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Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation 원문보기

Nature communications, v.10 no.1 = v.10, 2019년, pp.3090 -   

Park, Jun Sung ,  Lee, Junehawk ,  Jung, Eun Sun ,  Kim, Myeong-Heui ,  Kim, Il Bin ,  Son, Hyeonju ,  Kim, Sangwoo ,  Kim, Sanghyeon ,  Park, Young Mok ,  Mook-Jung, Inhee ,  Yu, Seok Jong ,  Lee, Jeong Ho

Abstract AI-Helper 아이콘AI-Helper

AbstractThe role of brain somatic mutations in Alzheimer’s disease (AD) is not well understood. Here, we perform deep whole-exome sequencing (average read depth 584×) in 111 postmortem hippocampal formation and matched blood samples from 52 patients with AD and 11 individuals not affecte...

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