초록 ▼

1) 뇌졸중 후 급성혈전용해 치료, 스텐트 삽입술 등의 프로토콜을 적립하고 치료효과에 영향을 미치는 인자 규명
2) 뇌졸중 환자의 임상적 특성에 따른 혈관 질환 양상 및 병인규명
3) 우리나라 뇌졸중 환자의 혈관 이상의 빈도규명
4) 뇌혈관 시술용 스텐트 및 혈전제거 치료법 개발
5) 뇌졸중 후 발생하는 우울증 및 강정조절장애에서 SSRI치료 효과를 입증
6) 우리나라 뇌졸중 환자의 삶의 질, 돌봄이의 부담에 영향을 미치는 인자를 규명
7) 대사증후군과 영양부족이 환자의 예후에 영향을 미치는 인자임을

1) 뇌졸중 후 급성혈전용해 치료, 스텐트 삽입술 등의 프로토콜을 적립하고 치료효과에 영향을 미치는 인자 규명
2) 뇌졸중 환자의 임상적 특성에 따른 혈관 질환 양상 및 병인규명
3) 우리나라 뇌졸중 환자의 혈관 이상의 빈도규명
4) 뇌혈관 시술용 스텐트 및 혈전제거 치료법 개발
5) 뇌졸중 후 발생하는 우울증 및 강정조절장애에서 SSRI치료 효과를 입증
6) 우리나라 뇌졸중 환자의 삶의 질, 돌봄이의 부담에 영향을 미치는 인자를 규명
7) 대사증후군과 영양부족이 환자의 예후에 영향을 미치는 인자임을 밝힘
8) 두개강내 뇌혈관 협착 환자에서 statin 치료는 협착의 진행을 막는 인자임을 규명
9) GRE로 확인된 초기 미세 출혈이 뇌출혈의 재발에 영향을 미치는 인자임을 밝힘
10) 면역조직화학기법과 분자생물학적인 방법을 이용하여 허혈 시 PDI, TrkA, Gal, NCX1, Ca2+-ATPase, GDNF, PLP합성효소의 발현 변화 양상을 규명
11) PLP등의 허혈과 관계된 물질과 cordiceps와 같은 천연물의 투여시 뇌허혈에서의 신경보호효과를 확인
12) 뇌허혈 동물모델에서 NSAIDS에 의한 chemical conditioning 효과밝힘
13) 뇌허혈 동물모델에서 ibudilast의 신경세포 보호효과 규명

Abstract ▼

1. Aim and purpose
As a single disorder, stroke is the most important cause of death in Korea. With the increasing number of aged people in Korea, stroke will be even more important problem in our society. Thus, clinical studies on the epidemiology, diagnosis, reatment as well as base researches

1. Aim and purpose
As a single disorder, stroke is the most important cause of death in Korea. With the increasing number of aged people in Korea, stroke will be even more important problem in our society. Thus, clinical studies on the epidemiology, diagnosis, reatment as well as base researches are definitively needed. For more effective research, investigators of diverse expertise should collaborate closely. We studied a variety of subjects in stroke ranging from acute treatment to basic research.
2. The spectra of our study
1) Protocol setup for the acute thrombolysis with the use of advances MR imaging and analysis of the factors influencing the clinical outcome of the patient.
2) Assessment of strokes in Koreans with the use of MRI and MRA: clinical characteristics, brain and vascular imaging findings, and clinical-imaging correlation
3) Management of post-stroke depression, emotional incontinence and fatigue.
4) Assessment of factors affecting the quality of life of stroke patients and caregivers
5) Assessment of relationship between the nutritional status and recurrence of stroke
6) Assessment of factors affecting the progression of intracranial atherosclerosis
7) Assessment of factors relating to the recurrent intracerebral hemorrhages
8) Assessment of neuron-glia interaction by observation of the patterns of appearance and disappearance of these cells. Expression of antioxicant, ion channel, GABA shunt enzyme in astroctye/microglia was also analyzed.
9) Assessment of neuroprotective effects of NSAID, valproic acid and ibudalist in the MCA occlusion model of the rat
3. Results
1) We set up a protocol for thrombolysis with the use of advances MR imaging and identified factors affecting the clinical outcome of the patients who receive thrombolytic therapy
2) With the use of MRI, we characterized clinical syndromes, related vascular pathogenesis as well as the general vascular characteristics in Korean stroke patients
3) We identified factors affecting the outcome of stent/angioplasty
4) We found that SSRI is effective in the management of post-stroke depression, emotional incontinence and anger-proneness. However, SSRI was not effective in treating fatigue suggesting that post-stroke fatigue is not simply related to the serotonergic system
5) We identified factors affecting the quality of life of stroke patients. We newly found that central post-stroke pain is one of the factors related to the quality of life in stroke patients
6) We found that factors affecting the caregiver burden in Korea included patients` physical status, depression, and caregiver`s emotional status. Being a daughter in law was also a factor related to the high burden, an observation suggesting unique cultural characteristics of Korea
7) We found that the presence of microbleeds in the initial GRE was a significant factor related to the recurrent intracerebral hemorrhages
8) We identified the time sequence of neuron-glia interaction in ischemic brain. Expression of various antioxicants, ion channel, GABA shunt enzyme in astroctye/microglia was also assessed.
9) We identified neuroprotective effects of NSAID, valproic acid and ibudalist in the MCA occlusion model of the rat
4. Application of the results
1) Protocol and guideline setup for thrombolysis, stent/angioplasty and embolectomy in the treatment of acute stroke patients
2) Identification of stroke subtypes and guideline setup for the diagnosis of stroke in Korean patients
3) Guideline for the management of post-stroke depression and emotional incontinence
4) Our results can be used as basic information in the policy to improve the quality of life of stroke patients and caregivers
5) Prospective study using stalin in the management of intracranial atherosclerosis
6) Development of neuroprotective strategy based on the results from neuron-glia interaction
7) Further understanding of the mechanism of neuroprotection of NSAID and ibudilast and future application of these agents in clinical trials

목차 Contents

• II. 총괄연구과제 연구결과...43
• 1. 연구개발과제의 배경 및 필요성...44
• 2. 국내외 기술개발 현황...45
• 3. 연구개발과제의 추진체계...54
• 4. 연구개발수행 내용 및 결과...56
• 5. 목표달성도 및 관련분야 기여도...61
• 6. 향후 연구성과 추진 계획...65
• 7. 연구개발결과의 파급효과...66
• 8. 연구개발결과의 활용계획 및 추가연구의 필요성...66
• IV. 제 1 세부 연구과제 연구결과...67
• 1. 연구개발과제의 목표...68
• 2. 연구개발과제의 추진체계...73
• 3. 연구개발수행 내용 및 결과...74
• 4. 참고문헌...78
• IV. 제 2 세부 연구과제...80
• 1. 연구개발과제의 목표...81
• 2. 연구개발과제의 추진체계...85
• 3. 연구개발수행 내용 및 결과...86
• 4. 참고문헌...90
• IV. 제 3 세부 연구과제...93
• 1. 연구개발과제의 목표...94
• 2. 연구개발과제의 추진체계...95
• 3. 연구개발수행 내용 및 결과...96
• 4. 참고문헌...102
• IV. 제 4 세부 연구과제 연구결과...103
• 1. 연구개발과제의 목표...104
• 2. 연구개발과제의 추진체계...107
• 3. 연구개발수행 내용 및 결과...110
• 4. 참고문헌...145
• IV. 제 5 세부 연구과제 연구결과...147
• 1. 연구개발과제의 목표...148
• 2. 연구개발과제의 추진체계...150
• 3. 연구개발수행 내용 및 결과...150
• 4. 참고문헌...155
• IV. 첨부서류...156
• 1. 자체평가의견서...157
• 2. 연구성과 실적 증빙서류...160
• 3. 기타 요청서류...160