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PH20 polypeptide variants, formulations and uses thereof 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-009/26
  • C12N-015/00
  • A61K-038/47
  • A61K-038/28
  • A61K-045/06
  • A61K-009/00
  • A61K-047/10
  • C12Q-001/34
  • A61K-038/00
출원번호 US-0694731 (2012-12-28)
등록번호 US-9447401 (2016-09-20)
발명자 / 주소
  • Wei, Ge
  • Shepard, H. Michael
  • Zhao, Qiping
  • Connor, Robert James
출원인 / 주소
  • Halozyme, Inc.
대리인 / 주소
    Dentons US LLP
인용정보 피인용 횟수 : 3  인용 특허 : 76

초록

Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

대표청구항

1. A modified PH20 polypeptide that exhibits increased stability in the presence of a phenolic preservative, comprising an amino acid replacement in an unmodified PH20 polypeptide, wherein: the amino acid replacement confers the increased stability;the amino acid replacement is replacement with prol

이 특허에 인용된 특허 (76)

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이 특허를 인용한 특허 (3)

  1. Maneval, Daniel C.; Shepard, H. Michael; Thompson, Curtis B., Combination therapy with an anti-hyaluronan agent and therapeutic agent.
  2. Maneval, Daniel C.; Shepard, H. Michael; Thompson, Curtis B., Combination therapy with an anti-hyaluronan agent and therapeutic agent.
  3. Jung, Hyun Ho; Yang, Gi Hyeok; Kim, Hyun Jee; Rhee, Chang Hoon, Long lasting effect of new botulinum toxin formulations.
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