항균제내성.주요 내성균.전국 모니터링.Antimicrobial resistance.Medically important resistant bacteria.Nationwide surveillance.
초록▼
전국 총 13 개 연구 참여기관 (서울, 경기, 강원, 충청, 영남 빛 호담 지역에 있는 대학 병원 12개와 임상병리검사 센터 1개)에서 2002년 상반기 중 3개월 동안 임상검체에서 분려된 주요 세균의 향균제 감수성 결과를 수칩하여 분석하였다. 또한 주요 내성 세균 균종을 7개의 세부과제, 즉 1) methicillin 내성 Staphylococcus aureus, 2) Vancomycin 내성 장구균, 3) Extended-spectrum ${\beta}$-lactamase 생성 Escherichia coli
전국 총 13 개 연구 참여기관 (서울, 경기, 강원, 충청, 영남 빛 호담 지역에 있는 대학 병원 12개와 임상병리검사 센터 1개)에서 2002년 상반기 중 3개월 동안 임상검체에서 분려된 주요 세균의 향균제 감수성 결과를 수칩하여 분석하였다. 또한 주요 내성 세균 균종을 7개의 세부과제, 즉 1) methicillin 내성 Staphylococcus aureus, 2) Vancomycin 내성 장구균, 3) Extended-spectrum ${\beta}$-lactamase 생성 Escherichia coli와 Klebsiella pneumoniae, 4) 플라스미드성 AmpC ${\beta}$-lactarnase 생성 E. coli와 K. pneumoniae, 5) Carbapenem 내성 Pseudomonas aeruginosa와 Acinetobacter baumannii, 6) Fluoroquinolone 내성 E. coli와 K. pneumoniae, 염색체성 AmpC ${\beta}$-lactamase 생성 Enterobacter cloacae, Citrobacter freundii 및 Serratia marcescens, 7) Penicillin 내성 Streptococcus pneumoniae 및 ampicillin 내성 Haemophilus influenzae로 나누어, 참여기관별로 일련균주 약 20주씩 수집하여 각 균종의 내성 기전 규명을 위한 선별 및 확인 시험을 수행하였다.
Abstract▼
Background: A rapid increase of antimicrobial-resistant bacteria has become a serious problem in many countries, but the resistance rate may very significantly depending on the countries and even on hospitals due to the extent of antimicrobial selective pressure and tile magnitude of cross infection
Background: A rapid increase of antimicrobial-resistant bacteria has become a serious problem in many countries, but the resistance rate may very significantly depending on the countries and even on hospitals due to the extent of antimicrobial selective pressure and tile magnitude of cross infection in hospitals. It has been known that antimicrobial-resistant bacteria are relatively more prevalent in Korea. Moreover, the antibiotic resistance problem has worsened noticeably during the past several years. Therefore the nationwide surveillance of antimicrobial resistance is very Important for the prudent antimicrobial therapy. The aim of this study was to determine the prevalence of resistance among frequently isolated gram-positive and -negative species of bacteria in Korea, and to determine the resistance mechanisms of resistant bacteria. Materials and Methods: Routine susceptibility data for medically Important bacteria isolated during 3 months of 2002 were collected from 13 university and hospital laboratories in Korea. for the determination of resistance mechanisms, 7 research subjects were divided and peformed. 1) Methicillin-resistant Staphylococcus aureus (MRSA), 2) Vancomycin-resistant enterococci (VRE), 3) Extended-spectrum ${\beta}$-lactamase-producing Escherichia coli and Klebsiella pneumoniae, 4) Plasmid-mediated AmpC ${\beta}$-lactamase-producing E. coli and K. pneumoniae, 5) Carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter baumannii, 6) Fluoroquinolone-resistant E. coli and K. pneumoniae, chromosomal mediated AmpC ${\beta}$-lactamase-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens, 7) Penicillin-resistant Streptococcus pneumoniae, and ampicillin-resistant Haemophilus influenzae. Twenty consecutive isolates of each strains were collected from 13 participating hospitals.
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