[보고서]더덕을 이용한 폐질환개선 및 면역증강 기능식품 소재개발

박홍제

보고서 정보

주관연구기관

제니스

연구책임자

박홍제

참여연구자

김병극 , 김규태 , 곽경숙 , 이지연 , 김진우 , 김인환 , 이호우 , 김태연 , 정위생 , 김대익 , 이진상 , 도은주 , 윤종국 , 권형민 , 김양희 , 한길환

보고서유형

최종보고서

발행국가

대한민국

언어

한국어

발행년월

2013-11

과제시작연도

2012

주관부처

중소기업청
Small and Medium Business Administration

등록번호

TRKO201800012406

과제고유번호

1425075903

사업명

중소기업기술혁신개발

DB 구축일자

2018-07-14

키워드

더덕.폐질환.면역증강.기능식품.

표 Kind of mushroom mycelium and binomial nomenclature
표 Operation conditions of ICP analysis
표 Operation conditions of mercury analysis
표 General characteristic of instrumental analysis
표 General characteristic of instrumental analysis
표 Structures of Oleanolic acid and Friedelin
표 General characteristic of instrumental analysis
표 General characteristic of instrumental analysis
표 Structures of platycodin D(MW=1225.34)
표 General characteristic of instrumental analysis
표 Structures of eleutheroside B(MW=372.37) and eleutheroside
표 General characteristic of instrumental analysis
표 Test group configuration and dose of the test group
표 Ingredient formula of fermented deodeok tea
표 Ingredient formula of fermented deodeok granule tea
표 Ingredient formula of fermented deodeok pildora tea
표 Mushroom mycelium that grow in brown rice
표 Deodeok fermentation that use fermented brown-rice
표 Growing mushrooms on root-crop cake a. Doragi, b. Deodeok
표 Mycelium growth photograph by kind of medium
표 The growth of the mushroom mycelium on the deodeok juice agar plate
표 The growth of the mushroom mycelium on the deodeok juice agar plate.
표 The growth of the mushroom mycelium at different temperatures on the D deodeok juice agar plate
표 The growth of the mushroom mycelium at different pH on the deodeok juice agar plate
표 Growth rate of mushroom for 17 days cultivation in different concentration deodeok juice medium
표 Variation of total sugar in different concentration deodeok juice medium
표 Variation of reducing sugar in different concentration deodeok juice medium
표 Variation of total protein(Secretion protein) in different concentration deodeok juice medium
표 Total polyphenol contents in different concentration deodeok juice medium
표 Total flavonoid contents in different concentration deodeok juice medium
표 DPPH radical scavenging activity in different concentration deodeok juice medium
표 Mycelial growth on the root vegetables with the coating polymer
표 Total sugar and reducing sugar of hot water and 80% ethanol extracts from the cultured Codonopsis lanceolatawith #232(Ganoderma lucidum) strain mycelium
표 Total protein of hot water and 80% ethanol extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 Total flavonoid contents of hot water and 80% ethanol extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 DPPH radical scavenging activity of hot water and 80% ethanol extracts from the cultured Codonopsis lanceolatawith #232(Ganoderma lucidum) strain mycelium
표 POV of hot water and 80% ethanol extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 Mycelial growth on the deodeok coated with 4% dextrin
표 Mycelial growth on the deodeok coated with 4% starch (The photo above is #232)
표 Mushroom mycelial growth on wheat flour-coated deodeok
표 Total sugar of water and various ethanol extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 Reducing sugar of water and various ethanol extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 Protein contents of water and various ethanol extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 Total polyphenol contents of water and various ethanol extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 Total flavonoid contents of water and various ethanol extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 DPPH radical scavenging activity of (a)water and ethanol extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium (b) Difference of inhibition level by extract concentration
표 POV of water and various ethanol extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 Effect of IC 50 concentration of DPPH radical scavenging activity of various extracts from the cultured (a)Codonopsis lanceolata & (b)Platycodon grandiflorum & (C)Acanthopanax koreanum with #232 strain mycelium
표 FRAP of various extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 FRAP of various extracts from the cultured (a)Codonopsis lanceolata & (b)Platycodon grandiflorum & (C)Acanthopanax koreanum with #232 (Ganoderma lucidum) strain mycelium
표 ABTS of various extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 ABTS radical scavenging activity of various extracts from the cultured (a)Codonopsis lanceolata & (b)Platycodon grandiflorum & (C)Acanthopanax koreanum with #232 (Ganoderma lucidum) strain mycelium
표 Phosphomolybdenum of various extracts from the cultured Codonopsis lanceolatawith #232 strain mycelium
표 Crude saponin content of fermented Root-crop
표 Crude saponin content of fermented root-crop
표 Changes of codonoside content by mushroom mycelial fermentation on deodeok
표 Changes of codonoside content by #232 strain mycelial fermentation on deodeok
표 Chromatogram of water-extract by #232 strain mycelial fermentation on deodeok. Fermentation before & after overlay chromatogram(Blue : fermentation after, Black: fermentation before)
표 Chromatogram of 50% EtOH-extract by #232 strain mycelial fermentation on deodeok. Fermentation before & after overlay chromatogram(Blue : fermentation after, Black: fermentation before)
표 Chromatogram of 100% EtOH-extract by #232 strain mycelial fermentation on deodeok. Fermentation before & after overlay chromatogram(Blue :fermentation after, Black: fermentation before)
표 GC-MS Scan chromatogram of deodeok.
표 GC-MS Scan chromatogram of water-extract by #232 strain mycelial fermentation on deodeok.
표 Platycodin D standard curve
표 Platycodin D content of fermented doragi
표 UPLC chromatogram of water-extract of doragi.
표 UPLC chromatogram of water-extract by #232 strain mycelial fermentation of doragi.
표 UPLC chromatogram of EtOH-extract of doragi.
표 UPLC chromatogram of EtOH-extract by #232 strain mycelial fermentation of doragi.
표 Cell viability of A549 cell for extract of solvent of Codonopsis lanceolata infected and non-infected mushroom mycelium
표 Cell viability of A549 cell for concentration of solvent extract of Codonopsis lanceolata infected and non-infected Ganoderma lucidum
표 Shape of A549 cell by concentration of extract
표 Cell viability of HepG2 cells origenating in hepatoma cell that use mushroom fermentation extract
표 Inhibition of RAW264.7 macrophage cell for extract of solvent of each infected and non-infected Ganoderma lucidum
표 Growth Inhibition of RAW264.7 macrophage cell for concentration of water extract of fermented deodeok
표 Inhibitory effects on NO production of solvent extracts from Codonopsis lanceolata infected and non-infected Ganoderma lucidum in LPS-induced RAW264.7 cells. All values are mean±SD(n=3)
표 Mushroom mycelium grown in the deodeok #028(Pleurotus eryngii), #373(Schizophyllum commune), #226(Cordyceps Militalis) strains
표 Total sugar and reducing sugar of hot water, 50% ethanol and 80% ethanol extracts from the cultured Codonopsis lanceolata with mushroom. #028: Pleurotus eryngii #226: Cordyceps Militalis #373: Schizophyllum commune
표 Protein contents of hot water, 50% ethanol and 80% ethanol extracts the cultured Codonopsis lanceolata with mushroom. #028: Pleurotus eryngii #226:Cordyceps Militalis #373: Schizophyllum commune:
표 Total polyphenol contents of hot water, 50% ethanol and 80% ethanol extracts from the cultured Codonopsis lanceolata with mushroom. #028: Pleurotus eryngii #226: Cordyceps Militalis #373: Schizophyllum commune
표 DPPH radical scavenging activity of hot water, 50% ethanol and 80% ethanol extracts from the cultured Codonopsis lanceolata with mushroom. #028: Pleurotus eryngii #226: Cordyceps Militalis #373: Schizophyllum commune
표 Crude saponin content of fermented root-crop by mushroom
표 Crude fiber & dietary fiber content of fermented root-crop by mushroom
표 Changes in organic acid contents of deodeok and doragi by fermentation
표 Body weights of rats administered with fermented deodeok extracts
표 GPT, GOT anf ALP activities in serum of rats administered with fermented deodeok extracts
표 Total sugar of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Reducing sugar of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Protein of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Total polyphenol contents of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Total flavonoid contents of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 DPPH radical scavenging activity of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 ABTS radical scavenging activity of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 FRAP of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Reducing power of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Superoxide radical(SOR) of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Oxygen radical scavenging activity of various extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Yield of hot water extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Total sugar of hot water extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Reducing sugar of hot water extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Protein of hot water extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Total polyphenol contents of hot water extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Total flavonoid contents of hot water extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 DPPH IC50 of hot water extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 FRAP of hot water extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Reducing power of hot water extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Yield of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Moisture of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 pH of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Ash of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Oganic acid of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Crude and dietary fiber of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Nucleotide of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Total sugar of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Reducing sugar of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Protein of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Total polyphenol contents of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Total flavonoid contents of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Crude saponin of control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 β-glucan of control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 β-glucan of fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Inulin of control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Inulin of control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 UPLC Chromatogram of water-extract of deodeok and fermented deodeok
표 UPLC Chromatogram of E50%-extract of deodeok and fermented deodeok
표 UPLC Chromatogram of E100%-extract of deodeok and fermented deodeok
표 UPLC Chromatogram of deodeok and fermented deodeok (water extract : black, 50% EtOH extract : violet, 100% EtOH : green)
표 UPLC Chromatogram of deodeok and fermented deodeok with #028(Pleurotus eryngii) strain mycelium (water extract : black, 50% EtOH extract : violet, 100% EtOH : green)
표 UPLC Chromatogram of deodeok and fermented deodeok with #226(Cordyceps Militalis) strain mycelium (water extract : black, 50% EtOH extract : violet, 100% EtOH : green)
표 UPLC Chromatogram of deodeok and fermented deodeok with #231(Ganoderma lucidum) strain mycelium (water extract : black, 50% EtOH extract : violet, 100% EtOH : green)
표 UPLC Chromatogram of deodeok and fermented deodeok with #373(Schizophyllum commune) strain mycelium (water extract : black, 50% EtOH extract : violet, 100% EtOH : green)
표 Oleanolic acid standard curve
표 Oleanolic acid standard calibration data
표 Oleanolic acid of the control and fermented Codonopsis lanceolate with #028(Pleurotus eryngii), #226(Cordyceps Militalis), #231(Ganoderma lucidum), #373(Schizophyllum commune) strains mycelium
표 Oleanolic acid of various extracts from the control and fermented Codonopsis lanceolate with #028(Pleurotus eryngii), #226(Cordyceps Militalis), #231(Ganoderma lucidum), #373(Schizophyllum commune) strains mycelium
표 Mass ion chromatogram of oleanolic acid standard.
표 Mass chromatogram of oleanolic acid standard.
표 Mass chromatogram of deodeok and fermented deodeok
표 Mass chromatogram of water, E50 and E100% extract of control deodeok
표 Mass chromatogram of water, E50 and E100% extract of fermented deodeok with #028 strain mycelium
표 Mass chromatogram of water, E50 and E100% extract of fermented deodeok with #226 strain.
표 Mass chromatogram of water, E50 and E100% extract of fermented deodeok with #231 strain.
표 Mass chromatogram of water, E50 and E100% extract of fermented deodeok with #373 strain.
표 DPPH radical scavenging activity of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 FRAP of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Reducing power of 50% ethanol extracts from the control and fermented Codonopsis lanceolate with #028, #226, #231, #373 strains.
표 Cell viability of A549 cell for concentration of various extract of Codonopsis lanceolata infected and non-infected mushroom mycelium.(a) dW, (b)infected and non-infected mushroom mycelium.(a) dW, (b)
표 Cell inhibition rate of A549 cell of survival rate for water, E50% and E100% extract of solvent of Codonopsis lanceolata infected and non-infected mushroom mycelium
표 Cell viability of HepG2 cell of survival rate for water, E50% and E100% extract of solvent of Codonopsis lanceolata infected and non-infected mushroom mycelium
표 Inhibition of RAW264.7 macrophage cell for concentration of water extract of Codonopsis lanceolata infected and non-infected mushroom mycelium. (a) dW, (b) EtOH 50%, (c) EtOH 100%. The data were expressed as the mean ± S.D. (n=3).
표 Nitric oxide inhibition activity for water, E50% and E100% extract of solvent of Codonopsis lanceolata infected and non-infected mushroom mycelium
표 Nitric oxide inhibition activity for water extract of Codonopsis lanceolata infected and non-infected #373 strain
표 Histopathological results of unfermented deodeok and #028 sample
표 Histopathological results of #226, #231 and #373 sample.
표 Staining observations of PAS of unfermented deodeok and #028 sample.
표 Staining observations of PAS of #226, #231 and #373 sample.
표 Distribution pattern observations of eosinophil of unfermented deodeok and #028 sample.
표 Distribution pattern observations of eosinophil of #226, #231 and #373 sample.
표 Immunostaining observations of CD4 T cell.
표 Immunostaining observations of CD8 T cell.
표 Immunostaining observations of CD68+ macrophage.
표 Immunostaining observations of syndecan-plasma cell.
표 Expression of results of cytokine.
표 Development process of leached tea.
표 Ingredient formula of fermented deodeok tea
표 Addition rate of fermented deodeok tea
표 Browning degree and turbidity of cultured deodeok tea with Pleurotus eryngii mycelia roasted under various manufacturing conditions
표 pH and reducing sugar of cultured deodeok tea with Pleurotus eryngii mycelia roasted under various manufacturing conditions
표 Total polyphenol contents of cultured deodeok tea with Pleurotus eryngii mycelia roasted under various manufacturing conditions
표 Total flavonoid contents of cultured deodeok tea with Pleurotus eryngii mycelia roasted under various manufacturing conditions
표 DPPH radical scavenging activity of cultured deodeok tea with Pleurotus eryngii mycelia roasted under various manufacturing conditions
표 FRAP of cultured deodeok tea with Pleurotus eryngii mycelia roasted under various manufacturing conditions
표 Reducing power of cultured deodeok tea with Pleurotus eryngii mycelia roasted under various manufacturing conditions
표 Preference for color, flavor, taste and overall acceptance of fermented deodeok tea with Pleurotus eryngii mycelia roasted under various manufacturing conditions
표 Browning degree and turbidity of cultured deodeok tea with Cordyceps Militalis mycelia roasted under various manufacturing conditions
표 pH and reducing sugar of cultured deodeok tea with Cordyceps Militalis mycelia roasted under various manufacturing conditions
표 Total polyphenol and flavonoid contents of cultured deodeok tea with Cordyceps Militalis mycelia roasted under various manufacturing conditions
표 DPPH radical scavenging activity of cultured deodeok tea with Cordyceps Militalis mycelia roasted under various manufacturing conditions
표 FRAP of cultured deodeok tea with Cordyceps Militalis mycelia roasted under various manufacturing conditions
표 Reducing power of cultured deodeok tea with Cordyceps Militalis mycelia roasted under various manufacturing conditions
표 Preference for color, flavor, taste and overall acceptance of fermented conditions
표 Browning degree, turbidity, pH and reducing sugar of fermented deodeok tea with Ganoderma lucidum mycelia roasted under various manufacturing conditions
표 Total polyphenol and flavonoid contents of fermented deodeok tea with Ganoderma lucidum mycelia roasted under various manufacturing conditions
표 DPPH radical scavenging activity, FRAP and reducing power of fermented deodeok tea with Ganoderma lucidum mycelia roasted under various manufacturing conditions
표 Preference for color, flavor, taste and overall acceptance of fermented deodeok tea with Ganoderma lucidum mycelia roasted under various manufacturing conditions
표 Browning degree, turbidity, pH, reducing sugar of cultured deodeok tea with Schizophyllum commune mycelia roasted under various manufacturing conditions
표 Total polyphenol and flavonoid contents of cultured deodeok tea with Schizophyllum commune mycelia roasted under various manufacturing conditions
표 DPPH radical scavenging activity, FRAP and reducing power of cultured deodeok tea with Schizophyllum commune mycelia roasted under various manufacturing conditions
표 Preference for color, flavor, taste and overall acceptance of fermented deodeok tea with Ganoderma lucidum mycelia roasted under various manufacturing conditions
표 Total sugar, reducing sugar and protein of cultured deodeok tea with 4 kinds of mycelia
표 Total polyphenol and flavonoid and DPPH radical scavenging activity of cultured deodeok tea with 4 kinds of mycelia
표 Material extract of granule tea.
표 Development process of granule tea.
표 Recipe development process of granule tea
표 Total sugar, reducing sugar and protein of cultured deodeok granule tea with 4 kinds of mycelia
표 Total polyphenol and flavonoid and DPPH radical scavenging activity of cultured deodeok granule tea with 4 kinds of mycelia
표 Development process of pill.
표 Recipe development process of pill
표 Total sugar, reducing sugar and protein of cultured deodeok pildora with 4 kinds of mycelia
표 Total polyphenol and flavonoid and DPPH radical scavenging activity of cultured deodeok pildora tea with 4 kinds of mycelia

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