$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] Reevaluation of the acute toxicity of palytoxin in mice: Determination of lethal dose 50 (LD50) and No-observed-adverse-effect level (NOAEL)

Toxicon, v.177, 2020년, pp.16 - 24  

Boente-Juncal, Andrea (Departamento de Farmacoloxí) ,  Vale, Carmen (a, Farmacia e Tecnologí) ,  Camiña, Mercedes (a Farmacé) ,  Cifuentes, J. Manuel (utica, Facultade de Veterinaria, Universidade de Santiago de Compostela) ,  Vieytes, Mercedes R. (Departamento de Farmacoloxí) ,  Botana, Luis M. (a, Farmacia e Tecnologí)

Abstract AI-Helper 아이콘AI-Helper

Abstract Palytoxin is an emergent toxin in Europe and one of the most toxic substances know to date. The toxin disrupts the physiological functioning of the Na+/K+-ATPase converting the enzyme in a permeant cation channel. Human intoxications by PLTX after consumption of contaminated fishery produc...

Keyword

참고문헌 (48)

  1. J. Phycol. Accoroni 52 1064 2016 10.1111/jpy.12464 Ostreopsis fattorussoi sp. nov. (Dinophyceae), a new benthic toxic Ostreopsis species from the eastern Mediterranean Sea 

  2. Toxicon Alcala 26 105 1988 10.1016/0041-0101(88)90142-0 Human fatality due to ingestion of the crab Demania reynaudii that contained a palytoxin-like toxin 

  3. Toxicon Aligizaki 51 418 2008 10.1016/j.toxicon.2007.10.016 First episode of shellfish contamination by palytoxin-like compounds from Ostreopsis species (Aegean Sea, Greece) 

  4. Mar. Drugs Amzil 10 477 2012 10.3390/md10020477 Ovatoxin-a and palytoxin accumulation in seafood in relation to Ostreopsis cf. ovata blooms on the French Mediterranean coast 

  5. Proc. Natl. Acad. Sci. U. S. A. Artigas 100 501 2003 10.1073/pnas.0135849100 Na+/K+-pump ligands modulate gating of palytoxin-induced ion channels 

  6. J. Gen. Physiol. Artigas 123 357 2004 10.1085/jgp.200308964 Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands 

  7. Toxins Boente-Juncal 11 2 E96 2019 10.3390/toxins11020096 Chronic in vivo effects of repeated exposure to low oral doses of tetrodotoxin: preliminary evidence of nephrotoxicity and cardiotoxicity 

  8. Anal. Chem. Ciminiello 78 6153 2006 10.1021/ac060250j The Genoa 2005 outbreak. Determination of putative palytoxin in Mediterranean Ostreopsis ovata by a new liquid chromatography tandem mass spectrometry method 

  9. Toxicon Del Favero 75 3 2013 10.1016/j.toxicon.2013.06.003 Toxicity of palytoxin after repeated oral exposure in mice and in vitro effects on cardiomyocytes 

  10. Toxicol. Lett. Del Favero 225 285 2014 10.1016/j.toxlet.2013.12.020 In vivo and in vitro effects of 42-hydroxy-palytoxin on mouse skeletal muscle: structural and functional impairment 

  11. vol. 7 2009 Scientific Opinion on Marine Biotoxins in Shellfish - Palytoxin Group Panel on contaminants in the food chain (CONTAM) 

  12. FEBS J. Fernandez 280 3906 2013 10.1111/febs.12390 The kinetic, mechanistic and cytomorphological effects of palytoxin in human intestinal cells (Caco-2) explain its lower-than-parenteral oral toxicity 

  13. Anal. Chem. Fraga 89 7438 2017 10.1021/acs.analchem.7b01003 First identification of palytoxin-like molecules in the atlantic coral species Palythoa canariensis 

  14. Mol. Pharmacol. Frelin 38 904 1990 Mechanism of the cardiotoxic action of palytoxin 

  15. Toxicon Hoffmann 51 1535 2008 10.1016/j.toxicon.2008.03.009 A case of palytoxin poisoning due to contact with zoanthid corals through a skin injury 

  16. Toxicon Ito 34 643 1996 10.1016/0041-0101(96)00005-0 Intestinal injuries caused by experimental palytoxicosis in mice 

  17. Katikou 695 2014 Seafood and Freshwater Toxins. Pharmacology, Physiology and Detection Palytoxin and analogs: ecobiology and origin, chemistry, and chemical analysis 

  18. Toxicon Kodama 27 1051 1989 10.1016/0041-0101(89)90156-6 Clinical and laboratory findings implicating palytoxin as cause of ciguatera poisoning due to Decapterus macrosoma (mackerel) 

  19. Science Moore 172 495 1971 10.1126/science.172.3982.495 Palytoxin: a new marine toxin from a coelenterate 

  20. Afr. J. Mar. Sci. Munday 28 447 2006 10.2989/18142320609504195 Toxicological requirements for risk assessment of shellfish contaminants: a review 

  21. Toxicon Munday 57 470 2011 10.1016/j.toxicon.2010.10.003 Palytoxin toxicology: animal studies 

  22. Environ. Toxicol. Pharmacol. Murphy 55 107 2017 10.1016/j.etap.2017.08.010 Prevalence and characteristics of inhalational and dermal palytoxin exposures reported to the National Poison Data System in the U.S 

  23. 2008 Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents 

  24. 2008 Test No. 425: Acute Oral Toxicity: Up-And-Down Procedure 

  25. Intern. Med. Okano 37 330 1998 10.2169/internalmedicine.37.330 Rhabdomyolysis and myocardial damage induced by palytoxin, a toxin of blue humphead parrotfish 

  26. Toxicon Onuma 37 55 1999 10.1016/S0041-0101(98)00133-0 Identification of putative palytoxin as the cause of clupeotoxism 

  27. Arch. Toxicol. Patocka 92 143 2018 10.1007/s00204-017-2105-8 Palytoxin congeners 

  28. Mar. Drugs Pelin 14 2016 10.3390/md14020033 Palytoxin-containing aquarium soft corals as an emerging sanitary problem 

  29. Toxicol. Lett. Pelin 229 440 2014 10.1016/j.toxlet.2014.07.022 The marine toxin palytoxin induces necrotic death in HaCaT cells through a rapid mitochondrial damage 

  30. Toxicon Poli 150 235 2018 10.1016/j.toxicon.2018.06.067 Toxicity and pathophysiology of palytoxin congeners after intraperitoneal and aerosol administration in rats 

  31. N. Z. J. Mar. Freshw. Res. Rhodes 36 631 2002 10.1080/00288330.2002.9517118 Uptake of palytoxin­like compounds by shellfish fed Ostreopsis siamensis (Dinophyceae) 

  32. Food Chem. Toxicol. Riobo 46 2639 2008 10.1016/j.fct.2008.04.020 Mouse bioassay for palytoxin. Specific symptoms and dose-response against dose-death time relationships 

  33. Toxicon Rossini 57 429 2011 10.1016/j.toxicon.2010.09.011 Palytoxin action on the Na(+),K(+)-ATPase and the disruption of ion equilibria in biological systems 

  34. Harmful Algae Santos 86 20 2019 10.1016/j.hal.2019.03.003 Ocurrence of Ostreopsis in two temperate coastal bays (SW iberia): insights from the plankton 

  35. Shimizu 527 2004 The Laboratory Mouse Routes of administration 

  36. Toxins Silva 7 859 2015 10.3390/toxins7030859 Emergent toxins in North Atlantic temperate waters: a challenge for monitoring programs and legislation 

  37. Toxicol. Lett. Sosa 191 253 2009 10.1016/j.toxlet.2009.09.009 Palytoxin toxicity after acute oral administration in mice 

  38. J. Nat. Toxins Taniyama 11 277 2002 Occurrence of a food poisoning incident by palytoxin from a serranid Epinephelus sp. in Japan 

  39. Toxicon Tartaglione 121 41 2016 10.1016/j.toxicon.2016.08.012 An aquarium hobbyist poisoning: identification of new palytoxins in Palythoa cf. toxica and complete detoxification of the aquarium water by activated carbon 

  40. Toxicol. Lett. Taylor 57 291 1991 10.1016/0378-4274(91)90203-I Non-specific binding of palytoxin to plastic surfaces 

  41. Respir Med Case Rep Thakur 20 4 2016 Palytoxin-induced acute respiratory failure 

  42. Tubaro 741 2014 Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection Palytoxin and analogues: biological effects and detection 

  43. J Am Assoc Lab Anim Sci Turner 50 600 2011 Administration of substances to laboratory animals: routes of administration and factors to consider 

  44. J. Neurosci. Res. Vale-Gonzalez 85 90 2007 10.1002/jnr.21095 Effects of the marine phycotoxin palytoxin on neuronal pH in primary cultures of cerebellar granule cells 

  45. J. Neurosci. Res. Vale 83 1393 2006 10.1002/jnr.20841 Modulation of calcium entry and glutamate release in cultured cerebellar granule cells by palytoxin 

  46. Br. J. Pharmacol. Vale 152 256 2007 10.1038/sj.bjp.0707389 Mitogen-activated protein kinases regulate palytoxin-induced calcium influx and cytotoxicity in cultured neurons 

  47. Mar. Pollut. Bull. Walsh 116 9 2017 10.1016/j.marpolbul.2016.12.053 More surprises in the global greenhouse: human health impacts from recent toxic marine aerosol formations, due to centennial alterations of world-wide coastal food webs 

  48. Ann. Emerg. Med. Wu 64 633 2014 10.1016/j.annemergmed.2014.06.001 Hyperkalemia, hyperphosphatemia, acute kidney injury, and fatal dysrhythmias after consumption of palytoxin-contaminated goldspot herring 

활용도 분석정보

상세보기
다운로드
내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

관련 콘텐츠

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로