[논문]Lipid- and gut microbiota-modulating effects of graphene oxide nanoparticles in high-fat diet-induced hyperlipidemic mice

Li, Juan; Yang, Shengmei; Yu, Jiaqi; Cui, Rongli; Liu, Ru; Lei, Runhong; Chang, Yanan; Geng, Huan; Qin, Yanxia; Gu, Weihong; Xia, Shibo; Chen, Kui; Kong, Jianglong; Chen, Guogang; Wu, Chongming; Xing, Gengmei

doi:10.1039/c8ra06058d

Lipid- and gut microbiota-modulating effects of graphene oxide nanoparticles in high-fat diet-induced hyperlipidemic mice 원문보기

RSC advances, v.8 no.55, 2018년, pp.31366 - 31371

Li, Juan (CAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Science (CAS) Beijing 100049 China xinggm@ihep.ac.cn) , Yang, Shengmei (CAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Science (CAS) Beijing 100049 China xinggm@ihep.ac.cn) , Yu, Jiaqi (Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193 China cmwu@implad.ac.cn) , Cui, Rongli (CAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy Physics, Chinese Academy of Science (CAS) Beijing 100049 China xinggm@ihep.ac.cn) , Liu, Ru (CAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety, Institute of High Energy) , Lei, Runhong , Chang, Yanan , Geng, Huan , Qin, Yanxia , Gu, Weihong , Xia, Shibo , Chen, Kui , Kong, Jianglong , Chen, Guogang , Wu, Chongming , Xing, Gengmei

Abstract ▼ AI-Helper

Graphene oxide (GO) suspensions can act as a good dispersant and drug delivery system for effective dispersion and drug sustained release. In this study, we investigated the impact of GO on blood/liver lipids and gut microbiota structure in high-fat diet (HFD)-induced hyperlipidemic mice. Oral administration of GO for 28 days remarkably decreased the lipid levels in blood and liver. GO did not decrease the total number of gut bacteria but increased the relative abundance of short-chain fatty acid (SCFA)-producing bacteria such as Clostridium clusters IV and Allobaculum spp. GO also enhanced the copying of bacterial butyryl coenzyme A transferase (BcoA), a key butyrate-producing gene. Although further pharmacological studies are still needed, these results provided an interesting hint that GO may exert beneficial effects on the host's metabolism via selective modulation of SCFA-producing gut microbes.The impact of GO on blood/liver lipids and gut microbiota structure in high-fat diet (HFD)-induced hyperlipidemic mice was investigated. Oral administration of GO for 28 days remarkably decreased lipid levels in blood and liver and GO did not decrease the total number of gut bacteria but increased the relative abundance of short-chain fatty acid (SCFA)-producing bacteria.

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Lipid- and gut microbiota-modulating effects of graphene oxide nanoparticles in high-fat diet-induced hyperlipidemic mice 원문보기

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