보고서 정보
주관연구기관 |
한국한의학연구원 Korea Institute of Oriental Medicine |
연구책임자 |
이시우
|
참여연구자 |
장은수
,
유종향
,
김상혁
,
백영화
,
김호석
,
김윤영
,
정종욱
,
고정현
,
장승희
,
유하나
,
고병희
,
김달래
,
안택원
,
유호룡
,
송호섭
,
송정모
,
구덕모
,
김종원
,
신미란
,
최희석
,
정용재
|
보고서유형 | 1단계보고서 |
발행국가 | 대한민국 |
언어 |
한국어
|
발행년월 | 2009-07 |
과제시작연도 |
2009 |
주관부처 |
교육과학기술부 Ministry of Education and Science Technology(MEST) |
등록번호 |
TRKO201700012089 |
과제고유번호 |
1345101232 |
사업명 |
미래기반기술개발 |
DB 구축일자 |
2017-11-13
|
키워드 |
한의학.체질의학.체질정보.체질진단.가계연구.체질정보은행.Traditional Korean Medicine.Constitutional Medicine.Constitutional Information.Constitutional Diagnosis.Family Study.Constitution Information Bank.
|
DOI |
https://doi.org/10.23000/TRKO201700012089 |
초록
▼
○ 다기관 임상연구 협력 네트워크 기반을 구축함.
- 3년에 걸쳐 21개 체질임상 증례수집 협력 네트워크를 구축함.
○ 임상증례 수집 관련 프로토콜과 증례기록지, 표준작업지침서 개발
- 임상증례 수집 관련 프로토콜과 증례기록지, 표준작업지침서를 개발 및 임상윤리위원회 연구승인을 득함.
○ 체질 증례 구축
- 일정기준의 약리 및 병증호전 기록이 구비된 체질확진자 증례로 총 2043건의 증례를 수집함.
- 3명 이상의 직계가족이나 3형제를 포함한 총 128가계 471명의 소가계 증례 및 4
○ 다기관 임상연구 협력 네트워크 기반을 구축함.
- 3년에 걸쳐 21개 체질임상 증례수집 협력 네트워크를 구축함.
○ 임상증례 수집 관련 프로토콜과 증례기록지, 표준작업지침서 개발
- 임상증례 수집 관련 프로토콜과 증례기록지, 표준작업지침서를 개발 및 임상윤리위원회 연구승인을 득함.
○ 체질 증례 구축
- 일정기준의 약리 및 병증호전 기록이 구비된 체질확진자 증례로 총 2043건의 증례를 수집함.
- 3명 이상의 직계가족이나 3형제를 포함한 총 128가계 471명의 소가계 증례 및 4대 9남매 62가계 164명으로 구성된 가계 등 2개 대가계 147명의 증례를 수집함.
○ 체질정보은행 구축 현황
- 다기관으로부터 대상자의 안면, 체형, 설문, 약리, 진단소견 등 체질임상정보와 혈액검사, DNA 등 생물학적 정보를 수집함.
- 전자증례기록지를 활용하여 체질를 웹기반으로 DB화하는 시스템을 구축함.
○ 체질요소인 안면, 체형, 음성, 성정 및 병증 소증 등에 대해 체질 특성을 밝힘
(출처 : 보고서 요약서 4p)
Abstract
▼
Chapter 3. Results of research and development
1. Establishment of a multi-institute cooperative clinical research network
A. Based on the initial cooperative clinical research network consisting of 4 oriental medical hospitals and 1 local clinic, we are planning to enlist a total of 21 orient
Chapter 3. Results of research and development
1. Establishment of a multi-institute cooperative clinical research network
A. Based on the initial cooperative clinical research network consisting of 4 oriental medical hospitals and 1 local clinic, we are planning to enlist a total of 21 oriental medical hospitals and clinics to establish a network for collecting cases on constitution confirmed subjects.
2. Arrangement of constitution clinical case collecting basis
A. Development of CRF(Case Report Form) and SOP(Standard Operating Procedure)
By recording the diagnosis of a constitution confirmed subject into 5 categories and marking the priority factors as well, we are going to deduct the items that affect constitution diagnosis.
3. Establishment of constitution cases
A. Current status on accumulated constitution confirmed cases
(1) Cases on subjects with records of pharmacological and symptomatic improvements, add up to 550 cases in the first year, 677 cases in the second, 816 cases in the third, resulting in a total of 2043 cases.
B. Current status on accumulated constitution cases in small family
(1) Cases on families with 3 or more direct line family members or 3 siblings, add up to 38 families 145 subjects in the first year, 47 familes 180 subjects in the second, 43 families 146 subjects in the third.
4. Establishment of Constituitional Information Bank
A. Establishment of Electronic Case Report Form input system
(1) Established a system that automatically saves the data collected from university hospitals, oriental medical hospitals, cooperative clinics etc. in the KIOM database server through realtime input via web-based eCRF.
B. Current status on the establishment of constitution information bank
(1) We have established a database with the clinical constitution data and biological data from the 2043 cases of constitution confirmed subjects, 471 cases of small family, 147 cases of large family
(2) Clinical constitution data: Demographic data, facial picture, voice, physique, personality, pathological and physiological symptom, disease, constitution pharmacology, expert's opinion on constitution diagnosis etc.
(3) Biological data: Blood test data, DNA data and other biological data
5. Clinical constitution data analysis
A. Facial characteristics
(1) There were more characteristics from the side of the face compared to the front. Distance ratio variable was most frequent and angle variable and distance variable followed after that. Also we discovered that the front and side distance, angle, and ratio differed among different sexes.
(2) Tae-eumins had a generally broad and flat face and a narrow forehead.
They had large cheekbones and large mandibles and thick lips. Also they had large round noses and thick ears.
(3) Soyangins had a smaller and rounder face compared to Soeumins and their foreheads and eyes were slightly protruded. They had high and sharp noses that were slightly upturned. They also had small mouths and thin lips.
(4) Soeumins had long faces and small eyes, having some distance between their eyes and eyebrows. They had small noses, large ears, thin chins, and large protruded lips.
B. Physical characteristics
(1) Tae-eumins were taller and heavier than the other constitutions and they also had larger measurements in the 8 circumferences 5 widths.
(2) Tae-eumins had the largest measurements in all 8 parts and Soyangins were next and Soeumins showed to be the smallest. When compensated to the height of the subjects, the distribution was similar. But when compensated to body weight, Soeumins showed higher measurements compared to Soyangins and Tae-eumins.
(3) From the measurement results, we discovered that Tae-eumins had relatively developed waist areas, Soeumins had developed hip and insignificant thorax areas, Soyangins had developed thorax areas and insignificant hip areas. Thus these results corresponded with the existing documents.
(4) Tae-eumins showed to have 'broad' costal angles while Soeumins had 'narrow' costal angles, and Soyangins had 'normal' costal angles.
C. Voice characteristics
(1) After analyzing the results of 144 variables on voice characteristics, we discovered 38 variables in men and 23 variables in women that expressed difference in constitution.
(2) When the voice was analyzed by Pitch, Formant, MDVP variable, all which can be physically translated, males showed a relatively stronger variable in Pitch(aF0, eF0, iF0, iT0, oF0, oT0, uF0, uT0, P10, P50, P90) and females showed a relatively stronger variable in Formant(aBw, aF2, eF2, iF2, uF1, uBw1). The difference between male and female was evident.
(3) Constitutional difference showed in the Pitch in males as Soyanins being the highest and Tae-eumins the next and Soeumins being last. The Formant variable in females showed partial difference, but the order didn't show much sequence. More research in this field is necessary.
D. Temperament, pathological and physiological symptom characteristics
(1) Through survey we found out that Tae-eumins had 89 items in Temperament, pathological and physiological symptom characteristics, Soeumins had 79, Taeyangins had 48, and Soyangins had 31.
(2) Tae-eumins eat more and faster than other constitutions. They tend to have a fair amount of perspiration on their face and head, and they feel refreshed after sweating. It takes them a long time to defecate and they tend to have some bubbles in their urine.
(3) Soeumins have stronger perseverance compared to other constitutions, and refrain from showing their feelings and also have rational judgement.
They tend to eat little and they barely sweat, and their hands and feet are cold. They like warm water but tend not to drink much.
(4) Soyangins tend to be impatient and express themselves freely and tend to have a temper. They sweat regularly and digest well, it takes them little time to defecate and they urinate often.
(5) There are very few Taeyangins, so there isn't much research on this constitution. In this study, we discovered that Taeyangins express themselves very clearly in the temperament aspect , and do not express themselves clearly in the pathological and physiological symptom aspect.
6. Establishment of large family cases
- There are two families that consented in this research. H-family with 4 generations, 9 brothers and sisters, 62 families and 164 subjects.
A-family with 3 generations, 10 families and 46 subjects.
A. Current status of cases in H-Family
(1) A family consisting 4 generations, 9 brothers and sisters, 62 families and 164 subjects. 105 constitution cases were collected.
B. Current status of cases in A-Family
(1) A family consisting 3 generations, 10 families and 46 subjects. 42 constitution cases were collected.
(출처 : SUMMARY 13p)
목차 Contents
- 표지 ... 1제 출 문 ... 2보고서 요약서 ... 4요 약 문 ... 5SUMMARY ... 13CONTENTS ... 22목차 ... 23제 1 장 연구개발과제의 개요 ... 24 1. 연구개발의 목적 ... 24 2. 연구개발의 필요성 ... 24 3. 연구개발의 범위 ... 25제 2 장 국내외 기술개발 현황 ... 26 1. 지금까지의 연구개발 실적 ... 26 2. 현기술상태의 취약성 ... 26 3. 앞으로의 전망 ... 27제 3 장 연구개발 수행내용 및 결과 ... 28 1. 다기관 임상연구 네트워크 구축 ... 28 2. 체질 증례 수집 기반 마련 ... 35 3. 체질 증례수집 및 모니터링 ... 48 4. 체질정보은행(CIB, Constitutional Information Bank) 구축 ... 60 5. 체질 정보 분석 ... 66 6. 대가계 체질 연구 ... 100 7. 동북아 체질임상연구 네트워크 구축 ... 109제 4 장 목표달성도 및 관련분야에의 기여도 ... 114 1. 목표달성도 및 기여도 ... 114 2. 연구개발의 최종목표 ... 114제 5 장 연구개발결과의 활용계획 ... 115 1. 추가연구의 필요성 ... 115 2. 타 연구에의 응용 ... 115 3. 연구결과를 활용한 eCAM(Evidence-Based Complementary and Alternative Medicine, ISSN 1741-427X; SCIE 등재지, IF 2.535) 특별호 발간 ... 115제 6 장 연구개발과정에서 수집한 해외과학기술정보 ... 117 1. 젓국의 체질의학 현황 ... 117 2. 일본의 체질의학 현황 ... 118 3. 사상의학에 대한 교류 및 인식 ... 119제 7 장 참고문헌 ... 120끝페이지 ... 121
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