[보고서]발아 벼를 이용한 당뇨병 예방 식품개발 및 산업화

정헌상

보고서 정보

주관연구기관

충북대학교 산학협력단

연구책임자

정헌상

참여연구자

이연리 , 이상훈 , 장귀영 , 강유리 , Li Meishan , 김민영 , 박혜진 , 김성태 , 그외 다수

보고서유형

최종보고서

발행국가

대한민국

언어

한국어

발행년월

2015-11

과제시작연도

2014

주관부처

농림축산식품부

사업 관리 기관

농림수산식품기술기획평가원

등록번호

TRKO201600000142

과제고유번호

1545008376

사업명

고부가가치식품기술개발

DB 구축일자

2016-04-02

표 Fig. 1-1. Changes in α-Glucosidase inhibition activities of germinated rough rice extracts with different germination times and parts
표 Fig. 1-2. Changes in α-amylase inhibition activities of germinated rough rice extracts with different germination times and parts
표 Fig. 1-3. Changes in dipeptidyl peptidase-4 (DPP-4) inhibition activities of germinated rough rice extracts with different germination times and parts
표 Fig. 1-4. Effect of rough rice extracts with different germination time, parts and extraction solvents on the cell viability and glucose uptake by 3T3-L1 adipocyte
표 Fig. 1-5. Effect of brown rice (IP-BR), germinated brown rice (IP-GBR) and germinated rough rice extracts (GIP-BR and GIP-HS) on the cell viability and glucose uptake by 3T3-L1 adipocyte
표 Fig. 1-6. Changes in angiotensin converting enzyme 1 (ACE) inhibition activities of germinated rough rice extracts with different germination times and parts.
표 Fig. 1-7. Changes in xanthine oxidase (XO) inhibition activities of germinated rough rice extracts with different germination times and parts
표 Fig. 1-8. Changes in pancreatic lipase inhibition activities of germinated rough rice extracts with different germination times and parts
$Fig. 2-1. Effects of 1st solvent fractionation fractions of germinated rough rice with various fractionation solvents on glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-1. Effects of 1st solvent fractionation fractions of germinated rough rice with various fractionation solvents on glucose uptake by 3T3-L1 adipocytes
$Fig. 2-2. Effects of 1st silica gel column chromatography fractions of germinated rough rice with different ethyl acetate concentrations on glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-2. Effects of 1st silica gel column chromatography fractions of germinated rough rice with different ethyl acetate concentrations on glucose uptake by 3T3-L1 adipocytes
$Extraction yields of 1st silica gel column chromatography fractions of germinated rough rice with different ethyl acetate concentrations$ 표 Extraction yields of 1st silica gel column chromatography fractions of germinated rough rice with different ethyl acetate concentrations
$Fig. 2-3. Effects of 2nd solvent fractionation fractions of germinated rough rice with various fractionation solvents on glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-3. Effects of 2nd solvent fractionation fractions of germinated rough rice with various fractionation solvents on glucose uptake by 3T3-L1 adipocytes
$Extraction yields of 2nd solvent fractionation fractions of germinated rough rice with various fractionation solvents.$ 표 Extraction yields of 2nd solvent fractionation fractions of germinated rough rice with various fractionation solvents.
$Fig. 2-4. Effects of 2nd silica gel column chromatography fractions of germinated rough rice with different ethyl acetate concentrations on glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-4. Effects of 2nd silica gel column chromatography fractions of germinated rough rice with different ethyl acetate concentrations on glucose uptake by 3T3-L1 adipocytes
$Extraction yields of 1st thin layer chromatography fractions of germinated rough rice with different elution distances$ 표 Extraction yields of 1st thin layer chromatography fractions of germinated rough rice with different elution distances
$Fig. 2-5. Effects of 1st thin layer chromatography fractions of germinated rough rice with different elution distances on glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-5. Effects of 1st thin layer chromatography fractions of germinated rough rice with different elution distances on glucose uptake by 3T3-L1 adipocytes
$Fig. 2-6. Effects of 2nd thin layer chromatography fractions of germinated rough rice with different elution distances on glucose uptake by 3T3-L1 adipocytes.$ 표 Fig. 2-6. Effects of 2nd thin layer chromatography fractions of germinated rough rice with different elution distances on glucose uptake by 3T3-L1 adipocytes.
$Fig. 2-7. HPLC chromatograms of 2nd thin layer chromatography fractions of germinated rough rice.$ 표 Fig. 2-7. HPLC chromatograms of 2nd thin layer chromatography fractions of germinated rough rice.
$Fig. 2-8. Comparison with HPLC chromatograms of 2nd thin layer chromatography #1 fractions and phenolic compounds found in standard mixture and UV spectrums of cinnamic acid in standard mixture and germinated rough rice.$ 표 Fig. 2-8. Comparison with HPLC chromatograms of 2nd thin layer chromatography #1 fractions and phenolic compounds found in standard mixture and UV spectrums of cinnamic acid in standard mixture and germinated rough rice.
$Fig. 2-9. Effects of germinated rough rice active fraction (GIP-HS_E_H) and their 1st silica gel column chromatography fractions (GIP-HS_E_H_S1~S5) with different concentrations on the glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-9. Effects of germinated rough rice active fraction (GIP-HS_E_H) and their 1st silica gel column chromatography fractions (GIP-HS_E_H_S1~S5) with different concentrations on the glucose uptake by 3T3-L1 adipocytes
$Fig. 2-10. Effects of germinated rough rice active fraction (GIP-HS_E_H) and their C18 column chromatography fractions (GIP-HS_E_H_C1~C5) on the glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-10. Effects of germinated rough rice active fraction (GIP-HS_E_H) and their C18 column chromatography fractions (GIP-HS_E_H_C1~C5) on the glucose uptake by 3T3-L1 adipocytes
$Fig. 2-11. Effects of germinated rough rice active fraction (GIP-HS_E_H) and their C18$ 표 Fig. 2-11. Effects of germinated rough rice active fraction (GIP-HS_E_H) and their C18
$Fig. 2-12. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5) and their 1st thin layer chromatography fractions (GIP-HS_E_H_C5_T1~T3) on the glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-12. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5) and their 1st thin layer chromatography fractions (GIP-HS_E_H_C5_T1~T3) on the glucose uptake by 3T3-L1 adipocytes
$Fig. 2-13. Preparative high performance liquid chromatography (Prep. HPLC) chromatogram of germinated rough rice active fraction (GIP-HS_E_H_C5_T2) for the glucose uptake by 3T3-L1 adipocytes.$ 표 Fig. 2-13. Preparative high performance liquid chromatography (Prep. HPLC) chromatogram of germinated rough rice active fraction (GIP-HS_E_H_C5_T2) for the glucose uptake by 3T3-L1 adipocytes.
$The extraction yields of preparative high performance liquid chromatography (Prep. HPLC) fractions of germinated rough rice active fraction (GIP-HS_E_H_C5_T2) for the glucose uptake by 3T3-L1 adipocytes$ 표 The extraction yields of preparative high performance liquid chromatography (Prep. HPLC) fractions of germinated rough rice active fraction (GIP-HS_E_H_C5_T2) for the glucose uptake by 3T3-L1 adipocytes
$Fig. 2-14. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5_T2) and their preparative high performance liquid chromatography fractions (GIP-HS_E_H_C5_T2 _P1~P4) on the glucose uptake by 3T3-L1 adipocytes.$ 표 Fig. 2-14. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5_T2) and their preparative high performance liquid chromatography fractions (GIP-HS_E_H_C5_T2 _P1~P4) on the glucose uptake by 3T3-L1 adipocytes.
$Fig. 2-15. Effects of combination fractions with preparative high performance liquid chromatography fractions (GIP-HS_E_H_C5_T2 _P1~T4) on the glucose uptake by 3T3-L1 adipocytes.$ 표 Fig. 2-15. Effects of combination fractions with preparative high performance liquid chromatography fractions (GIP-HS_E_H_C5_T2 _P1~T4) on the glucose uptake by 3T3-L1 adipocytes.
$Fig. 2-16. Gas chromatogram of germinated rough rice active fractions (GIP-HS_E_H_C5) on the glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-16. Gas chromatogram of germinated rough rice active fractions (GIP-HS_E_H_C5) on the glucose uptake by 3T3-L1 adipocytes
$The fatty acid compositions of germinated rough rice active fraction (GIP-HS_E_H) and their C18 column chromatography fractions (GIP-HS_E_H_C1~C5) for the glucose uptake by 3T3-L1 adipocytes$ 표 The fatty acid compositions of germinated rough rice active fraction (GIP-HS_E_H) and their C18 column chromatography fractions (GIP-HS_E_H_C1~C5) for the glucose uptake by 3T3-L1 adipocytes
$Fig. 2-17. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5), linoleic acid and conjugated linoleic acid with different concentrations on the glucose uptake by 3T3-L1 adipocytes.$ 표 Fig. 2-17. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5), linoleic acid and conjugated linoleic acid with different concentrations on the glucose uptake by 3T3-L1 adipocytes.
$Fig. 2-18. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5) and their unsaponifiable matters (USM) with different KOH concentrations on the glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-18. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5) and their unsaponifiable matters (USM) with different KOH concentrations on the glucose uptake by 3T3-L1 adipocytes
$Fig. 2-19. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5) and their iaion HP-20 column chromatography fractions (GIP-HS_E_H_C5_D1~4) on the glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-19. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5) and their iaion HP-20 column chromatography fractions (GIP-HS_E_H_C5_D1~4) on the glucose uptake by 3T3-L1 adipocytes
$Extraction yields of preparative HPLC fractions of GIP-HS_E_H_C5_D3$ 표 Extraction yields of preparative HPLC fractions of GIP-HS_E_H_C5_D3
$Fig. 2-20. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5_D3) and their preparative HPLC fractions (GIP-HS_E_H_C5_D3_P1~4) on the glucose uptake by 3T3-L1 adipocytes.$ 표 Fig. 2-20. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5_D3) and their preparative HPLC fractions (GIP-HS_E_H_C5_D3_P1~4) on the glucose uptake by 3T3-L1 adipocytes.
$Fig. 2-21. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5_D3_P3) and their recycling HPLC fractions (GIP-HS_E_H_C5_D3_P3_R1~2) on the glucose uptake by 3T3-L1 adipocytes$ 표 Fig. 2-21. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5_D3_P3) and their recycling HPLC fractions (GIP-HS_E_H_C5_D3_P3_R1~2) on the glucose uptake by 3T3-L1 adipocytes
표 Fig. 2-22. Analytical HPLC chromatogram
$Fig. 2-23. Effects of active fraction (GIP-HS_E_H_C5) and major phenolic acids on the glucose uptake by 3T3-L1 adipocytes with different concentrations$ 표 Fig. 2-23. Effects of active fraction (GIP-HS_E_H_C5) and major phenolic acids on the glucose uptake by 3T3-L1 adipocytes with different concentrations
$Fig. 3-1. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5) and pioglitazone with different concentrations on the glucose uptake by 3T3-L1 adipocytes.$ 표 Fig. 3-1. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5) and pioglitazone with different concentrations on the glucose uptake by 3T3-L1 adipocytes.
표 Fig. 3-2. Immunofluorescence study of the glucose transporter 4 (GLUT-4).
표 Fig. 3-3. Immunofluorescence study of the activated insulin receptor substrate 1 (IRS-1).
$Fig. 3-4. Regulation of insulin receptor substrate 1 (IRS1), activated IRS1 (pIRS1(Tyr632))), phosphoinositide 3-kinase (PI3Kinase), protein kinase B (AKT) and activated AKT pAKT(Ser473)), glucose transporter 4 (GLUT4) and peroxisome proliferator-activated receptor- γ (PPAR-γ) expression of germinated rough rice active fraction (GIP-HS_E_H_C5) and pioglitazone.$ 표 Fig. 3-4. Regulation of insulin receptor substrate 1 (IRS1), activated IRS1 (pIRS1(Tyr632))), phosphoinositide 3-kinase (PI3Kinase), protein kinase B (AKT) and activated AKT pAKT(Ser473)), glucose transporter 4 (GLUT4) and peroxisome proliferator-activated receptor- γ (PPAR-γ) expression of germinated rough rice active fraction (GIP-HS_E_H_C5) and pioglitazone.
$Fig. 4-1. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5; C5) on changes of body weights in type II diabetic C57BLKS/J-db/db mice for 9 weeks$ 표 Fig. 4-1. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5; C5) on changes of body weights in type II diabetic C57BLKS/J-db/db mice for 9 weeks
$Fig. 4-2. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5; C5) on changes of blood glucose in type II diabetic C57BLKS/J-db/db mice for 9 weeks$ 표 Fig. 4-2. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5; C5) on changes of blood glucose in type II diabetic C57BLKS/J-db/db mice for 9 weeks
$Fig. 4-3. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5; C5) on glucose tolerance test in type II diabetic C57BLKS/J-db/db mice for 9 weeks.$ 표 Fig. 4-3. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5; C5) on glucose tolerance test in type II diabetic C57BLKS/J-db/db mice for 9 weeks.
$Fig. 4-4. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5; C5) on serum$ 표 Fig. 4-4. Effects of germinated rough rice active fraction (GIP-HS_E_H_C5; C5) on serum
표 Fig. 4-5. Representative observations of histopathological lesions of liver, pancreas and kidney in C57BLKS/J-db/m+ mice (A) and C57BLKS/J-db/db mice (B-E).
$Fig. 4-6. Effects of active fraction from germinated rough rice on the expressions of the insulin receptor substrate 1 (IRS1), phospho-IRS1 (pIRS1) Tyr 608, phosphatidylinositol 3 kinases (PI3K), Akt, phospho-Akt (pAkt)Ser473, glucose transporter type 4 (GLUT4) and glyceraldehyde 3 phosphate dehydrogenase (GAPDH) in skeletal muscles of C57BLKS/J-db/db mice or C57BLKS/J-db/db mice$ 표 Fig. 4-6. Effects of active fraction from germinated rough rice on the expressions of the insulin receptor substrate 1 (IRS1), phospho-IRS1 (pIRS1) Tyr 608, phosphatidylinositol 3 kinases (PI3K), Akt, phospho-Akt (pAkt)Ser473, glucose transporter type 4 (GLUT4) and glyceraldehyde 3 phosphate dehydrogenase (GAPDH) in skeletal muscles of C57BLKS/J-db/db mice or C57BLKS/J-db/db mice
$Fig. 4-7. Effects of germinated rice extract C5 fraction (GRE C5) on the expression levels of the insulin receptor substrate 1 (IRS1) and phospho-IRS1 Tyr608 (pIRS1) in skeletal muscles of C57BLKS/J-db/db mice or C57BLKS/J-db/db mice$ 표 Fig. 4-7. Effects of germinated rice extract C5 fraction (GRE C5) on the expression levels of the insulin receptor substrate 1 (IRS1) and phospho-IRS1 Tyr608 (pIRS1) in skeletal muscles of C57BLKS/J-db/db mice or C57BLKS/J-db/db mice
$Fig. 4-8. Effects of germinated rice extract C5 fraction (GRE C5) on the expression levels of phosphatidylinositol 3 kinases (PI3K), Akt, phospho-Akt Ser473 (pAkt) and glucose transporter type 4 (GLUT4) in skeletal muscles of C57BLKS/J-db/db mice or C57BLKS/J-db/db mice$ 표 Fig. 4-8. Effects of germinated rice extract C5 fraction (GRE C5) on the expression levels of phosphatidylinositol 3 kinases (PI3K), Akt, phospho-Akt Ser473 (pAkt) and glucose transporter type 4 (GLUT4) in skeletal muscles of C57BLKS/J-db/db mice or C57BLKS/J-db/db mice
표 Fig. 4-9. Representative observations of skeletal muscles stained with Fluorescein sothiocyanate (FITC) for Akt in C57BLKS/J-db/db mice or C57BLKS/J-db/db mice
표 Fig. 4-10. Representative observations of skeletal muscles stained with rhodamine for phospho-Akt ser473 (pAkt) in C57BLKS/J-db/db mice or C57BLKS/J-db/db mice
표 Fig. 4-11. Representative observations of skeletal muscles stained with Fluorescein isothiocyanate (FITC) for glucose transporter type 4 (GLUT4) in C57BLKS/J-db/db mice or C57BLKS/J-db/db mice
표 Fig. 6-1. The powders of germinated rough rice Shindongjin and Ilpum.
표 Fig. 6-2. The prototype of germinated rough rice Shindongjin and Ilpum powders.
표 Fig. 6-3. The size distributions of germinated rough rice Shindongjin and Ilpum powders.
표 Fig. 6-4. The Sunsik powders of germinated rough rice Shindongjin and Ilpum.with different sub-material ratios
표 The contents of major phenolic compounds of germinated rough rice Shindongjin and Ilpum powders
표 Fig. 6-5. The prototype of germinated rough rice Shindongjin and Ilpum Sunsik powders with sub-material different ratios
표 Fig. 6-6. The size distributions of germinated rough rice Shindongjin and Ilpum Sunsik powders with different sub-material ratios
표 Fig. 6-7. The beverages containing water extracts of germinated rough rice Shindongjin and Ilpum with different concentrations
표 Fig. 6-8. The prototype of the beverages containing water extracts of germinated rough rice Shindongjin and Ilpum with different concentrations.
표 Fig. 6-9. The prototype capsules containing powders of germinated rough rice Shindongjin and Ilpum.
표 Fig. 7-1. Effects of prototypes containing the germinated rough rice powder of Shindongjin and Ilpum on the glucose uptake by 3T3-L1 adipocytes
표 Fig. 8-1. The size distributions of germinated Ilpum Sunsik powders
$Fig. 9-1. Changes in ferulic acid content and glucose uptake activity of active fraction (GIP-HS_E_H_C5) from germinated rough rice with different storage conditions.$ 표 Fig. 9-1. Changes in ferulic acid content and glucose uptake activity of active fraction (GIP-HS_E_H_C5) from germinated rough rice with different storage conditions.
표 Fig. 9-2. Changes in ferulic acid content of Sunsik prototypes from germinated rough rice with different storage temperatures and periods
표 Fig. 9-3. Effects of Sunsik prototypes from germinated rough rice on the glucose uptake by 3T3-L1 adipocytes with different storage conditions and package materials.
표 Fig. 10-1. Photographs of Monascus pilosus (305-9) cultivated brown rice from germinated rough rice with different germination temperatures and periods

과제명(ProjectTitle) :	-
연구책임자(Manager) :	-
과제기간(DetailSeriesProject) :	-
총연구비 (DetailSeriesProject) :	-
키워드(keyword) :	-
과제수행기간(LeadAgency) :	-
연구목표(Goal) :	-
연구내용(Abstract) :	-
기대효과(Effect) :	-

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 제목(한글), 저자명(한글), 발행일자, 전자원문, 초록(한글), 초록(영문) 관리번호, 제목(한글), 제목(영문), 저자명(한글), 저자명(영문), 주관연구기관(한글), 주관연구기관(영문), 발행일자, 총페이지수, 주관부처명, 과제시작일, 보고서번호, 과제종료일, 주제분류, 키워드(한글), 전자원문, 키워드(영문), 입수제어번호, 초록(한글), 초록(영문), 목차
저장형식	Text(ASCII format) Excel format
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

발아 벼를 이용한 당뇨병 예방 식품개발 및 산업화
Industrialization and Development of Foods for Prevention of Diabetes using Germinated Rough Rice 원문보기

초록 ▼

Abstract ▼

목차 Contents

표/그림 (68)

표/그림 (68)

연구자의 다른 보고서 :

참고문헌 (25)

연구과제 타임라인

관련 콘텐츠

원문 보기

이 보고서와 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

발아 벼를 이용한 당뇨병 예방 식품개발 및 산업화 Industrialization and Development of Foods for Prevention of Diabetes using Germinated Rough Rice 원문보기

초록 ▼

Abstract ▼

목차 Contents

표/그림 (68) 모든 표/그림 보기

표/그림 (68) 슬라이드로 보기

연구자의 다른 보고서 :

정헌상 (14) 이상훈 (6) 장귀영 (3) Li Meishan (2) 김민영 (4) 박혜진 (1) 김성태 (2)

참고문헌 (25)

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

관련 콘텐츠

원문 보기

이 보고서와 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

발아 벼를 이용한 당뇨병 예방 식품개발 및 산업화
Industrialization and Development of Foods for Prevention of Diabetes using Germinated Rough Rice 원문보기

표/그림 (68)

표/그림 (68)