초록

혈액여과기의 개발은 여과막의 설정과 여과기의 제조, 생체외 성능 평가, 동물실험, 임상시험으로 나눌 수 있다. 본 연구에서는 Amicon사의 PS 중공사막을 사용하여 혈액여과기를 제작하고, 분획분자량과 한외여과속도, 청소율 등을 측정하여 그 성능을 평가함으로써 혈액여과기의 최적설계와 개선 방향을 제시하였다.

Abstract ▼

Hemofilter was optimally designed and manufactured using polysulfone hollow fiber membrane of Amicon Co. with surface area of 0.6 $m^{2}$. Pressure drop across the dialysate inlet and outlet ports as well as blood inlet and outlet ports were measured for the optimum design of the device.

Hemofilter was optimally designed and manufactured using polysulfone hollow fiber membrane of Amicon Co. with surface area of 0.6 $m^{2}$. Pressure drop across the dialysate inlet and outlet ports as well as blood inlet and outlet ports were measured for the optimum design of the device. Priming volume of the device was also calculated for the clinical application.
In vitro tests of the hemofilter were performed with solutions.
Molecular weight cut-off of the hemofilter was measured with PEG and dextran aqueous solutions of various molecular weights and it was ranged from 9,500 to 38,900, which is the same as those of the commercialized ones. Ultrafiltration rates were measured with pure water in a static system and flowing system. Ultrafiltration rate of the hemofilter was 129 m$\ell$/hr $m^{2}$ mmHg, which was 2.4 times greater than those of the other commercialized ones.
The clearance of urea, creatinine, and vitamine $B_{12}$ were measured using aqueous solutions. The clearances of the hemofilter were smaller than those of the other commercialized ones except the Diafilter-3 of Amicon Co., which was made of the same hollow fiber membrane as in this work. Therefore, design of hemofilter in this study was partly proved to be better than that of Diafilter-30 of Amicon Co..
Clearance of the hemofilter mainly depends on the membrane properties, and the membrane used in this study did not show the excellent diffusive properties of the solutes through the membrane while it has superior ultrafiltration characteristics to the others.
In terms of the medical applications the hemofilter manufactured in this work is good for the patient who needs the removal of excess water.
Technologies and know-how built up in manufacturing hemofilter can substitute the hemodialysis method or overcome the problems encountered in hemodialysis. Since the hemofilter and the other accessories are currently supplied to hospitals at high price, its development can also make contributions to the public welfares.

목차 Contents

• 제1장 서론...19
• 제1절 혈액여과의 역사적 배경...19
• 제2절 혈액 여과막의 제조...26
• 제3절 혈액여과기의 모듈 및 장치...40
• 제4절 보충액의 제조...50
• 제5절 혈액응고방지제의 문제점과 연구방향...55
• 제2장 이론적 배경...57
• 제1절 Clearance와 Dialysance...57
• 제2절 물질전달 특성...60
• 제3절 한외여과 특성...61
• 제3장 실험...63
• 제1절 실험재료...63
• 제2절 시험용 모듈 제작...65
• 제3절 분획분자량의 조사 실험...65
• 제4절 정지계에서 한외여과속도의 측정실험...70
• 제5절 Clearance 실험...70
• 제6절 혈액여과기의 압력강하 측정실험...75
• 제4장 결과 및 검토...78
• 제1절 혈액여과기의 설계...78
• 제2절 혈액여과기의 압력강하...81
• 제3절 분획분자량의 측정...83
• 제4절 한외여과 실험...87
• 제5절 Clearance 실험...90
• 제5장 결론...95
• 참고문헌...97