The present invention relates to the identification of p53 biomarker profiles that predict response in patients with hyperproliferative disease such as cancer to a therapy, and their use in methods of treating such patients with an anti-hyperproliferative disease gene therapy.
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1.-50. (canceled) 51. A method of treating a subject using p53 gene therapy comprising: a) identifying a subject having a tumor, wherein the tumor cells comprise at least one wild type p53 alleles; andb) treating the patient with the p53 gene therapy. 52. The method of claim 51, wherein the p53 gene
1.-50. (canceled) 51. A method of treating a subject using p53 gene therapy comprising: a) identifying a subject having a tumor, wherein the tumor cells comprise at least one wild type p53 alleles; andb) treating the patient with the p53 gene therapy. 52. The method of claim 51, wherein the p53 gene therapy is carried out using a p53 gene comprised in a non-viral vector. 53. The method of claim 52, wherein the non-viral vector is entrapped in a lipid vehicle. 54. The method of claim 53, wherein the lipid vehicle is a liposome or a nanoparticle. 55. The method of claim 51, wherein the p53 gene therapy is carried out using a p53 gene comprised in a viral vector. 56. The method of claim 55, wherein the viral vector is a retroviral vector, an adenoviral vector, an adeno-associated viral vector, a pox viral vector, a polyoma viral vector, a lentiviral vector, or a herpes viral vector. 57. The method of claim 51, wherein the tumor is a benign tumor growth further defined as is benign prostatic hyperplasia, oral leukoplakia, a colon polyp, an esophageal pre-cancerous growth or a benign lesion. 58. The method of claim 51, wherein the tumor is a cancer, further defined as an oral cancer, oropharyngeal cancer, nasopharyngeal cancer, respiratory cancer, urogenital cancer, gastrointestinal cancer, central or peripheral nervous system tissue cancer, an endocrine or neuroendocrine cancer or hematopoietic cancer, glioma, sarcoma, carcinoma, lymphoma, melanoma, fibroma, meningioma, brain cancer, oropharyngeal cancer, nasopharyngeal cancer, renal cancer, biliary cancer, pheochromocytoma, pancreatic islet cell cancer, Li-Fraumeni tumors, thyroid cancer, parathyroid cancer, pituitary tumors, adrenal gland tumors, osteogenic sarcoma tumors, multiple neuroendrcine type I and type II tumors, breast cancer, lung cancer, head and neck cancer, prostate cancer, esophageal cancer, tracheal cancer, liver cancer, bladder cancer, stomach cancer, pancreatic cancer, ovarian cancer, uterine cancer, cervical cancer, testicular cancer, colon cancer, rectal cancer or skin cancer. 59. The method of claim 56, wherein the viral vector is an adenoviral vector.
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