Djajadisastra, J.
(Dept. of Pharmacy, Fac. of Mathematics＆Science, University of Indonesia)
,
Anwar, E.
(Dept. of Pharmacy, Fac. of Mathematics＆Science, University of Indonesi)
,
Milani, E.
(Dept. of Pharmacy, Fac. of Mathematics＆Science, University of Indonesia)
Indonesia is a tropical country having a temperature range of 25-35$^{\circ}C$ which can affect the skin and causes damages like aging. This aging process is due, at least, to free radical reactions. For this reason, many attempts had been done to find out creams containing natural antiox...
Indonesia is a tropical country having a temperature range of 25-35$^{\circ}C$ which can affect the skin and causes damages like aging. This aging process is due, at least, to free radical reactions. For this reason, many attempts had been done to find out creams containing natural antioxidant compound which have a potential of free radical scavenger. Kluwek, a fermented form of foot ball fruit or picung (Pangium edule.Reinw), had been proved to contain antioxidant compound in its methanol fraction oil to which antiaging cream was formulated. Stability evaluation was conducted for cream with Kluwek oil compared to base cream, including organoleptic (colour and odour), pH, viscosity, particle size, centrifugation test and flow characteristics either in room temperature (27$^{\circ}C$) or stress condition (4$^{\circ}C$ and 5$0^{\circ}C$) for 8 weeks continuously, and six times cycling test at 4$^{\circ}C$ and 5$0^{\circ}C$ every 24 hours. The results showed that cream with Kluwek oil and base cream were stable at temperature 27 and 4$^{\circ}C$, cycling test and centrifugation test, but not stable at 5$0^{\circ}C$. Free radical evaluation was done by Electron Spin Resonance and the result showed that cream with Kluwek oil had less free radicals compared to base cream.
Indonesia is a tropical country having a temperature range of 25-35$^{\circ}C$ which can affect the skin and causes damages like aging. This aging process is due, at least, to free radical reactions. For this reason, many attempts had been done to find out creams containing natural antioxidant compound which have a potential of free radical scavenger. Kluwek, a fermented form of foot ball fruit or picung (Pangium edule.Reinw), had been proved to contain antioxidant compound in its methanol fraction oil to which antiaging cream was formulated. Stability evaluation was conducted for cream with Kluwek oil compared to base cream, including organoleptic (colour and odour), pH, viscosity, particle size, centrifugation test and flow characteristics either in room temperature (27$^{\circ}C$) or stress condition (4$^{\circ}C$ and 5$0^{\circ}C$) for 8 weeks continuously, and six times cycling test at 4$^{\circ}C$ and 5$0^{\circ}C$ every 24 hours. The results showed that cream with Kluwek oil and base cream were stable at temperature 27 and 4$^{\circ}C$, cycling test and centrifugation test, but not stable at 5$0^{\circ}C$. Free radical evaluation was done by Electron Spin Resonance and the result showed that cream with Kluwek oil had less free radicals compared to base cream.
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문제 정의
The study aim is to investigate the physical stability of creams containing kluwek oil derived from methanol fraction ofpicung and the radical scaveging activity as well.
제안 방법
identification of kluwek oil, the free radical test on kluwek oil, formulating the cream, investigation of the cream including pH, viscocity, particle diameter, centrifugation and Electron Spin Resonance Spectrometer for free radicals counting on cream blanc and cream with kluwek oil after keeping on 27 and 50° C for 0 week and 8 weeks.
The investigation on pH was only done at room temperature every day, the viscosity and the organoleptic performance was done every week and the measurement of the particle diameter was cmly done on the 0 week and the 8th week.
대상 데이터
The natural material used in this study was kluwek oil derived from the seed ofpicung(Pangium edule Reinw.)f a fermented herbs spicy. The seed ofpicung, whether it was fermented or not, was known to have a strong antioxidant activity, even stronger than Butyl Hydroxy Toluen (BHT).
The material used were kluwek, methanol, aq.demineralisates, cetyl alcohol, stearic acid, glyceryl mono phoshate, vaseline, propylene glycol, triethanol amin, triethanol amin, nipagin, nipasol. The equipments were laboratory glass wares, analytical balance (Shimadzu), blender (National), vacuum rotary evaporator, water-bath, centrifugation (Kubota 1500), pH meter, Viscometer (Brookfield), electron microscopy, Electron Spin Resonance (ESR)
성능/효과
2. On Electron Spin Resonance measurement it was shown that cream with Kluwek oil had less free radicals after 8 weeks incubating at 50° C compared to cream without Kluwek oil, indicating that Kluwek oil has a free radical scavenger activity.
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