초록 ▼

연구팀은 탄자니아에 서식하는 수종의 생물자원으로부터 항암, 항균 화합물을 규명하고, 탄자니아 연구팀과 협력 연구를 통해 아프리카에 자생하는 유용소재를 발굴하고 효능기전을 공동 연구하여 부가가치가 우수한 천연물 신약 및 기능성 식의약품 소재를 개발하였음. 이를 위해 탄자니아 연구진으로부터 잔지바르와 다레살렘에 자생하는 천연 생물자원소재를 제공받고, 국내에서 확보된 효능소재를 대상으로 활성기전을 규명함. 또한 효능이 우수한 아프리카 시료에 함유된 기능성 성분을 단리하고 화학구조를 규명한 후에 활성을 검증함. 또한 개발된 연구결과물의 산

연구팀은 탄자니아에 서식하는 수종의 생물자원으로부터 항암, 항균 화합물을 규명하고, 탄자니아 연구팀과 협력 연구를 통해 아프리카에 자생하는 유용소재를 발굴하고 효능기전을 공동 연구하여 부가가치가 우수한 천연물 신약 및 기능성 식의약품 소재를 개발하였음. 이를 위해 탄자니아 연구진으로부터 잔지바르와 다레살렘에 자생하는 천연 생물자원소재를 제공받고, 국내에서 확보된 효능소재를 대상으로 활성기전을 규명함. 또한 효능이 우수한 아프리카 시료에 함유된 기능성 성분을 단리하고 화학구조를 규명한 후에 활성을 검증함. 또한 개발된 연구결과물의 산업화를 위한 사전 예비조사를 수행하였음. 즉, 탄자니아 국적인 기업인, 교수, 학생, 소비자, 연구자, NGO 및 한국에 연수중인 아프리카인을 대상으로 사전 타당도 조사를 시행하여, 아프리카 생물자원의 산업화에 대한 긍정적 반응을 확인함. 이상의 한-아프리카 협력연구를 통해, 식의약품으로의 산업화 기반을 확립하였으며, 한국과 아프리카 과학기술 협력 교류 및 과학기술 인력 양성이 이루어짐.
(출처 : 보고서 요약서 3P)

Abstract ▼

Ⅰ. Research Goal

This project aims to utilize natural bio-resources in Tanzania for functional food, cosmetics and drug by the establishment of Korea-Africa Cooperation Research.
The final goal of the project is to build up capacity to produce functional food, cosmetics and drug using Tanz

Ⅰ. Research Goal

This project aims to utilize natural bio-resources in Tanzania for functional food, cosmetics and drug by the establishment of Korea-Africa Cooperation Research.
The final goal of the project is to build up capacity to produce functional food, cosmetics and drug using Tanzania local bio-resources as well as to improve science and technology in Africa.
The products will be commercialized for the local market in Tanzania. Tanzania is known for its rich biodiversity resources due to its unique location where it has provided the country with fuels, traditional and western medicinal drugs and raw materials for food.
Though, biodiversity is important for the socio-economic development of Tanzania, the full potential of the biodiversity has yet develop. It may be crucial for African development and improvement of health condition to maximize the hidden potential of the bio-resources in order to develop, produce and commercialize products using natural raw materials in Tanzania.
The Duksung Women’s University, which has built up the ability and capacity in the area of research on natural products since 1920, wants to support the aim of the research through sharing of Korean high-end technologies with Tanzanian partners to develop new functional food, drug and cosmetics.
In addition, this will provide a stepping stone for the Africans to be independently sustainable in the long term and contribute to the health and socio-economic development of the continent. East Africa, a region embracing Kenya, Uganda and Tanzania, is one of the richest areas on the African continent in terms of its flora and fauna. This natural wealth is, to a very large extent, the product of the region’s enormous diversity of habitat and climate.

Ⅱ. Objectives

The main objective of this project is to establish a research partners in University of Dar es Salaam, Tanzania. Combining the local extraction of bio-resources in Tanzania and the high-end technologies in Korea, both Korea and Tanzania will join in a deeper cooperation to maximize the potential of biodiversity products and commercialize them in the local markets in Africa. The spillover effect will be seen through the growth of science and technology related industries around Africa.

Ⅲ. Research Contents

This project will be a joint effort between South Korea and Tanzania where involved partners are Duksung Women’s University, two Korean companies from the food and pharmaceutical sector, the Ministry of Science, as well as the University of Dar es Salaam, Tanzania.
The purpose of study is to verify the New Functional Medicinal plants cultivated in Africa in cooperation with Korea and Tanzania research teams.
We are identified bioactive components with anticancer and antibacterial activities from plants cultivated in Tanzania. Through cooperative research between Korea and Tanzania, it is expected the profit on bio-industry profit and scientific development. The research of this study was to investigate the biological potentials of ethanol extracts from medicinal plants, Adansonia digitata, Azadirachta indica, Kigelia africana, Mangifera indica and Moringa oleifera, were grown in East Africa regions. This study was performed to investigate the cytotoxicity in HCT116, HT-29 and A2058 cell lines. It was also performed antibacterial activity against 20 bacterial strains by agar diffusion method. Bioactive compounds were isolated with activity-guided fractionation and isolation method. The chemical structure was determined by spectroscopic methods, mainly NMR and HR-MS analysis. These compounds exhibited significant cytotoxicity and antibacerial activities. The present study was also investigate the molecular mechanisms of phenolic acids isolated from African plans, against HT-29, HCT116 and A2058 cancer cells.
As a results, it is suggested that HCT116 human colon cancer cells are highly sensitive to growth inhibition by Moringa oleifera and Kigekia africana via the activation of apoptosis, as evidenced by activation of MAPK-mediated signaling as well as alteration in Bcl-2 family expression and activation of caspase-9, -3. It suggests that Moringa oleifera and Kigekia africana is a promising candidates for development of nutraceuticals.

Ⅳ. Expectations

The expected benefits of this research project to be carried out will accrue to both Korea and Tanzania, eventually to the rest of Africa, through the establishment of research partners in the University of Dar es Salaam, Tanzania. Areas of research include utilizing biodiversity resources that is abundant in Tanzania to develop new functional food, drugs for the local markets. The emphasis of this project includes the transfer of high end technology from Korea, development of human resources, the aptitude of self-sustenance and nurturing of local experts in the science and technology field in Tanzania. The expected outcome is the ability to contribute and improve the health conditions.
(출처 : SUMMARY 7P)

목차 Contents

• 표지 ... 1제출문 ... 2보고서 요약서 ... 3요약문 ... 4SUMMARY ... 7CONTENTS ... 9목차 ... 10제1장 연구개발과제의 개요 ... 11 제1절 연구개발의 필요성 ... 11 제2절 선행연구 수행 내용 및 결과 ... 24제2장 연구개발 수행 내용 및 결과 ... 45 제1절 연구개발 수행 내용 ... 45 제2절 연구개발 수행 ... 51제4장 목표달성도 및 관련분야에의 기여도 ... 101 제1절 연구개발과제의 목표달성도 ... 101 제2절 관련분야 기여도 ... 102 제3절 탄자니아 생물자원을 활용한 기관별 R&D 협력모델 ... 104제5장 연구개발결과의 활용계획 ... 114 제1절 바이오의약품 글로벌 역량강화 통해 창조경제 견인 ... 114 제2절 성장동력인 바이오산업 활성화에 활용 ... 115제6장 연구개발과정에서 수립한 해외과학기술정보 ... 117 제1절 EU, 2015년 밀라노 엑스포 관련 농업 혁신 아젠다 ... 118 제2절 미국, 첨단 기술을 활용한 농생명 산업의 변화 ... 120 제3절 일본, 농생명분야 향후 추진과제 및 영역 설정 ... 122 제4절 중국의 바이오산업 육성 계획 ... 122 제5절 시사점 ... 123제7장 참고문헌 ... 124APPENDIX. 설문지, 분석결과 ... 125끝페이지 ... 160