[논문]Schisandrin Attenuates Lipopolysaccharide-Induced Lung Injury by Regulating TLR-4 and Akt/FoxO1 Signaling Pathways

Sun, Kai; Huang, Rong; Yan, Li; Li, Dan-Tong; Liu, Yu-Ying; Wei, Xiao-Hong; Cui, Yuan-Chen; Pan, Chun-Shui; Fan, Jing-Yu; Wang, Xian; Han, Jing-Yan

doi:10.3389/fphys.2018.01104

[해외논문] Schisandrin Attenuates Lipopolysaccharide-Induced Lung Injury by Regulating TLR-4 and Akt/FoxO1 Signaling Pathways 원문보기

Frontiers in physiology, v.9, 2018년, pp.1104 -

Sun, Kai (Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University) , Huang, Rong (Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University) , Yan, Li (Tasly Microcirculation Research Center, Peking University Health Science Center) , Li, Dan-Tong (Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University) , Liu, Yu-Ying (Tasly Microcirculation Research Center, Peking University Health Science Center) , Wei, Xiao-Hong (Tasly Microcirculation Research Center, Peking University Health Science Center) , Cui, Yuan-Chen (Tasly Microcirculation Research Center, Peking University Health Science Center) , Pan, Chun-Shui (Tasly Microcirculation Research Center, Peking University Health Science Center) , Fan, Jing-Yu (Tasly Microcirculation Research Center, Peking Universit) , Wang, Xian , Han, Jing-Yan

Abstract ▼ AI-Helper

Objective: Acute lung injury is a severe clinic condition with limited therapeutic approaches. This study evaluated whether schisandrin (Sch), an ingredient of Schisandra chinensis, has preventive effects on endothelium and epithelium injury induced by lipopolysaccharide (LPS) and the underlying mechanisms.Methods: Male Wistar rats were continuously infused with LPS (5 mg/kg/h) via the left jugular vein for 90 min. In some rats, Sch (2.5 mg/kg/h) was administrated through the left jugular vein 30 min before LPS infusion. Leukocyte recruitment, levels of inflammatory cytokines, lung histology and edema, vascular and alveolar barrier disruption and related proteins were evaluated at indicated time point after LPS challenge.Results: LPS infusion for 90 min resulted in an increased leukocyte adhesion to pulmonary venules and overproduction of cytokine and chemokine in both serum and lung homogenate. At 8 h after termination of LPS infusion, obvious Evans blue extravasation and lung edema were observed, along with an increased apoptosis, a decreased expression of tight junction and adherent junction proteins, and a reduction in von Willebrand factor (vWF) and keratin, all of which were attenuated by Sch treatment. Meanwhile, the LPS-elicited activation of TLR-4/NF-κB/MAPK and FoxO1 signaling was inhibited by Sch.Conclusion: The present study revealed that pretreatment with Sch alleviated lung endothelium and epithelium injury after LPS stimulation, which is attributable to inhibition of cell injury and activation of cell regeneration via regulation of TLR-4/NF-κB/MAPK and Akt/FoxO1 signaling pathway.

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[해외논문] Schisandrin Attenuates Lipopolysaccharide-Induced Lung Injury by Regulating TLR-4 and Akt/FoxO1 Signaling Pathways 원문보기

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