초록 ▼

The invention concerns a process for the manufacture of collagen membranes for medical applications, in which process the collagen raw materials obtained from cattle or pig collagen are mechanically freed of fatty residues and treated with diluted alkali and acids and, if need be, enzymes. It is tho

The invention concerns a process for the manufacture of collagen membranes for medical applications, in which process the collagen raw materials obtained from cattle or pig collagen are mechanically freed of fatty residues and treated with diluted alkali and acids and, if need be, enzymes. It is thoroughly washed between these steps to thus clean the collagen raw material eliminating the accompanying contamination. It is then processed further while obtaining a collagen matrix with a dry weight of approximately 25% by weight. Thus obtained are collagen membranes, in which the original integral cohesion remains and with which a fast hemostatic effect is achieved; said membranes are also extremely flexible and they adhere well to the surface of a wound.

대표청구항 ▼

A process for the manufacture of collagen membranes having an integral cohesion of fine fibers corresponding to that of a collagen raw material, and having a dry weight of approximately 25% by weight consisting essentially of, the step of: (a) mechanically freeing fatty residues from a collagen raw

A process for the manufacture of collagen membranes having an integral cohesion of fine fibers corresponding to that of a collagen raw material, and having a dry weight of approximately 25% by weight consisting essentially of, the step of: (a) mechanically freeing fatty residues from a collagen raw material and washing the raw material; (b) treating the collagen raw material with a strong alkali unit the amide nitrogen content is less than or equal to 0.35 mmol/g collagen; (c) treating the alkali-treated raw material with a strong acid at a pH value of less than or equal to 1 and subsequently washing the treated materials with water to obtain a dry weight of between 10 and 14% by weight, in which process the pH value increases to between 2.5 and 3.5; (d) shrinking the washed material by adding thereto an inorganic saline solution; (e) swelling the shrunken material by squeezing off the inorganic saline solution and washing the shrunken material with water to reach a dry weight of between 40 and 50% by weight; (f) repeating steps (d) and (e) at least twice; (g) removing water from the resulting matrix product of step (f) by the addition of a solvent; and (h) drying the matrix in a stretched form, to obtain a membrane wherein the integral cohesion of the fibers of the membrane\s matrix correspond to that of a collagen raw material and having a dry weight of approximately 25% by weight.