[보고서]2016년 식품 중 잔류농약 위해평가 등을 통한 안전관리 연구

이규식

2016년 식품 중 잔류농약 위해평가 등을 통한 안전관리 연구
Study on Safety Management by Risk Assessment of Pesticide Residues in Foods - 2016 원문보기

보고서 정보
주관연구기관	식품의약품안전평가원 National Institute of Food and Drug Safety Evaluation
연구책임자	이규식
참여연구자	강길진 , 장문익 , 도정아 , 정지윤 , 이상목 , 이현숙 , 천소영 , 강희승 , 임승희 , 박신민 , 박원민 , 윤지혜 , 주윤지 , 최윤주 , 김지영 , 이지선 , 홍순근 , 이영주 , 송지영 , 한아름 , 강혜라 , 박인주
보고서유형	최종보고서
발행국가	대한민국
언어	한국어
발행년월	2016-12
과제시작연도	2016
주관부처	식품의약품안전처 Ministry of Food and Drug Safety
등록번호	TRKO201700017616
과제고유번호	1475009280
사업명	식품등안전관리
DB 구축일자	2017-11-25
키워드	잔류농약.위해평가.시험법.표준품.시험법 검증.Pesticide residue.Risk assessment.Analytical method.Pesticide standard.Validation.
DOI	https://doi.org/10.23000/TRKO201700017616

초록 ▼

잔류농약으로부터 안전한 식품을 국민들에게 공급하기 위해 신규농약에 대한 시험법을 개발하고, 기준 제·개정 농약에 대한 위해평가를 수행하였다. 또한, 우리나라 잔류농약 국가검사기관에 농약 표준품을 제공하여 신속 검사를 지원하고 일관된 결과를 도출하도록 하였다.
2016년 신규 기준 설정 농약 12종(벤조빈디플루피르, 사이클라닐리프롤, 스피로사민, 아이소페타미드, 테부플로퀸, 톨펜피라드, 트리데모르프, 페녹사설폰, 펜플루펜, 플로르피라우시펜벤질, 피카뷰트라족스, 피플루뷰마이드)에 대한 시험법을 개발하고 지방청(서울청) 및 산업체(한국식품과학연구원)과 연계하여 시험법의 특이성, 직선성, 정량한계, 정확성, 정밀성 등을 토대로 실험실간 시험법 검증을 완료하였다. 이 중 사이클라닐리프롤, 아이소페타미드, 테부플로퀸, 피카뷰트라족스 및 피플루뷰마이드는 잔류물의 대상에 대사산물이 포함되었기에 두 물질을 동시에 분석할 수 있도록 개발하였다. 또한, 아이소페타미 등 신규 및 기준확대 농약 169종에 대한 위해평가를 실시하였으며, 위험성 확인 및 결정을 위해 국내외 독성자료를 확보하고 안전성에 대한 검토를 거쳐 ADI, NOAEL, 안전계수를 제시하였다. 식품섭취량, 국민평균 체중 등을 반영하여 노출평가를 수행하였고, 인체안전기준치인 ADI 대비 TMDI 값을 산출하여 위해평가를 수행하였다. 169종 중 166종 농약은 ADI 대비 TMDI가 80% 미만으로 안전한 수준으로 평가되었며, 옥사밀 등 3종은 80%가 넘어 재평가를 수행하여 일부기준을 삭제하였다. 또한, 신규농약인 테부플로퀸 등 15종은 원제의 일반독성, 유전독성, 발암성, 생식 및 기형독성, 대사 및 기타 독성 등 각 독성분야의 전문가들과 안전성을 검토하여 ADI를 결정하였다. 마지막으로 지방식약청과 시․도 보건환경연구원 및 국립농산물품질관리원 시험연구소 등 국가 잔류농약 검사기관을 대상으로 신속한 분석업무를 지원하기 위해 잔류농약 표준시약을 지원하였다. 이를 위해 ‘잔류농약데이터베이스’ 홈페이지를 활용하여 표준시약 현황을 수시로 업그레이드 하여 실시간 공유하였고, 온라인 접수를 통하여 신속하게 필요한 표준시약을 공유하였다. 36개 기관에서 표준품 지원 신청품목은 알드린 등 562종이었으며, 2,232건 지원을 완료하였다. 이는 각 기관에 신속히 농약 표준품을 지원하고 기관 간 분석오차를 줄여 우리나라 시험검사 시스템의 신뢰도를 높일 수 있었던 것으로 판단된다.

(출처 : 국문요약문 4P)

Abstract ▼

This study was conducted to ensure the safety of pesticide residue in food. To provide scientific evidence to support this claim. performing risk assessments to establish MRL and developing analytical method to confirm suitability of MRL were conducted. In addition, reagent share system was carried out to cut down national budget and to buildup rapid and efficient pesticide residue test among national inspection institutes. First of all, Analytical methods for newly registered 12 pesticides (benzovindiflupyr, cyclaniliprole, spiroxamine, isopetamid, tebufloquin, tolfenpyrad, tridemorph, fenoxasulfone, penflufen, florpyrauxifen-benzyl, picarbutrazox, pyflubumide) were developed. The developed methods of 12 newly registered pesticides were validated by the parameter such as linearity, specificity, limit of quantification, precision, and recovery in representative crops and completed inter-laboratory validation with regional MFDS (Seoul) and KAFRI(Korea Advanced Food Research Instiitude). Risk assessment was conducted to evaluate MRL proposals of 169 pesticides including isopetamid by reviewing the domestic and foreign toxic materials, providing ADI, NOAEL, aRfD, safety factor, performing exposure assessment based on national average weight, judging the safety by calculating ADI contrast TMDI percentage, and finally creating toxic profiles and updating.
In results of risk assessment, 166 kinds of pesticides have been assessed as safe. Pesticides standards were shared 2,232 species including Aldrin in the 36 national pesticide residue inspection institutes.

(출처 : Summary 5P)

목차 Contents

표지 ... 1
자체연구개발과제 최종보고서 ... 2
국문 요약문 ... 4
Summary ... 5
목차 ... 6
제1장 연구개발과제의 개요 ... 8
제1절 연구개발과제의 목표 ... 8
제2절 연구개발과제의 필요성 ... 9
제2장 연구개발과제의 국내·외 연구개발 현황 ... 14
제1절 국내 연구개발 현황 ... 14
제2절 국외 연구개발 현황 ... 24
제3장 연구개발과제의 연구수행 내용 및 결과 ... 31
제1절 잔류농약 시험법 확립 및 검증 ... 31
제2절 잔류농약 위해평가 ... 555
제3절 국가 잔류농약 표준품 지원 ... 622
제4장 연구개발과제의 연구결과 고찰 및 결론 ... 639
제1절 잔류농약 시험법 확립 ... 639
제2절 잔류농약 위해평가 ... 643
제3절 국가 잔류농약 표준품 지원 ... 643
제5장 연구개발과제의 목표달성도 및 관련분야에의 기여도 ... 644
제1절 목표달성도 ... 644
제2절 관련 분야에의 기여도 ... 645
제6장 연구개발과제의 연구개발 결과 활용계획 ... 646
제1절 활용성과 ... 646
제2절 활용계획 ... 646
제7장 참고문헌 ... 649
제8장 첨부서류 ... 651
끝페이지 ... 704

표/그림 (300)

표 Status of establishment of MRLs in livestocks
표 Validation parameters
표 Guidelines on method development of pesticide residue : fortification concentration and replication
표 Guidelines on method development of pesticide residue recovery and relative standard deviation
표 Guidelines on method development of pesticide residue : Limit of quantitation
표 Representative agricultural products for development of pesticide residue analytical method
표 Procedures for development of an analytical method for the determination of pesticide residue in agricultural products
표 식품의약품안전처 위해평가 관여 부서
표 Status of the pesticide standards sharing
표 일본의 위험 관리와 위험 평가 조직 구성도
표 Registration status and MRLs established by overseas countries of benzovindiflupyr
표 Molecular structure of benzovindiflupyr
표 Physicochemical characteristics of benzovindiflupyr
표 Scheme for preparing matrix-matched calibration standards
표 pKa graph of benzovindiflupyr
표 Comparisons of SPE cartridge for benzovindiflupyr
표 Effects of silica cartridge for benzovindiflupyr elution efficiency
표 Effects of silica cartridge for benzovindiflupyr elution efficiency
표 Comparisons of elution solvent ratio on benzovindiflupyr elution efficiency
표 Procedure of extraction for benzovindiflupyr analysis
표 Procedure of partition for benzovindiflupyr analysis
표 Procedure of purification for benzovindiflupyr analysis
표 Flow chart for benzovindiflupyr
표 Selected-ion of LC-MS/MS for benzovindiflupyr
표 LC-MS/MS chromatograms of benzovindiflupyr standard in mandarin matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of benzovindiflupyr standard in potato matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of benzovindiflupyr standard in pepper matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of benzovindiflupyr standard in soybean matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of benzovindiflupyr standard in huelled rice matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg and (G) 0.5 mg/kg
표 Matrix-matched calibration curves of corresponding to: benzovindiflupyr in (A) mandarin, (B) potato, (C) pepper, (D) soybean and (E) hulled rice
표 Validation results of analytical method for the determination of benzovindiflupyr residues in samples
표 Representative MRM(quantification ion) chromatograms of benzovindiflupyr corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of benzovindiflupyr corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of benzovindiflupyr corresponding to: (A) standard solution at 0.05 mg/kg, (B) pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of benzovindiflupyr corresponding to: (A) standard solution at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of benzovindiflupyr corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Analytical conditions for the determination of benzovindiflupyr
표 Selected-ion of LC-MS/MS for benzovindiflupyr
표 LC/MSMS Standard chromatograms of Benzovindiflupyr at (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg, and (G) 0.5 mg/kg
표 LC/MSMS Standard chromatograms of Benzovindiflupyr in Mandarine at (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg, and (G) 0.5 mg/kg
표 LC/MSMS Standard chromatograms of Benzovindiflupyr in Potato at (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg, and (G) 0.5 mg/kg
표 LC/MSMS Standard chromatograms of Benzovindiflupyr in Red pepper at (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg, and (G) 0.5 mg/kg
표 LC/MSMS Standard chromatograms of Benzovindiflupyr in Soybean at (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg, and (G) 0.5 mg/kg
표 LC/MSMS Standard chromatograms of Benzovindiflupyr in Hulled rice at (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg, and (G) 0.5 mg/kg
표 Calibration curves of matix matched standard of Benzovindiflupyr in (A) Mandarin, (B) Potato, (C) Red pepper, (D) Soybean and (E) Hulled rice
표 Recoveries of fortied Benzovindiflupyr in samples
표 Representative MRM(quantification ion) chromatograms of Benzovindiflupyr corresponding to: (A) standard solution at 0.05 mg/kg, (B) Tangerine control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of Benzovindiflupyr corresponding to: (A) standard solution at 0.05 mg/kg, (B) Potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of Benzovindiflupyr corresponding to: (A) standard solution at 0.05 mg/kg, (B) Red pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of Benzovindiflupyr corresponding to: (A) standard solution at 0.05 mg/kg, (B) Soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of Benzovindiflupyr corresponding to: (A) standard solution at 0.05 mg/kg, (B) Hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Validation results of Benzovindiflupyr
표 Inter-laboratory validation results of analytical method for cyclaniliprole in samples
표 Proposed metabolic pathways of cyclaniliprole in plant
표 Registration status and MRLs established by overseas countries of cyclaniliprole
표 Molecular structure of cyclaniliprole and NK-1375
표 Physicochemical characteristics of cyclaniliprole
표 Scheme for preparing matrix-matched calibration standards
표 Extraction efficiency of acetonitrile for cyclaniliprole and NK-1375 analysis
표 Effects of pH for cyclaniliprole and NK-1375 partition efficiency in soybean sample
표 Effects of hydration time for cyclaniliprole and NK-1375 extraction efficiency in soybean sample
표 pKa graph of cyclaniliprole
표 Comparisons of SPE cartridge for cyclaniliprole and NK-1375 analysis
표 Comparisons of elution solvent ratio on cyclaniliprole and NK-1375 elution efficiency
표 Procedure of extraction for cyclaniliprole and NK-1375 analysis
표 Procedure of partition for cyclaniliprole and NK-1375 analysis
표 Procedure of purification for cyclaniliprole and NK-1375 analysis
표 Flow chart for cyclaniliprole and NK-1375 analysis
표 Spectrum of (A) cyclaniliprole and (B) NK-1375
표 LC-UVD chromatogram of cyclaniliprole and NK-1375 in agricultural products
표 Analytical conditions for the determination of cyclaniliprole and NK-1375
표 Selected-ion of LC-MS/MS for cyclaniliprole and NK-1375
표 LC-MS/MS chromatograms of cyclaniliprole standard in mandarin matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of cyclaniliprole standard in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of cyclaniliprole standard in pepper matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of cyclaniliprole standard in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of cyclaniliprole standard in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of NK-1375 standard in mandarin matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of NK-1375 standard in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of NK-1375 standard in pepper matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of NK-1375 standard in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of NK-1375 standard in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 Matrix-matched calibration curves of cyclaniliprole(1) and NK-1375(2) corresponding to: (A) mandarin, (B) potato, (C) pepper, (D) soybean and (E) hulled rice
표 Validation results of analytical method for the determination of cyclaniliprole and NK-1375 residues in samples
표 Representative MRM(quantification ion) chromatograms of cyclaniliprole corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of cyclaniliprole corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of cyclaniliprole corresponding to: (A) standard solution at 0.05 mg/kg, (B) pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of cyclaniliprole corresponding to: (A) standard solution at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of cyclaniliprole corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of NK-1375 corresponding to: (A) standard solution at 1 mg/kg, (B) mandarin control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of NK-1375 corresponding to: (A) standard solution at 1 mg/kg, (B) potato control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of NK-1375 corresponding to: (A) standard solution at 1 mg/kg, (B) pepper control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of NK-1375 corresponding to: (A) standard solution at 1 mg/kg, (B) soybean control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of NK-13751 corresponding to: (A) standard solution at 1 mg/kg, (B) hulled rice control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Analytical conditions for the determination of cyclaniliprole and NK-1375
표 Selected-ion of LC-MS/MS for cyclaniliprole and NK-1375
표 LC-MS/MS chromatograms of Cyclaniliprole standard in mandarin matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of Cyclaniliprole standard in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of Cyclaniliprole stnadard in pepper matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of Cyclaniliprole standard in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of Cyclaniliprole standard in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of NK-1375 Standard in mandarin matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of NK-1375 standard in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of NK-1375 standard in pepper matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of NK-1375 standard in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of NK-1375 standard in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 Calibration curves of matix matched standard of cyclaniliprole and NK-1375 in (A) mandarin, (B) potato, (C) pepper, (D) soybean and (E) hulled rice
표 Validation results of analytical method for the determination of cyclaniliprole and NK-1375 residues in samples
표 Representative MRM(quantification ion) chromatograms of Cyclaniliprole corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of Cyclaniliprole corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of Cyclaniliprole corresponding to: (A) standard solution at 0.05 mg/kg, (B) pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of Cyclaniliprole corresponding to: (A) standard solution at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of Cyclaniliprole corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of NK-1375 corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of NK-1375 corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of NK-1375 corresponding to: (A) standard solution at 0.05 mg/kg, (B) pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of NK-1375 corresponding to: (A) standard solution at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of NK-1375 corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Validation results of Cyclaniliprole과 NK-1375
표 Inter-laboratory validation results of analytical method for cyclaniliprole in samples
표 Inter-laboratory validation results of analytical method for NK-1375 in samples
표 Registration status and MRLs established by overseas countries of spiroxamine
표 Molecular structure of spiroxamine
표 Physicochemical characteristics of spiroxamine
표 Scheme for preparing matrix-matched calibration standards
표 pKa graph of spiroxamine
표 Comparisons of SPE cartridge for spiroxamine analysis
표 Comparisons of SPE cartridge for spiroxamine analysis
표 Effects of pH for spiroxamine partition efficiency in mandarin sample
표 Comparisons of elution solvents for spiroxamine analysis
표 Comparisions of solvent ratio on spiroxamine elution efficiency
표 Procedure of extraction for spiroxamine analysis
표 Procedure of partition for spiroxamine analysis
표 Procedure of purification for spiroxamine analysis
표 Flow chart for spiroxamine
표 Analytical conditions for the determination of spiroxamine
표 Selected-ion of LC-MS/MS for spiroxamine
표 LC-MS/MS chromatograms of spiroxamine standards in mandarin matrix (A) 0.0005 mg/kg, (B) 0.001 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of spiroxamine standards in potato matrix (A) 0.0005 mg/kg, (B) 0.001 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of spiroxamine standards in pepper matrix (A) 0.0005 mg/kg, (B) 0.001 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of spiroxamine standards in soybean matrix (A) 0.0005 mg/kg, (B) 0.001 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 LC-MS/MS chromatograms of spiroxamine standards in hulled rice matrix (A) 0.0005 mg/kg, (B) 0.001 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg and (G) 0.1 mg/kg
표 Matrix-matched calibration curves of spiroxamine corresponding to: (A) mandarin, (B) potato, (C) pepper, (D) soybean and (E) hulled rice
표 Validation results of analytical method for the determination of spiroxamine residue in samples
표 Representative MRM(quantification ion) chromatograms of spiroxamine corresponding to: (A) standard solution at 0.01 mg/kg, (B) mandarin control, (C) spiked at 0.001 mg/kg, (D) spiked at 0.01 mg/kg and (E) spiked at 0.05 mg/kg
표 Representative MRM(quantification ion) chromatograms of spiroxamine corresponding to: (A) standard solution at 0.01 mg/kg, (B) potato control, (C) spiked at 0.001 mg/kg, (D) spiked at 0.01 mg/kg and (E) spiked at 0.05 mg/kg
표 Representative MRM(quantification ion) chromatograms of spiroxamine corresponding
표 Representative MRM(quantification ion) chromatograms of spiroxamine corresponding to: (A) standard solution at 0.01 mg/kg, (B) soybean control, (C) spiked at 0.001 mg/kg, (D) spiked at 0.01 mg/kg and (E) spiked at 0.05 mg/kg
표 Representative MRM(quantification ion) chromatograms of spiroxamine corresponding to: (A) standard solution at 0.01 mg/kg, (B) hulled rice control, (C) spiked at 0.001 mg/kg, (D) spiked at 0.01 mg/kg and (E) spiked at 0.05 mg/kg
표 Molecular structure of isofetamid and its metabolite GPTC
표 Physicochemical characteristics of isofetamid and GPTC
표 Comparison of SPE cartridges and elution solvents for isofetamid and GPTC analysis
표 Procedure of partition for isofetamid and GPTC analysis
표 Procedure of purification for isofetamid and GPTC analysis
표 Flow chart for isofetamid and its metabolite GPTC
표 Analytical conditions for the determination of isofetamid and GPTC
표 Selected-ion of LC-MS/MS for isofetamid and GPTC
표 LC-MS/MS MRM chromatograms of isofetamid standard in pepper matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid standard in mandarin matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid standard in potato matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid standard in soybean matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid standard in hulled rice matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC standard in pepper matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC standard in mandarin matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC standard in potato matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC standard in soybean matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC standard in hulled rice matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 Calibration curve of matrix matched standard of A, isofetamid; B, GPTC in 1, pepper; 2, mandarin, 3, potato; 4, soybean; 5, hulled rice
표 Validation results of analytical method for the determination of isofetamid and its metabolite GPTC residues in food samples
표 LC-MS/MS MRM chromatograms of isofetamid in pepper matrix (A) standard at 0.5 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid in mandarin matrix (A) standard at 0.5 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid in potato matrix (A) standard at 0.5 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid in soybean matrix (A) standard at 0.5 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid in hulled rice matrix (A) standard at 0.5 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC in pepper matrix (A) standard at 0.5 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC in mandarin matrix (A) standard at 0.5 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC in potato matrix (A) standard at 0.5 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC in soybean matrix (A) standard at 0.5 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC in hulled rice matrix (A) standard at 0.5 mg/kg, (B) control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Analytical conditions for the determination of isofetamid and GPTC
표 Selected-ion of LC-MS/MS for isofetamid and GPTC
표 LC-MS/MS MRM chromatograms of isofetamid standard in pepper matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid standard in mandarin matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid standard in potato matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid standard in soybean matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of isofetamid standard in hulled rice matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC standard in mandarin matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC standard in potato matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC standard in soybean matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 LC-MS/MS MRM chromatograms of GPTC standard in hulled rice matrix (A) 0.001 mg/kg, (B) 0.002 mg/kg, (C) 0.005 mg/kg, (D) 0.01 mg/kg, (E) 0.02 mg/kg, (F) 0.05 mg/kg, and (G) 0.1 mg/kg
표 Validation results of analytical method for the determination of Isofetamid and GPTC residues in samples
표 MRM (quantification ion) chromatogram of (A) Isofetamid standard in Pepper matrix at 0.05 mg/kg, (B) Pepper control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 MRM (quantification ion) chromatogram of (A) Isofetamid standard in mandarin matrix at 0.05 mg/kg, (B) Apple control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 MRM (quantification ion) chromatogram of (A) Isofetamid standard in Potato matrix at 0.05 mg/kg, (B) Potato control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 MRM (quantification ion) chromatogram of (A) Isofetamid standard in soybean matrix at 0.05 mg/kg, (B) Potato control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 MRM (quantification ion) chromatogram of (A) Isofetamid standard in Hulled Rice matrix at 0.05 mg/kg, (B) Hulled Rice control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 MRM (quantification ion) chromatogram of (A) GPTC standard in Pepper matrix at 0.05 mg/kg, (B) Pepper control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 MRM (quantification ion) chromatogram of (A) GPTC standard in mandarin matrix at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 MRM (quantification ion) chromatogram of (A) GPTC standard in Potato matrix at 0.05 mg/kg, (B) Potato control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 MRM (quantification ion) chromatogram of (A) GPTC standard in soybean matrix at 0.05 mg/kg, (B) Apple control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 MRM (quantification ion) chromatogram of (A) GPTC standard in Hulled Rice matrix at 0.05 mg/kg, (B) Hulled Rice control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Validation results of Isofetamid와 GPTC
표 Inter-laboratory validation results of analytical method for isofetamid in samples
표 Inter-laboratory validation results of analytical method for GPTC in samples
표 Registration status and MRLs established by overseas countries of tebufloquin
표 Proposed metabolic pathways of tebufloquin in rice plant
표 Molecular structure of tebufloquin and tebufloquin M1
표 Physicochemical characteristics of tebufloquin and tebufloquin M1
표 Scheme for preparing matrix-matched calibration standards
표 pKa graph of (A) tebufloquin and (B) tebufloquin M1
표 Comparisons of SPE cartridge for tebufloquin and tebufloquin M1 analysis
표 Comparisons of elution solvents for tebufloquin and tebufloquin M1 analysis
표 Effects of C18 cartridge on tebufloquin and tebufloquin M1 elution efficiency
표 Comparisons of solvent ratio on tebufloquin and tebufloquin M1 elution efficiency
표 Procedure of extraction for tebufloquin and tebufloquin M1 analysis
표 Procedure of partition for tebufloquin and tebufloquin M1 analysis
표 Procedure of purification for tebufloquin and tebufloquin M1 analysis
표 Flow chart for tebufloquin and tebufloquin M1
표 LC-UVD spectrum of (A) tebufloquin and (B) tebufloquin M1
표 LC-UVD chromatogram corresponding to (A) standard solution at 0.5 mg/kg, (B) control mandarin, and (C) spiked at 0.5 mg/kg
표 Analytical conditions for the determination of tebufloquin and tebufloquin M1
표 Selected-ion of LC-MS/MS for tebufloquin and tebufloquin M1
표 LC-MS/MS chromatograms of tebufloquin standard in mandarin matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of tebufloquin standard in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of tebufloquin standard in pepper matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of tebufloquin standard in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of tebufloquin standard in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of tebufloquin M1 standard in mandarin matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of tebufloquin M1 standard in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of tebufloquin M1 standard in pepper matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of tebufloquin M1 standard in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 LC-MS/MS chromatograms of tebufloquin M1 standard in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg and (G) 0.5 mg/kg
표 Matrix-matched calibration curves of corresponding to: (1) tebufloquin and (2) tebufloquin M1 in (A) mandarin, (B) potato, (C) pepper, (D) soybean and (E) hulled rice
표 Validation results of analytical method for the determination of tebufloquin and tebufloquin M1 residues in samples
표 Representative MRM(quantification ion) chromatograms of tebufloquin corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of tebufloquin corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of tebufloquin corresponding to: (A) standard solution at 0.05 mg/kg, (B) pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of tebufloquin corresponding to: (A) standard solution at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of tebufloquin corresponding to: (A) standard solution at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of tebufloquin M1 corresponding to: (A) standard solution at 1 mg/kg, (B) mandarin control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of tebufloquin M1 corresponding to: (A) standard solution at 1 mg/kg, (B) potato control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of tebufloquin M1 corresponding to: (A) standard solution at 1 mg/kg, (B) pepper control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of tebufloquin M1 corresponding to: (A) standard solution at 1 mg/kg, (B) soybean control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Representative MRM(quantification ion) chromatograms of tebufloquin M1 corresponding to: (A) standard solution at 1 mg/kg, (B) hulled rice control, (C) spiked at 0.01 mg/kg, (D) spiked at 0.1 mg/kg and (E) spiked at 0.5 mg/kg
표 Analytical conditions for the determination of Tebufloquin and Tebufloquin M1
표 Selected-ion LC-MSMS for Tebufloquin and Tebufloquin M1
표 LC-MS/MS MRM chromatograms of Tebufloquin standard in mandarin matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of Tebufloquin standard in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of Tebufloquin standard in pepper matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of Tebufloquin standard in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of Tebufloquin standard in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of Tebufloquin M1 standard in mandarin matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of Tebufloquin M1 standard in potato matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of Tebufloquin M1 standard in pepper matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of Tebufloquin M1 standard in soybean matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 LC-MS/MS MRM chromatograms of Tebufloquin M1 standard in hulled rice matrix (A) 0.005 mg/kg, (B) 0.01 mg/kg, (C) 0.02 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.2 mg/kg, and (G) 0.5 mg/kg
표 Calibration curves of Tebufloquin and Tebufloiquin M1 by matrix (A) mandarin, (B) potato, (C) pepper, (D) soybean and (E) hulled rice
표 Validation results of analytical method for the determination of Tebufloquin and Tebufloiquin M1 in samples
표 MRM (quantification ion) chromatograms of (A) Tebufloquin standard in mandarin matrix at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 MRM (quantification ion) chromatograms of (A) Tebufloquin standard in potato matrix at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 MRM (quantification ion) chromatograms of (A) Tebufloquin standard in pepper matrix at 0.05 mg/kg, (B) pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 MRM (quantification ion) chromatograms of (A) Tebufloquin standard in soybean matrix at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 MRM (quantification ion) chromatograms of (A) Tebufloquin standard in hulled rice matrix at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 MRM (quantification ion) chromatograms of (A) Tebufloquin M1 standard in mandarin matrix at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 MRM (quantification ion) chromatograms of (A) Tebufloquin M1 standard in potato matrix at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 MRM (quantification ion) chromatograms of (A) Tebufloquin M1 standard in pepper matrix at 0.05 mg/kg, (B) pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 MRM (quantification ion) chromatograms of (A) Tebufloquin M1 standard in soybean matrix at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 MRM (quantification ion) chromatograms of (A) Tebufloquin M1 standard in hulled rice matrix at 0.05 mg/kg, (B) hulled rice control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Validation results of Tebufloquin과 Tebufloquin M1
표 Inter-laboratory validation results of analytical method for tebufloquin in samples
표 Inter-laboratory validation results of analytical method for tebufloquin M1 in samples
표 Proposed metabolic pathways of tolfenpyrad in plant
표 Registration status and MRLs established by overseas countries of tolfenpyrad
표 Molecular structure of tolfenpyrad
표 Physicochemical characteristics of tolfenpyrad
표 Scheme for preparing matrix-matched calibration standards
표 pKa graph of tolfenpyrad
표 Comparisons of SPE cartridge for tolfenpyrad analysis
표 Comparisons of elution solvent ratio on tolfenpyrad elution efficiency
표 Comparisons of SPE cartridge for tolfenpyrad analysis
표 Comparisons of elution solvent ratio on tolfenpyrad elution efficiency
표 Procedure of extraction for tolfenpyrad analysis
표 Procedure of partition for tolfenpyrad analysis
표 Procedure of purification for tolfenpyrad analysis
표 Flow chart for tolfenpyrad
표 Spectrum of tolfenpyrad
표 Analytical conditions for the determination of tolfenpyrad
표 Selected-ion of LC-MS/MS for tolfenpyrad
표 LC-MS/MS chromatograms of tolfenpyrad standard in mandarin matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of tolfenpyrad standard in potato matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of tolfenpyrad standard in pepper matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of tolfenpyrad standard in soybean matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of tolfenpyrad standard in huelled rice matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg
표 LC-MS/MS chromatograms of tolfenpyrad standard in alomond matrix (A) 0.001 mg/kg, (B) 0.005 mg/kg, (C) 0.01 mg/kg, (D) 0.05 mg/kg, (E) 0.1 mg/kg, (F) 0.25 mg/kg
표 Matrix-matched calibration curves of corresponding to: tolfenpyrad in (A) mandarin, (B) potato, (C) pepper, (D) soybean, (E) hulled rice and (F) almond
표 Validation results of analytical method for the determination of tolfenpyrad residues in samples
표 Representative MRM(quantification ion) chromatograms of tolfenpyrad corresponding to: (A) standard solution at 0.05 mg/kg, (B) mandarin control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of tolfenpyrad corresponding to: (A) standard solution at 0.05 mg/kg, (B) potato control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of tolfenpyrad corresponding to: (A) standard solution at 0.05 mg/kg, (B) pepper control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg
표 Representative MRM(quantification ion) chromatograms of tolfenpyrad corresponding to: (A) standard solution at 0.05 mg/kg, (B) soybean control, (C) spiked at 0.005 mg/kg, (D) spiked at 0.05 mg/kg and (E) spiked at 0.25 mg/kg

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2016년 식품 중 잔류농약 위해평가 등을 통한 안전관리 연구
Study on Safety Management by Risk Assessment of Pesticide Residues in Foods - 2016 원문보기

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2016년 식품 중 잔류농약 위해평가 등을 통한 안전관리 연구 Study on Safety Management by Risk Assessment of Pesticide Residues in Foods - 2016 원문보기

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