초록 ▼

The invention relates to complex compound as well as their salts consisting of at least one metal ion and one complexing agent of general formula I [ STR 1 ] in which Z.sup.1, Z.sup.2 and s have different meanings, as well as their use for the production of agents for radiation therapy and for NMR d

The invention relates to complex compound as well as their salts consisting of at least one metal ion and one complexing agent of general formula I [ STR 1 ] in which Z.sup.1, Z.sup.2 and s have different meanings, as well as their use for the production of agents for radiation therapy and for NMR diagnosis and diagnostic radiology, especially for contrasting the hepatobiliary system. Further, the invention relates to a process for the production of these compounds and agents.

대표청구항 ▼

[ We claim:] [1.] A complex compound of at least one metal ion of an element of atomic numbers 21-29, 42 44 or 58-83 and a complexing agent of formula I [ STR 7 ] in which Z.sup.1 and Z.sup.2, independently of one another, stand for a hydrogen atom, the radical --(CH.sub.2).sub.m --(C.sub.6 H.sub.4)

[ We claim:] [1.] A complex compound of at least one metal ion of an element of atomic numbers 21-29, 42 44 or 58-83 and a complexing agent of formula I [ STR 7 ] in which Z.sup.1 and Z.sup.2, independently of one another, stand for a hydrogen atom, the radical --(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R, or the radical --(CH.sub.2).sub.m --(C.sub.6 H.sub.10).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.10).sub.l --(O).sub.r --R, whichm and n mean a number from 0-5,q, k, l and r mean numbers 0 or 1 ands means numbers 1 or 2,R means a hydrogen atom, an optionally OR.sup.1 -substituted straight-chain or branched C.sub.1 -C.sub.6 alkyl radical or a CH.sub.2 --COOR.sup.1 group,in which R.sup.1 means a hydrogen atom, a C.sub.1 -C.sub.6 alkyl radical or a benzyl group,provided that in each case one of substituents Z.sup.1 or Z.sup.2 stands for a hydrogen atom and the other does not stand for hydrogen, and that a direct oxygen-oxygen bond is not allowed,and further provided that carboxylic acid groups not required to complex metal ions are optionally present partially or completely as a salt of an amino acid or an amino acid amide or as a salt of an inorganic or organic base.