초록

Ⅳ. 연구개발결과
- 오가피와 문주란 추출물 복합제의 표준제조공정 확립 및 지표성분 도출
- 기존 제품인 5% minoxidil과 동등한 효능을 발휘하는 천연물 발모제 개발 기술 확보
- 기전연구 결과 오가피와 문주란 추출물 복합제가 dermal papilla cells에서 모발의 성장에 관여하는 wnt/β-catenin pathway 활성화 및 세포주기 진행에 관여하는 단백질의 발현을 조절하여 세포성장 유도하는 것을 확인
- 단회투여독성시험, 4주 DRF 시험, 항원성시험, 피부자극시험, 안점막자극시험 완료

Abstract ▼

Ⅳ. Result of research and development
- Establishment of the manufacturing process and the marker compounds for Acanthopanax koreanum and Critinum asiaticum complex extracts
- Development of Acanthopanax koreanum and Critinum asiaticum complex extracts having the hair regrowth promoting effect

Ⅳ. Result of research and development
- Establishment of the manufacturing process and the marker compounds for Acanthopanax koreanum and Critinum asiaticum complex extracts
- Development of Acanthopanax koreanum and Critinum asiaticum complex extracts having the hair regrowth promoting effects similar to 5% minoxidil in animal studies
- Finding that Acanthopanax koreanum and Critinum asiaticum complex extracts induce hair cell proliferation through the regulation of protein expression involved in the cell cycle and activation of wnt/β-catenin pathway involved in hair growth in dermal papilla cells
- Completion of single dose toxicity study, repeated dose 4 week dose-range finding toxicity study, antigenicity study, skin irritation test, and eye irritation test