초록 ▼

○ 연구결과
가. 고순도 단량체의 제조법 확립
○ Glycolide 정제공정 및 polymorphic structure 조절
○ Trimethylene carbonate 제조
나. 스타형 공중합체 소재 개발
○ Glycolide-Caprolactone계 소재
○ Glycolide-Trimethylene carbonate계 소재
다. 공중합체의 미세구조와 물성의 상관관계를 규명
라. Scale-up 중합 공정 최적화
마. 저온 방사 공정 개발
○ 단축 압출기 방사 공정 개발

○ 연구결과
가. 고순도 단량체의 제조법 확립
○ Glycolide 정제공정 및 polymorphic structure 조절
○ Trimethylene carbonate 제조
나. 스타형 공중합체 소재 개발
○ Glycolide-Caprolactone계 소재
○ Glycolide-Trimethylene carbonate계 소재
다. 공중합체의 미세구조와 물성의 상관관계를 규명
라. Scale-up 중합 공정 최적화
마. 저온 방사 공정 개발
○ 단축 압출기 방사 공정 개발
○ Monofilament 섬유의 가공 공정 개발
바. 분해성 소재의 분해특성 연구

Abstract ▼

Poly(glycolide) (PG) and its copolymers have attracted much interest because they have an extremely low immunogenicity and are biodegradable in human body. Owing to these advantageous properties, PG and its copolymers are used in medicine, in particular as surgical sutures. Copolyesters built up of

Poly(glycolide) (PG) and its copolymers have attracted much interest because they have an extremely low immunogenicity and are biodegradable in human body. Owing to these advantageous properties, PG and its copolymers are used in medicine, in particular as surgical sutures. Copolyesters built up of glycolyl (GL) and ε-caprolactone (CL) or trimethylene carbonate (TMC) units are interesting because they allow a broad variation of their chemical and physical properties. Poly(glycolide) is a rigid, highly crystalline material with a T_m around 218 °C. It is insoluble in most organic solvents and has a high crystal density 0.7 g/cm'). But. poly(ε-caprolactone) (PCL) and poly(trimethylene carbonate) (PTMC) are more flexible materials with low T_g and T_m.
The purifying process and polymorphic structure control of glycolide and trimethylene carbonate was studied. P(GL/CL) and P(GL/TMC) were synthesized VIa a bulk polymerization with stannous octo ate as catalyst. Star-shaped P(GL/CL) and P(GL/TlVIC) were also synthesized with multifunctional hydroxy compound as initiator in the presence of stannous octoate. By this way it was possible to prepare the star-shaped copolymers with higher molecular weight and lower melt viscosity compared with the linear ones obtained by stannous octoate only. For the characterization of the star-shaped copolymer structure, model reaction was carried out usmg oligomerization. The scale-up copolymerization up to 100 g was studied and there was no decrease in the property.
Their physicochemical properties were investigated by using GPC, viscometer, NMR DSC and wide-angle-X-ray diffraction (WAXD). Especially, the correlationship bet\veen microstructure and physical properties m the copolymers with vanous monomer compositions was studied by NMR measurements. By the DSC analysis, the star-shaped copolymers showes lower T_g and T_m than the linear copolymers.
To carry out melt spinning, a ram-type spinning equipment was investigated and a single extruder process was designed. The melting temperature of the copolymers in the extruder was slightly higher (ca. 5~ 10 °C) than Till of the copolymers to reduce thermal degradation of polymer. The spun fibers were drawn under various conditions such as rate, ratio and temperature and the relationship between structure and properties was traced. The tensile modulus and strength of the spun star-shaped copolymer fibers were up to 233 kpsi and 62 kpsi, respectively. It confirmed that the mechanical properties of star-shaped copolymers as the material for monofilament suture are superior to those of the linear copolymer with the same monomer composition.
The hydrolytic degradation of the copolymers and the spun copolymer fibers in PBS solution (pH 7.4 at 37 'C) was studied by examining the changes of mass, viscosity.
thermal properties and mechanical properties. As the composition of glycolide increases and the crystallinity decreases in the copolymers. the degradation rate increases.
Especially. the degradation rate is accelerated after 2 weeks.

목차 Contents

• 표지 ... 1
• 제출문 ... 3
• 요약문 ... 5
• 영문요약문(SUMMARY) ... 9
• 목차 ... 11
• 제1장 서론 ... 13
• 제2장 국내·외 기술개발 현황 ... 17
• 1. 국내·외 연구 및 개발 현황 ... 17
• 2. 시장성격, 규모 및 산업계의 현황 ... 17
• 3. 연구개발의 필요성과 중요성 ... 18
• 제3장 연구개발수행 내용 및 결과 ... 21
• 제1절 PG-PCL계 Monofilament 흡수성 봉합사의 개발 ... 21
• 제2절 트리메틸렌 카보네이트계 Monofilament 흡수성 봉합사 소재의 개발 ... 115
• 제4장 연구개발목표 달성도 및 대외기여도 ... 171
• 1. 연구개발목표의 달성도 ... 171
• 2. 관련분야에 대한 기술발전의 기여도 ... 172
• 제5장 연구개발결과의 활용성과 및 계획 ... 173
• 1. 계량적 성과 ... 173
• 2. 성과내용기술 ... 173
• 3. 활용계획 ... 174
• 제6장 기타 중요변경사항 ... 175
• 제7장 참고문헌 ... 177
• 최종보고서 요약 (초록) ... 179
• 끝페이지 ... 179