초록 ▼

There is provided a process for the preparation of a polymerizable composition comprising a cross-linker and a polymerizable monomer of formula (I) comprising (i) contacting a compound of formula (II) with an acid such as an imobilized acid; and (ii) neutralizing product of (i) such that a crosslink

There is provided a process for the preparation of a polymerizable composition comprising a cross-linker and a polymerizable monomer of formula (I) comprising (i) contacting a compound of formula (II) with an acid such as an imobilized acid; and (ii) neutralizing product of (i) such that a crosslinker is formed.

대표청구항 ▼

What is claimed is: 1. A process for the preparation of a polymerizable composition comprising polymerizable monomer of formula I: said process comprising the steps of: (i) contacting a compound of formula II with an immobilized acid to thereby form a composition comprising the monomer of fo

What is claimed is: 1. A process for the preparation of a polymerizable composition comprising polymerizable monomer of formula I: said process comprising the steps of: (i) contacting a compound of formula II with an immobilized acid to thereby form a composition comprising the monomer of formula (I) and an acid by-product thereof, wherein X, Y, Z, P, and Q are independently selected from a hydrocarbyl group or hydrogen, A is (CH2)n, wherein n is 0 or 1; R1 corresponds to either formula IIIA or formula IIIB where R2 is selected from the group consisting of H, methyl, ethyl, propyl, and butyl, and and R3 is an unsaturated C2-5 alkyl; and (ii) neutralizing the composition of step (i) with an immobilized hydroxide, to thereby provide a composition comprising the monomer of formula I and a cross-linker. 2. A process according to claim 1 wherein the immobilized acid is a strong acid. 3. A process according to claim 1 wherein the acid is immobilized on an ion exchange resin. 4. A process according to claim 1 wherein X and Y are independently selected from hydrocarbon groups having from 1 to 20 carbon atoms and hydrogen. 5. A process according to claim 1 wherein R1 corresponds to formula IIIA, and R2 is CH3. 6. A process according to claim 1 wherein X is H; Y is H, Z is H, n=0, R1 corresponds to formula IIIA, and R2 is CH3. 7. A process according to claim 6 wherein prior to said said contacting, the immobilized acid is contained, and after said contacting, passing a gas through the contained immobilized acid. 8. A process according to claim 7 wherein the gas is air. 9. A process according to claim 7 wherein the immobilized acid is contacted with the compound of formula II in the absence of an organic solvent. 10. A process according to claim 1 wherein said contacting is performed in the presence of water. 11. A process according to claim 7, wherein prior to said contacting, the immobilized acid is contained in a fluidized bed reactor. 12. A process according to claim 7, further comprising after said passing step, extracting the gas from the contained immobilized acid. 13. A process according to claim 1, further comprising, after said neutralizing, polymerizing the composition formed in step (ii), to thereby form a polymer. 14. A process according to claim 1, wherein said acid by-product formed in step (i) is methacrylic acid. 15. A process according to claim 1, wherein said acid by-product formed in step (i) is acrylic acid. 16. A process according to claim 13, further comprising forming the polymer formed in said polymerizing step into an ocular device. 17. A polymerizable monomer or composition formed by the process of claim 1. 18. A polymer formed by the process of claim 13. 19. An ocular device comprising the polymer formed by the process of claim 13. 20. A process for the preparation of a polymerizable composition comprising a polymerizable monomer of formula I: said process comprising the steps of: (i) contacting a compound of formula II with an immobilized acid having a pKa of less than 3 to thereby form a composition comprising the monomer of formula (I) and an acid by-product thereof, wherein X and Y are independently selected from hydrocarbon groups having 1 to 20 carbon atoms and hydrogen, Z, P, and Q are independently selected from a hydrocarbyl group or hydrogen, A is (CH2)n, wherein n is 0 or 1; R1 corresponds to either formula IIIA or formula IIIB where R2 is selected from the group consisting of H, methyl, ethyl, propyl, and butyl, and R3 is an unsaturated C2-5 alkyl; and (ii) neutralizing the composition of step (i) with an immobilized hydroxide, to thereby provide a composition comprising the monomer of formula I and a cross-linker. 21. The process of claim 1, effective to form a composition comprising said monomer of formula (I) and about 0.50 percent or less of said cross-linker. 22. The process of claim 7, wherein said contacting results in formation of P—C(O)-Q, and said passing step is effective to remove said P—C(O)-Q from said composition. 23. The process of claim 22, wherein said process is effective to provide essentially quantitative conversion of the compound of formula (II) to the monomer of formula (I). 24. The process of claim 13, wherein the resulting polymer comprises 5% or less of a polymer formed by polymerization of said cross-linker. 25. The process of claim 3, wherein prior to said neutralizing, said immobilized acid is removed by filtration. 26. The process of claim 1, wherein the polymerizable monomer of formula (I) is glycerine methacrylate (GMA), the compound of formula (II) is 2,2-dimethyl-1,3-dioxolan-4-yl methyl methacrylate (GMAK), the acid by-product is methacrylic acid (MA), and the cross-linker is glycerol dimethacrylate.