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NTIS 바로가기International journal of cosmetic science, v.41 no.6, 2019년, pp.548 - 557
Chowjarean, V. (Department of Pharmaceutical Technology, College of Pharmacy, Rangsit University, Pathumthani, 12000,) , Phiboonchaiyanan, P.P. (Cosmeceutical Research, Development and Testing Center, College of Pharmacy, Rangsit University, Pathumthani, 12000,) , Harikarnpakdee, S. (Cosmeceutical Research, Development and Testing Center, College of Pharmacy, Rangsit University, Pathumthani, 12000,) , Tengamnuay, P. (Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand)
AbstractObjectiveGrammatophyllum speciosum is utilized to treat sore throats and bronchitis In Thai folk medicine. This study evaluated the in vitro activity and clinical efficacy of a G. speciosum pseudobulb decoction.MethodsMeasure of in vitro anti‐ageing activity was performed using nonR...
RésuméObjectifGrammatophyllum speciosum est utilisé pour traiter les maux de gorge et les bronchites dans la médecine populaire thaïlandaise. Cette étude a évalué in vitro l’activité et l’efficacité clinique d’une décoction de pseudobulbes de G. speciosum.MéthodesLa mesure in vitro de l’activité anti‐âge a été réalisée à l’aide de dosages non cellulaires ainsi que dans des cellules de fibroblastes humains CRL 2097. Une méthode de test de patch a été utilisée pour déterminer l’irritation cutanée chez 24 volontaires thaïlandais en bonne santé. Un essai randomisé en double aveugle, contrôlé contre placebo, a été mené auprès de 24 sujets pendant 56 jours après l’application sur le visage pour évaluer l’efficacité. Les résultats ont été mesurés par Visioface® et Cutometer® MPA 580 et au moyen d’observations visuelles.RésultatsLa teneur totale en polyphénols antioxydants dans l’extrait éthanolique de G. speciosum (GSE) était de 48,19 ± 0,39 mg équivalent EGCG par gramme. Le GSE a montré une activité antiélastase puissante et plus élevée que l’EGCG. L’extrait a été capable de protéger les fibroblastes humains contre la mort cellulaire induite par l’anion superoxyde à la concentration de 10 μg ml‐1. Dans une étude clinique, l’application sur le visage d’un sérum contenant 0,5 % du GSE a permis d’augmenter la distensibilité de la peau chez des volontaires sains en toute sécurité. La viscoélasticité de la peau et le volume des rides ont également été significativement réduits (P < 0.05).ConclusionAinsi, les études in vitro tout comme les études cliniques ont illustré les bénéfices antirides/anti‐âge du GSE sur la peau humaine.
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