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All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits 원문보기

eLife, v.7, 2018년, pp.e32478 -   

Hadden, Jodi A (Department of Chemistry and Biochemistry University of Delaware Newark United States) ,  Perilla, Juan R (Department of Chemistry and Biochemistry University of Delaware Newark United States) ,  Schlicksup, Christopher John (Department of Molecular and Cellular Biochemistry Indiana University Bloomington United States) ,  Venkatakrishnan, Balasubramanian (Department of Molecular and Cellular Biochemistry Indiana University Bloomington United States) ,  Zlotnick, Adam (Department of Molecular and Cellular Biochemistry Indiana University Bloomington United States) ,  Schulten, Klaus (Department of Physics University of Illinois at Urbana-Champaign Urbana United States)

Abstract AI-Helper 아이콘AI-Helper

The hepatitis B virus capsid represents a promising therapeutic target. Experiments suggest the capsid must be flexible to function; however, capsid structure and dynamics have not been thoroughly characterized in the absence of icosahedral symmetry constraints. Here, all-atom molecular dynamics sim...

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