초록 ▼

본 연구의 목표는 텍스트 마이닝 기술을 이용하여 추출된 정보를 이용하여 세포사멸 신호 전달 기작을 수학적/동력학적으로 예측하고 신호전달 경로의 제어가 가능한 시스템 개발이 최종 목표임. 아래는 이러한 목표를 기반으로 하여 연구를 진행한 세부 결과임.1. 시스템생물학을 in-Silico 상에서 연구하기 위한 표준인 SBML 구조를 심도있게 연구하였고, apoptosis pathway 및 기타 신호전달 기작을 시각화 하기 위해 KEGG 자료 구조를 연구하였음.2. Signal transduction 및 생ㄹ체반응기작을 시각화 하는 네트

본 연구의 목표는 텍스트 마이닝 기술을 이용하여 추출된 정보를 이용하여 세포사멸 신호 전달 기작을 수학적/동력학적으로 예측하고 신호전달 경로의 제어가 가능한 시스템 개발이 최종 목표임. 아래는 이러한 목표를 기반으로 하여 연구를 진행한 세부 결과임.1. 시스템생물학을 in-Silico 상에서 연구하기 위한 표준인 SBML 구조를 심도있게 연구하였고, apoptosis pathway 및 기타 신호전달 기작을 시각화 하기 위해 KEGG 자료 구조를 연구하였음.2. Signal transduction 및 생ㄹ체반응기작을 시각화 하는 네트워크 에디터 개발 및 동역학 시뮬레이션을 위한 모델을 정의하였음.3. 제 2세부과제 연구결과를 이용하여 intrinsic apoptosis pathway를 모델링 하였음.4. 기 구축된 외부 signal transduction 모델을 importing 할 수 있는 모듈을 개발하였음.

Abstract ▼

The dynamic modeling of bio-system is a core technology, for predicting the biochemical behavior of components that consist of complex network of molecules in the living things. Several years ago, the developed countries have launched several huge research projects and it is expected that many advan

The dynamic modeling of bio-system is a core technology, for predicting the biochemical behavior of components that consist of complex network of molecules in the living things. Several years ago, the developed countries have launched several huge research projects and it is expected that many advanced technology and scientific results will be developed and uncovered soon to precisely understand the basic nature of bio-system So, it is most important to invest in the systems biology field to keep up with these world-wide trend because the results that would be extracted or developed will have a greate impact on the whole field of the bio-science. Here we have developed new technology and software, BiPS, that constructs biochemical pathways like signal transduction by using graphical tools. BiPS (Bio Pathway Simulator) consists of four main modules: 1) Model Editor, 2) Model Generator, 3) Dynamic Simulator, and 4) SBML Converter. The Model Editor module is responsible for drawing or editing newly defined bio-pathway like signal transduction Molecules and theirs relationships that are involved in the specific bio-pathway are describe by diagrams such as ovals, squares, arrows, and etc. The Model Generator module automatically converts the visually represented bio-pathway model into a concrete data structure that contains a set of kinetic equations representing the relationships among molecules. After completing model creation and generation process, the Dynamic Simulator module simulates the bio-pathway model in real time. The SBML Converter module export the newly defined bio-pathway model that is generated by the Model Editor and the Model Generator to the data structure compatible with the SBML. BiPS can also import the model that is defined by SBML into BiPS Model Editor after some internal modification. The newly developed system will be released after extensive stability and verification test by many researchers.