin NM Proviral latency, persistent human immunodeficiency virus infection, and the development of latency reversing agents J Infect Dis 2017 215 suppl3 S111 S118 10.1093/infdis/jiw618 28520964
49. Søgaard OS Graversen ME Leth S Olesen R Brinkmann CR Nissen SK The depsipeptide romidepsin reverses HIV-1 latency in vivo PLoS Pathog 2015 11 e1005142 10.1371/journal.ppat.1005142 26379282
50. Paredes R, Vandekerkchove L, Clotet B, Moutchen M, De Wit S, Podzamczer D, et al. ABX464 decreases total HIV DNA in PBMC’s when administered during 28 days to HIV-infected patients who are virologically suppressed. In: 9th IAS conference HIV Sci IAS 2017, Paris, France.
51. Bialek JK Dunay GA Voges M Schäfer C Spohn M Stucka R Targeted HIV-1 latency reversal using CRISPR/Cas9-derived transcriptional activator systems PLoS ONE 2016 11 e0158294 10.1371/journal.pone.0158294 27341108
52. Tebas P Stein D Tang WW Frank I Wang SQ Lee G Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV N Engl J Med 2014 370 901 910 10.1056/NEJMoa1300662 24597865
53. Ho Y-C Shan L Hosmane NN Wang J Laskey SB Rosenbloom DIS Replication-competent non-induced proviruses in the latent reservoir increase barrier to HIV-1 cure Cell 2013 155 540 551 10.1016/j.cell.2013.09.020 24243014
54. Anderson E, Hill S, Bell J, Simonetti FR, Rehm C, Jones S, et al. Accumulation and persistence of deleted HIV proviruses following prolonged ART. In: 9th IAS Conference HIV Sci IAS 2017, MOAA0102 Paris, France.
55. Maldarelli F Wu X Su L Simonetti FR Shao W Hill S Specific HIV integration sites are linked to clonal expansion and persistence of infected cells Science 2014 345 179 183 10.1126/science.1254194 24968937
56. Regan JF Kamitaki N Legler T Cooper S Klitgord N Karlin-Neumann G A rapid molecular approach for chromosomal phasing PLoS ONE 2015 10 e0118270 10.1371/journal.pone.0118270 25739099
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.