[논문]Distinct immunoreactivity pattern to Bacillus mannanilyticus in a subgroup of anti-NMDA receptor encephalitis

Shin, Yong-Won; Lee, Soon-Tae; Kim, Young-Sook; Han, Dohyun; Nogi, Yuichi; Chu, Kon; Lee, Sang Kun

doi:10.1016/j.jneuroim.2020.577215

[해외논문] Distinct immunoreactivity pattern to Bacillus mannanilyticus in a subgroup of anti-NMDA receptor encephalitis

Journal of neuroimmunology, v.342, 2020년, pp.577215 -

Shin, Yong-Won (Department of Neurology, Seoul National University Hospital) , Lee, Soon-Tae (Department of Neurology, Seoul National University Hospital) , Kim, Young-Sook (Department of Neurology, Seoul National University Hospital) , Han, Dohyun (Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital) , Nogi, Yuichi (Extremobiosphere Research Center, Japan Agency for Marine-Earth Science and Technology) , Chu, Kon (Department of Neurology, Seoul National University Hospital) , Lee, Sang Kun (Department of Neurology, Seoul National University Hospital)

Abstract ▼ AI-Helper

Abstract Over half of anti-NMDA receptor encephalitis (NMDARE) is unrelated to etiologies such as teratomas or herpes simplex encephalitis. Bacillus mannanilyticus nonribosomal peptide synthetase (NRPS) shares a protein sequence with GluN1. After confirming the anti-NRPS antibody immunoreactivity in an index patient by liquid chromatography-tandem mass spectrometry (LC-MS/MS), we identified 24/57 (42%) patients with similar immunoreactivity patterns by western blotting. These patients mostly (20/24 [83%]) did not have ovarian teratomas, had fewer medial temporal (2/24 [8%]) and any (5/24 [21%]) brain lesions and less pleocytosis (13/24 [54%]). These results identified an anti-NMDARE subgroup with a distinct immunoreactivity pattern, which needs further investigation. Highlights NRPS from Bacillus mannanilyticus shares a protein sequence with GluN1. Anti-NRPS immunoreactivity was confirmed by LC-MS/MS in a patient with anti-NMDARE. Most patients with anti-NRPS immunoreactivity did not have ovarian teratomas. These patients also had less brain lesions and pleocytosis. Distinct immunoreactivity pattern may further classify anti-NMDARE. Graphical abstract [DISPLAY OMISSION]

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참고문헌 (15)

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[해외논문] Distinct immunoreactivity pattern to Bacillus mannanilyticus in a subgroup of anti-NMDA receptor encephalitis

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[해외논문] Distinct immunoreactivity pattern to Bacillus mannanilyticus in a subgroup of anti-NMDA receptor encephalitis

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