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Neuroprotective Effects of Polydeoxyribonucleotide in a Murine Model of Cadmium Toxicity 원문보기

Oxidative medicine and cellular longevity, v.2018, 2018년, pp.4285694 -   

Marini, Herbert R. (Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy) ,  Puzzolo, Domenico (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy) ,  Micali, Antonio (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy) ,  Adamo, Elena Bianca (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy) ,  Irrera, Natasha (Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy) ,  Pisani, Antonina (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy) ,  Pallio, Giovanni (Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy) ,  Trichilo, Vincenzo (Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy) ,  Malta, Consuelo (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy) ,  Bitto, Alessandra (Department of Clinical and Experimental Medicine, University of M) ,  Squadrito, Francesco ,  Altavilla, Domenica ,  Minutoli, Letteria

Abstract AI-Helper 아이콘AI-Helper

Cadmium (Cd) is a harmful heavy metal, which causes severe brain damage and neurotoxic effects. Polydeoxyribonucleotide (PDRN) stimulates adenosine A2A receptor, thus contrasting several deleterious mechanisms in course of tissue damages. We aimed to investigate the possible neuroprotective effect o...

참고문헌 (59)

  1. 1 ATSDR Agency for Toxic Substance and Disease Registry 2012 Atlanta U.S. Toxicological Profile for Cadmium, Department of Health and Humans Services, Public Health Service, Centers for Disease Control 

  2. 2 Järup L. Akesson A. Current status of cadmium as an environmental health problem Toxicology and Applied Pharmacology 2009 238 3 201 208 10.1016/j.taap.2009.04.020 2-s2.0-67649654113 19409405 

  3. 3 Chunhabundit R. Cadmium exposure and potential health risk from foods in contaminated area, Thailand Toxicological Research 2016 32 1 65 72 10.5487/TR.2016.32.1.065 2-s2.0-84959278411 26977260 

  4. 4 López E. Figueroa S. Oset-Gasque M. J. González M. P. Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture British Journal of Pharmacology 2003 138 5 901 911 10.1038/sj.bjp.0705111 2-s2.0-0037349147 12642392 

  5. 5 Habeebu S. S. Liu Y. Park J. D. Klaassen C. D. Strain differences in the toxicity of cadmium to trigeminal ganglia in mice Toxicology and Applied Pharmacology 2001 177 3 200 207 10.1006/taap.2001.9311 2-s2.0-0035894328 11749119 

  6. 6 Poliandri A. H. Cabilla J. P. Velardez M. O. Bodo C. C. Duvilanski B. H. Cadmium induces apoptosis in anterior pituitary cells that can be reversed by treatment with antioxidants Toxicology and Applied Pharmacology 2003 190 1 17 24 10.1016/S0041-008X(03)00191-1 2-s2.0-0037708924 12831779 

  7. 7 Wätjen W. Beyersmann D. Cadmium-induced apoptosis in C6 glioma cells: influence of oxidative stress BioMetals 2004 17 1 65 78 10.1023/A:1024405119018 2-s2.0-0142171680 14977363 

  8. 8 Sugawara N. Aoshima K. Kasuya M. Effect of cadmium chloride and Cd-metallothionein on the nervous tissue culture Toxicology Letters 1983 16 1-2 95 101 6340247 

  9. 9 Webster W. S. Valois A. A. The toxic effects of cadmium on the neonatal mouse CNS Journal of Neuropathology and Experimental Neurology 1981 40 3 247 257 10.1097/00005072-198105000-00003 2-s2.0-0019852348 7218003 

  10. 10 Carageorgiou H. Tzotzes V. Pantos C. Mourouzis C. Zarros A. Tsakiris S. In vivo and in vitro effects of cadmium on adult rat brain total antioxidant status, acetylcholinesterase, (Na+, K+)-ATPase and Mg2+-ATPase activities: protection by L-cysteine Basic & Clinical Pharmacology & Toxicology 2004 94 3 112 118 10.1111/j.1742-7843.2004.pto940303.x 15049340 

  11. 11 Demir N. Akkoyunlu G. Yargicoglu P. Agar A. Tanriöver G. Demir R. Fiber structure of optic nerve in cadmium-exposed diabetic rats: an ultrastructural study The International Journal of Neuroscience 2009 113 3 323 337 10.1080/00207450390162128 2-s2.0-0037358955 

  12. 12 Liu J. Qu W. Kadiiska M. B. Role of oxidative stress in cadmium toxicity and carcinogenesis Toxicology and Applied Pharmacology 2009 238 3 209 214 10.1016/j.taap.2009.01.029 2-s2.0-67649641505 19236887 

  13. 13 Jeong E. M. Moon C. H. Kim C. S. Cadmium stimulates the expression of ICAM-1 via NF- κ B activation in cerebrovascular endothelial cells Biochemical and Biophysical Research Communications 2004 320 3 887 892 10.1016/j.bbrc.2004.05.218 2-s2.0-3042834731 15240131 

  14. 14 Qu W. Ke H. Pi J. Acquisition of apoptotic resistance in cadmium-transformed human prostate epithelial cells: Bcl-2 overexpression blocks the activation of JNK signal transduction pathway Environmental Health Perspectives 2007 115 7 1094 1100 10.1289/ehp.10075 2-s2.0-34548234344 17637928 

  15. 15 Yuan Y. Wang Y. Hu F. F. Cadmium activates reactive oxygen species-dependent AKT/mTOR and mitochondrial apoptotic pathways in neuronal cells Biomedical and Environmental Sciences 2016 29 2 117 126 10.3967/bes2016.013 2-s2.0-84962511272 27003169 

  16. 16 Chen L. Xu B. Liu L. Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death Free Radical Biology & Medicine 2011 50 5 624 632 10.1016/j.freeradbiomed.2010.12.032 2-s2.0-79551488995 21195169 

  17. 17 Wang B. Du Y. Cadmium and its neurotoxic effects Oxidative Medicine and Cellular Longevity 2013 2013 12 898034 10.1155/2013/898034 2-s2.0-84884232816 

  18. 18 Al Omairi N. E. Radwan O. K. Alzahrani Y. A. Kassab R. B. Neuroprotective efficiency of Mangifera indica leaves extract on cadmium-induced cortical damage in rats Metabolic Brain Disease 2018 33 4 1121 1130 10.1007/s11011-018-0222-6 29557530 

  19. 19 Binder D. K. Scharfman H. E. Brain-derived neurotrophic factor Growth Factors 2009 22 3 123 131 10.1080/08977190410001723308 2-s2.0-5744233877 15518235 

  20. 20 Acheson A. Conover J. C. Fandl J. P. A BDNF autocrine loop in adult sensory neurons prevents cell death Nature 1995 374 6521 450 453 10.1038/374450a0 2-s2.0-0028923784 7700353 

  21. 21 Huang E. J. Reichardt L. F. Neurotrophins: roles in neuronal development and function Annual Review of Neuroscience 2001 24 1 677 736 10.1146/annurev.neuro.24.1.677 2-s2.0-0034927081 11520916 

  22. 22 Maisonpierre P. C. le Beau M. M. Espinosa R. III Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations Genomics 1991 10 3 558 568 10.1016/0888-7543(91)90436-I 2-s2.0-0025720531 1889806 

  23. 23 Gomes C. V. Kaster M. P. Tomé A. R. Agostinho P. M. Cunha R. A. Adenosine receptors and brain diseases: neuroprotection and neurodegeneration Biochimica et Biophysica Acta (BBA) - Biomembranes 2011 1808 5 1380 1399 10.1016/j.bbamem.2010.12.001 2-s2.0-79953220421 21145878 

  24. 24 Jeon S. J. Rhee S. Y. Ryu J. H. Activation of adenosine A2A receptor up-regulates BDNF expression in rat primary cortical neurons Neurochemical Research 2011 36 12 2259 2269 10.1007/s11064-011-0550-y 2-s2.0-80755133374 21792677 

  25. 25 Diógenes M. J. Fernandes C. C. Sebastião A. M. Ribeiro J. A. Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices Journal of Neuroscience 2004 24 12 2905 2913 10.1523/JNEUROSCI.4454-03.2004 2-s2.0-1642423944 15044529 

  26. 26 Tebano M. T. Martire A. Potenza R. L. Adenosine A(2A) receptors are required for normal BDNF levels and BDNF-induced potentiation of synaptic transmission in the mouse hippocampus Journal of Neurochemistry 2008 104 1 279 286 10.1111/j.1471-4159.2007.05046.x 2-s2.0-37249068571 18005343 

  27. 27 Fontinha B. M. Diógenes M. J. Ribeiro J. A. Sebastião A. M. Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine Neuropharmacology 2008 54 6 924 933 10.1016/j.neuropharm.2008.01.011 2-s2.0-42049108834 18384819 

  28. 28 Borrie S. C. Brems H. Legius E. Bagni C. Cognitive dysfunctions in intellectual disabilities: the contributions of the Ras-MAPK and PI3K-AKT-mTOR pathways Annual Review of Genomics and Human Genetics 2017 18 1 115 142 10.1146/annurev-genom-091416-035332 2-s2.0-85028769921 

  29. 29 Shaw R. J. Cantley L. C. Ras, PI(3)K and mTOR signalling controls tumour cell growth Nature 2006 441 7092 424 430 10.1038/nature04869 2-s2.0-33745307617 16724053 

  30. 30 Liu Y. W. Yang T. Zhao L. Activation of adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome Scientific Reports 2016 6 1, article 33614 10.1038/srep33614 2-s2.0-84988517565 27647162 

  31. 31 Altavilla D. Bitto A. Polito F. Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers Cardiovascular & Hematological Agents in Medicinal Chemistry 2009 7 4 313 321 10.2174/187152509789541909 2-s2.0-74049097935 19860658 

  32. 32 Minutoli L. Arena S. Bonvissuto G. Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats Fertility and Sterility 2011 95 4 1510 1513 10.1016/j.fertnstert.2010.07.1047 2-s2.0-79952449200 20797711 

  33. 33 Altavilla D. Squadrito F. Polito F. Activation of adenosine A2A receptors restores the altered cell-cycle machinery during impaired wound healing in genetically diabetic mice Surgery 2011 149 2 253 261 10.1016/j.surg.2010.04.024 2-s2.0-78751575958 20570301 

  34. 34 Minutoli L. Antonuccio P. Squadrito F. Effects of polydeoxyribonucleotide on the histological damage and the altered spermatogenesis induced by testicular ischaemia and reperfusion in rats International Journal of Andrology 2012 35 2 133 144 10.1111/j.1365-2605.2011.01194.x 2-s2.0-84858279066 21651579 

  35. 35 Minutoli L. Arena S. Antonuccio P. Role of inhibitors of apoptosis proteins in testicular function and male fertility: effects of polydeoxyribonucleotide administration in experimental varicocele BioMed Research International 2015 2015 9 248976 10.1155/2015/248976 2-s2.0-84939639870 

  36. 36 Squadrito F. Micali A. Rinaldi M. Polydeoxyribonucleotide, an adenosine-A2A receptor agonist, preserves blood testis barrier from cadmium-induced injury Frontiers in Pharmacology 2017 7 10.3389/fphar.2016.00537 2-s2.0-85012106596 

  37. 37 https://grants.nih.gov/grants/olaw/guide-for-the-care-and-use-of-laboratory-animals.pdf 

  38. 38 http://ec.europa.eu/environment/chemicals/lab_animals/legislation_en.htm 

  39. 39 Vorhees C. V. Williams M. T. Morris water maze: procedures for assessing spatial and related forms of learning and memory Nature Protocols 2006 1 2 848 858 10.1038/nprot.2006.116 2-s2.0-33846461062 17406317 

  40. 40 Minutoli L. Marini H. Rinaldi M. A dual inhibitor of cyclooxygenase and 5-lipoxygenase protects against kainic acid-induced brain injury Neuromolecular Medicine 2015 17 2 192 201 10.1007/s12017-015-8351-0 2-s2.0-84937763492 25893744 

  41. 41 Franklin K. B. J. Paxinos G. The Mouse Brain in Stereotaxic Coordinates 2007 3rd Amsterdam Elsevier 

  42. 42 Minutoli L. Micali A. Pisani A. Research article flavocoxid protects against cadmium-induced disruption of the blood-testis barrier and improves testicular damage and germ cell impairment in mice Toxicological Sciences 2015 148 1 311 329 10.1093/toxsci/kfv185 2-s2.0-84947741717 26424772 

  43. 43 Gong P. Chen F. Liu X. Gong X. Wang J. Ma Y. Protective effect of caffeic acid phenethyl ester against cadmium-induced renal damage in mice The Journal of Toxicological Sciences 2012 37 2 415 425 10.2131/jts.37.415 2-s2.0-84859302754 22467032 

  44. 44 Ientile R. Currò M. Caccamo D. Transglutaminase 2 and neuroinflammation Amino Acids 2015 47 1 19 26 10.1007/s00726-014-1864-2 2-s2.0-84942801440 25398223 

  45. 45 Rinaldi M. Micali A. Marini H. Cadmium, organ toxicity and therapeutic approaches: a review on brain, kidney and testis damage Current Medicinal Chemistry 2017 24 35 3879 3893 10.2174/0929867324666170801101448 2-s2.0-85038219056 28762312 

  46. 46 Rizwan M. Ali S. Adrees M. A critical review on effects, tolerance mechanisms and management of cadmium in vegetables Chemosphere 2017 182 90 105 10.1016/j.chemosphere.2017.05.013 2-s2.0-85018726738 28494365 

  47. 47 Chen L. Liu L. Luo Y. Huang S. MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis Journal of Neurochemistry 2008 105 1 251 261 10.1111/j.1471-4159.2007.05133.x 2-s2.0-41149128223 18021293 

  48. 48 Lykissas M. G. Batistatou A. K. Charalabopoulos K. A. Beris A. E. The role of neurotrophins in axonal growth, guidance, and regeneration Current Neurovascular Research 2007 4 2 143 151 10.2174/156720207780637216 2-s2.0-34248155631 17504212 

  49. 49 Laplante M. Sabatini D. M. mTOR signaling in growth control and disease Cell 2012 149 2 274 293 10.1016/j.cell.2012.03.017 2-s2.0-84859778293 22500797 

  50. 50 Takei N. Nawa H. mTOR signaling and its roles in normal and abnormal brain development Frontiers in Molecular Neuroscience 2014 7 10.3389/fnmol.2014.00028 2-s2.0-84899144736 

  51. 51 Chen S.-D. Wu C.-L. Hwang W.-C. Yang D.-I. More insight into BDNF against neurodegeneration: anti-apoptosis, anti-oxidation, and suppression of autophagy International Journal of Molecular Sciences 2017 18 3 10.3390/ijms18030545 2-s2.0-85014530452 28273832 

  52. 52 Marini H. Altavilla D. Bellomo M. Modulation of IL-1 β gene expression by lipid peroxidation inhibition after kainic acid-induced rat brain injury Experimental Neurology 2004 188 1 178 186 10.1016/j.expneurol.2004.03.023 2-s2.0-2942612996 15191814 

  53. 53 Marini H. Costa C. Passaniti M. Levetiracetam protects against kainic acid-induced toxicity Life Sciences 2004 74 10 1253 1264 10.1016/j.lfs.2003.08.006 2-s2.0-9144234719 14697408 

  54. 54 Provias J. P. Ackerley C. A. Smith C. Becker L. E. Cadmium encephalopathy: a report with elemental analysis and pathological findings Acta Neuropathologica 1994 88 6 583 586 10.1007/BF00296497 2-s2.0-0027993419 7879607 

  55. 55 Mills J. H. Kim D. G. Krenz A. Chen J. F. Bynoe M. S. A2A adenosine receptor signaling in lymphocytes and the central nervous system regulates inflammation during experimental autoimmune encephalomyelitis Journal of Immunology 2012 188 11 5713 5722 10.4049/jimmunol.1200545 2-s2.0-84862073627 22529293 

  56. 56 WANG S. HU P. WANG H. Effects of Cd(2+) on AMPA receptor-mediated synaptic transmission in rat hippocampal CA1 area Toxicology Letters 2008 176 3 215 222 10.1016/j.toxlet.2007.11.008 2-s2.0-38749149906 18248923 

  57. 57 Bar-Sela S. Reingold S. Richter E. D. Amyotrophic lateral sclerosis in a battery-factory worker exposed to cadmium International Journal of Occupational and Environmental Health 2001 7 2 109 112 10.1179/oeh.2001.7.2.109 11373040 

  58. 58 Okuda B. Iwamoto Y. Tachibana H. Sugita M. Parkinsonism after acute cadmium poisoning Clinical Neurology and Neurosurgery 1997 99 4 263 265 10.1016/S0303-8467(97)00090-5 2-s2.0-0031454212 9491302 

  59. 59 Chin-Chan M. Navarro-Yepes J. Quintanilla-Vega B. Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases Frontiers in Cellular Neuroscience 2015 9 10.3389/fncel.2015.00124 2-s2.0-84927610673 

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