Abstract ▼

Purpose& contents
This study aims to identify the function of SREBP-1 in inflammation-mediated metabolic disease and to characterize the regulatory mechanism of metabolic disease using SREBP-1a deficient and SREBP-1c knockout mice. This research will suggest basic information for the discovery of

Purpose& contents
This study aims to identify the function of SREBP-1 in inflammation-mediated metabolic disease and to characterize the regulatory mechanism of metabolic disease using SREBP-1a deficient and SREBP-1c knockout mice. This research will suggest basic information for the discovery of therapeutic medicine to treat chronic metabolic disease and the development of metabolic disease by diet-induced inflammation.

Result
[1st year]
Functional characterization of SREBP-1a and SREBP-1c involved in inflammation in macrophages
• Inflammatory response from bone marrow of SREBP-1a DF and SREBP-1c KO mice
• Identification of cellular metabolic change and inflammation-mediated expression level of SREBP-1a and SREBP-1c genes
• Regulatory mechanism of SREBP-1 processing induced by inflammation in macrophages
• Identification of target genes related to SREBP-1 processing by LPS treatment in bone marrow-derived macrophages

[2nd year]
Identification of tergat gene of inflammation-mediated SREBP-1 and functional study in macrophages
• Identification of target genes of SREBP-1 in SREBP-1a deficient macrophages
• Comparison of inflammation induced by LPS in both SREBP-1a DF and SREBP-1c KO macrophages
• Identification of target gene, KLF6 of SREBP-1 in macrophages
• Regulatory mechanism of inflammatory response by corosolic acid in macrophages
• Characterization of new target genes involved in metaflammation and SREBP-1 gene expression in liver and macrophage of IDH2 knockout mice

[3차년도]
Contral stratagy and regulatory mechanism of metabolammation induced by SREBP-1 in diet-mediated obesity animal model
• Investigation of cellular metabolic change and inflammation in high fat/high sucrose diet-mediated obese mice
• Functional study of transcriptional network and regulatory mechanism of metabolism by key transcription factors in lipid metabolism and immune system
• Regulatory mechanism of mTOR-induced autophagy in macrophages
• Regulatory mechanism of inflammation by IDH2 in macrophages

Expected Contribution
1) The studies planned in this project with a new animal model will provide insight into how inflammation drive metabolic syndrome
2) The studies establish of effective therapeutic strategies through regulation of SREBP-1a in metabolic syndrome.
3) As finding new therapeutic target for metabolic disease, it will suggest information for the general health and long term economic stability of Country and Mankind moving forward.

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 목차 ... 2
• 연구계획 요약문 ... 3
• 연구결과 요약문 ... 4
• 한글요약문 ... 4
• SUMMARY ... 5
• 연구내용 및 결과 ... 6
• 1. 연구개발과제의 개요 ... 6
• 2. 국내외 기술개발 현황 ... 10
• 3. 연구수행 내용 및 결과 ... 10
• 4. 목표달성도 및 관련분야에의 기여도 ... 23
• 5. 연구결과의 활용계획 ... 25
• 6. 연구과정에서 수집한 해외 과학기술정보 ... 26
• 7. 참고문헌 ... 26
• 8. 연구성과 ... 27
• 9. 국가과학기술지식정보서비스에 등록한 연구시설‧장비 현황 ... 28
• 10. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 28
• 11. 기타사항 ... 28
• 끝페이지 ... 28