Provided is a collagen sponge which has compressive strength (stress) equivalent to that of a tissue into which the collagen sponge is to be implanted, has no unevenness in structure and stress, and has a pore structure for allowing cells to infiltrate thereinto. The collagen sponge is obtained by s
Provided is a collagen sponge which has compressive strength (stress) equivalent to that of a tissue into which the collagen sponge is to be implanted, has no unevenness in structure and stress, and has a pore structure for allowing cells to infiltrate thereinto. The collagen sponge is obtained by subjecting a collagen dispersion, a collagen solution, or a mixture thereof having a collagen concentration of 50 mg/ml or more to freeze-drying and insolubilization treatment thereafter. The collagen sponge thus obtained has a stress of from 10 kPa to 30 kPa when loaded with 10% strain, has in its surface and inside a pore structure having a mean pore diameter ranging from 50 μm to 400 μm, and has a pore diameter standard deviation equal to or less than 80% of the mean pore diameter.
대표청구항▼
1-4. (canceled) 5. A method for preparing a collagen sponge consisting essentially of collagen, said method comprising: 1) subjecting a collagen dispersion, a collagen solution, or a mixture thereof having a collagen concentration of 50 mg/ml or more to centrifugation to uniformize a structure and s
1-4. (canceled) 5. A method for preparing a collagen sponge consisting essentially of collagen, said method comprising: 1) subjecting a collagen dispersion, a collagen solution, or a mixture thereof having a collagen concentration of 50 mg/ml or more to centrifugation to uniformize a structure and stress of the collagen sponge,2) subjecting the collagen dispersion, the collagen solution, or the mixture from step 1) to a freeze-drying treatment, and3) subjecting the collagen dispersion, the collagen solution, or the mixture from step 2) to an insolubilization treatment, to obtain the collagen sponge has a stress of from 10 kPa to 30 kPa when loaded with 10% strain, has in its surface and inside a pore structure with a pore diameter standard deviation equal to or less than 40% of a mean pore diameter. 6. The method according to claim 5, wherein the freeze-drying treatment comprises freezing the collagen dispersion, the collagen solution, or the mixture from step 1), and then drying under reduced pressure while temperature being increased. 7. The method according to claim 5, wherein the insolubilization treatment comprises a cross-linking agent treatment and a defoaming under pressure treatment. 8. The method according to claim 6, wherein the insolubilization treatment comprises a cross-linking agent treatment and a defoaming under pressure treatment. 9. The method according to claim 5, wherein the centrifugation is performed after the collagen dispersion, the collagen solution, or the mixture thereof is filled in a container for freeze-drying. 10. The method according to claim 5, wherein pH of the collagen dispersion, the collagen solution, or the mixture thereof is from 4 to 10. 11. The method according to claim 9, wherein pH of the collagen dispersion, the collagen solution, or the mixture thereof is from 4 to 10.
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