[논문]Advances in biomaterials for adipose tissue reconstruction in plastic surgery

Peng, Zhiyu; Tang, Pei; Zhao, Li; Wu, Lina; Xu, Xiujuan; Lei, Haoyuan; Zhou, Min; Zhou, Changchun; Li, Zhengyong

doi:10.1515/ntrev-2020-0028

[해외논문] Advances in biomaterials for adipose tissue reconstruction in plastic surgery 원문보기

Nanotechnology Reviews, v.9 no.1, 2020년, pp.385 - 395

Peng, Zhiyu (Department of Burn and Plastic Surgery, West China School of Medicine, West China Hospital, Sichuan University, 610041, Chengdu, China) , Tang, Pei (Department of Burn and Plastic Surgery, West China School of Medicine, West China Hospital, Sichuan University, 610041, Chengdu, China) , Zhao, Li (National Engineering Research Center for Biomaterials, Sichuan University, 610064, Chengdu, China) , Wu, Lina (National Engineering Research Center for Biomaterials, Sichuan University, 610064, Chengdu, China) , Xu, Xiujuan (National Engineering Research Center for Biomaterials, Sichuan University, 610064, Chengdu, China) , Lei, Haoyuan (Department of Burn and Plastic Surgery, West China School of Medicine, West China Hospital, Sichuan University, 610041, Chengdu, China) , Zhou, Min (National Engineering Research Center for Biomaterials, Sichua) , Zhou, Changchun , Li, Zhengyong

Abstract ▼ AI-Helper

AbstractAdipose tissue reconstruction is an important technique for soft tissue defects caused by facial plastic surgery and trauma. Adipose tissue reconstruction can be repaired by fat transplantation and biomaterial filling, but there are some problems in fat transplantation, such as second operation and limited resources. The application of advanced artificial biomaterials is a promising strategy. In this paper, injectable biomaterials and three-dimensional (3D) tissue-engineered scaffold materials for adipose tissue reconstruction in plastic surgery are reviewed. Injectable biomaterials include natural biomaterials and artificial biomaterials, which generally have problems such as high absorptivity of fillers, repeated injection, and rejection. In recent years, the technology of new 3D tissue-engineering scaffold materials with adipose-derived stem cells (ADSCs) and porous scaffold as the core has made good progress in fat reconstruction, which is expected to solve the current problem of clinical adipose tissue reconstruction, and various biomaterials preparation technology and transformation research also provide the basis for clinical transformation of fat tissue reconstruction.

Keyword

참고문헌 (73)

10.1016/j.bjps.2015.07.022 Lequeux C, Rodriguez J, Boucher F, Rouyer O, Damour O, Mojallal A, et al. In vitro and in vivo biocompatibility, bioavailability and tolerance of an injectable vehicle for adipose-derived stem/stromal cells for plastic surgery indications. Plast Reconstr Aesthet Surg. 2015;68(11):1491-7. 10.1016/j.bjps.2015.07.022. PubMed PMID: 26282247. Epub 2015/08/05.

상세보기
10.1097/PRS.0b013e31829ad2fa Auclair E, Blondeel P, Del Vecchio DA. Composite breast augmentation: soft-tissue planning using implants and fat. Plast Reconstr Surg. 2013;132(3):558-68. 10.1097/PRS.0b013e31829ad2fa. PubMed PMID: 23985632.

상세보기
10.1093/annonc/mdw022 Malvezzi M, Carioli G, Bertuccio P, Rosso T, Boffetta P, Levi F, et al. European cancer mortality predictions for the year 2016 with focus on leukaemias. Ann Oncol. 2016;27(4):725-31. 10.1093/annonc/mdw022. PubMed PMID: 26812903. Epub 2016/01/26.

상세보기
10.1093/asj/sjx078 Cohen SR, Hewett S, Ross L, Delaunay F, Goodacre A, Ramos C, et al. Regenerative cells for facial surgery: biofilling and biocontouring. Aesthet Surg J. 2017;37(Suppl 3):S16-32. 10.1093/asj/sjx078. PubMed PMID: 29025218.

상세보기
10.1007/s13770-018-0158-2 Cho K-H, Uthaman S, Park I-K, Cho C-S. Injectable biomaterials in plastic and reconstructive surgery: a review of the current status. Tissue Eng Regen Med. 2018;15(5):559-74. 10.1007/s13770-018-0158-2. PubMed PMID: 30603579.

상세보기
10.1097/01.prs.0000252001.59162.c9 Coleman SR, Saboeiro AP. Fat grafting to the breast revisited: safety and efficacy. Plast Reconstr Surg. 2007;119(3):775-87. 10.1097/01.prs.0000252001.59162.c9. PubMed PMID: 17312477.

상세보기
Van Nieuwenhove I, Tytgat L, Ryx M, Blondeel P, Stillaert F, Thienpont H, et al. Soft tissue fillers for adipose tissue regeneration: from hydrogel development toward clinical applications. Acta Biomater. 2017;63:37-49. 10.1016/j.actbio.2017.09.026. PubMed PMID: 28941654, Epub 2017/09/20.
10.1016/j.biotechadv.2013.12.010 Radhakrishnan J, Krishnan UM, Sethuraman S. Hydrogel based injectable scaffolds for cardiac tissue regeneration. Biotechnol Adv. 2014;32(2):449-61. 10.1016/j.biotechadv.2013.12.010. PubMed PMID: 24406815. Epub 2014/01/07.

상세보기
10.1088/1748-6041/11/1/014110 Spector M, Lim TC. Injectable biomaterials: a perspective on the next wave of injectable therapeutics. Biomed Mater. 2016;11(1):014110. 10.1088/1748-6041/11/1/014110. PubMed PMID: 26836246.

상세보기
10.1111/j.1524-4725.2008.34253.x Alam M, Gladstone H, Kramer EM, Murphy JP, Nouri K, Neuhaus IM, et al. ASDS guidelines of care: injectable fillers. Dermatol Surg. 2008;34(Suppl 1):S115-S48. 10.1111/j.1524-4725.2008.34253.x. PubMed PMID: 18547175.

상세보기
10.1007/s10856-015-5566-4 Van Hoorick J, Declercq H, De Muynck A, Houben A, Van Hoorebeke L, Cornelissen R, et al. Indirect additive manufacturing as an elegant tool for the production of self-supporting low density gelatin scaffolds. J Mater Sci Mater Med. 2015;26(10):247. 10.1007/s10856-015-5566-4. PubMed PMID: 26411443. Epub 2015/09/28.

상세보기
10.1007/978-981-13-0947-2_10 Ercan H, Durkut S, Koc-Demir A, Elcin AE, Elcin YM. Clinical applications of injectable biomaterials. Adv Exp Med Biol. 2018;1077:163-82. 10.1007/978-981-13-0947-2_10. PubMed PMID: 30357689.
10.1002/adhm.201700897 Sheikholeslam M, Wright MEE, Jeschke MG, Amini-Nik S. Biomaterials for skin substitutes. Adv Healthc Mater. 2018;7(5):1700897(1-20). 10.1002/adhm.201700897. PubMed PMID: 29271580. Epub 2017/12/22.

상세보기
10.1007/s13770-017-0060-3 Jin G-Z, Kim H-W. Effects of type I collagen concentration in hydrogel on the growth and phenotypic expression of rat chondrocytes. Tissue Eng Regen Med. 2017;14(4):383-91. 10.1007/s13770-017-0060-3. PubMed PMID: 30603494.

상세보기
10.1007/s13770-017-0063-0 Luca A, Butnaru M, Maier SS, Knieling L, Bredetean O, Verestiuc L, et al. Atelocollagen-based hydrogels crosslinked with oxidised polysaccharides as cell encapsulation matrix for engineered bioactive stromal tissue. Tissue Eng Regen Med. 2017;14(5):539-56. 10.1007/s13770-017-0063-0. PubMed PMID: 30603508.

상세보기
10.1002/cbdv.201700557 Felician FF, Xia C, Qi W, Xu H. Collagen from marine biological sources and medical applications. Chem Biodivers. 2018;15(5):e1700557. 10.1002/cbdv.201700557. PubMed PMID: 29521032. Epub 2018/05/21.

상세보기
10.1016/j.fsc.2006.11.001 Rostan E. Collagen fillers. Facial Plast Surg Clin North Am. 2007;15(1):55-61. 10.1016/j.fsc.2006.11.001. PubMed PMID: 17317556.

상세보기
10.1007/978-3-319-18603-0_6 Kastellorizios M, Tipnis N, Burgess DJ. Foreign body reaction to subcutaneous implants. Adv Exp Med Biol. 2015;865:93-108. 10.1007/978-3-319-18603-0_6. PubMed PMID: 26306445.

상세보기
10.3346/jkms.2014.29.S3.S217 Lee JH, Choi YS, Kim SM, Kim YJ, Rhie JW, Jun YJ. Efficacy and safety of porcine collagen filler for nasolabial fold correction in Asians: a prospective multicenter, 12 months follow-up study. J Korean Med Sci. 2014;29(Suppl 3):S217-21. 10.3346/jkms.2014.29.S3.S217. PubMed PMID: 25473212. Epub 2014/11/21.

상세보기
10.1002/btpr.1555 Kim BS, Choi JS, Kim JD, Yoon HI, Choi YC, Cho YW. Human collagen isolated from adipose tissue. Biotechnol Prog. 2012;28(4):973-80. 10.1002/btpr.1555. PubMed PMID: 22549937. Epub 2012/06/08.

상세보기
10.1007/s00253-005-0180-x Baez J, Olsen D, Polarek JW. Recombinant microbial systems for the production of human collagen and gelatin. Appl Microbiol Biotechnol. 2005;69(3):245-52. 10.1007/s00253-005-0180-x. PubMed PMID: 16240115. Epub 2005/11/15.

상세보기
10.1016/j.carbpol.2012.10.028 Collins MN, Birkinshaw C. Hyaluronic acid based scaffolds for tissue engineering - a review. Carbohydr Polym. 2013;92(2):1262-79. 10.1016/j.carbpol.2012.10.028. PubMed PMID: 23399155. Epub 2012/10/17.

상세보기
10.2147/CIA.S3118 Bogdan Allemann I, Baumann L. Hyaluronic acid gel (Juvederm) preparations in the treatment of facial wrinkles and folds. Clin Interv Aging. 2008;3(4):629-34. 10.2147/cia.s3118. PubMed PMID: 19281055.
10.1002/term.378 Tan H, Li H, Rubin JP, Marra KG. Controlled gelation and degradation rates of injectable hyaluronic acid-based hydrogels through a double crosslinking strategy. J Tissue Eng Regen Med. 2011;5(10):790-7. 10.1002/term.378. PubMed PMID: 22002922. Epub 2011/01/10.

상세보기
10.1002/jbm.a.34901 Korurer E, Kenar H, Doger E, Karaoz E. Production of a composite hyaluronic acid/gelatin blood plasma gel for hydrogel-based adipose tissue engineering applications. J Biomed Mater Res A. 2014;102(7):2220-9. 10.1002/jbm.a.34901. PubMed PMID: 23913820. Epub 2013/08/10.

상세보기
10.1021/acs.bioconjchem.5b00209 Domingues RMA, Silva M, Gershovich P, Betta S, Babo P, Caridade SG, et al. Development of injectable hyaluronic acid/cellulose nanocrystals bionanocomposite hydrogels for tissue engineering applications. Bioconjug Chem. 2015;26(8):1571-81. 10.1021/acs.bioconjchem.5b00209. PubMed PMID: 26106949. Epub 2015/07/20.

상세보기
10.1016/j.msec.2015.04.004 Fan M, Ma Y, Zhang Z, Mao J, Tan H, Hu X. Biodegradable hyaluronic acid hydrogels to control release of dexamethasone through aqueous Diels-Alder chemistry for adipose tissue engineering. Mater Sci Eng C Mater Biol Appl. 2015;56:311-7. 10.1016/j.msec.2015.04.004. PubMed PMID: 26249595. Epub 2015/04/15.

상세보기
10.1055/s-0037-1601851 Fallacara A, Manfredini S, Durini E, Vertuani S. Hyaluronic acid fillers in soft tissue regeneration. Facial Plast Surg. 2017;33(1):87-96. 10.1055/s-0036-1597685. PubMed PMID: 28226376. Epub 2017/02/22.

상세보기
10.1016/j.carbpol.2006.03.014 Aiping Z, Tian C, Lanhua Y, Hao W, Ping L. Synthesis and characterization of N-succinyl-chitosan and its self-assembly of nanosphere. Carbohydr Polym. 2006;66:274-9. 10.1016/j.carbpol.2006.03.014

상세보기
10.1007/s13233-013-1023-8 Tan H, Luan H, Hu Y, Hu X. Covalently crosslinked chitosan-poly(ethylene glycol) hybrid hydrogels to deliver insulin for adipose-derived stem cells encapsulation. Macromol Res. 2012;21:392-9. 10.1007/s13233-013-1023-8

상세보기
10.22203/eCM.v024a23 Tuin A, Zandstra J, Kluijtmans S, Bouwstra J, Harmsen M, Luyn M. Hyaluronic acid-recombinant gelatin gels as a scaffold for soft tissue regeneration. Eur Cell Mater. 2012;24:220-330. 10.22203/eCM.v024a23
10.5301/ijao.5000553 Zeno Alarake N, Frohberg P, Groth T, Pietzsch M. Mechanical properties and biocompatibility of in situ enzymatically cross-linked gelatin hydrogels. Int J Artif Organs. 2017;40(4):159-68. 10.5301/ijao.5000553

상세보기
10.1097/PRS.0000000000002019 Zhang S, Lu Q, Cao T, Toh WS. Adipose tissue and extracellular matrix development by injectable decellularized adipose matrix loaded with basic fibroblast growth factor. Plast Reconstr Surg. 2016;137(4):1171-80. 10.1097/PRS.0000000000002019

상세보기
10.1088/1748-6041/10/4/045010 Brown C, Yan J, Han TT, Marecak D, Amsden B, Flynn L. Effect of decellularized adipose tissue particle size and cell density on adipose-derived stem cell proliferation and adipogenic differentiation in composite methacrylated chondroitin sulphate hydrogels. Biomed Mater. 2015;10(4):045010. 10.1088/1748-6041/10/4/045010

상세보기
10.1002/jbm.a.36025 Tan Q-W, Zhang Y, Luo J-C, Zhang D, Xiong B-J, Yang J-Q, et al. Hydrogel derived from decellularized porcine adipose tissue as a promising biomaterial for soft tissue augmentation. J Biomed Mater Res A. 2017;105(6):1756-64. 10.1002/jbm.a.36025

상세보기
10.1097/00000637-199101000-00009 Lemperle G, Ott H, Charrier U, Hecker J, Lemperle M. PMMA microspheres for intradermal implantation: part I, animal research. Ann Plast Surg. 1991;26(1):57-63. 10.1097/00000637-199101000-00009

상세보기
10.1055/s-0032-1305786 Greco T, Antunes M, Yellin S. Injectable fillers for volume replacement in the aging face. Facial Plast Surg. 2012;28(1):8-20. 10.1055/s-0032-1305786

상세보기
Attenello NH, Maas CS. Injectable fillers: review of material and properties. Facial Plast Surg. 2015;31(1):29-34. 10.1055/s-0035-1544924, PubMed PMID: 25763894, Epub 2015/03/12.
10.1016/j.anplas.2017.09.001 Garson S, Delay E, Sinna R, Cornette de Saint Cyr B, Taha F. The third dimension of the face aging, improvement of its understanding. Ann Chir Plast Esthet. 2017;62(5):387-98. 10.1016/j.anplas.2017.09.001. PubMed PMID: 28943216. Epub 2017/09/22.

상세보기
10.1111/dsu.12128 Bartus C, William Hanke C, Daro-Kaftan E. A decade of experience with injectable poly-l-lactic acid: a focus on safety. Dermatol Surg. 2013;39(5):698-705. 10.1111/dsu.12128. PubMed PMID: 23379657. Epub 2013/02/04.

상세보기
10.1001/jamafacial.2013.337 Kontis TC. Contemporary review of injectable facial fillers. JAMA Facial Plast Surg. 2013;15(1):58-64. 10.1001/jamafacial.2013.337. PubMed PMID: 23183718.

상세보기
10.1016/S0094-1298(20)32760-7 Hobar PC, Pantaloni M, Byrd HS. Porous hydroxyapatite granules for alloplastic enhancement of the facial region. Clin Plast Surg. 2000;27(4):557-69. PubMed PMID: 11039889.

상세보기
Luebberding S, Alexiades-Armenakas M. Facial volume augmentation in 2014: overview of different filler options. J Drugs Dermatol. 2013;12(12):1339-44. PubMed PMID: 24301234.
10.1007/s10856-012-4806-0 Phull MK, Eydmann T, Roxburgh J, Sharpe JR, Lawrence-Watt DJ, Phillips G, et al. Novel macro-microporous gelatin scaffold fabricated by particulate leaching for soft tissue reconstruction with adipose-derived stem cells. J Mater Sci Mater Med. 2013;24(2):461-7. 10.1007/s10856-012-4806-0. PubMed PMID: 23143193. Epub 2012/11/10.

상세보기
10.1039/C9TB00093C Song P, Hu C, Pei X, Sun J, Sun H, Wu L, et al. Dual modulation on crystallinity and macro/micro structures of 3D printed porous titanium implants to enhance the stability and osseointegration. J Mater Chem B. 2019;7(17):2865-77.

상세보기
10.1007/s42242-019-00046-7 Zhang B, Sun H, Wu L, Ma L, Xing F, Kong Q, et al. 3D printing of calcium phosphate bioceramic with tailored biodegradation rate for skull bone tissue reconstruction. Bio-Design Manuf. 2019;2:161-71.

상세보기
10.1016/j.compositesb.2018.08.047 Zhang B, Pei X, Song P, Sun H, Li H, et al. Porous bioceramics produced by inkjet 3D printing: effect of printing ink formulation on the ceramic macro and micro porous architectures control. Compos B Eng. 2018;155:112-21.

상세보기
10.1016/j.biomaterials.2015.01.025 Chhaya MP, Melchels FPW, Holzapfel BM, Baldwin JG, Hutmacher DW. Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing. Biomaterials. 2015;52:551-60. 10.1016/j.biomaterials.2015.01.025. PubMed PMID: 25818460. Epub 2015/03/18.

상세보기
10.1016/j.tibtech.2017.10.015 Moroni L, Boland T, Burdick JA, De Maria C, Derby B, Forgacs G, et al. Biofabrication: a guide to technology and terminology. Trends Biotechnol. 2018;36(4):384-402. 10.1016/j.tibtech.2017.10.015. PubMed PMID: 29137814. Epub 2017/11/11.

상세보기
10.1007/978-981-13-0950-2_1 Wang X, Liu C. 3D Bioprinting of adipose-derived stem cells for organ manufacturing. Adv Exp Med Biol. 2018;1078:3-14. 10.1007/978-981-13-0950-2_1. PubMed PMID: 30357615.
10.1088/1758-5082/3/1/015005 Gruene M, Pflaum M, Deiwick A, Koch L, Schlie S, Unger C, et al. Adipogenic differentiation of laser-printed 3D tissue grafts consisting of human adipose-derived stem cells. Biofabrication. 2011;3(1):015005. 10.1088/1758-5082/3/1/015005. PubMed PMID: 21358040. Epub 2011/03/01.

상세보기
10.3390/ijms140917986 Jin HJ, Bae YK, Kim M, Kwon S-J, Jeon HB, Choi SJ, et al. Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy. Int J Mol Sci. 2013;14(9):17986-8001. 10.3390/ijms140917986. PubMed PMID: 24005862.

상세보기
Combellack EJ, Jessop ZM, Naderi N, Griffin M, Dobbs T, Ibrahim A, et al. Adipose regeneration and implications for breast reconstruction: update and the future. Gland Surg. 2016;5(2):227-41. 10.3978/j.issn.2227-684X.2016.01.01. PubMed PMID: 27047789.
10.1007/s00266-007-9019-4 Yoshimura K, Sato K, Aoi N, Kurita M, Hirohi T, Harii K. Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells. Aesthetic Plast Surg. 2008;32(1):48-57. 10.1007/s00266-007-9019-4. PubMed PMID: 17763894. Epub 2007/09/01.

상세보기
10.1088/1758-5082/4/2/025007 Yao R, Zhang R, Luan J, Lin F. Alginate and alginate/gelatin microspheres for human adipose-derived stem cell encapsulation and differentiation. Biofabrication. 2012;4(2):025007. 10.1088/1758-5082/4/2/025007. PubMed PMID: 22556122. Epub 2012/05/04. .

상세보기
10.1016/j.biomaterials.2012.03.026 Turner AEB, Yu C, Bianco J, Watkins JF, Flynn LE. The performance of decellularized adipose tissue microcarriers as an inductive substrate for human adipose-derived stem cells. Biomaterials. 2012;33(18):4490-9. 10.1016/j.biomaterials.2012.03.026. PubMed PMID: 22456084. Epub 2012/03/26.

상세보기
10.1089/ten.tea.2011.0467 Butler MJ, Sefton MV. Cotransplantation of adipose-derived mesenchymal stromal cells and endothelial cells in a modular construct drives vascularization in SCID/bg mice. Tissue Eng Part A. 2012;18(15-16):1628-41. 10.1089/ten.TEA.2011.0467. PubMed PMID: 22655687. Epub 2012/07/09.

상세보기
10.1002/term.1903 Li K, Li F, Li J, Wang H, Zheng X, Long J, et al. Increased survival of human free fat grafts with varying densities of human adipose-derived stem cells and platelet-rich plasma. J Tissue Eng Regen Med. 2017;11(1):209-19. 10.1002/term.1903. PubMed PMID: 24978937. Epub 2014/06/30.

상세보기
10.1002/term.1480 Ogushi Y, Sakai S, Kawakami K. Adipose tissue engineering using adipose-derived stem cells enclosed within an injectable carboxymethylcellulose-based hydrogel. J Tissue Eng Regen Med. 2013;7(11):884-92. 10.1002/term.1480. PubMed PMID: 22489051. Epub 2012/04/04.

상세보기
Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 1983;219(4587):983-5. 10.1126/science.6823562. PubMed PMID: 6823562.
10.1016/j.biomaterials.2009.10.057 Kim MH, Hong HN, Hong JP, Park CJ, Kwon SW, Kim SH, et al. The effect of VEGF on the myogenic differentiation of adipose tissue derived stem cells within thermosensitive hydrogel matrices. Biomaterials. 2010;31(6):1213-8. 10.1016/j.biomaterials.2009.10.057. PubMed PMID: 19914711. Epub 2009/11/14.

상세보기
10.1088/1748-605X/aac22d Gorkun AA, Shpichka AI, Zurina IM, Koroleva AV, Kosheleva NV, Nikishin DA, et al. Angiogenic potential of spheroids from umbilical cord and adipose-derived multipotent mesenchymal stromal cells within fibrin gel. Biomed Mater. 2018;13(4):044108. 10.1088/1748-605X/aac22d. PubMed PMID: 29722292.

상세보기
10.1016/j.actbio.2013.06.046 Chang K-H, Liao H-T, Chen J-P. Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: in vitro and in vivo studies. Acta Biomater. 2013;9(11):9012-26. 10.1016/j.actbio.2013.06.046. PubMed PMID: 23851171. Epub 2013/07/10.

상세보기
10.3390/ma4010288 Ovsianikov A, Deiwick A, Van Vlierberghe S, Pflaum M, Wilhelmi M, Dubruel P, et al. Laser fabrication of 3D gelatin scaffolds for the generation of bioartificial tissues. Materials (Basel). 2011;4(1):288-99. 10.3390/ma4010288. PubMed PMID: 28879989.

상세보기
10.1155/2019/2180925 Xing F, Li L, Zhou C, Long C, Wu L, Lei H, et al. Regulation and directing stem cell fate by tissue engineering functional microenvironments: scaffold physical and chemical cues. Stem Cells Int. 2019;2019:2180925.

상세보기
10.1038/nbt.2958 Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol. 2014;32(8):773-85. 10.1038/nbt.2958. PubMed PMID: 25093879.

상세보기
10.1126/scitranslmed.3002331 Hillel AT, Unterman S, Nahas Z, Reid B, Coburn JM, Axelman J, et al. Photoactivated composite biomaterial for soft tissue restoration in rodents and in humans. Sci Transl Med. 2011;3(93):93ra67. 10.1126/scitranslmed.3002331. PubMed PMID: 21795587.

상세보기
10.1016/j.ejpb.2015.08.004 Patrulea V, Ostafe V, Borchard G, Jordan O. Chitosan as a starting material for wound healing applications. Eur J Pharm Biopharm. 2015;97(Pt B):417-26. 10.1016/j.ejpb.2015.08.004. PubMed PMID: 26614560.

상세보기
10.2174/0929867324666170511123101 Echave MC, Saenz del Burgo L, Pedraz JL, Orive G. Gelatin as biomaterial for tissue engineering. Curr Pharm Des. 2017;23(24):3567-84. 10.2174/0929867324666170511123101. PubMed PMID: 28494717.

상세보기
Bartis D, Pongracz J. Three dimensional tissue cultures and tissue engineering. 1st ed. University of Pecs Press, University of Pecs; 2011, 10.13140/2.1.2793.5047
10.5051/jpis.2013.43.6.251 Bencherif SA, Braschler TM, Renaud P. Advances in the design of macroporous polymer scaffolds for potential applications in dentistry. J Periodontal Implant Sci. 2013;43(6):251-61. 10.5051/jpis.2013.43.6.251. PubMed PMID: 24455437. Epub 2013/12/31.

원문보기 상세보기
10.1007/s00253-013-4853-6 Ferris CJ, Gilmore KG, Wallace GG, In het Panhuis M. Biofabrication: an overview of the approaches used for printing of living cells. Appl Microbiol Biotechnol. 2013;97(10):4243-58. 10.1007/s00253-013-4853-6. PubMed PMID: 23525900. Epub 2013/03/24.

상세보기
10.1021/la402346z Ovsianikov A, Muhleder S, Torgersen J, Li Z, Qin X-H, Van Vlierberghe S, et al. Laser photofabrication of cell-containing hydrogel constructs. Langmuir. 2014;30(13):3787-94. 10.1021/la402346z. PubMed PMID: 24033187. Epub 2013/10/01.

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해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
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