초록 ▼

본 사업단은 경희대학교 치과대학, 약학대학, 의과대학의 융합연구를 통하여 부정교합 환자의 3차원 진단정보를 통해 정상 교합위치에 도달하기 위한 4차원 역치료계획시스템을 개발하는데 있음. 이 같은 교정치료계획시스템은 교정력에만 의존하는 기존 교정치료에 치아이동방향과 속도를 조절하고, 치주조직 재생과 항균작용을 하는 약물을 선택적으로 전달하는 방법을 병행하여 교정기간과 부작용을 최소화하는 하이브리드 방식의 교정치료시스템으로 개발된 하이브리드 4차원 교정치료시스템을 이용한 부정교합 치료과정에서 얻어지는 대량의 정량적 파라미터들을 효율적으

본 사업단은 경희대학교 치과대학, 약학대학, 의과대학의 융합연구를 통하여 부정교합 환자의 3차원 진단정보를 통해 정상 교합위치에 도달하기 위한 4차원 역치료계획시스템을 개발하는데 있음. 이 같은 교정치료계획시스템은 교정력에만 의존하는 기존 교정치료에 치아이동방향과 속도를 조절하고, 치주조직 재생과 항균작용을 하는 약물을 선택적으로 전달하는 방법을 병행하여 교정기간과 부작용을 최소화하는 하이브리드 방식의 교정치료시스템으로 개발된 하이브리드 4차원 교정치료시스템을 이용한 부정교합 치료과정에서 얻어지는 대량의 정량적 파라미터들을 효율적으로 데이터베이스화하고, 교정치료의 규격화 및 최적화를 하기 위한 교정치료 프로토콜의 개발하고자 함. 교정치료 전후에 측모두부방사선사진과 Morpheus 3D를 촬영하여 세계 최초로 치아의 2차원적인 움직임과 입술 주위 연조직의 3차원적인 움직임을 개발하였고 개발된 치아 이동 촉진용 제제의 in vivo 평가법의 개발은 새로운 치과용 제제 평가 툴을 제공했다는 점에서 향후 치과용 의약품의 평가에 폭넓게 활용될 수 있을 전망이며 컴퓨터상에서 개발된 알고리즘과 개발된 로드셀 기반의 교정력측정장치는 치과는 물론 타 분야에 폭넓게 활용될 수 있을 것으로 전망됨.

(출처 : 요약서 3p)

Abstract ▼

The aim of this work was to develop the hybrid 4D orthodontic treatment system for high-speed orthodontic treatment. The finding showed that Corticision and Piezopuncture which are individually customized tooth movement techniques for the first time in the world and announced that Corticision is eff

The aim of this work was to develop the hybrid 4D orthodontic treatment system for high-speed orthodontic treatment. The finding showed that Corticision and Piezopuncture which are individually customized tooth movement techniques for the first time in the world and announced that Corticision is effective method for accelerating orthodontic tooth movement. Trademark rights of Corticision was applied and registered based on established basic researches and clinical applications. Because Corticision with blade artificially damages gingiva and cortical bone and causes bleeding and repulsion of patients, we suggested and studied Piezopuncture procedure with piezosurgical device instead of blade for the first time in the world. Found that orthodontic tooth movement of Beagle dog applied piezosurgical stimulation is accelerated. Since the velocity of anterior teeth retraction is important for the bialveolar protrusion common in Asians, we studied the effect of application of PBM on the velocity of anterior teeth en masse retraction for the first time in the world. As a result, we found about 60% increase in the velocity of anterior teeth retraction. It revealed that company's manufacturing methods give more influence on the difference of surface roughness of brackets than raw material of brackets after analysis using an AFM for the first time in the world. It revealed that more surface roughness changes were found on orthodontic wires than brackets after rubbing wires in brackets experimentally, based on comparison of the surface roughness among them using an AFM. Researches on the movement of 2D tooth movement on lateral cephalometric X-ray and 3D soft tissue movement on Morpheus 3D around the lips before and after orthodontic treatment were conducted for the first time in the world. 3D assessment of alteration of tooth, hard tissue (CBCT) and soft tissue (facial scanner) after mandibular orthognathic surgery was firstly performed at the same time in the world. After mandibular orthognathic surgery, the mandible anteroposteriorly retracted 5.8mm from menton and horizontally transferred 2.54mm on average to nonworking side and vertically moved 1.64mm on average to upper side. Taking together, after mandibular retraction surgery, the horizontal transfer ratio of soft tissue showed tendency to increase from lips to end of chin and the vertical transfer ratio was similar. We compared tooth movement velocity between Beagle with tablet-formed L-thyroxine and control. As a result, the group with I pd. attachment showed 20% increase in tooth movement. We identified dental cytokinetic drug candidates to facilitate tooth movement through screening of 56 natural single compounds with known chemical structure by the ability to induce osteoblatic cell differentiation in MC3T3-E1 cell line. As a result, ginsenoside Re, Rh2 and Rd were found to enhance mineralization and differentiation of osteoblastic cells. The effect of Red ginseng extract, which contains the found candidates in great amount, in facilitation of tooth movement was evaluated in vivo. Additionally, we evaluated the osteoblast differentiation-enhancing effects of nectandrine A and lyoniside and identified related mechanism. Furthermore, we developed the biocompatible sustained drug delivery system with L-thyroxine as a medicine preparation for tooth movement facilitation. We established evaluation method in vivo for in vivo function study of L-thyroxine sustained release prepartion. This evaluation method can also be used as a novel evaluation tool for orthodentic medicines. These results are expected to contribute to high speed orthodontics and increased success rate of orthodontics. We developed the initial orthodontic force measurement device for evaluating the orthodontic force according to the orthodontic appliances. This device was upgraded loadcell-embedded orthodontic force measurement device and was evaluated by three malocclusion classes. Finally, we developed the semi-automatic orthodontic force measurement device with microsyringe pump and two real-time digital camera devices. These devices gave the detailed information about the orthodontic tooth movement according to three malocclusion classes. Furthermore, we developed real-time orthodontic force measurement device using the tooth movement and wire reaction through electrodynamics on a wax-embedded Typodont system for measuring 3D orthodontic force. We made the optimization program of an archwire shape expected after orthodontic treatment through the dental tooth segmentation method from malocclusion CT images. We developed the 3D image reconstruction, the finite element method from 3D CT image, and CT image calibration method. Based on these methods, we constructed the mechanical finite element analytic model based on 3-point bending on three tooth, and setup the boundary condition and analyzed the degree-of-freedom analysis through measuring the wire reaction.

After developing the inverse orthodontic treatment system, first part and third part will collaborate in conducting pre-clinical tests. 3D assessment data of facial soft tissue after orthodontic treatment using anatomic landmarks on 3D scanning images will provide 3D images to the company for more accurate simulation for therapy. 3D assessment of alteration of tooth, hard tissue (CBCT) and soft tissue (facial scanner) after mandibular orthognathic surgery were performed at the same time. Further study for the 3D changes of hard and soft tissue of orthognathic surgery patient will be performed at the same time. In addition, by providing these results to the 3D soft tissue analysis program and retro orthodontic treatment plan system, accurate 3D simulation before orthognathic surgery will be applicable. Our results could contribute to high-speed orthodontics based on improved patient compliance, and decreased medical cost based on high-speed orthodontics. Our results could contribute to the innovative shorten of orthodontic treatment period, and decrease of pain, side effect, and cost to patients through optimal treatment process. Also, it could contribute to high value-added industrial growth through technology transfer of inverse treatment planning system including optimization algorithm in several dental treatment.

(출처 : SUMMARY 6p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 요 약 문 ... 4
• SUMMARY ... 6
• CONTENTS ... 8
• 목차 ... 10
• 제1장 연구개발과제의 개요 ... 12
• 제1절 연구개발의 목적 ... 12
• 제2절 연구개발의 필요성 ... 13
• 제3절 연구개발대상 기술의 경제적, 산업적 중요성 ... 17
• 제2장 국내외 기술개발 현황 ... 22
• 제1절 교정치료에 따른 연조직의 변화 ... 22
• 제2절 교정치료시 치아 이동에 따른 연조직의 변화에 대한 연구 ... 25
• 제3절 교정치료시 사용되는 여러 종류의 브라켓 슬롯과 호선의 표면 조도 ... 26
• 제4절 교정적 치아이동 속도를 가속화시키기 위한 개별 치아 선택성 약물 및 기술(술식) ... 26
• 제5절 치아이동 속도 조절을 위한 약물전달체 ... 29
• 제6절 치아이동 속도 조절을 위한 약물전달체의 연구개발 실적 ... 31
• 제7절 치료계획시스템 ... 37
• 제8절 교정력측정장치 ... 37
• 제3장 연구개발수행 내용 및 결과 ... 41
• 제1절 4차원 교정치료시스템을 위한 임상 프로토콜 구성 ... 41
• 제2절 교정치료 전후의 치아 경조직과 안면 연조직의 3차원적인 변화에 대한 연구 ... 58
• 제3절 교정적 치아이동 촉진을 위한 맞춤형 기술(술식)의 상용화 및 맞춤형 약물전달시스템 연구 ... 62
• 제4절 개별 치아 맞춤형 약물전달시스템의 개발 ... 67
• 제5절 하이브리드 4차원 교정치료계획시스템 개발 ... 110
• 제4장 목표달성도 및 관련분야에의 기여도 ... 213
• 제1절 4차원 하이브리드 교정치료시스템용 임상 프로토콜 개발 ... 213
• 제2절 개별 치아 맞춤형 약물전달시스템의 개발 ... 214
• 제3절 하이브리드 4차원 교정치료계획시스템 개발 ... 214
• 제5장 연구개발결과의 활용계획 ... 216
• 제1절 연구개발결과 활용 방안 ... 216
• 제2절 기대성과 ... 218
• 제6장 연구개발과정에서 수집한 해외과학기술정보 ... 221
• 제1절 교정치료시스템 ... 221
• 제2절 약물전달시스템 ... 222
• 제3절 인비절라인(Invisalign)과 인코그니토(Incognito) ... 223
• 제7장 연구시설ㆍ장비 현황 ... 226
• 제1절 전산모사용클러스터시스템 ... 226
• 제2절 Workstation Computer ... 226
• 제8장 참고문헌 ... 226
• 끝페이지 ... 226