농림기술관리센터 Agricultural Research & Development Promotion Center
등록번호
TRKO201100001391
과제고유번호
1380002107
사업명
농림기술개발
DB 구축일자
2013-04-18
초록▼
본 연구는 수목정유로부터 항균, 항진균 및 육모기능성물질 개발을 위해 다음과 같은 연구를 수행하였다. 1. 수목정유로부터 항진균물질의 개발 Microsporum canis (KCTC6951), Trichophyton mentagrophytes (KCTC 6077), Pityrosporum ovale (Malassezia furfur, KCTC 7734), Propionibacterium acne (KCTC 3314), Fusobacterium nucleatum (KCTC 2640)에 대한 편백정유의 항진균활성을 검정한다.
본 연구는 수목정유로부터 항균, 항진균 및 육모기능성물질 개발을 위해 다음과 같은 연구를 수행하였다. 1. 수목정유로부터 항진균물질의 개발 Microsporum canis (KCTC6951), Trichophyton mentagrophytes (KCTC 6077), Pityrosporum ovale (Malassezia furfur, KCTC 7734), Propionibacterium acne (KCTC 3314), Fusobacterium nucleatum (KCTC 2640)에 대한 편백정유의 항진균활성을 검정한다. 활성물질을 구명하기위해 편백정유의 분획을 실시하고 물질을 밝힘으로써 항진균활성의 발현 기작을 밝힌다. 2. 수목정유로부터 항균물질의 개발 수목정유로부터 항균 물질을 개발하기 위해 Klebsiella pneumoniae (KCTC2241), Listeria monocytogenes (KCTC3569), Salmonella typhimurium (KCTC12401), Staphylococcus aureus (KCCM11764), Escherichia coli O157:H7 (KCCM40406), Legionella pneumophila (ATCC33216), Methicilline-resistant Staphylococcus aureus (MRSA)에 대한 국내산 편백정 유의 항박테리아활성을 평가한다. 항균효과를 발현하는 정유의 성분 혹은 성분 혼합체를 검출하고 항균발현 기작을 밝힌다. 3. 수목정유로부터 육모기능성 물질의 개발 HaCaT cell의 육모에 영향하는 유전자의 발현에 대한 편백정유의 영향을 조사하고 육모에 영향하는 유전자 발현에 관여하는 활성분획의 성분을 확인한다. C57BL/6 마우스를 이용하여 정유의 육모에 대한 in vivo 효능을 평가한다.
Abstract▼
1. Development of antifungal materials from plant essential oil The Antifungal activity of C. obtusa oils was examined agianst Microsporum canis (KCTC6951), Trichophyton mentagrophytes (KCTC 6077), Pityrosporum ovale (Malassezia furfur, KCTC 7734), Propionibacterium acne (KCTC 3314), Fusobacterium n
1. Development of antifungal materials from plant essential oil The Antifungal activity of C. obtusa oils was examined agianst Microsporum canis (KCTC6951), Trichophyton mentagrophytes (KCTC 6077), Pityrosporum ovale (Malassezia furfur, KCTC 7734), Propionibacterium acne (KCTC 3314), Fusobacterium nucleatum (KCTC 2640). In order to identify the antifungal components from C. obtusa oil, C. obtusa oil was fractionated by column chromatography. Antifungal activities of the fractions was tested and active compounds of active fractions was identified by several equipments. So, the antifungal mechanism of C. obtusa oil was evaluated. 2. Development of antibacterial materials from plant essential oil The antibacterial activity of essential oil from leaves and twigs of C. obtusa was determined against Klebsiella pneumoniae (KCTC2241), Listeria monocytogenes (KCTC3569), Salmonella typhimurium (KCTC12401), Staphylococcus aureus (KCCM11764), Escherichia coli (KCCM40406), Legionella pneumophila (ATCC33216), and Methicilline-resistant Staphylococcus aureus (MRSA). Antibacterial activity of the subfractions of C. obtusa oil fractionated by column chromatography was tested, and the major constituents of active fractions were identified by GC/MS analysis. 3. Investigation of functional hair growth material from plant essential oil We examined the hair growth promoting effect of C. obtusa oil and its fractions. The gene expression of several growth factors related to the hair growth cycle was investigated. Chemical composition of active fraction of C. obtusa oil was analyzed by equipments. Also, the hair growth promoting effect of C. obtusa oil was evaluated using by animal models as a C57BL/6 mouse.
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