The present invention relates to a composition for muscle function improvement or exercise ability enhancement, the composition including kirenol, a Siegesbeckia herba extract, or a fraction of the Siegesbeckia herba extract as an active ingredient. Kirenol, the Siegesbeckia herba extract containing
The present invention relates to a composition for muscle function improvement or exercise ability enhancement, the composition including kirenol, a Siegesbeckia herba extract, or a fraction of the Siegesbeckia herba extract as an active ingredient. Kirenol, the Siegesbeckia herba extract containing kirenol, or the Siegesbeckia herba extract fraction according to the present invention has an excellent effect of increasing muscle mass by increasing the protein expression of p-mTOR, which is a major gene concerned with muscle functions. Also, kirenol, the Siegesbeckia herba extract containing kirenol, or the Siegesbeckia herba extract fraction according to the present invention has an effect of remarkably enhancing exercise ability by increasing the protein expression of PGC-1α, which is a major gene concerned with exercise ability. In addition, the present invention is a natural product, and thus is safe for use without side effects and can be used as a medicine or food.
대표청구항▼
1. A method of improving muscle functions or enhancing exercise ability, the method comprising administering an effective amount of composition including a Siegesbeckia herba extract or a fraction of the Siegesbeckia herba extract as an active ingredient to a subject. 2. The method of claim 1, where
1. A method of improving muscle functions or enhancing exercise ability, the method comprising administering an effective amount of composition including a Siegesbeckia herba extract or a fraction of the Siegesbeckia herba extract as an active ingredient to a subject. 2. The method of claim 1, wherein the Siegesbeckia herba extract is an extract obtained from one or more selected from the group consisting of Siegesbeckia glabrescens Mak., Siegesbeckia pubescens Mak., and Siegesbeckia orientalis L. 3. The method of claim 1, wherein the Siegesbeckia herba extract is obtained by extracting Siegesbeckia herba using one or more solvents selected from the group consisting of water, organic solvents having one to six carbon atoms, subcritical fluids, and supercritical fluids. 4. The method of claim 3, wherein the organic solvent having one to six carbon atoms is one or more selected from the group consisting of alcohols, acetone, ethers, benzene, chloroform, ethyl acetate, methylene chloride, hexane, cyclohexane, and petroleum ethers, all of which have one to six carbon atoms. 5. The method of claim 1, wherein the Siegesbeckia herba extract is obtained by extracting Siegesbeckia herba under ultra-high pressure conditions of 100 MPa or more. 6. The method of claim 1, wherein the fraction of the Siegesbeckia herba extract is obtained by fractionating the Siegesbeckia herba extract using ethyl acetate, methanol, or a solvent mixture of ethyl acetate and methanol. 7. The method of claim 1, wherein the improvement of muscle functions or enhancement of exercise ability is accomplished by treating, preventing or improving one or more diseases selected from the group consisting of atony, muscle atrophy, muscular dystrophy, muscle degeneration, myasthenia, and sarcopenia. 8. A method of improving muscle functions or enhancing exercise ability, the method comprising administering an effective amount of a composition including a compound represented by Structural Formula 1 as an active ingredient to a subject: 9. The method of claim 8, wherein the compound represented by Structural Formula 1 is kirenol represented by Structural Formula 2: 10. The method of claim 8, wherein the compound represented by Structural Formula 1 is separated from extracts of one or more selected from the group consisting of Siegesbeckia glabrescens Mak., Siegesbeckia pubescens Mak., and Siegesbeckia orientalis L. or is separated from a fraction of the extracts. 11. The method of claim 8, wherein the improvement of muscle functions or enhancement of exercise ability is accomplished by treating, preventing or improving one or more diseases selected from the group consisting of atony, muscle atrophy, muscular dystrophy, muscle degeneration, myasthenia, and sarcopenia.
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