Abstract ▼

Purpose&contents
The present research aims to develop single/multi-physical stimuli cell culture platforms based on multi-scale polymer processing and microfluidic technologies for improvement of mesenchymnal stem cell proliferation/differentiation through optimizing the multi-physical stimuli. W

Purpose&contents
The present research aims to develop single/multi-physical stimuli cell culture platforms based on multi-scale polymer processing and microfluidic technologies for improvement of mesenchymnal stem cell proliferation/differentiation through optimizing the multi-physical stimuli. We aslo investigate the possibility of the mass production of the cell culture platforms.
▶ Develop single physical stimuli gradient cell culture platforms to enhance the proliferation/differentiation of mesenchymal stem cells
▶ Develop multi physical stimuli gradient cell culture platforms to enhance the proliferation/differentiation of mesenchymal stem cells
▶ Develop standard physical stimuli cell culture platforms and establish the mass production techniques

Result
▶ Develop single physical stimuli gradient cell culture platforms to enhance the proliferation/differentiation of mesenchymal stem cells
• Develop step-gradient surface stimuli cell culture platform
• Develop step-gradient geometric stimuli cell culture platform
• Develope continuouss gradient shear stress stimuli cell culture platform
• Establish cell culture conditions on the single physical stimuli gradient platforms
• Suggest optimized physical stimuli for proliferation/differentiation of mesenchymal stem cells on the single physical stimuli gradient cell culture platforms

▶ Develop multi physical stimuli gradient cell culture platforms to enhance the proliferation/differentiation of mesenchymal stem cells
• Develop multi (double) physical stimuli gradient cell culture platforms
• Develop multi (triple) physical stimuli gradient cell culture platforms
• Establish cell culture conditions on the multi physical stimuli gradient platforms
• Suggest optimized physical stimuli for proliferation/differentiation of mesenchymal stem cells on the multi physical stimuli gradient cell culture platforms

▶ Develop standard physical stimuli cell culture platforms and establish the mass production techniques
• Establish the mass production techniques for the single/multi physical stimuli platforms based on the optimized physical stimuli
• Establish standard physical cell culture platforms and evaluate the proliferation/differentiation of mesenchymal stem cells

Expected Contribution
- Become a pioneer in the field of stem cell research by developing multi physical stimuli cell culture platform for studying mechanotransduction
- Suggest a new standard physical stimuli cell culture platform to the stem cell research field by optimizing the single/multi-physical stimuli that enhances the proliferation/differentiation of stem cells
- Standardize the physical stimuli cell culture platform by developing the mass production techniques
- Influence the research field and industry field by developing various polymer molding techniques
- Obtain patent and transfer of technical know-how about new concepts and fabrication techniques of the developed cell culture platform
- Train highly educated people whose experts in converged research field

( 출처 : SUMMARY 5p )

목차 Contents

• 표지 ... 1
• 목차 ... 2
• 연구계획 요약문 ... 3
• 연구결과 요약문 ... 4
• 한글요약문 ... 4
• SUMMARY ... 5
• 연구내용 및 결과 ... 6
• 1. 연구개발과제의 개요 ... 6
• 2. 국내외 기술개발 현황 ... 8
• 3. 연구수행 내용 및 결과 ... 13
• 4. 목표달성도 및 관련분야에의 기여도 ... 85
• 5. 연구결과의 활용계획 ... 91
• 6. 연구과정에서 수집한 해외 과학기술정보 ... 92
• 7. 주관연구책임자 대표적 연구실적 ... 93
• 8. 참고문헌 ... 94
• 9. 연구성과 ... 96
• 10. 국가과학기술지식정보서비스에 등록한 연구시설‧장비 현황 ... 119
• 11. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 119
• 12. 기타사항 ... 121
• 별첨1 대 표 연 구 실 적 ... 122
• 별첨2 세부 목표 관련 증빙 ... 137
• 끝페이지 ... 182