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Preclinical evaluation of a nanoformulated antihelminthic, niclosamide, in ovarian cancer

Oncotarget, v.7 no.8, 2016년, pp.8993 - 9006  

Lin, Chi-Kang (Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan) ,  Bai, Meng-Yi (Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan) ,  Hu, Teh-Min (School of Pharmacy, National Defense Medical Center, Taipei, Taiwan) ,  Wang, Yu-Chi (Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan) ,  Chao, Tai-Kuang (Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan) ,  Weng, Shao-Ju (Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan) ,  Huang, Rui-Lan (Department of Obstetrics and Gynecology, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan) ,  Su, Po-Hsuan (Department of Obstetrics and Gynecology, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan) ,  Lai, Hung-Cheng (Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan)

Abstract AI-Helper 아이콘AI-Helper

Ovarian cancer treatment remains a challenge and targeting cancer stem cells presents a promising strategy. Niclosamide is an “old” antihelminthic drug that uncouples mitochondria of intestinal parasites. Although recent studies demonstrated that niclosamide could be a potential anticancer agent, it...

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