[보고서]한약재 생리활성성분 분리 및 효능 연구

보고서 정보

주관연구기관

서울대학교 산학협력단
Seoul National University

보고서유형

최종보고서

발행국가

대한민국

언어

한국어

발행년월

2011-12

과제시작연도

2011

주관부처

식품의약품안전청
Korea Food & Drug Administration

등록번호

TRKO201600010659

과제고유번호

1475006477

사업명

의약품등안전관리

DB 구축일자

2016-10-29

키워드

생리활성성분.분리.표준품.효능평가.표준화.bioactive component.isolation.standard.bioassay.standardization.

DOI

https://doi.org/10.23000/TRKO201600010659

표 콜라겐으로 유도된 혈소판 응집에 대한 백출(A) 및 비교생약(B) 추출물의 효능
표 The control levels of dopamine : 3.85±0.27 nmol/mg protein . Means±SEM (n=4-6)
표 Effects of the extracts of herbal medicines on PC12 cell viability. Cell viability was measured using MTT method. Means±SEM (n=6-8)
표 Effects of herbal extracts on Cl- influx from IMR-32 cells. Fluorescence was monitored in the excitation wavelength at 355nm and the emission wavelength at 450nm using the Cl--sensitive indicator, N - ( 6 - m e t h o x y q u i n o l y l ) acetoetylester (MQAE). Contents of influxed Cl- ion were expressed as the ration of F/Fo.
표 Effects of herbal extracts on Locomotor activity in mice (n=9～10). Each bar represents the mean ± S.E.M of the moved distance or movement time for 10 minutes.
표 Effects of herbal extracts on activity on the rotating rod in mice (n=9～10). Each bar represents the mean ± S.E.M of the endurance time or falling frequency for 20 minutes.
표 Effects of herbal extracts on activity on swimming pool in mice(n=10). Each bar represents the mean ± S.E.M of immobile duration and mobile duration in swimming pool
표 Effects of herbal medicine on urine volume in conscious male rats. Each point connected by line represents the mean ± S.E.M of urine volume of each time in 5 rats in metabolic cage
표 Effects of herbal extracts on urine volume in conscious male rats. Each bar represents the mean ± S.E.M of total urine volume collected in 4 hours in 5 rats in metabolic cage
표 The effects of (A) 70% EtOH extract of Atractylodes japonica, or (B) water extracts of Atractylodes japonica on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of Atractylodes japonica, or (B) water extracts of Atractylodes japonica on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 The effects of (A) 70% EtOH extract of Atractylodes chinensis, or (B) water extracts of Atractylodes chinensis on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of Atractylodes chinensis, or (B) water extracts of Atractylodes chinensis on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 The effects of (A) 70% EtOH extract of Atractylodes macrocephala, or (B) water extracts of Atractylodes macrocephala on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of Atractylodes macrocephala, or (B) water extracts of Atractylodes macrocephala on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 콜라겐으로 유도한 혈소판 응집에 대한 익모초 (Leonuri herba) 추출물 (A) 과 compounds (B) 의 효능
표 Effects of Leonuri Herba extract on [Cl-]i in neuroblastoma cells. Effects of Leonuri Herba extract on [Cl-]i in neuroblastoma cells.
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 익모초 추출물의 억제 효능
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 rutin, leonurine의 억제 효능
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 원지 추출물의 억제 효능
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 애기풀 추출물의 억제 효능
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 소초 추출물의 억제 효능
표 산사의 flavonoid 성분
표 산사의 70% EtOH 추출물 및 H2O 추출물의 제조
표 기본생약 산사나무 열매와 비교생약인 산당화의 수율
표 산사나무 열매의 MeOH 추출물 및 분획물의 제조
표 산사 분획물로부터 화합물의 분리
표 산사 분리 화합물 목록
표 제공된 산사와 비교 생약시료의 추출물
표 산사 유래 화합물의 구조
표 콜라겐, 트롬빈, 아라키돈산으로 유도된 혈소판 응집에 대한 산사 추출물의 효능
표 콜라겐, 트롬빈, 아라키돈산으로 유도된 혈소판 응집에 대한 산당화 추출물의 효능
표 출혈시간에 대한 산사 추출물의 지연 효능
표 대조군의 Dopamine 함량: 3.85±0.27 nmol/mg
표 산사 추출물의 PC12 cell viability에 대한 효과
표 The effects of (A) 70% EtOH extract of Crataegus pinnatifida, or (B) water extracts of Crataegus pinnatifida on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of Crataegus pinnatifida, or (B) water extracts of Crataegus pinnatifida on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 The effects of (A) 70% EtOH extract of Chaenomeles speciosa or (B) water extract of Chaenomeles speciosa on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of Chaenomeles speciosa, or (B) water extracts of Chaenomeles speciosa on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 급성 염증에 대한 산사 추출물의 효능
표 3종의 대계 생약 시료의 수율
표 Serum TNF-αlevels
표 Caspase-3 activitie
표 TUNEL assay
표 TUNEL assay
표 Anticonvulsant effects of Cirsii Herba extract in mice. Each line represents the mean ± SEM of % of animals with hind-limb extension by currents (pulse width-0.5 ms, frequency- 100 pulses/sec. shock duration-1 sec.). Control versus treatment groups
표 The effects of Lupeol on the scopolamine-induced memory impairment mouse model in the passive avoidance task.
표 5종의 인진호 생약 시료의 수율
표 ALT activity
표 AST activity
표 H&E staining
표 Hepatic glutathione content & Lipid peroxidation
표 Serum TNF-αlevels
표 iNOS, COX-2, and HO-1 protein expression
표 iNOS, COX-2, TNF-α, and HO-1 mRNA expression
표 출혈시간에 대한 인진호(Artemisia calillaris) 추출물의 지연 효능
표 Anticonvulsant effects of EtOH extracts of Artemisia capillaris herba. Each line represents % of animals with hind-limb extension by currents. DZP means diazepam
표 Effects of EtOH extracts of Artemisia Capillaris herba on seizure induced by chemicals. Each bar represents the mean ± S.E.M of seizure %(* p <0.05, ** p<0.01 versus vehicle control group).
표 Effects of scoparone and hyperoside on activity on the rotating rod in mice (n=9～ 10). Each bar represents the mean ± S.E.M of the endurance time or falling frequency for 20 minutes.
표 Locomotor activity in mice (n=9～10). Each bar represents the mean ± S.E.M of the moved distance or movement duration for 10 minutes.
표 Effects of scoparone and hyperoside on Cl- influx from IMR-32 cells. Fluorescence was monitored in the excitation wavelength at 355nm and the emission wavelength at 450nm using the Cl--sensitive indicator, N-(6-methoxyquinolyl) acetoetylester (MQAE). Contents of influxed Cl- ion were expressed as the ration of Fo/F.
표 Effects of scopolin and chlorogenic acid on Cl- influx from IMR-32 cells. Fluorescence was monitored in the excitation wavelength at 355nm and the emission wavelength at 450nm using the Cl--sensitive indicator, N-(6-methoxyquinolyl) acetoetylester (MQAE). Contents of influxed Cl- ion were expressed as the ration of Fo/F.
표 Anticonvulsant effect of Scoparone and Scopolin. Each line represents % of animals with hind-limb extension by currents
표 The effects of (A) 70% EtOH extract of Artemisia capillaris, (B) water extracts of Artemisia capillaris,on the percentage of time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice
표 Isorhamnetin의 항암 효능
표 산사 분리 화합물 목록
표 제공된 산사와 비교 생약시료의 추출물
표 대계 분리 화합물
표 제공된 대계 생약시료의 추출물
표 제공된 대계 분리 화합물
표 제공된 인진호와 비교 생약시료의 추출물
표 List of the constituents detected by GC-MS system
$Total ion chromatogram of the hexane fraction of Aucklandia lappa$ 표 Total ion chromatogram of the hexane fraction of Aucklandia lappa
표 List of the constituents detected by GC-MS system.
$Total ion chromatogram of the hexane fraction of Inula helenium.$ 표 Total ion chromatogram of the hexane fraction of Inula helenium.
표 분리한 성분의 종류 및 시료 제공 현황
표 Structure of the isolated compounds from the roots of Aucklandia lappa
표 1H- (upper) and 13C-NMR spectra (below) of the newly isolated compound, aucklandianol A.
표 DEPT specrum of aucklandianol A.
표 NOESY spectrum of aucklandianol A (left) and selected NOE (right).
표 HMBC spectrum of aucklandianol A (left) and selected HMBC coorelation (right).
표 1H- (left) and 13C-NMR spectra (right) of costunolide.
표 1H- (left) and 13C-NMR spectra (right) of dehydrocostuslactone.
표 Conduritols A-F
표 백수오로부터 화합물의 분리 scheme
표 Effects of herbal extracts on dopamine levels in PC12 cells. The control levels of dopamine: 3.85±0.27 nmol/mg protein. Means±SEM (n=4-6).
표 Effects of the extracts of herbal medicines on L-DOPA-induced cytotoxicity in PC12 cells. Cell viability was measured using MTT method. Means±SEM (n=6-8).
표 Effects of herbal extracts on EF stress-induced locomotor activity and dopamine levels of brain in mice. The results were expressed as means±SEM (n=8-10)
표 Effects of herbal extracts on Cl- influx from IMR-32 cells.
표 Effects of herbal extracts on Locomotor activity in mice (n=9～10). Each bar represents the mean ± S.E.M of the moved distance or movement time for 10 minutes.
표 Effects of herbal extracts on activity on the rotating rod in mice (n= 9～10). Each bar represents the mean ± S.E.M of the endurance time or falling frequency for 20 minutes.
표 The effects of 70% EtOH extract of Cynanchi Wilfordii on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of Cynanchi Wilfordii, or (B) water extracts of Cynanchi Wilfordii on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 The effects of (A) 70% EtOH extract of Cynanchum auriculatum, or (B) water extracts of Cynanchum auriculatum on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 홍화로부터 분리된 활성화합물
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 홍화 추출물의 억제 효능
표 Effects of herbal extracts on dopamine levels in PC12 cells. The control levels of dopamine: 3.85±0.27 nmol/mg protein. Means±SEM (n=4-6).
표 Effects of the extracts of herbal medicines on L-DOPA-induced cytotoxicity in PC12 cells. Cell viability was measured using MTT method. Means±SEM (n=6-8).
표 Effects of Carthami Flos extracts on Locomotor activity in mice (n=9～10). Each bar represents the mean ± S.E.M of the moved distance, movement duration, total turn angle degree and rearing frequency for 10 minutes.
표 Effects of Carthami Flos extracts on activity on the rotating rod in mice (n=9～10). Each bar represents the mean ± S.E.M of endurance time on the rotating rod and falling frequency from rotating rod.
표 Effect of Carthami Flos extract on activity on swimming pool in mice (n=10) Each bar represents the mean ± S.E.M. of immobile duration and mobile duration in swimming pool.
표 Anticonvulsant effects of Carthami Flos extract in mice. Each line represents the mean ± SEM of % of animals with hind-limb extension by currents (pulse width-0.5 ms, frequency-100 pulses/ sec. shock duration-1 sec.).
표 Effects of Carthami Flos extract on [Cl-]i in neuroblastoma cells
표 하수오로부터 분리된 활성화합물
표 콜라겐으로 유도된 혈소판 응집에 대한 하수오(Polygonum multiflorum) 추출물의 효능
표 출혈시간에 대한 하수오(Polygonum multiflorum) 추출물의 지연 효능
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 하수오 추출물의 억제 효능
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 하수오 성분들의 억제 효능
표 Effects of herbal extracts on dopamine levels in PC12 cells. The control levels of dopamine: 3.85±0.27 nmol/mg protein. Means±SEM (n=4-6).
표 Effects of the extracts of herbal medicines on L-DOPA-induced cytotoxicity in PC12 cells. Cell viability was measured using MTT method. Means±SEM (n=6-8).
표 Effects of water extracts and EtOH extracts of Polygoni Multiflori Radix on Cl- influx from IMR-32 cells.
표 Effects of water extracts and EtOH extracts of Polygoni Multiflori Radix on Locomotor activity in mice (n=9～10). Each bar represents the mean ± S.E.M of the moved distance, movement duration or rearing frequency for 10 minutes.
표 Effects of water extracts and EtOH extracts of Polygoni Multiflori Radix on activity on the rotating rod in mice (n=9～10). Each bar represents the mean ± S.E.M of the endurance time or falling frequency for 20 minutes.
표 Effects of water extracts and EtOH extracts of Poligoni Multiforix Radix on activity on swimming pool in mice(n=10).
표 Structure of compounds (1-24) isolated from S. acutum
표 Isolated compounds from S. acutum
표 생리활성 연구용 제출 시료
표 분석팀 제공 시료
표 콜라겐으로 유도된 혈소판 응집에 대한 방기(A) 및 비교생약(B) 추출물의 효능
표 Key HMBC correlations for adenosine
표 Important HMBC correlations for 6‴-feruloylspinosin
표 Key HMBC correlations of magnoflorine
표 NMR data of 6‴-feruloylspinosin in DMSO-d6 at room temperature
표 NMR data of zizyphus saponin III in pyridine-d5 (500 MHz)
표 NMR data of isospinosin in DMSO-d6 + D2O at room temperature
표 Important HMBC correlations for isospinosin in DMSO-d6 + D2O
표 NMR data of jujuboside B in pyridine-d5 (400 MHz)
표 NMR data of spinosin in DMSO-d6 + D2O at room temperature
표 NMR data of hovetrichoside C in CD3OD
표 Key HMBC correlations for hovetrichoside C
표 NMR data of jujuboside A in pyridine-d5 (400 MHz)
표 NMR data of jujuboside A2 in pyridine-d5 (500 MHz)
표 NMR data of 6‴-p-coumaroylspinosin in DMSO-d6 at room temperature
표 콜라겐, 트롬빈, 아라키돈산으로 유도된 혈소판 응집에 대한 산조인 추출물의 효능
표 콜라겐, 트롬빈, 아라키돈산으로 유도된 혈소판 응집에 대한 면조인 추출물의 효능
표 출혈시간에 대한 산조인 추출물의 지연 효능
표 콜라겐, 트롬빈, ADP, 아라키돈산으로 유도된 혈소판 응집에 대한 산조인 생리활성성분 6종의 효능
표 콜라겐으로 유도된 thromboxane A2 생성에 대한 jujuboside B의 효능
표 산조인, 면조인의 물 및 EtOH 추출물에서 TNF-a에 의한 adhesion molecules (ICAM-1, VCAM-1)의 발현 억제능
표 The control levels of dopamine : 3.85±0.27 nmol/mg protein. Means±SEM (n=4-6)
표 Effects of the extracts of herbal medicines on PC12 cell viability. Cell viability was measured using MTT method. Means±SEM (n=6-8)
표 Effects of herbal extracts on Cl- influx from IMR-32 cells. Fluorescence was monitored in the excitation wavelength at 355nm and the emission wavelength at 450nm using the Cl--sensitive indicator, N-(6-methoxyquinolyl) acetoetylester (MQAE). Contents of influxed Cl- ion were expressed as the ration of F/Fo.
표 Effects of herbal extracts on Locomotor activity in mice (n=9～10). Each bar represents the mean ± S.E.M of the moved distance or movement time for 10 minutes.
표 Effects of natural products (10 mg/kg) on Locomotor activity in mice (n=9～10). Each bar represents the mean ± S.E.M of the moved distance or movement time for 10 minutes.
표 Effects of herbal extracts on activity on the rotating rod in mice (n=9～10). Each bar represents the mean ± S.E.M of the endurance time or falling frequency for 20 minutes.
표 Effects of herbal extracts on activity on the rotating rod in mice (n=9～10). Each bar represents the mean ± S.E.M of the endurance time or falling frequency for 20 minutes.
표 Effects of herbal extracts on thiopental-induced sleepling test in mice (n=9~10). Each bar represents the mean ± S.E.M of on set time and duration time
표 Anticonvulsant effects of EtOH extracts of Artemisia capillaris herba. Each line represents % of animals with hind-limb extension by currents. DZP means diazepam.
표 The effects of (A) 70% EtOH extract of Zizyphus jujuba var. spinosa or (B) water extracts of Zizyphus jujuba var. spinosa on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of Zizyphus mauritiana or (B) water extract of Zizyphus mauritiana on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) jujuboside B or (B) spinosin on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of Zizyphus jujuba var. spinosa or (B) water extracts of Zizyphus jujuba var. spinosa on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 The effects of (A) 70% EtOH extract of Zizyphus mauritiana or (B) water extracts of Zizyphus mauritiana on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 The effects of (A) jujuboside B or (B) spinosin on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 Effect of Zizyphus jujuba extracts on cell viability, NO production, and NF-ƙB in RAW 264.7 marcophage.
표 Effects of compounds from Zizyphus jujuba herbal extract on cell viability and NO production in RAW 264.7 marcophage.
표 산조인 및 면조인 추출물의 파골세포 형성 억제능
표 산조인으로부터 분리된 성분의 파골세포 형성 억제능
표 Betulinic acid의 골 흡수 억제능 (A) 및 골 기질 분해 관여 효소 억제능 (B)
표 난소를 적출한 생쥐 모델에서 betulinic acid의 투여로 인한 몸무게 변화
표 Effects of Rehmanniae Radix extracts on Locomotor activity in mice (n=9～10). Each bar represents the mean ± S.E.M of the moved distance, movement duration, total turn angle degree and rearing frequency for 10 minutes.
표 Effects of Rehmanniae Radix extracts on activity on the rotating rod in mice (n=9～10). Each bar represents the mean ± S.E.M of endurance time on the rotating rod and falling frequency from rotating rod.
표 Effect of Rehmanniae Radix extract on activity on swimming pool in mice (n=10) Each bar represents the mean ± S.E.M. of immobile duration and mobile duration in swimming pool.
표 Anticonvulsant effects of Rehmanniae Radix extract in mice. Each line represents the mean ± SEM of % of animals with hind-limb extension by currents (pulse width-0.5 ms, frequency-100 pulses/ sec. shock duration-1 sec.). Control versus treatment groups.
표 The effects of (A) 70% EtOH extract of Rehmanniae Radix preparata, or (B) water extracts of Rehmanniae Radix preparata on the scopolamine-induced memory impairments in the passive avoidance task.
표 Key HMBC correlations of jujuboside A
표 Key HMBC correlations of jujuboside B
표 Important correlations of sugar parts of jujuboside A2
표 Key correlations of 6-deoxy-α-L-talopyranoside moiety in jujuboside A2
표 Key HMBC correlations of 6-deoxy-L-talopyranose
표 Important correlations of sugar parts of zizyphus saponin III
표 Key HMBC correlations of ebelin lactone
표 Key HMBC correlations of alphitolic acid
표 NMR data of ebelin lactone and 17(Z)-ebelin lactone in CDCl3
표 Important HMBC correlations for spinosin
표 The possible HMBC correlations of 2-hydroxynaringenin
표 Important HMBC correlations for 6‴-p-coumaroylspinosin
표 Isolated compounds from Alismatis Rhizoma
표 생리활성 연구용 제출 시료
표 분석팀 제공 시료
표 콜라겐으로 유도된 혈소판 응집에 대한 택사 추출물의 효능
표 The control levels of dopamine : 3.85±0.27 nmol/mg protein .
표 Effects of the extracts of herbal medicines on PC12 cell viability. Cell viability was measured using MTT method.
표 Effects of herbal extracts and natural products on Cl- influx from IMR-32 cells Fluorescence was monitored in the excitation wavelength at 355nm and the emission wavelength at 450nm using the Cl--sensitive indicator, N-(6-methoxyquinolyl) acetoetylester (MQAE). Contents of influxed Cl- ion were expressed as the ration of F/Fo.
표 Effects of herbal extracts on Locomotor activity in mice (n=9～10). Each bar represents the mean ± S.E.M of the moved distance and movement duration for 10 minutes.
표 Effects of herbal extracts on activity on the rotating rod in mice (n=9～10). Each bar represents the mean ± S.E.M of endurance time on the rotating rod and falling frequency from rotating rod.
표 Effect of herbal extract on activity on swimming pool in mice (n=10) Each bar represents the mean ± S.E.M. of immobile duration and mobile duration in swimming pool.
표 Effects of herbal medicine on urine volume in conscious male rats. Each point connected by line represents the mean ± S.E.M of urine volume of each time (A) and each bar represents the mean ± S.E.M of total urine volume collected in 4 hours (B) in 5 rats in metabolic cage
표 The effects of (A) 70% EtOH extract of Alisma orientale, or (B) water extracts of Alisma orientale on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of Alisma orientale, or (B) water extracts of Alisma orientale on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 Effect of Kalopanacis Cortex ethanol extract on arthritis score (left) and histological changes of knee joint of CIA-induced mouse. Values are means ± SD (n=10).
표 Effect of Kalopanacis Cortex ethanol extract on the production of anti-CII mAb and TNF-α in sera of CIA-induced mouse. Values are means ± SD (n=10).
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 해동피 추출물의 억제 효능
표 콜라겐으로 유도된 혈소판 응집에 대한 진피(A) 및 비교생약(B) 추출물의 효능
표 Effects of herbal extracts on Cl- influx from IMR-32 cells. Fluorescence was monitored in the excitation wavelength at 355nm and the emission wavelength at 450nm using the Cl—sensitive indicator, N-(6-methoxyquinolyl) acetoetylester (MQAE). Contents of influxed Cl- ion were expressed as the ration of F/Fo
표 Effects of herbal extracts on Locomotor activity in mice (n=9～10). Each bar represents the mean ± S.E.M of the moved distance and movement duration for 10 minutes.
표 Effects of herbal extracts on activity on the rotating rod in mice (n=9～10). Each bar represents the mean ± S.E.M of endurance time on the rotating rod and falling frequency from rotating rod.
표 The effects of (A) 70% EtOH extract of Citrus unshiu, or (B) water extracts of Citrus unshiu on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of Citrus unshiu, or (B) water extracts of Citrus unshiu on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 The effects of (A) 70% EtOH extract of Citrus reticulata, or (B) water extracts of Citrus reticulata on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of Citrus reticulata, or (B) water extracts of Citrus reticulata on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 Effects of Phlomis Rhizoma extracts on Locomotor activity in mice (n=9～10). Each bar represents the mean ± S.E.M of the moved distance, movement duration, total turn angle degree and rearing frequency for 10 minutes.
표 Effects of Phlomis Rhizoma extracts on activity on the rotating rod in mice (n=9～10). Each bar represents the mean ± S.E.M of endurance time on the rotating rod and falling frequency from rotating rod.
표 Effect of Phlomis Rhizoma extract on activity on swimming pool in mice (n=10) Each bar represents the mean ± S.E.M. of immobile duration and mobile duration in swimming pool.
표 Anticonvulsant effects of Phlomis Rhizoma extract in mice. Each line represents the mean ± SEM of % of animals with hind-limb extension by currents (pulse width-0.5 ms, frequency- 100 pulses/sec. shock duration-1 sec.). Control versus treatment groups
표 Effects of Phlomis Rhizoma extract on [Cl-]i in neuroblastoma cells. Fluorescence was monitored in the excitation wavelength at 365nm and the emission wavelength at 450 nm using the Cl--sensitive indicator, N-(6-methoxyquinolyl) acetoetylester (MQAE). Contents of influxed Cl- ion were expressed as a peak.
표 The effects of (A) 70% EtOH of Dipsaci Radix, (B) water extracts of Dipsaci Radix, or (C) 70% EtOH of Phlomis umbrosa on the scopolamine-induced memory impairment mouse model in the passive avoidance task.
표 The effects of (A) Dipsacus saponin A, or (B) Akebia saponin D on the scopolamine-induced memory impairment mouse model in the passive avoidance task.
표 The effects of (A) Dipsacus saponin A, or (B) Akebia saponin D on the percentage time spent in and the number of entries into open arms of the elevated plus-maze over a 5 min test period in mice.
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 속단 추출물의 억제 효능
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 속단 성분들의 억제 효능
표 난소적출 동물모델에서 속단에서 분리된 oleanolic acid의 항골다공증 효능 평가
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 우슬 추출물의 억제 효능
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 천우슬, 회우슬 추출물의 억제 효능
표 생쥐 골수 대식세포에서 RANKL로 유도한 파골세포 형성에 대한 우슬 성분의 억제 효능
표 콜라겐으로 유도된 혈소판 응집에 대한 천마(A) 및 비교생약(B) 추출물의 효능
표 The control levels of dopamine : 3.85±0.27 nmol/mg protein .
표 Effects of the extracts of herbal medicines on PC12 cell viability. Cell viability was measured using MTT method.
표 The effects of (A) 70% EtOH extract of Gastrodia elata, or (B) water extracts of Gastrodia elata on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH or (B) water extract of Gastrodia elata on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 The effects of 4-hydroxybenzyl alcohol on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 The effects of (A) 70% EtOH extract of steamed Gastrodia elata, or (B) water extracts of steamed Gastrodia elata on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of (A) 70% EtOH extract of steamed Gastrodia elata, or (B) water extracts of steamed Gastrodia elata on the percentage time spent on open arms and the number of entries into open arms of the elevated plus-maze test during 5 min in mice.
표 The effects of (A) gastrodigenin or (B) 4-hydroxybenzyl methyl ether on the scopolamine-induced memory impairments in the passive avoidance task.
표 The effects of 70% EtOH extract of Gastrodia elata on the bilateral common carotid artery occlusion (BCCAO) induced hippocampal neuronal cell death. Photomicrographs of Nissl staining of the hippocampus (A), the percentages of viable neurons (B) in CA1 are expressed. Magnification: 200X. Bar = 100 μm

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한약재 생리활성성분 분리 및 효능 연구
Study on the Isolation and Efficacy of Bioactive Components from Oriental herbal Medicines 원문보기

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