$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Prophylactic use of probiotic chocolate modulates intestinal physiological functions in constipated rats

Journal of the science of food and agriculture, v.99 no.6, 2019년, pp.3045 - 3056  

Lee, Chul Sang (College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea) ,  Tan, Pei Lei (College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea) ,  Eor, Ju Young (College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea) ,  Choi, Da Hye (Lotte R&D Center, Seoul, South Korea) ,  Park, Miri (Lotte R&D Center, Seoul, South Korea) ,  Seo, Sung Keum (Lotte R&D Center, Seoul, South Korea) ,  Yoon, Seokmin (Lotte R&D Center, Seoul, South Korea) ,  Yang, Siyoung (Lotte R&D Center, Seoul, South Korea) ,  Kim, Sae Hun (College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea)

Abstract AI-Helper 아이콘AI-Helper

AbstractBACKGROUNDThis study investigated the in vivo prophylactic effect of probiotic chocolate on constipation. Rats were administered chocolate containing 2.5 × 1010 CFU g−1 of probiotics daily for 4 weeks and treated with loperamide (5 mg kg−1) daily at the fourth week of treat...

주제어

참고문헌 (61)

  1. Kakino M , Tazawa S , Maruyama H , Tsuruma K , Araki Y , Shimazawa M et al ., Laxative effects of agarwood on low‐fiber diet‐induced constipation in rats . BMC Complement Altern Med 10 : 68 ( 2010 ). https://doi.org/10.1186/1472‐6882‐10‐68. 

  2. Miller LE , Ibarra A , Ouwehand AC and Zimmermann AK , Normative values for stool frequency and form using Rome III diagnostic criteria for functional constipation in adults: systematic review with meta‐analysis . Ann Gastroenterol 30 : 161 – 167 ( 2017 ). https://doi.org/10.20524/aog.2016.0108. 

  3. Lee HY , Kim JH , Jeung HW , Lee CU , Kim DS , Li B et al ., Effects of Ficus carica paste on loperamide‐induced constipation in rats . Food Chem Toxicol 50 : 895 – 902 ( 2012 ). https://doi.org/10.1016/j.fct.2011.12.001. 

  4. Dimidi E , Christodoulides S , Fragkos KC , Scott SM and Whelan K , The effect of probiotics on functional constipation in adults: a systematic review and meta‐analysis of randomized controlled trials . Am J Clin Nutr 100 : 1075 – 1084 ( 2014 ). https://doi.org/10.3945/ajcn.114.089151. 

  5. Shimotoyodome A , Meguro S , Hase T , Tokimitsu I and Sakata T , Decreased colonic mucus in rats with loperamide‐induced constipation . Comp Biochem Physiol A Mol Integr Physiol 126 : 203 – 212 ( 2000 ). https://doi.org/10.1016/S1095‐6433(00)00194‐X. 

  6. Lin CH , Lin JW , Liu YC , Chang CH and Wu RM , Risk of Parkinson's disease following severe constipation: a nationwide population‐based cohort study . Parkinsonism Relat Disord 20 : 1371 – 1375 ( 2014 ). https://doi.org/10.1016/j.parkreldis.2014.09.026. 

  7. Locke GR , Pemberton JH and Phillips SF , AGA technical review on constipation . Gastroenterology 119 : 1766 – 1778 ( 2000 ). https://doi.org/10.1053/gast.2000.20392. 

  8. Siegers C , von Hertzberg‐Lottin E , Otte M and Schneider B , Anthranoid laxative abuse: a risk for colorectal cancer? Gut 34 : 1099 – 1101 ( 1993 ). https://doi.org/10.1136/gut.34.8.1099. 

  9. Mori T , Shibasaki Y , Matsumoto K , Shibasaki M , Hasegawa M , Wang E et al ., Mechanisms that underlie µ ‐ opioid receptor agonist‐induced constipation: differential involvement of mu‐opioid receptor sites and responsible regions . J Pharmacol Exp Ther 347 : 91 – 99 ( 2013 ). https://doi.org/10.1124/jpet.113.204313. 

  10. Neri F , Cavallari G , Tsivian M , Bianchi E , Aldini R , Cevenini M et al ., Effect of colic vein ligature in rats with loperamide‐induced constipation . J Biomed Biotechnol 2012 : 1 – 5 ( 2012 ). https://doi.org/10.1155/2012/896162. 

  11. Kojima R , Doihara H , Nozawa K , Kawabata‐Shoda E , Yokoyama T and Ito H , Characterization of two models of drug‐induced constipation in mice and evaluation of mustard oil in these models . Pharmacology 84 : 227 – 233 ( 2009 ). https://doi.org/10.1159/000236524. 

  12. Wang J , Han M , Zhang G , Qiao S , Li D and Ma X , The signal pathway of antibiotic alternatives on intestinal microbiota and immune function . Curr Protein Pept Sci 17 : 785 – 796 ( 2016 ). https://doi.org/10.2174/1389203717666160526123351s. 

  13. Bron PA , van Baarlen P and Kleerebezem M , Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa . Nat Rev Microbiol 10 : 66 – 78 ( 2011 ). https://doi.org/10.1038/nrmicro2690. 

  14. Ma N , Guo P , Zhang J , He T , Kim SW , Zhang G et al ., Nutrients mediate intestinal bacteria‐mucosal immune crosstalk . Front Immunol 9 : 5 ( 2018 ). https://doi.org/10.3389/fimmu.2018.00005. 

  15. Liu H , Zhang J , Zhang S , Yang F , Thacker PA , Zhang G et al ., Oral administration of Lactobacillus fermentum I5007 favors intestinal development and alters the intestinal microbiota in formula‐fed piglets . J Agric Food Chem 62 : 860 – 866 ( 2014 ). https://doi.org/10.1021/jf403288r. 

  16. Lu Y , Fan C , Li P , Lu Y , Chang X and Qi K , Short chain fatty acids prevent high‐fat‐diet‐induced obesity in mice by regulating G protein‐coupled receptors and gut microbiota . Sci Rep 6 : 37589 ( 2016 ). https://doi.org/10.1038/srep37589. 

  17. Chen J , Li Y , Tian Y , Huang C , Li D , Zhong Q et al ., Interaction between microbes and host intestinal health: modulation by dietary nutrients and gut–brain–endocrine–immune axis . Curr Protein Pept Sci 16 : 592 – 603 ( 2015 ). https://doi.org/10.2174/1389203716666150630135720. 

  18. Li C , Nie SP , Zhu KX , Xiong T , Li C , Gong J et al ., Effect of Lactobacillus plantarum NCU116 on loperamide‐induced constipation in mice . Int J Food Sci Nutr 66 : 533 – 538 ( 2015 ). https://doi.org/10.3109/09637486.2015.1024204. 

  19. Tee WF , Nazaruddin R , Tan YN and Ayob MK , Effects of encapsulation on the viability of potential probiotic Lactobacillus plantarum exposed to high acidity condition and presence of bile salts . Food Sci Technol Int 20 : 399 – 404 ( 2014 ). https://doi.org/10.1177/1082013213488775. 

  20. Ding WK and Shah NP , Effect of various encapsulating materials on the stability of probiotic bacteria . J Food Sci 74 : M100 – M107 ( 2009 ). https://doi.org/10.1111/j.1750‐3841.2009.01067.x. 

  21. Whorwell PJ , Altringer L , Morel J , Bond Y , Charbonneau D , O'Mahony L et al ., Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome . Am J Gastroenterol 101 : 1581 – 1590 ( 2006 ). https://doi.org/10.1111/j.1572‐0241.2006.00734.x. 

  22. Possemiers S , Marzorati M , Verstraete W and Van de Wiele T , Bacteria and chocolate: a successful combination for probiotic delivery . Int J Food Microbiol 141 : 97 – 103 ( 2010 ). https://doi.org/10.1016/j.ijfoodmicro.2010.03.008. 

  23. Kakino M , Izuta H , Ito T , Tsuruma K , Araki Y , Shimazawa M et al ., Agarwood induced laxative effects via acetylcholine receptors on loperamide‐induced constipation in mice . Biosci Biotechnol Biochem 74 : 1550 – 1555 ( 2010 ). https://doi.org/10.1271/bbb.100122. 

  24. Kim BK , Lee IO , Tan PL , Eor JY , Hwang JK and Kim SH , Protective effect of Lactobacillus fermentum LA12 in an alcohol‐induced rat model of alcoholic steatohepatitis . Korean J Food Sci Anim Resour 37 : 931 – 939 ( 2017 ). https://doi.org/10.5851/kosfa.2017.37.6.931. 

  25. Kim Y , Koh JH , Ahn YJ , Oh S and Kim SH , The synergic anti‐inflammatory impact of Gleditsia sinensis Lam. and Lactobacillus brevis KY21 on intestinal epithelial cells in a DSS‐induced colitis model . Korean J Food Sci Anim Resour 35 : 604 – 610 ( 2015 ). https://doi.org/10.5851/kosfa.2015.35.5.604. 

  26. Batalha VL , Ferreira DG , Coelho JE , Valadas JS , Gomes R , Temido‐Ferreira M et al ., The caffeine‐binding adenosine a 2A receptor induces age‐like HPA‐axis dysfunction by targeting glucocorticoid receptor function . Sci Rep 6 : 31493 ( 2016 ). https://doi.org/10.1038/srep31493. 

  27. Zhong W , Li Q , Xie G , Sun X , Tan X , Sun X et al ., Dietary fat sources differentially modulate intestinal barrier and hepatic inflammation in alcohol‐induced liver injury in rats . Am J Physiol Gastrointest Liver Physiol 305 : G919 – G932 ( 2013 ). https://doi.org/10.1152/ajpgi.00226.2013. 

  28. Zheng G , Fon GV , Meixner W , Creekmore A , Zong Y , Dame M et al ., Chronic stress and intestinal barrier dysfunction: glucocorticoid receptor and transcription repressor HES1 regulate tight junction protein Claudin‐1 promoter . Sci Rep 7 : 4502 ( 2017 ). https://doi.org/10.1038/s41598‐017‐04755‐w. 

  29. Liu X and Wang JM , Iridoid glycosides fraction of Folium syringae leaves modulates NF‐κB signal pathway and intestinal epithelial cells apoptosis in experimental colitis . PLoS One 6 : e24740 ( 2011 ). https://doi.org/10.1371/journal.pone.0024740. 

  30. Canuelo A , Siles E , Martinez‐Romero R , Peinado M and Martinez‐Lara E , The nitric oxide system response to hypoxia/reoxygenation in the aged cerebral cortex . Exp Gerontol 42 : 1137 – 1145 ( 2007 ). https://doi.org/10.1016/j.exger.2007.09.006. 

  31. Sugimoto N , Matsuzaki K , Ishibashi H , Tanaka M , Sawaki T , Fujita Y et al ., Upregulation of aquaporin expression in the salivary glands of heat‐acclimated rats . Sci Rep 3 : 1763 ( 2013 ). https://doi.org/10.1038/srep01763. 

  32. Kim JE , Go J , Sung JE , Lee HA , Yun WB , Hong JT et al ., Uridine stimulate laxative effect in the loperamide‐induced constipation of SD rats through regulation of the mAChRs signaling pathway and mucin secretion . BMC Gastroenterol 17 : 21 ( 2017 ). https://doi.org/10.1186/s12876‐017‐0576‐y. 

  33. Castillo M , Martín‐Orúe SM , Manzanilla EG , Badiola I , Martín M and Gasa J , Quantification of total bacteria, enterobacteria and lactobacilli populations in pig digesta by real‐time PCR . Vet Microbiol 114 : 165 – 170 ( 2006 ). https://doi.org/10.1016/j.vetmic.2005.11.055. 

  34. Ramos‐Romero S , Hereu M , Molinar‐Toribio E , Almajano MP , Méndez L , Medina I et al ., Effects of the combination of ω‐3 PUFAs and proanthocyanidins on the gut microbiota of healthy rats . Food Res Int 97 : 364 – 371 ( 2017 ). https://doi.org/10.1016/j.foodres.2017.04.024. 

  35. Reichardt N , Duncan SH , Young P , Belenguer A , Leitch CM , Scott KP et al ., Phylogenetic distribution of three pathways for propionate production within the human gut microbiota . ISME J 8 : 1323 – 1335 ( 2014 ). https://doi.org/10.1038/ismej.2014.14. 

  36. Matsuda K , Tsuji H , Asahara T , Matsumoto K , Takada T and Nomoto K , Establishment of an analytical system for the human fecal microbiota, based on reverse transcription‐quantitative PCR targeting of multicopy rRNA molecules . Appl Environ Microbiol 75 : 1961 – 1969 ( 2009 ). https://doi.org/10.1128/AEM.01843‐08. 

  37. Fu C , Carter J , Li Y , Porter J and Kerley M , Comparison of agar plate and real‐time PCR on enumeration of Lactobacillus , Clostridium perfringen s and total anaerobic bacteria in dog faeces . Lett Appl Microbiol 42 : 490 – 494 ( 2006 ). https://doi.org/10.1111/j.1472‐765X.2006.01893.x. 

  38. Matsuki T , Watanabe K , Fujimoto J , Kado Y , Takada T , Matsumoto K et al ., Quantitative PCR with 16S rRNA‐gene‐targeted species‐specific primers for analysis of human intestinal bifidobacteria . Appl Environ Microbiol 70 : 167 – 173 ( 2004 ). https://doi.org/10.1128/AEM.70.1.167‐173.2004. 

  39. Shen J , Zhang B , Wei G , Pang X , Wei H , Li M et al ., Molecular profiling of the Clostridium leptum subgroup in human fecal microflora by PCR‐denaturing gradient gel electrophoresis and clone library analysis . Appl Environ Microbiol 72 : 5232 – 5238 ( 2006 ). https://doi.org/10.1128/AEM.00151‐06. 

  40. Ahmed S , Macfarlane GT , Fite A , McBain AJ , Gilbert P and Macfarlane S , Mucosa‐associated bacterial diversity in relation to human terminal ileum and colonic biopsy samples . Appl Environ Microbiol 73 : 7435 – 7442 ( 2007 ). https://doi.org/10.1128/AEM.01143‐07. 

  41. Kim SE , Choi SC , Park KS , Park MI , Shin JE , Lee TH et al ., Change of fecal flora and effectiveness of the short‐term VSL# 3 probiotic treatment in patients with functional constipation . J Neurogastroenterol Motil 21 : 111 – 120 ( 2015 ). https://doi.org/10.5056/jnm14048. 

  42. Han SH , Hong KB , Kim EY , Ahn SH and Suh HJ , Effect of dual‐type oligosaccharides on constipation in loperamide‐treated rats . Nutr Res Pract 10 : 583 – 589 ( 2016 ). https://doi.org/10.4162/nrp.2016.10.6.583. 

  43. Wintola OA , Sunmonu TO and Afolayan AJ , The effect of Aloe ferox Mill. in the treatment of loperamide‐induced constipation in Wistar rats . BMC Gastroenterol 10 : 95 ( 2010 ). https://doi.org/10.1186/1471‐230X‐10‐95. 

  44. Müller‐Lissner SA , Kaatz V , Brandt W , Keller J and Layer P , The perceived effect of various foods and beverages on stool consistency . Eur J Gastroenterol Hepatol 17 : 109 – 112 ( 2005 ). DOI: 10.1097/00042737‐200501000‐00020 . 

  45. Khalif IL , Quigley EM , Konovitch EA and Maximova ID , Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation . Dig Liver Dis 37 : 838 – 849 ( 2005 ). https://doi.org/10.1016/j.dld.2005.06.008. 

  46. Huang C , Song P , Fan P , Hou C , Thacker P and Ma X , Dietary sodium butyrate decreases postweaning diarrhea by modulating intestinal permeability and changing the bacterial communities in weaned piglets . J Nutr 145 : 2774 – 2780 ( 2015 ). https://doi.org/10.3945/jn.115.217406. 

  47. Fanning AS , Ma TY and Anderson JM , Isolation and functional characterization of the actin binding region in the tight junction protein ZO‐1 . FASEB J 16 : 1835 – 1837 ( 2002 ). https://doi.org/10.1096/fj.02‐0121fje. 

  48. King LS and Agre P , From structure to disease: the evolving tale of aquaporin biology . Nat Rev Mol Cell Biol 5 : 687 – 698 ( 2004 ). https://doi.org/10.1038/nrm1469. 

  49. Ikarashi N , Kon R and Sugiyama K , Aquaporins in the colon as a new therapeutic target in diarrhea and constipation . Int J Mol Sci 17 : E1172 ( 2016 ). https://doi.org/10.3390/ijms17071172. 

  50. Y Amamoto T , Kuramoto H and Kadowaki M , Downregulation in aquaporin 4 and aquaporin 8 expression of the colon associated with the induction of allergic diarrhea in a mouse model of food allergy . Life Sci 81 : 115 – 120 ( 2007 ). https://doi.org/10.1016/j.lfs.2007.04.036. 

  51. Bertiaux‐Vandaële N , Youmba SB , Belmonte L , Lecleire S , Antonietti M , Gourcerol G et al ., The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype . Am J Gastroenterol 106 : 2165 – 2173 ( 2011 ). https://doi.org/10.1038/ajg.2011.257. 

  52. Wang Y , Kirpich I , Liu Y , Ma Z , Barve S , McClain CJ et al ., Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia‐inducible factor, promotes intestinal integrity and ameliorates alcohol‐induced liver injury . Am J Pathol 179 : 2866 – 2875 ( 2011 ). https://doi.org/10.1016/j.ajpath.2011.08.039. 

  53. Takeda Y , Nakase H , Namba K , Inoue S , Ueno S , Uza N et al ., Upregulation of T‐bet and tight junction molecules by Bifidobactrium longum improves colonic inflammation of ulcerative colitis . Inflamm Bowel Dis 15 : 1617 – 1618 ( 2009 ). https://doi.org/10.1002/ibd.20861. 

  54. Ley RE , Turnbaugh PJ , Klein S and Gordon JI , Microbial ecology: human gut microbes associated with obesity . Nature 444 : 1022 – 1023 ( 2006 ). https://doi.org/10.1038/4441022a. 

  55. Zhu L , Liu W , Alkhouri R , Baker RD , Bard JE , Quigley EM et al ., Structural changes in the gut microbiome of constipated patients . Physiol Genomics 46 : 679 – 686 ( 2014 ). https://doi.org/10.1152/physiolgenomics.00082.2014. 

  56. Huijghebaert S , Awouters F and Tytgat G , Racecadotril versus loperamide: antidiarrheal research revisited . Dig Dis Sci 48 : 239 – 250 ( 2003 ). https://doi.org/10.1023/A:1021989606317. 

  57. Ren X , Liu L , Gamallat Y , Zhang B and Xin Y , Enteromorpha and polysaccharides from enteromorpha ameliorate loperamide‐induced constipation in mice . Biomed Pharmacother 96 : 1075 – 1081 ( 2017 ). https://doi.org/10.1016/j.biopha.2017.11.119. 

  58. Si JM , Yu YC , Fan YJ and Chen SJ , Intestinal microecology and quality of life in irritable bowel syndrome patients . World J Gastroenterol 10 : 1802 – 1805 ( 2004 ). https://doi.org/10.3748/wjg.v10.i12.1802. 

  59. Arques JL , Rodriguez E , Langa S , Landete JM and Medina M , Antimicrobial activity of lactic acid bacteria in dairy products and gut: effect on pathogens . Biomed Res Int 2015 : 584183 ( 2015 ). https://doi.org/10.1155/2015/584183. 

  60. Roškar I , Švigelj K , Štempelj M , Volfand J , Štabuc B , Malovrh Š et al ., Effects of a probiotic product containing Bifidobacterium animalis subsp. animalis IM386 and Lactobacillus plantarum MP2026 in lactose intolerant individuals: randomized, placebo‐controlled clinical trial . J Funct Foods 35 : 1 – 8 ( 2017 ). https://doi.org/10.1016/j.jff.2017.05.020. 

  61. Kailasapathy K and Chin J , Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifidobacterium spp . Immunol Cell Biol 78 : 80 – 88 ( 2000 ). https://doi.org/10.1046/j.1440‐1711.2000.00886.x. 

LOADING...

관련 콘텐츠

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로