초록

○ 연구결과
현재 유행하고 있는 말라리아는 삼일열말라리아로 과거에 유행했던 종과는 약간의 유전적변이를 나타내고 있으나， 역시 긴잠복기를 갖는 특징을 유지하고 있었으며 중국얼룩날개모기가 주로 매개하고 있으며 경기도서북부 휴전션지역에서부터 후방으로， 서에서 동쪽으로 확산되고 있으며 기후조건의 변화로 매개모기종이 이 질병을 매개하기에 최적의 환경조건들이 성립되어 있었다.

Abstract ▼

It was just beginning of malarial outbreak after detecting one case of malaria patient at Paju-gun in 1993. So it was very emergent to investigate about entity of reemerging vivax malaria in Korea.
In this study, we planed to understand of clinical characters of malaria patients, to grip where th

It was just beginning of malarial outbreak after detecting one case of malaria patient at Paju-gun in 1993. So it was very emergent to investigate about entity of reemerging vivax malaria in Korea.
In this study, we planed to understand of clinical characters of malaria patients, to grip where the source of origin came from, through the comparisons of specific gene sequences which were already well studied, and to estimate the routes and patterns of malaria transmission. Also we planed to determine the species of mosquito which are play a impotant role in malaria transmission. Finally, we set up the schedule to study about ecological characters of malaria vector for the control of malaria in Kyonggido.
As the results of these studies, it was proved that the species of prevalence was vivax malaria as the past years. But it was figured out the circumsporozoite protein gene had some genetic variations, compared with those of others. And some vivax malaria patients showed a long incubation periods. Anopheles sinensis mainly mediated the vivax malaria transmission. It was figured out using polymerase chain reaction and DNA hybridization. Malaria transmission was steady progressed from Dimilitalized zone to South, and from West to East. It could be estimated by the measurements of anti-malaria antibodies of inhabitnats in epidemic area or near the epidemic area by Indirect immuno-fluorecent antibody test. Additionally, the increasement of malaria patients depended on that of mosquito populations which let the change of weather conditions done, respectively.

목차 Contents

• 표 지 ... 1
• 연구개발 최종보고서 ... 2
• 제 출 문 ... 3
• 요 약 문 ... 4
• 영 문 요 약 문 ... 6
• 목 차 ... 7
• 제 1 장 서론 ... 9
• 1. 연구개발의 목적 ... 9
• 2. 연구의 필요성 ... 10
• 3. 범위 ... 11
• 제 2 장 국내외 기술개발현황 ... 12
• 제 3 장 연구개발수행 내용 및 결과 ... 13
• 제 1 세부과제 ... 13
• 제 2 세부과제 ... 23
• 제 3 세부과제 경기북부지역 말라리아 매개모기 생태조사 ... 44
• 제 4 장 연구개발목표 달성도 및 대외기여도 ... 68
• 제 5 장 연구개발결과의 활용성과 및 계획 ... 69
• 제 6 장 기타 중요변경사항 ... 70
• 제 7 장 참고문헌 ... 71
• 최종보고서 요약 (초록) ... 72
• 끝페이지 ... 72