초록 ▼

본 연구의 결과 기존 주름개선 가능성 물질로서 대표적인 레티노이드 보다 우수한 신규 레티노이드계 주름개선물질인 레티닐 레티노에이트 뿐아니라 향 후 잠재력이 있는 레티닐 폴리하이드록시 벤조산 에스터 31종을 설계 합생하고 이중 11개의 활성도가 우수한 유도체들을 개발할 수 있어 향후 레티노이드류 개발의 근간을 이룰 수 있었다. 개발되어진 신규 레티닐 폴리하이드록시벤조산 에스터류의 경우 활성도를 창출된 화합물들이 주름 개선제나 미백제로 사용할 수 있음은 물론 태양화상(sunburn)을 일으키는 UVB (290-315 nm) 나 (SG1

본 연구의 결과 기존 주름개선 가능성 물질로서 대표적인 레티노이드 보다 우수한 신규 레티노이드계 주름개선물질인 레티닐 레티노에이트 뿐아니라 향 후 잠재력이 있는 레티닐 폴리하이드록시 벤조산 에스터 31종을 설계 합생하고 이중 11개의 활성도가 우수한 유도체들을 개발할 수 있어 향후 레티노이드류 개발의 근간을 이룰 수 있었다. 개발되어진 신규 레티닐 폴리하이드록시벤조산 에스터류의 경우 활성도를 창출된 화합물들이 주름 개선제나 미백제로 사용할 수 있음은 물론 태양화상(sunburn)을 일으키는 UVB (290-315 nm) 나 (SG1031), 또는 UVA (315-400 nm)의 차광에 효능을 가져 항노화의 기본을 다질 수 있는 잠재된 가능성 신소재임을 알 수 있다. (SG1001, SG1013, SG1029). 피부학적 생리활성 연구를 위해 세포에서의 콜라겐 증가량 뿐아니라 무모생쥐를 대상으로 15주간의 장기간 자외선 조사 후에 신규 레티노이드 물질의 도포를 통하여 거칠고 굵은 주름의 증가를 감소시킴을 알 수 있었으며, Neo Capsule 제제인 BDPC제제를 개발하여 얀체 피부내 경피 흡수 활성도를 증진시킬 수 있었으며, 피부사용성 및 안정성을 보다 증진시켜 줄 수 있는 레시친계 겔네트워크 유화 화장료를 개발하여 이를 현재 기능성 심사 허가 진행 중에 있어 항노화 신규 소재 , 특수 제제 그리고 화장료를 국내 및 해외시장의 보급하여 국내 기능성 소재 개발 기술의 우위성 및 국내 상품의 경쟁력 강화 및 국민건강과 복지에 이바지하게 되라라 사료됨.

Abstract ▼

I. Objects
All organIsms are aging with being older and skin IS also. Korea National Statistical Office forecasted that in about 2019, the portion of men after 65 years old may be over the 14% of the total population volume. So, the effort to find the method of maintaining the beauty and health a

I. Objects
All organIsms are aging with being older and skin IS also. Korea National Statistical Office forecasted that in about 2019, the portion of men after 65 years old may be over the 14% of the total population volume. So, the effort to find the method of maintaining the beauty and health and to find the reason to cause the aging phenomenon has given continuously. Therefore, many people want to have the beautiful and healthy skin. Usually some functional, structural changes in skin appear as older.
Related to the skin agIng process, anti-wrinkle materials and products containing collagen that occupies about 70-80% in ECM that IS one of the important factor in skin elasticity and tension are on sales, but there has not been any development of more effect ive mater ial than ret inol. Even though its excellent effect, ret inol and retinoid derivatives have so limited uses because of its phototoxicity and unstability in nature, so it is difficult to apply to cosmetics. Many researchers wanted to find more effective new anti-wrinkle material than retinol, but they could not. So they developed not more effective anti-wrinkle material but derivatives that was improved the phase-stabi I i ty or skin penetrat ing rate of ret inol. In Enprani Inc., we found that ret inyl ret inoate that was a newly developed ret inoid by us 1 s super ior to retinol in effectiveness, safety, stability. From this, we can expect the possibility of development about more effective retinoid derivatives. On this foundation, we want to develop some kinds of new retinoid derivatives to Improve skin aging resulted from wrinkle, liver spot and dark spot and to study the mass-producing process of it. After the verification of its effects, we want to develop a new anti-wrinkle product uSIng the materials and processes with good skin-delivery effect.
II. Contents and ranges of developments
In our study, we could develop synthesis method of new anti-wrinklc materials kinds of retinoid and BOPC material which is neo-capsule material for improving drug del ivery lil skin. We developed cosmetics using gel-networking system for good delivery in skin and were verified anti-wrinkle efficacy in skin testing in VIVO, and were preparing to get the permission as functional cosmetics from KFOA. It IS important to develop the most effective retinol and its derivative and we have a basement of developing the anti-wrinkle cosmetics using special delivery system. Also, it is synthesized ret inyl ret inoate and 31 kinds of ret inyl polyhydroxybenzoic acid ester and in these materials, we developed 11 kinds of good derivatives. In case of new retinyl polyhydroxybenzoic acid esters, it is used as an anti-wrinkle or whitening material and it has an effect of UVB/UVA prevent ion, so it IS new funct ional mater ial potentially giving anti-aging effect. Especially, the activity of SGlOOl, SGlO13, SGI029 and SGI03I is remarkable. 0.0005% of SGIOOI has efficacy of 64.78% is simi lar and better than retinol has efficacy 55.59%. SGlOOl and SGlOll has better efficacy of melanin inhibition than Melasolv and SGI03l has good efficacy of tyrosinase inhibition. Finally, SG103l has efficacy of anti-wrinkle and whitening effect is new cosmetic material having good effect. It is decreased of rough wrinkle using new retinoid material after UV in 15 weeks at hairless mouse for biological study of new retinoid. After UV radiation, TEWL is decreased for 12 weeks and recovered for the reaction of skin.In UV radiation for a long time, it IS affected distribution of calcium Ion in stratum corneum and aggravation of skin barrier causing to the functional difference of lipid barrier and increasing of large lamellated corpuscles of Vater-Pacini, Pacinian corpuscles.
It is thought that UV radiation for a long time cause inhibition of function and structure of skin barrier. It is predicted that the recovering of skin barrier has an important role to lipid barrier of stratum corneum and corneocyte envelopeCinvolucrin etc.) after UV radiat ion. Because collagen and elast in in dermis have an effect from UV radiation for a long period, retinoid has also decreasing effect. Therefore, we predict in domestic and global market, retinyl retinoate, new anti-wrinkle material will contribute to predominance of development of functional material, strong competitive power of product and good health and welfare within the country.
IV. Plan to use the results
1. We wish to use the material containing newly developed retinoid that was choosed by its safety, efficacy, sclerite absorptiveness as a functional anti-wrinkle agent with
the satisfaction of comsumer.
2. We wish to find and use the new retinoid derivatives that has the ability to synthesize collagen and the ability to inhibit of melanin and is more effective In wrinkle, liver spot, dark spot.
3. We wish to find and use the photo-aging ;md the cell-protecting process of new retinoid derivatives with the change model of skin under the light.
On the foundation of these results, we want to distribute the material that IS superior anti-aging agent to the former retinoid type, and want to strengthen the competitivc power of domestic goods by the distribution of it in world market and to contribute to the wclfare and health of conswners.

목차 Contents

• 표지 ... 1
• 목차 ... 3
• 제출문 ... 4
• 보고서요약서 ... 6
• SUMMARY ... 9
• INDEX ... 26
• 목차 ... 28
• 제 1 장 연구개발과제의 개요 ... 30
• 1. 연구의 필요성 ... 30
• 2. 연구목표 및 범위 ... 31
• 3. 연차별 기술적 정량연구목표(MBO) ... 31
• 4. 연구과제의 구성 및 추진체계 ... 32
• 5. 연차/단계별 연구수행일정 ... 33
• 제 2 장 국내외 기술개발 현황 ... 34
• 1. 국내외 관련분야에 대한 기술개발현황 ... 34
• 2. 연구결과가 국내.외 기술개발현황에서 차지하는 위치 ... 38
• 제 3 장 연구개발수행 내용 및 결과 ... 40
• 1. 총괄연구개발과제의 최종 연구개발 내용 및 결과 ... 40
• 2. 총괄연구개발과제의 연구결과 고찰 및 결론 ... 71
• 제 4 장 목표달성도 및 관련분야에의 기여도 ... 73
• 1. 총괄연구개발과제의 목표달성도 ... 73
• 2. 연구개발결과의 파급효과 ... 75
• 제 5 장 연구개발결과의 활용계획 ... 76
• 1. 연구개발결과의 활용계획 및 추가연구의 필요성 ... 76
• 2. 사업화(기업화) 목표 달성도 및 계획 ... 76
• 제 6 장 연구개발과정에서 수집한 해외과학기술정보 ... 80
• 제 7 장 참고문헌 ... 113
• 제 8 장 첨부서류 ... 115