초록 ▼

본 과제의 목표는 감각과 지각, 주의와 학습, 사회적 행동에 관련된 고등 인지기능의 실체를 인지신경과학적 연구를 통해 밝히는 것이다. 제 1세부과제에서는 시각적 맥락효과 중 과밀효과에 주안, 사람 및 동물에 대한 신경생리, fMRI, 정신물리 실험을 통해 해당 현상의 신경학적 특성(발생 범위 및 발생 특성) 및 발생 단계를 확인하였다. 제 2세부과제에서는 인간의 주의(Attention)과 관련 체계적인 연구 진행을 통하여 신경생물학적 연구 및 인지신경과학적 연구의 통합을 시도하고 정상모델과 질환모델을 통해 기초 데이터 확립에서부터

본 과제의 목표는 감각과 지각, 주의와 학습, 사회적 행동에 관련된 고등 인지기능의 실체를 인지신경과학적 연구를 통해 밝히는 것이다. 제 1세부과제에서는 시각적 맥락효과 중 과밀효과에 주안, 사람 및 동물에 대한 신경생리, fMRI, 정신물리 실험을 통해 해당 현상의 신경학적 특성(발생 범위 및 발생 특성) 및 발생 단계를 확인하였다. 제 2세부과제에서는 인간의 주의(Attention)과 관련 체계적인 연구 진행을 통하여 신경생물학적 연구 및 인지신경과학적 연구의 통합을 시도하고 정상모델과 질환모델을 통해 기초 데이터 확립에서부터 응용에 이르는 연구 싸이클을 확립하였다. 제 3세부과제에서는 기능적, 구조적 자기공명영상기법과 인지/사회심리학적 연구방법을 접목하는 다각적인 융합연구들을 통해 내측 전전두피질을 중심으로 한 신경회로가 이타성, 타인의 심리상태 추론, 사회적 가치 판단 등 다양한 사회적 심리현상들에 독특한 방식으로 관여한다는 사실들을 규명함으로써 정교한 사회적 인지 및 행동의 신경생물학적 모형을 구축하기 위한 토대를 마련하였다.

(출처 : 보고서 요약서 3p)

Abstract ▼

Ⅲ. Results
[Project 1]
● The correlates of the gap effect in reducing saccadic latency was sought and analyzed in the context of interaction of visual representations of fixation and saccade target stimuli.
The spike activity of V1 was found to be correlated with the gap effect and occurren

Ⅲ. Results
[Project 1]
● The correlates of the gap effect in reducing saccadic latency was sought and analyzed in the context of interaction of visual representations of fixation and saccade target stimuli.
The spike activity of V1 was found to be correlated with the gap effect and occurrence of express saccades. Furthermore, the cortical state before target onset was found to influence subsequent processing of visual target and the latency of behaviroal response toward the stimulus.

● A large scale fMRI study including all early visual cortical areas was conducted to reveal correlation structures of noise and spontaneous activity. We found that anicotropic correlation structure exists.

● We measured interaction between crowding effect and binocular rivalry that were used simultaneously in the same experiment. Based on this, we proposed that the origin of crowding effect resides between V1 and V4.

[Project 2]
● Discovered research themes new to the attention field and produce global-level results through experimentation and theoretical exploration.

● Published highly influential papers to secure a predominant position in the field of attention. Promoted collaboration and exchange between educational systems through joint research and train next generation research human resources based on new paradigms.

● Provided key dataset for attentional mechanism in the human and animal brain

● Development of novel analysis tool for neural signal obtained from human and animal

● Provided a database for multiple biosignals and eye-tracking signal

● Developemnt of computational models for assessing attention-related brain activity

● Established fundamental research to develop attention related pathological models and their treatment.

● Created a database to establishing a brain cognitive neuroscientific model for application in educational settings.

● Accumulated baseline data necessary for treating attention deficits, autism, and developmental disorders.

● Established fundamentals behavioral paradigm for late-onset attention and learning deficiency. Provide baseline data for social neurosicence, and neuroeconomics research.

[Project 3]
● Neural data revealed a spatial gradient in activity within the medial prefrontal cortex (MPFC), such that ventral parts predominantly represented self-regarding values and dorsal parts predominantly represented other-regarding values.

● Our study extended previous studies on social comparison by considering the impact of social comparison on financial decisions and the modulatory role of cultural variation in such processes, revealing the neural basis underlying the difference between Eastern and Western cultures in the degree to which decisions are influenced by social comparison.

● The strength of functional connectivity between the VS and the vmPFC predicted individual variability in the degree to which participants’ decisions were affected by relative incomes. Additional model-based fMRI analysis further confirmed the primary role of the vmPFC in biasing decisions based on relative incomes.

● We found that temporal parietal junction (TPJ) region was more activated when participants experienced that other participants chose the same choices than different choices and the vACC region was more related to similar other compared to dissimilar other.

● Among the reputation concern group, the female participants showed the increased utilitarian responses the control during moral dilemma decision.

● The present study newly verified the modulation effect by cultural factors by observing the significant relationship between collectivism bias and neural signals in posterior cingulate cortex, one of the main brain region of cortical midline structure. We verified the relationship between the strength of functional connectivity among subregions of cortical midline structure and self-construals related to individualism/collectivism.

● It was found that the CRPS patients performed significantly worse in social-cognitive task, compared to health controls. Some of the patients showed a deficit in executive function, which was related to reduced cortical thickness in prefrontal regions. In our another study, 75% of the patients exhibited suicidal ideation that were influenced by severity of pain, depressive symptoms and decrease of functioning.

(출처 : SUMMARY 14p)

목차 Contents

• 표지 ... 1제 출 문 ... 2보고서 요약서 ... 3요 약 문 ... 4SUMMARY ... 12CONTENTS ... 16목차 ... 17제 1장 연구개발과제의 개요 ... 18 제 1절 연구개발의 필요성 및 범위 ... 18제 2장 국내외 기술개발 현황 ... 22 [1세부과제] ... 22 [2세부과제] ... 26 [3세부과제] ... 31제 3장 연구개발수행 내용 및 결과 ... 36 제 1절 연구수행 내용 및 결과 ... 36제 4장 목표달성도 및 관련분야에의 기여도 ... 146 [1세부과제] ... 146 [2세부과제] ... 148 [3세부과제] ... 150제 5장 연구개발결과의 활용계획 ... 154제 6장 연구개발과정에서 수집한 해외과학기술정보 ... 158 [1세부과제] ... 158 [2세부과제] ... 160 [3세부과제] ... 161제 7장 연구시설·장비 현황 ... 165 제 1절 영장류 사육 및 연구시설 ... 165제 8장 참고문헌 ... 169끝페이지 ... 183