Hydrophilic coating and a method for the preparation thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-006/083
A61F-013/00
B05D-003/02
출원번호
US-0540108
(2003-12-19)
등록번호
US-8728508
(2014-05-20)
우선권정보
DK-2002 01970 (2002-12-20)
국제출원번호
PCT/DK03/00927
(2003-12-19)
§371/§102 date
20060626
(20060626)
국제공개번호
WO2004/056909
(2004-07-08)
발명자
/ 주소
Nielsen, Bo Rud
Madsen, Niels Jorgen
출원인 / 주소
Coloplast A/S
대리인 / 주소
Coloplast Corp., Coloplast A/S
인용정보
피인용 횟수 :
0인용 특허 :
8
초록▼
The present invention provides a method for the preparation of a cross-linked hydrophilic coating of a hydrophilic polymer on a substrate polymer surface of a medical device, involving the use of a polymer solution comprising 1-20% by weight of a hydrophilic polymer, 0-5% by weight of additive(s), a
The present invention provides a method for the preparation of a cross-linked hydrophilic coating of a hydrophilic polymer on a substrate polymer surface of a medical device, involving the use of a polymer solution comprising 1-20% by weight of a hydrophilic polymer, 0-5% by weight of additive(s), and the balance of a vehicle with plasticizing effect on the hydrophilic polymer, wherein the vehicle comprises at least one plasticizer having a solubility in water of at least 6 g/L, a boiling point above 210° C. at 760 mmHg, and Hansen δH parameter of less than 20. Furthermore, the invention provides a medical device, e.g. a catheter or guide wire, provided with such a hydrophilic coating. The invention also provides the use of specific polymer solution for the preparation of a cross-linked hydrophilic coating.
대표청구항▼
1. A method for the preparation of a cross-linked hydrophilic coating of a hydrophilic polymer on a substrate polymer surface of a medical device, said method comprising the steps of: (i) providing a medical device having a substrate polymer surface;(ii) providing a polymer solution comprising 1-20%
1. A method for the preparation of a cross-linked hydrophilic coating of a hydrophilic polymer on a substrate polymer surface of a medical device, said method comprising the steps of: (i) providing a medical device having a substrate polymer surface;(ii) providing a polymer solution comprising 1-20% by weight of a hydrophilic polymer, 0-5% by weight of additive(s), and the balance of said solution being a vehicle having at least one plasticizer with a solubility in water of at least 6 g/L, a boiling point above 210° C. at 760 mmHg, and a Hansen δH parameter of less than 20 wherein the plasticizer is selected from the group consisting of dimethyl sulfone, ethylene carbonate, glycerol diacetate, glycerol triacetate, hexomethylphosphoramide, isophorone, methyl salicylate, N-acetyl morpholine, propylene carbonate, quinoline, sulfolane, and triethyl phosphate;(iii) applying said polymer solution to said substrate polymer surface;(iv) evaporating at least a part of the vehicle from said polymer solution present on said substrate polymer surface at a temperature of 25°-100° C.; and(v) curing said hydrophilic polymer without rewetting the medical device, wherein said curing occurs by irradiation and is the only irradiation step in the process. 2. The method according to claim 1, wherein the polymer solution is applied to said substrate polymer surface in a single application step. 3. The method according to claim 1, wherein the vehicle comprises at least one solvent. 4. The method according to claim 3, wherein the polymer solution consists of 1-20% by weight of the hydrophilic polymer, 0-5% by weight of additive(s), 1-40% by weight of plasticizer(s), and 50-95% by weight of solvent(s). 5. The method according to claim 1, wherein the substrate polymer is polyurethane. 6. The method according to claim 1, wherein the hydrophilic polymer is polyvinyl pyrrolidone. 7. A medical device comprising a substrate polymer surface having thereon a cross-linked hydrophilic coating of a hydrophilic polymer, said medical device being obtained by the method of claim 1. 8. A medical device comprising a hydrophilic coating of a cross-linked hydrophilic polymer, said coating having a hydrophilic plasticizer with a solubility in water of at least 6 g/L, a boiling point above 210° C. at 760 mmHg, and a Hansen δH parameter of less than 20, said medical device being prepared according to the method of claim 1. 9. A method of use of a polymer solution for the preparation of a cross-linked hydrophilic coating, wherein said polymer solution includes 1-20% by weight of a hydrophilic polymer, 0-5% by weight of additive(s), and the balance of said solution being a vehicle having a plasticizing effect on the hydrophilic polymer and including at least one plasticizer having a solubility in water of at least 6 g/L, a boiling point above 210° C. at 760 mmHg, and a Hansen δH parameter of less than 20 wherein the plasticizer is selected from the group consisting of dimethyl sulfone, ethylene carbonate, glycerol diacetate, glycerol triacetate, hexamethylphosophoramide, isophorone, methyl salicylate, N-acetyl morpholine, propylene carbonate, quinoline, sulfolane, and triethyl phosphate, said method comprising the steps of; (a) applying said polymer solution to said substrate polymer surface;(b) evaporating at least a part of the vehicle from said polymer solution present on said substrate polymer surface at a temperature of 25°-100° C.; and curing said hydrophilic polymer by irradiation without rewetting the medical device,wherein said method includes only a single irradiation step. 10. The method according to claim 5, wherein the hydrophilic polymer is polyvinyl pyrrolidone. 11. A method for the preparation of a cross-linked hydrophilic coating of a hydrophilic polymer on a substrate polymer surface of a medical device, said method consisting of the steps of: (i) providing a medical device having a substrate polymer surface;(ii) providing a polymer solution having 1-20% by weight of a hydrophilic polymer, 0-5% by weight of additive(s), and the balance of said solution being a vehicle having at least one plasticizer with a solubility in water of at least 6 g/L, a boiling point above 210° C. at 760 mmHg, and a Hansen δH parameter of less than 20 wherein the plasticizer is selected from the group consisting of dimethyl sulfone, ethylene carbonate, glycerol diacetate, glycerol triacetate, hexamethylphosphoramide, isophorone, methyl salicylate, N-acetyl morpholine, propylene carbonate, quinoline sulfolane, and triethyl phosphate;(iii) applying said polymer solution to said substrate polymer surface;(iv) evaporating at least a part of the vehicle from said polymer solution present on said substrate polymer surface at a temperature of 25°-100° C.; and(v) curing said hydrophilic polymer. 12. The method according to claim 11, wherein the polymer solution is applied to said substrate polymer surface in one single application step. 13. The method according to claim 11, wherein the vehicle comprises at least one solvent. 14. The method according to claim 13, wherein the polymer solution consists of 1-20% by weight of the hydrophilic polymer, 0-5% by weight of additive(s), 1-40% by weight of plasticizer(s), and 50-95% by weight of solvent(s). 15. The method according to claim 11, wherein the substrate polymer is polyurethane. 16. The method according to claim 11, wherein the hydrophilic polymer is polyvinyl pyrrolidone. 17. A medical device comprising a substrate polymer surface having thereon a cross-linked hydrophilic coating of a hydrophilic polymer, said medical device being obtained by the method of claim 11. 18. A medical device comprising a hydrophilic coating of a cross-linked hydrophilic polymer, said coating having a hydrophilic plasticizer with a solubility in water of at least 6 g/L, a boiling point above 210° C. at 760 mmHg, and a Hansen δH parameter of less than 20, said medical device being prepared according to the method of claim 11. 19. A method of use of a polymer solution for the preparation of a cross-linked hydrophilic coating, wherein said polymer solution includes 1-20% by weight of a hydrophilic polymer, 0-5% by weight of additive(s), and the balance of said solution being a vehicle having a plasticizing effect on the hydrophilic polymer and including at least one plasticizer having a solubility in water of at least 6 g/L, a boiling point above 210° C. at 760 mmHg, and a Hansen δH parameter of less than 20 wherein the plasticizer is selected from the group consisting of dimethyl sulfone, ethylene carbonate, glycerol diacetate, glycerol triacetate, hexamethylphosphoramide, isophorone, methyl salicylate, N-acetyl morpholine, propylene carbonate, quinoline, sulfolane, and triethyl phosphate, said method consisting of the steps of: (a) applying said polymer solution to said substrate polymer surface;(b) evaporating at least a part of the vehicle from said polymer solution present on said substrate polymer surface at a temperature of 25°-100° C.; and curing said hydrophilic polymer by irradiation,wherein said method includes only a single irradiation step. 20. The method according to claim 15, wherein the hydrophilic polymer is polyvinyl pyrrolidone. 21. The method according to claim 1, wherein evaporating at least part of said vehicle takes place at a temperature of 70°-100° C. 22. The method according to claim 9, wherein evaporating at least part of said vehicle takes place at a temperature of 70°-100° C. 23. The method according to claim 11, wherein evaporating at least part of said vehicle takes place at a temperature of 70°-100° C.
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이 특허에 인용된 특허 (8)
Malhotra Shadi L. (Mississauga CAX), Ink jet transparencies and papers.
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