초록 ▼

연구결과
필요성 및 목표
○ 기능성화장품 기준 및 시험방법 중 일반시험법 등이 대한약전과 달라 공정서 일원화의 필요성 제기
○ 기능성화장품 기준 및 시험방법의 노후된 시험법을 최신 과학적 시험법으로 개선 요구
○ 기능성화장품 기준 및 시험방법 중 미확립된 제제시험법 확립 필요
방 법 및 결 과
○ 기능성화장품 기준 및 시험방법 중 일반시험법, 시약·시액 및 표준액 등 용어 및 체제 재정비
○ 기존 기능성화장품 각조 시험방법을 최신 분석법으로 개선
기대성과
○ 기능성화장품 기준 및 시험

연구결과
필요성 및 목표
○ 기능성화장품 기준 및 시험방법 중 일반시험법 등이 대한약전과 달라 공정서 일원화의 필요성 제기
○ 기능성화장품 기준 및 시험방법의 노후된 시험법을 최신 과학적 시험법으로 개선 요구
○ 기능성화장품 기준 및 시험방법 중 미확립된 제제시험법 확립 필요
방 법 및 결 과
○ 기능성화장품 기준 및 시험방법 중 일반시험법, 시약·시액 및 표준액 등 용어 및 체제 재정비
○ 기존 기능성화장품 각조 시험방법을 최신 분석법으로 개선
기대성과
○ 기능성화장품 기준 및 시험방법 고시 개정을 통한 업계의 품질관리에 도움
○ 화장품의 사전·사후관리에 도움

Abstract ▼

According to the Cosmetics Act, functional cosmetics are classified into those that help to lighten the skin, those that help to improve wrinkles and those that block out UV rays. Test methods of materials and products of the functional cosmetics are currently provided to the related industries thro

According to the Cosmetics Act, functional cosmetics are classified into those that help to lighten the skin, those that help to improve wrinkles and those that block out UV rays. Test methods of materials and products of the functional cosmetics are currently provided to the related industries through the criteria and test method for the functional cosmetics. However, some of the test methods included in the criteria and test methods for the functional cosmetics are so outdated that they bring problems with maintaining quality control. Thus, the need for improvement of the test methods came up and also establishment of the test methods of some functional ingredients, which have not been set up so far, has been required. This study aims to improve the criteria and test methods for the functional cosmetics into the newest scientific test methods, and to establish the test method of ethyl ascorbyl ether(EAE) which has not been established yet. And also it intends to establish and provide an analysis method by which high-frequency sunscreen ingredients can be simultaneously and promptly analyzed. In order to improve quantitative method of the functional cosmetics containing niacinamid, albutin and adenosine, cream forms which are difficult to pretreat were selected. For pretreatment solvent, mobile phase, methanol of 10% and tetrahydrofuran of 10% were compared and examined. Based on extract, content and toxicity level, methanol was chosen as the main solvent. Plus, for products that include difficulty in dispersion, tetrahydrofuran of 10% was selected as a cosolvent. For quantitative test of niacinamid, albutin and adenosine cream substances, liquid chromatography was used. And according to the ‘Guidelines for validation of the test method for medical substances, etc’, validation was conducted. Liquid chromatography was used to establish quantitative methods for liquid, lotion and cream forms of ethyl ascorbyl ether(EAE) ingredient, and validation of recovery rate and accuracy was conducted by using each ingredient. In order to establish simultaneous analysis of 8 kinds of high-frequency sunscreen ingredients, methanol was chosen as a pretreatment solvent and liquid chromatography was used as the analysis equipment. The simultaneous analysis of high-frequency sunscreen ingredients was established so that 8 kinds of ingredients can be promptly analyzed, and validation was completed. Cross-validation of both the simultaneous analysis of the high-frequency sunscreen ingredients and the established test methods was conducted by outside agencies and it showed consistent results. Some of the general test methods included in the criteria and test methods for functional cosmetics have been improved into newest methods, and also the terms have been standardized according to the Korean Pharmacopoeia. The analysis methods, which have been established in this study, will be provided through ‘Criteria and test methods for functional cosmetics’ and ‘Guidelines for analysis method for the restricted ingredients in cosmetics’, and they will be expected to greatly contribute to quality control of the functional cosmetics.

목차 Contents

• 표지 ... 1
• 자체연구개발과제 최종보고서 ... 2
• 국문 요약문 ... 3
• Summary ... 4
• 목 차 ... 5
• 연구개발과제 연구결과 ... 6
• 제1장 연구개발과제의 개요 ... 6
• 제1절 연구개발과제의 목표 ... 6
• 제2절 연구개발과제의 필요성 ... 6
• 제2장 연구개발과제의 국내․외 연구개발 현황 ... 6
• 제3장 연구개발과제의 연구수행 내용 및 결과 ... 17
• 제1절 연구수행 내용 ... 17
• 제2절 연구수행 결과 ... 45
• 제4장 연구개발과제의 연구결과 고찰 및 결론 ... 86
• 제1절 나이아신아마이드, 알부틴, 아데노신, 나이아신아마이드/아데노신, 알부틴/아데노신 각조시험법 정량법 개선 ... 86
• 제2절 에칠아스코빌에텔 신규제제시험법 확립 ... 87
• 제3절 다빈도 자외선차단성분 동시분석법 확립 ... 88
• 제4절 일반시험법 개선 ... 88
• 제5장 연구개발과제의 목표달성도 및 관련분야에의 기여도 ... 90
• 제1절 목표달성도 ... 90
• 제2절 관련분야에의 기여도 ... 91
• 제6장 연구개발과제의 연구개발 결과 활용계획 ... 106
• 제1절 활용성과 ... 106
• 제2절 활용계획 ... 106
• 제7장 참고문헌 ... 107
• 제8장 첨부서류 ... 108
• 끝페이지 ... 109