[논문]Dietary Isoliquiritigenin at a Low Dose Ameliorates Insulin Resistance and NAFLD in Diet-Induced Obesity in C57BL/6J Mice

Lee, Youngmi; Kwon, Eun-Young; Choi, Myung-Sook

doi:10.3390/ijms19103281

Dietary Isoliquiritigenin at a Low Dose Ameliorates Insulin Resistance and NAFLD in Diet-Induced Obesity in C57BL/6J Mice 원문보기

International journal of molecular sciences, v.19 no.10, 2018년, pp.3281 -

Lee, Youngmi (Department of Food Science and Nutrition, Kyungpook National University, 1370 San-Kyuk Dong Puk-Ku, Daegu 41566, Korea) , Kwon, Eun-Young (6k5rsg@hanmail.net (Y.L.)) , Choi, Myung-Sook (savage20@naver.com (E.-Y.K.))

Abstract ▼ AI-Helper

Isoliquiritigenin (ILG) is a flavonoid constituent of Glycyrrhizae plants. The current study investigated the effects of ILG on diet-induced obesity and metabolic diseases. C57BL/6J mice were fed a normal diet (AIN-76 purified diet), high-fat diet (40 kcal% fat), and high-fat diet +0.02% (w/w) ILG for 16 weeks. Supplementation of ILG resulted in decreased body fat mass and plasma cholesterol level. ILG ameliorated hepatic steatosis by suppressing the expression of hepatic lipogenesis genes and hepatic triglyceride and fatty acid contents, while enhancing β-oxidation in the liver. ILG improved insulin resistance by lowering plasma glucose and insulin levels. This was also demonstrated by the intraperitoneal glucose tolerance test (IPGTT). Additionally, ILG upregulated the expression of insulin signaling-related genes in the liver and muscle. Interestingly, ILG elevated energy expenditure by increasing the expression of thermogenesis genes, which is linked to stimulated mitochondrial biogenesis and uncoupled cellular respiration in brown adipose tissue. ILG also suppressed proinflammatory cytokine levels in the plasma. These results suggest that ILG supplemented at 0.02% in the diet can ameliorate body fat mass, plasma cholesterol, non-alcoholic fatty liver disease, and insulin resistance; these effects were partly mediated by increasing energy expenditure in high-fat fed mice.

주제어

참고문헌 (57)

1. Drewnowski A. Specter S.E. Poverty and Obesity: The Role of Energy Density and Energy Costs Am. J. Clin. Nutr. 2004 79 6 16 10.1093/ajcn/79.1.6 14684391

상세보기
2. Prentice A.M. Jebb S.A. Fast Foods, Energy Density and Obesity: A Possible Mechanistic Link Obes. Rev. 2003 4 187 194 10.1046/j.1467-789X.2003.00117.x 14649369

상세보기
3. Jung U.J. Choi M. Obesity and its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease Int. J. Mol. Sci. 2014 15 6184 6223 10.3390/ijms15046184 24733068

상세보기
4. Spiegelman B.M. Flier J.S. Obesity and the Regulation of Energy Balance Cell 2001 104 531 543 10.1016/S0092-8674(01)00240-9 11239410

상세보기
5. Masoodi M. Kuda O. Rossmeisl M. Flachs P. Kopecky J. Lipid Signaling in Adipose Tissue: Connecting Inflammation & Metabolism Biochim. Biophys. Acta 2015 1851 503 518 25311170
6. Guilherme A. Virbasius J.V. Puri V. Czech M.P. Adipocyte Dysfunctions Linking Obesity to Insulin Resistance and Type 2 Diabetes Nat. Rev. Mol. Cell Boil. 2008 9 367 377 10.1038/nrm2391 18401346

상세보기
7. Bjorndal B. Burri L. Staalesen V. Skorve J. Berge R.K. Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents J. Obes. 2011 2011 490650 10.1155/2011/490650 21403826

상세보기
8. Choi S.H. Ginsberg H.N. Increased very Low Density Lipoprotein (VLDL) Secretion, Hepatic Steatosis, and Insulin Resistance Trends Endocrinol. Metab. 2011 22 353 363 10.1016/j.tem.2011.04.007 21616678

상세보기
9. Shibata S. A Drug over the Millennia: Pharmacognosy, Chemistry, and Pharmacology of Licorice Yakugaku Zasshi 2000 120 849 862 10.1248/yakushi1947.120.10_849 11082698

상세보기
10. Watanabe Y. Nagai Y. Honda H. Okamoto N. Yamamoto S. Hamashima T. Ishii Y. Tanaka M. Suganami T. Sasahara M. Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice Sci. Rep. 2016 6 23097 10.1038/srep23097 26975571

상세보기
11. Honda H. Nagai Y. Matsunaga T. Okamoto N. Watanabe Y. Tsuneyama K. Hayashi H. Fujii I. Ikutani M. Hirai Y. Isoliquiritigenin is a Potent Inhibitor of NLRP3 Inflammasome Activation and Diet-induced Adipose Tissue Inflammation J. Leukoc. Biol. 2014 96 1087 1100 10.1189/jlb.3A0114-005RR 25210146

상세보기
12. Kim Y.M. Kim T.H. Kim Y.W. Yang Y.M. Hwang S.J. Lee J.R. Kim S.C. Kim S.G. Inhibition of Liver X Receptor-Α-Dependent Hepatic Steatosis by Isoliquiritigenin, a Licorice Antioxidant Flavonoid, as Mediated by JNK1 Inhibition Free Radic. Biol. Med. 2010 49 1722 1734 10.1016/j.freeradbiomed.2010.09.001 20840863

상세보기
13. Park S. Choe Y. Kim J. Chang K. Lee H. Lee D. Isoliquiritigenin Impairs Insulin Signaling and Adipocyte Differentiation through the Inhibition of Protein-Tyrosine Phosphatase 1B Oxidation in 3T3-L1 Preadipocytes Food Chem. Toxicol. 2016 93 5 12 10.1016/j.fct.2016.04.017 27117918

상세보기
14. Du F. Gesang Q. Cao J. Qian M. Ma L. Wu D. Yu H. Isoliquiritigenin Attenuates Atherogenesis in Apolipoprotein E-Deficient Mice Int. J. Mol. Sci. 2016 17 1932 10.3390/ijms17111932 27869741

상세보기
15. Liu X. Zhu Q. Zhang M. Yin T. Xu R. Xiao W. Wu J. Deng B. Gao X. Gong W. Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice Via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway Oxid. Med. Cell. Longev. 2018 2018 7161592 10.1155/2018/7161592 29854090

상세보기
16. Strycharz J. Rygielska Z. Swiderska E. Drzewoski J. Szemraj J. Szmigiero L. Sliwinska A. SIRT1 as a Therapeutic Target in Diabetic Complications Curr. Med. Chem. 2018 25 1002 1035 10.2174/0929867324666171107103114 29110598

상세보기
17. Gooda Sahib N. Saari N. Ismail A. Khatib A. Mahomoodally F. Abdul Hamid A. Plants’ Metabolites as Potential Antiobesity Agents Sci. World J. 2012 2012 436039 10.1100/2012/436039 22666121

상세보기
18. Loftus T.M. Jaworsky D.E. Frehywot G.L. Townsend C.A. Ronnett G.V. Lane M.D. Kuhajda F.P. Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors Science 2000 288 2379 2381 10.1126/science.288.5475.2379 10875926

상세보기
19. Nguyen P. Leray V. Diez M. Serisier S. Bloc’h J.L. Siliart B. Dumon H. Liver Lipid Metabolism J. Anim. Physiol. Anim. Nutr. 2008 92 272 283 10.1111/j.1439-0396.2007.00752.x 18477307

상세보기
20. Musso G. Gambino R. Cassader M. Recent Insights into Hepatic Lipid Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD) Prog. Lipid Res. 2009 48 1 26 10.1016/j.plipres.2008.08.001 18824034

상세보기
21. Fraulob J.C. Ogg-Diamantino R. Fernandes-Santos C. Aguila M.B. Mandarim-de-Lacerda C.A. A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High Fat Diet J. Clin. Biochem. Nutr. 2010 46 212 223 10.3164/jcbn.09-83 20490316

상세보기
22. Van der Heijden R.A. Sheedfar F. Morrison M.C. Hommelberg P.P. Kor D. Kloosterhuis N.J. Gruben N. Youssef S.A. De Bruin A. Hofker M.H. High-Fat Diet Induced Obesity Primes Inflammation in Adipose Tissue Prior to Liver in C57BL/6j Mice Aging 2015 7 256 268 10.18632/aging.100738 25979814

상세보기
23. Roat R. Rao V. Doliba N.M. Matschinsky F.M. Tobias J.W. Garcia E. Ahima R.S. Imai Y. Alterations of Pancreatic Islet Structure, Metabolism and Gene Expression in Diet-Induced Obese C57BL/6J Mice PLoS ONE 2014 9 e86815 10.1371/journal.pone.0086815 24505268

상세보기
24. Barthel A. Schmoll D. Novel Concepts in Insulin Regulation of Hepatic Gluconeogenesis Am. J. Physiol. Endocrinol. Metab. 2003 285 E685 E692 10.1152/ajpendo.00253.2003 12959935

상세보기
25. Kubota T. Kubota N. Kumagai H. Yamaguchi S. Kozono H. Takahashi T. Inoue M. Itoh S. Takamoto I. Sasako T. Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle Cell Metab. 2011 13 294 307 10.1016/j.cmet.2011.01.018 21356519

상세보기
26. Cho H. Mu J. Kim J.K. Thorvaldsen J.L. Chu Q. Crenshaw E.B. 3rd Kaestner K.H. Bartolomei M.S. Shulman G.I. Birnbaum M.J. Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKB Beta) Science 2001 292 1728 1731 10.1126/science.292.5522.1728 11387480

상세보기
27. Kido Y. Burks D.J. Withers D. Bruning J.C. Kahn C.R. White M.F. Accili D. Tissue-Specific Insulin Resistance in Mice with Mutations in the Insulin Receptor, IRS-1, and IRS-2 J. Clin. Investig. 2000 105 199 205 10.1172/JCI7917 10642598

상세보기
28. Boss O. Samec S. Paoloni-Giacobino A. Rossier C. Dulloo A. Seydoux J. Muzzin P. Giacobino J. Uncoupling Protein-3: A New Member of the Mitochondrial Carrier Family with Tissue-specific Expression FEBS Lett. 1997 408 39 42 10.1016/S0014-5793(97)00384-0 9180264

상세보기
29. Choi C.S. Fillmore J.J. Kim J.K. Liu Z.X. Kim S. Collier E.F. Kulkarni A. Distefano A. Hwang Y.J. Kahn M. Overexpression of Uncoupling Protein 3 in Skeletal Muscle Protects Against Fat-Induced Insulin Resistance J. Clin. Investig. 2007 117 1995 2003 10.1172/JCI13579 17571165

상세보기
30. Boudina S. Sena S. Sloan C. Tebbi A. Han Y.H. O’neill B.T. Cooksey R.C. Jones D. Holland W.L. McClain D.A. Early Mitochondrial Adaptations in Skeletal Muscle to Diet-Induced Obesity are Strain Dependent and Determine Oxidative Stress and Energy Expenditure but Not Insulin Sensitivity Endocrinology 2012 153 2677 2688 10.1210/en.2011-2147 22510273

상세보기
31. Sharma B.K. Patil M. Satyanarayana A. Negative Regulators of Brown Adipose Tissue (BAT)-mediated Thermogenesis J. Cell. Physiol. 2014 229 1901 1907 10.1002/jcp.24664 24809334

상세보기
32. Seale P. Bjork B. Yang W. Kajimura S. Chin S. Kuang S. Scime A. Devarakonda S. Conroe H.M. Erdjument-Bromage H. PRDM16 Controls a Brown Fat/Skeletal Muscle Switch Nature 2008 454 961 967 10.1038/nature07182 18719582

상세보기
33. Seale P. Kajimura S. Yang W. Chin S. Rohas L.M. Uldry M. Tavernier G. Langin D. Spiegelman B.M. Transcriptional Control of Brown Fat Determination by PRDM16 Cell Metab. 2007 6 38 54 10.1016/j.cmet.2007.06.001 17618855

상세보기
34. Schug T.T. Li X. Sirtuin 1 in Lipid Metabolism and Obesity Ann. Med. 2011 43 198 211 10.3109/07853890.2010.547211 21345154

상세보기
35. Baur J.A. Ungvari Z. Minor R.K. Le Couteur D.G. De Cabo R. Are Sirtuins Viable Targets for Improving Healthspan and Lifespan? Nat. Rev. Drug Discov. 2012 11 443 461 10.1038/nrd3738 22653216

상세보기
36. Alcaín F.J. Villalba J.M. Sirtuin Activators Expert Opin. Ther. Pat. 2009 19 403 414 10.1517/13543770902762893 19441923

상세보기
37. Boutant M. Joffraud M. Kulkarni S.S. García-Casarrubios E. García-Roves P.M. Ratajczak J. Fernández-Marcos P.J. Valverde A.M. Serrano M. Cantó C. SIRT1 Enhances Glucose Tolerance by Potentiating Brown Adipose Tissue Function Mol. Metab. 2015 4 118 131 10.1016/j.molmet.2014.12.008 25685699

상세보기
38. Poher A. Altirriba J. Veyrat-Durebex C. Rohner-Jeanrenaud F. Brown Adipose Tissue Activity as a Target for the Treatment of Obesity/Insulin Resistance Front. Physiol. 2015 6 4 10.3389/fphys.2015.00004 25688211

상세보기
39. López-Jaramillo P. Gómez-Arbeláez D. López-López J. López-López C. Martínez-Ortega J. Gómez-Rodríguez A. Triana-Cubillos S. The Role of Leptin/Adiponectin Ratio in Metabolic Syndrome and Diabetes Horm. Mol. Biol. Clin. Investig. 2014 18 37 45 10.1515/hmbci-2013-0053 25389999

상세보기
40. Dandona P. Aljada A. Bandyopadhyay A. Inflammation: The Link between Insulin Resistance, Obesity and Diabetes Trends Immunol. 2004 25 4 7 10.1016/j.it.2003.10.013 14698276

상세보기
41. Rosen E.D. Spiegelman B.M. Adipocytes as Regulators of Energy Balance and Glucose Homeostasis Nature 2006 444 847 853 10.1038/nature05483 17167472

상세보기
42. Kim A.Y. Park Y.J. Pan X. Shin K.C. Kwak S. Bassas A.F. Sallam R.M. Park K.S. Alfadda A.A. Xu A. Obesity-Induced DNA Hypermethylation of the Adiponectin Gene Mediates Insulin Resistance Nat. Commun. 2015 6 7585 10.1038/ncomms8585 26139044

상세보기
43. Yamauchi T. Kamon J. Minokoshi Y.A. Ito Y. Waki H. Uchida S. Yamashita S. Noda M. Kita S. Ueki K. Adiponectin Stimulates Glucose Utilization and Fatty-Acid Oxidation by Activating AMP-Activated Protein Kinase Nat. Med. 2002 8 1288 1295 10.1038/nm788 12368907

상세보기
44. Finucane F. Luan J. Wareham N. Sharp S. O’Rahilly S. Balkau B. Flyvbjerg A. Walker M. Højlund K. Nolan J. Correlation of the Leptin: Adiponectin Ratio with Measures of Insulin Resistance in Non-Diabetic Individuals Diabetologia 2009 52 2345 2349 10.1007/s00125-009-1508-3 19756488

상세보기
45. Bing C. Is Interleukin-1β a Culprit in Macrophage-Adipocyte Crosstalk in Obesity? Adipocyte 2015 4 149 152 10.4161/21623945.2014.979661 26167419

상세보기
46. Gao D. Madi M. Ding C. Fok M. Steele T. Ford C. Hunter L. Bing C. Interleukin-1β Mediates Macrophage-Induced Impairment of Insulin Signaling in Human Primary Adipocytes Am. J. Physiol. Endocrinol. Metab. 2014 307 E289 E304 10.1152/ajpendo.00430.2013 24918199

상세보기
47. Sell H. Dietze-Schroeder D. Kaiser U. Eckel J. Monocyte Chemotactic Protein-1 is a Potential Player in the Negative Cross-Talk between Adipose Tissue and Skeletal Muscle Endocrinology 2006 147 2458 2467 10.1210/en.2005-0969 16439461

상세보기
48. Chang T. Chen J. Emerging Role of Chemokine CC Motif Ligand 4 Related Mechanisms in Diabetes Mellitus and Cardiovascular Disease: Friends Or Foes? Cardiovasc. Diabetol. 2016 15 117 10.1186/s12933-016-0439-9 27553774

상세보기
49. Folch J. Lees M. Sloane Stanley G.H. A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues J. Biol. Chem. 1957 226 497 509 13428781
50. Hulcher F.H. Oleson W.H. Simplified Spectrophotometric Assay for Microsomal 3-Hydroxy-3-Methylglutaryl CoA Reductase by Measurement of Coenzyme A J. Lipid Res. 1973 14 625 631 4147523

상세보기
51. Bradford M.M. A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding Anal. Biochem. 1976 72 248 254 10.1016/0003-2697(76)90527-3 942051

상세보기
52. Lazarow P.B. [19] Assay of peroxisomal β-oxidation of fatty acids Methods Enzymol. 1981 72 315 319 10.1016/S0076-6879(81)72021-4 7031421
53. Davidson A.L. Arion W.J. Factors Underlying Significant Underestimations of Glucokinase Activity in Crude Liver Extracts: Physiological Implications of Higher Cellular Activity Arch. Biochem. Biophys. 1987 253 156 167 10.1016/0003-9861(87)90648-5 3813560

상세보기
54. Alegre M. Fillat C. Guinovart J.J. Determination of Glucose-6-Phosphatase Activity using the Glucose Dehydrogenase-Coupled Reaction Anal. Biochem. 1988 173 185 189 10.1016/0003-2697(88)90176-5 2847588

상세보기
55. Bentle L.A. Lardy H.A. Interaction of Anions and Divalent Metal Ions with Phosphoenolpyruvate Carboxykinase J. Biol. Chem. 1976 251 2916 2921 1270433
56. Shapiro D.J. Nordstrom J.L. Mitschelen J.J. Rodwell V.W. Schimke R.T. Micro Assay for 3-Hdyroxy-3-Methylglutaryl-CoA Reductase in Rat Liver and in L-Cell Fibroblasts Biochim. Biophys. Acta 1974 370 369 377 10.1016/0005-2744(74)90098-9 4441486

상세보기
57. Gillies P.J. Rathgeb K.A. Perri M.A. Robinson C.S. Regulation of Acyl-CoA: Cholesterol Acyltransferase Activity in Normal and Atherosclerotic Rabbit Aortas: Role of a Cholesterol Substrate Pool Exp. Mol. Pathol. 1986 44 329 339 10.1016/0014-4800(86)90046-8 3720921

상세보기

LOADING...

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Dietary Isoliquiritigenin at a Low Dose Ameliorates Insulin Resistance and NAFLD in Diet-Induced Obesity in C57BL/6J Mice 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (57)

이 논문을 인용한 문헌

연구과제 타임라인

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Dietary Isoliquiritigenin at a Low Dose Ameliorates Insulin Resistance and NAFLD in Diet-Induced Obesity in C57BL/6J Mice 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (57)

이 논문을 인용한 문헌

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트