[논문]Mycosynthesis, characterization, anticancer and antibacterial activity of silver nanoparticles from endophytic fungus Talaromyces purpureogenus

Hu, Xiaowen; Saravanakumar, Kandasamy; Jin, Tieyan; Wang, Myeong-Hyeon

doi:10.2147/IJN.S200817

Mycosynthesis, characterization, anticancer and antibacterial activity of silver nanoparticles from endophytic fungus Talaromyces purpureogenus 원문보기

International journal of nanomedicine, v.14, 2019년, pp.3427 - 3438

Hu, Xiaowen (Department of Medical Biotechnology, College of Biomedical Sciences, Kangwon National University , Chuncheon 200-701 , South Korea) , Saravanakumar, Kandasamy (Department of Medical Biotechnology, College of Biomedical Sciences, Kangwon National University , Chuncheon 200-701 , South Korea) , Jin, Tieyan (Department of Food Science and Engineering, College of Agricultural, Yanbian University , Yanji , Jilin , People’s Republic of China) , Wang, Myeong-Hyeon (Department of Medical Biotechnology, College of Biomedical Sciences, Kangwon National University , Chuncheon 200-701 , South Korea)

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Background: Biogenic silver nanoparticles (AgNPs) have wider range of biomedical applications. The present work synthesized Tp-AgNPs using mycelial extract of endophytic fungus Talaromyces purpureogenus (MEEF), characterized, and analyzed for antibacterial, anti-proliferation and cell wounding healing activities.Methods: The synthesized Tp-AgNPs were characterized by UV-visible spectrophotometer (UV-Vis), field emission transmission electron microscopy (FETEM) with energy-dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), particle size analysis (PSA) and X-ray diffraction (XRD). Further, antibacterial activity was determined by Kirby–Bauer test and anti-proliferation activity was tested in human lung carcinoma A549 by water-soluble tetrazolium and flow cytometer assay. In addition, cell wounding healing activity was determined by scratch assay.Results: UV-Vis results displayed a strong absorption peak from 390 nm to 420 nm, which indicated the successful synthesis of Tp-AgNPs. FETEM-EDS results indicated the round and triangle shaped Tp-AgNPs with the average size of 25 nm in accordance with PSA. FTIR analysis indicated the involvement of various functional molecules from MEEF in the synthesis of Tp-AgNPs. XRD result proved nature of Tp-AgNPs as a high-quality crystal. The Tp-AgNPs significantly inhibited the growth of bacterial pathogens at the minimal inhibitory concentration of 16.12 μg.mL−1 for Gram+, and 13.98 μg.mL−1 for Gram− bacteria. Further, Tp-AgNPs (2 μg.mL−1) showed a strong anti-proliferation effect in A549. Interestingly, Tp-AgNPs was not cytotoxic to normal NIH3T3 cells. In addition, the NPs exhibited a strong cell wounding healing activity.Conclusion: This work biosynthesized AgNPs with strong antibacterial, anticancer and cell wound healing properties using endophytic fungus T. purpureogenus.

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1. Thakkar KN , Mhatre SS , Parikh RY . Biological synthesis of metallic nanoparticles . Nanomedicine . 2017 ; 6 : 257 – 262 . doi: 10.1016/j.nano.2009.07.002

상세보기
2. Shanmuganathan R , MubarakAli D , Prabakar D , et al. An enhancement of antimicrobial efficacy of biogenic and ceftriaxone-conjugated silver nanoparticles: green approach . Environ Sci Pollution Res . 2018 ; 25 ( 11 ): 10362 – 10370 . doi: 10.1007/s11356-017-9367-9

상세보기
3. Pugazhendhi A , Prabakar D , Jacob JM , Karuppusamy I , Saratale RG . Synthesis and characterization of silver nanoparticles using Gelidium amansii and its antimicrobial property against various pathogenic bacteria . Microb Pathog . 2018 ; 114 : 41 – 45 . doi: 10.1016/j.micpath.2017.11.013 29146498

상세보기
4. Saravanan M , Barik SK , MubarakAli D , Prakash P , Pugazhendhi A . Synthesis of silver nanoparticles from Bacillus brevis (NCIM 2533) and their antibacterial activity against pathogenic bacteria . Microb Pathog . 2018 ; 116 : 221 – 226 . doi: 10.1016/j.micpath.2018.01.038 29407231

상세보기
5. Singh MR , Black K . Anomalous dipole–dipole interaction in an ensemble of quantum emitters and metallic nanoparticle hybrids . J Phys Chem C . 2018 ; 122 ( 46 ): 26584 – 26591 . doi: 10.1021/acs.jpcc.8b06352

상세보기
6. Singh MR , Chandra Sekhar M , Balakrishnan S , Masood S . Medical applications of hybrids made from quantum emitter and metallic nanoshell . J Appl Phys . 2017 ; 122 ( 3 ): 034306 . doi: 10.1063/1.4994308

상세보기
7. Singh MR , Guo J,J , Cid JM , De Hoyos Martinez JE . Control of fluorescence in quantum emitter and metallic nanoshell hybrids for medical applications . J Appl Phys . 2017 ; 121 ( 9 ): 094303 . doi: 10.1063/1.4977756

상세보기
8. Cox JD , Singh MR , von Bilderling C , Bragas AV . A nonlinear switching mechanism in quantum dot and metallic nanoparticle hybrid systems . Adv Opt Mater . 2013 ; 1 ( 6 ): 460 – 467 . doi: 10.1002/adom.v1.6
9. Schindel D , Singh MR . A study of energy absorption rate in a quantum dot and metallic nanosphere hybrid system . J Phy Condens Matter . 2015 ; 27 ( 34 ): 345301 .
10. Singh D , Rathod V , Ninganagouda S , Herimath J , Kulkarni P . Biosynthesis of silver nanoparticles by endophytic fungi Pencillium sp. Isolated from Curcuma Longa (turmeric) and its antibacterial activity against pathogenic gram-negative bacteria . J Pharm Res . 2013 ; 7 : 448 – 453 . doi: 10.1016/j.jopr.2013.06.003

상세보기
11. Shah M , Fawcett D , Sharma S , Tripathy SK . G.E.J. Poinern Green synthesis of metallic nanoparticles via biological entities . Materials . 2015 ; 8 : 7278 – 7308 . doi: 10.3390/ma8125486 28793638

상세보기
12. Chernousova S , Epple M . Silver as antibacterial agent: ion, nanoparticle, and metal . Angew Chem Int Ed Engl . 2013 ; 52 : 1636 – 1653 . doi: 10.1002/anie.201205923 23255416

상세보기
13. Zhao XX , Zhou LF , Rajoka MSR , et al. Fungal silver nanoparticle: synthesis, application and challengess . Crit Rev Biotechnol . 2018 ; 38 ( 6 ): 817 – 835 . doi: 10.1080/07388551.2017.1414141 29254388

상세보기
14. Jena P , Mohanty S , Mallick R , Jacob B , Sonawane A . Toxicity and antibacterial assessment of chitosan-coated silver nanoparticles on human pathogens and macrophage cells . Int J Nanomedicine . 2012;7:1805-1818. doi: 10.2147/IJN.S28077..
15. Zhang L , Gu FX , Chan JM , Wang AZ , Langer RS , Farokhzad OC . Nanoparticles in medicine: therapeutic applications and developments . Clin Pharmacol Ther . 2008 ; 83 ( 5 ): 761 – 769 . doi: 10.1038/sj.clpt.6100400 17957183

상세보기
16. Le OB , Stellacci F . Antibacterial activity of silver nanoparticles: a surface science insight . Nano Today . 2015 ; 10 : 339 – 354 . doi: 10.1016/j.nantod.2015.04.002

상세보기
17. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. World cancer statistics . GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68(6):394–424. doi:10.3322/caac.21492
18. Giard DJ , Aaronson SA , Todaro GJ , et al. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors . J Natl Cancer Inst . 1973 ; 51 ( 5 ): 1417 – 1423 . doi: 10.1093/jnci/51.5.1417 4357758

상세보기
19. Pugazhendhi A , Edison TNJI , Karuppusamy I , Kathirvel B . Inorganic nanoparticles: a potential cancer therapy for human welfare . Int J Pharm . 2018 ; 539 ( 1 ): 104 – 111 . doi: 10.1016/j.ijpharm.2018.01.034 29366941

상세보기
20. Coccia M , Wang L . Path-breaking directions of nanotechnology-based chemotherapy and molecular cancer therapy . Technol Forecast Soc Change . 2015 ; 94 : 155 – 169 . doi: 10.1016/j.techfore.2014.09.007

상세보기
21. Estanqueiro M , Amaral MH , Conceicao J , Sousa LJM . Nanotechnological carriers for cancer chemotherapy, The state of the art . Colloids Surf B . 2015 ; 126 : 631 – 648 . doi: 10.1016/j.colsurfb.2014.12.041

상세보기
22. Santoni M , Massari F , Del Re M , et al. Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer . Expert Opin Invest Drugs . 2015 ; 24 : 809 – 824 . doi: 10.1517/13543784.2015.1020370

상세보기
23. Wang C , Makila EM , Kaasalainen MH , et al. Dual-drug delivery by porous silicon nanoparticles for improved cellular uptake., sustained release., and combination therapy . Acta Biomater . 2015 ; 16 : 206 – 214 . doi: 10.1016/j.actbio.2015.01.021 25637067

상세보기
24. Devanesan S , AlSalhi MS , Vishnubalaji R . Rapid biological synthesis of silver nanoparticles using plant seed extracts and their cytotoxicity on colorectal cancer cell lines . J Clust Sci . 2017 ; 28 : 595 – 605 . doi: 10.1007/s10876-016-1134-4

상세보기
25. Nakkala JR , Mata R , Sadras SR . Green synthesized nano silver: synthesis, physicochemical profiling, antibacterial, anticancer activities and biological in vivo toxicity . J Colloid Interface Sci . 2017 ; 499 : 33 – 45 . doi: 10.1016/j.jcis.2017.03.090 28363102

상세보기
26. Preetha D , Prachi K , Chirom A . Synthesis and characterization of silver nanoparticles using cannonball leaves and their cytotoxic activity against MCF-7 cell line . J Nanotechnol . 2013 ; 2 : 421 – 428 .
27. Kulkarni RR , Shaiwale NS , Deobagkar DN . Synthesis and extracellular accumulation of silver nanoparticles by employing radiation-resistant Deinococcus radiodurans, their characterization, and determination of bioactivity . Int J Nanomed . 2015 ; 10 : 963 – 974 .

상세보기
28. Mishra Y , Singh A , Batra A , Sharma MM . Understanding the biodiversity and biological applications of endophytic fungi: a review . J Microb Biochem Technol . 2014 ; S8 : 004 .
29. Ma L , Su W , Liu JX , et al. Optimization for extracellular biosynthesis of silver nanoparticles by Penicillium aculeatum Su1 and their antimicrobial activity and cytotoxic effect compared with silver ions . Mater Sci Eng C . 2017 ; 77 : 963 – 971 . doi: 10.1016/j.msec.2017.03.294

상세보기
30. Saravanakumar , K. , Shanmugam S. , Varukattu N.B , et al. Biosynthesis and characterization of copper oxide nanoparticles from indigenous fungi and its effect of photothermolysis on human lung carcinoma . J Photochem Photobiol B . 2019 ; 190 : 103 – 109 . doi: 10.1016/j.jphotobiol.2018.02.005 30508758

상세보기
31. Saravanakumar K , Wang M-H . Trichoderma based synthesis of anti-pathogenic silver nanoparticles and their characterization, antioxidant and cytotoxicity properties . Microb Pathog . 2018 ; 114 : 269 – 273 . doi: 10.1016/j.micpath.2017.12.005 29208539

상세보기
32. Shukla H , Sandhu SS . Mycofabrication and characterization of silver nanoparticles by using some endophytic fungi with special reference to their antimicrobial potential . Int J Nanotechnol Appl . 2017 ; 7 : 7 – 22 .
33. Johnson PB , Christy RW . Optical constants of the noble metals . Phys Rev B . 1972 ; 6 ( 12 ): 4370 – 4379 . doi: 10.1103/PhysRevB.6.4370

상세보기
34. Xu J , Han X , Liu H , Hu Y . Synthesis and optical properties of silver nanoparticles stabilized by gemini surfactant . Colloids Surf A . 2006 ; 273 ( 1–3 ): 179 – 183 . doi: 10.1016/j.colsurfa.2005.08.019

상세보기
35. Saravanakumar , K. , Jeevithan E , Chelliah R , et al. Zinc-chitosan nanoparticles induced apoptosis in human acute T-lymphocyte leukemia through activation of tumor necrosis factor receptor CD95 and apoptosis-related genes . Int J Biol Macromol . 2018 ; 119 : 1144 – 1153 . doi: 10.1016/j.ijbiomac.2018.08.017 30092310

상세보기
36. Brumfitt W , Hamilton-Miller JM , Franklin I . Antibiotic activity of natural products: 1 . Propolis Microbios . 1990 ; 62 ( 250 ): 19 – 22 . 2110610
37. Ahmad N , Sharma S , Alam MK , et al. Rapid synthesis of silver nanoparticles using dried medicinal plant of basil . Colloids Surf B . 2010 ; 81 ( 1 ): 81 – 86 . doi: 10.1016/j.colsurfb.2010.06.029

상세보기
38. Singh MR , Schindel DG , Hatef A . Dipole-dipole interaction in a quantum dot and metallic nanorod hybrid system . Appl Phys Lett . 2011 ; 99 ( 18 ): 181106 . doi: 10.1063/1.3658395

상세보기
39. Hatef A , Sadeghi SM , Singh MR . Coherent molecular resonances in quantum dot–metallic nanoparticle systems: coherent self-renormalization and structural effects . Nanotechnology . 2012 ; 23 ( 20 ): 205203 . doi: 10.1088/0957-4484/23/20/205203 22543983

상세보기
40. Saravanakumar , K. , Chelliah R , Shanmugam S , et al. Green synthesis and characterization of biologically active nanosilver from seed extract of Gardenia jasminoides Ellis . J Photochem Photobiol B . 2018 ; 185 : 126 – 135 . doi: 10.1016/j.jphotobiol.2018.05.032 29886331

상세보기
41. Deene M , Lingappa K . Microwave assisted rapid and green synthesis of silver nanoparticles using a pigment produced by Streptomyces coelicolor klmp33 . Bioinorg Chem Appl . 2013 ; 2013 : Article 341798 . 24068978
42. Pavani KV , Gayathramma K , Aparajitha B , Shah S . Phyto-synthesis of silver nanoparticles using extracts of ipomoea indica flowers . Am J Nanomater . 2013 ; 1 ( 1 ): 2013 .
43. Aravinthan A , Govarthanan M , Selvam K , et al. Sunroot mediated synthesis and characterization of silver nanoparticles and evaluation of its antibacterial and rat splenocyte cytotoxic effects . Int J Nanomed . 2015 ; 10 : 1977 – 1983 . doi: 10.2147/IJN.S79106

상세보기
44. Fadel QJ , Al-Mashhedy LAM . Biosynthesis of silver nanoparticles using peel extract of Raphanus sativus L . Biotechnol Ind J . 2017 ; 13 ( 1 ): 120 .
45. Carlson , C , Hussain SM , Schrand AMK , et al. Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species . J Phy Chem B . 2008 ; 112 ( 43 ): 13608 – 13619 . doi: 10.1021/jp712087m

상세보기
46. Mishra , AR , Zheng J , Tang X , et al. Silver nanoparticle-induced autophagic-lysosomal disruption and NLRP3-Inflammasome Activation in HepG2 cells is size-dependent . Toxicol Sci . 2016 ; 150 ( 2 ): 473 – 487 . doi: 10.1093/toxsci/kfw011 26801583

상세보기
47. Liu , W , Wu Y , Wang C , et al. Impact of silver nanoparticles on human cells: effect of particle size . Nanotoxicology . 2010 ; 4 ( 3 ): 319 – 330 . doi: 10.3109/17435390.2010.483745 20795913

상세보기
48. Akter , M , Sikder MT , Rahman MM , et al. A systematic review on silver nanoparticles-induced cytotoxicity: physicochemical properties and perspectives . J Adv Res . 2018 ; 9 : 1 – 16 . doi: 10.1016/j.jare.2017.10.008 30046482

상세보기
49. Ottoni CA , Simoes MF , Fernandes S , et al. Screening of ﬁlamentous fungi for antimicrobial silver nanoparticles synthesis . AMB Expr . 2017 ; 7 ( 31 ). doi: 10.1186/s13568-017-0332-2

상세보기
50. Tahira A , Mohd SK , Hemalatha S . A facile and rapid method for green synthesis of Silver Myco nanoparticles using endophytic fungi . Int J Nano Dimension . 2018 ; 9 ( 4 ): 435 – 441 .
51. Mohamed MA , HUSSEIN HM ALIAAM . Antifungal activity of different size controlled stable silver nanoparticles biosynthesized by the endophytic fungus Aspergillus terreus . J Phytopathology Pest Manag . 2018 ; 5 ( 2 ): 88 – 107 .
52. Prabu KS , Rajkuberan C , Sathishkumar G , et al. Antimicrobial and larvicidal activity of eco-friendly silver nanoparticles synthesized from endophytic fungi Phomopsis liquidambaris . Biocata Agricl Biotechnol . 2018 ; 16 : 22 – 30 . doi: 10.1016/j.bcab.2018.07.006

상세보기
53. Mohammad F , Saeed F . Biosynthesis of antibacterial silver nanoparticles by endophytic fungus Nemania sp. Isolated From Taxus baccata L.(Iranian Yew) . Zahedan J Res Med Sci . 2018 ; 20 ( 6 ): e57916 .
54. Sahadevan N , Sebastian JM , Sunil MA , Soman S , Radhakrishnan EK , Mathew J . Efficient visible light induced synthesis of silver nanoparticles by Penicillium polonicum ARA 10 isolated from Chetomorpha antennina and its antibacterial efficacy against Salmonella enterica serova Typhimurium . J Photochem Photobiol B . 2018 ; 180 : 175 – 185 . doi: 10.1016/j.jphotobiol.2018.02.005 29453129

상세보기
55. Balakumaran MD , Ramachandran R , Kalaichelvan PT . Exploitation of endophytic fungus, Guignardia mangiferae for extracellular synthesis of silver nanoparticles and their in vitro biological activities . Microbiol Res . 2015 ; 178 : 9 – 17 . doi: 10.1016/j.micres.2015.05.009 26302842

상세보기
56. Hemashekhar B , Chandrappa CP , Govindappa M , Chandrasekhar N , Nagaraju G , Ramachandra YL . Green synthesis of silver nanoparticles from Endophytic fungus Aspergillus niger isolated from Simarouba glauca leaf and its Antibacterial and Antioxidant activity . Inter J Eng Res Appl. 2017 ; 7 ( 8 ): 17 – 24 .
57. Reena R , Dushyant S , Monika C , Yadav JP . Green synthesis, characterization and antibacterial activity of silver nanoparticles of endophytic fungi Aspergillus terreus . J Nanomed Nanotechnol . 2017 ; 8 : 4 .
58. Shaheen TI , Abeer AAEA . In-situ green myco-synthesis of silver nanoparticles onto cotton fabrics for broad spectrum antimicrobial activity . Int J Biol Macromol . 2018 ; 118 : 2121 – 2130 . doi: 10.1016/j.ijbiomac.2018.07.062 30012491

상세보기
59. Singh DK , Kumar J , Sharma VK , et al. Mycosynthesis of bactericidal silver and polymorphic gold nanoparticles–physicochemical variation effects and mechanism . Nanomadicine. 2018 ; 13 ( 2 ): 191 – 207 .
60. Vivian C , Lisa OGA , Tong KS. Synthesis of silver nanoparticles mediated by endophytic fungi associated with orchids and its antibacterial activity . Materials Today: Proceedings . 2018 ; 5 ( 10 ;Part 2): 22093 – 22100.
61. Tej S , Kumari J , Amar P , Ajeet S , Ranchan C , Chandel SS . Biosynthesis, characterization and antibacterial activity of silver nanoparticles using an endophytic fungal supernatant of Raphanus sativus . J Genetic Eng Biotechnol . 2017 ; 15 : 31 – 39 . doi: 10.1016/j.jgeb.2017.04.005

상세보기
62. Govindappa M , Farheen H , Chandrappa CP , Channabasava RVR , Vinay BR . Mycosynthesis of silver nanoparticles using extract of endophytic fungi, Penicillium species of Glycosmis mauritiana, and its antioxidant, antimicrobial, anti-inflammatory and tyrokinase inhibitory activity . Adv Nat Sci . 2016 ; 7 ( 3 ): Article035014 .
63. Vardhana J , Kathiravan G . Biosynthesis of silver nanoparticles by endophytic fungi Pestaloptiopsis pauciseta isolated from the leaves of Psidium guajava linn . Int J Pharm Sci Rev Res . 2015 ; 31 ( 1 ): 29 – 31 .
64. Parthasarathy R , Sathiyabama M , Prabha T . Biosynthesis of silver nanoparticles using an endophytic fungus, Curvularia lunata and its antimicrobial potential . J Nanosci Nanoeng . 2015 ; 1 ( 4 ): 241 – 247 .
65. Vasudeva RN , Pushpalatha B , Sukhendu BG , Vijaya T . Endophytic fungal assisted synthesis of silver nanoparticles, characterization, and antimicrobial activity . Asian J Pharm Clinl Res . 2015 ; 8 ( 3 ): 113 – 116 .
66. Lamabam SD , Joshi SR . Ultrastructures of silver nanoparticles biosynthesized using endophytic fungi . J Microsc Ultrastruct . 2015 ; 3 : 29 – 37 . doi: 10.1016/j.jmau.2014.10.004 30023179

상세보기
67. Dattu S , Vandana R , Shivaraj N , Jyothi H , Ashish KS , Jasmine M . Optimization and characterization of silver nanoparticle by endophytic fungi Penicillium sp. Isolated from Curcuma longa (Turmeric) and application studies against MDR E. coli and S. aureus . Bioinorg Chem Appl . 2014 ; 2014 : Article 40S021 .
68. Rodrigues AG , Ping LY , Marcato PD , et al. Biogenic antimicrobial silver nanoparticles produced by fungi . Appl Microbiol Biotechnol . 2013 ; 97 : 775 – 782 . doi: 10.1007/s00253-012-4209-7 22707055

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Mycosynthesis, characterization, anticancer and antibacterial activity of silver nanoparticles from endophytic fungus Talaromyces purpureogenus 원문보기

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Mycosynthesis, characterization, anticancer and antibacterial activity of silver nanoparticles from endophytic fungus Talaromyces purpureogenus 원문보기

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